Is Lactoflavin safe in cosmetics?
Lactoflavin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Lactoflavin
Also known as: Riboflavin (vitamin B2), Vitamin B2 (riboflavin), Aqua-Flave, Benzo(g)pteridine-2,4(3H,10H)-dione, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-, Dermadram (+15 more)
INCI: LACTOFLAVIN
Lactoflavin (CAS 83-88-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; colorant (CI 75170). NOAEL 160 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 83-88-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent; colorant (CI 75170)
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FDA lists riboflavin as exempt from certification under 21 CFR 73; also GRAS as food additive (21 CFR 184.1695)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lactoflavin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Lactoflavin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 25 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Routes of Exposure
The substance can be absorbed into the body by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Lactoflavin across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
4 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOAEL | =160 mg/kg-day | Rat | oral | subchronic | EFSA |
| ADI | <=0.5 mg/kg | Human | oral | - | WHO JECFA ADI |
| LD50 | >10000 mg/kg | Rat | oral | - | ChemIDplus |
| LD50 | >40000 mg/kg | Rat | oral | - | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Flavouring and nutrient
Pharmaceutical
Softener and conditioner
Regulatory List Membership (3)
EU Regulated in Personal Care
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Lactoflavin.
Regulatory Flags
colorant
fda_food_additive
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Lactoflavin by CAS number or substance name.
Studies
3
Lowest NOAEL
25 mg/kg bw/day
Highest NOAEL
400 mg/kg bw/day
COSMOS_DB
Known Synonyms
Riboflavin (vitamin B2)
Vitamin B2 (riboflavin)
Aqua-Flave
Benzo(g)pteridine-2,4(3H,10H)-dione, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-
Dermadram
EINECS 201-507-1
Fiboflavin
Hyflavin
Isoalloxazine, 7,8-dimethyl-10-D-ribityl-
Isoalloxazine, 7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-
D-Ribitol, 1-deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo(g)pteridin-10(2H)-yl)-
Riboflavinequinone
Vitamin Bi
Riboflavinum
UNII-TLM2976OFR
1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
6,7-Dimethyl-9-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)-Benzo[g]pteridine-2,4(3H,10H)-dione
7,8-dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione
7,8-dimethyl-10-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]-2H,3H,4H,10H-benzo[g]pteridine-2,4-dione
Chemical Function
Dye
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
general_foods
pharmaceutical
Europe; supplements
Europe; food_additive; supplements
Europe; Personal care
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
RIBOFLAVIN
ChEMBL ID
CHEMBL1534
Max Phase
4
Adverse Event Associations
4115
Frequently Asked Questions
Is Lactoflavin allowed in the EU?
Lactoflavin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lactoflavin do in cosmetics?
Lactoflavin functions as: Skin conditioning agent; colorant (CI 75170). It is classified as a cosmetic ingredient in our database. CAS number: 83-88-5.
What is the NOAEL for Lactoflavin?
The NOAEL (No Observed Adverse Effect Level) for Lactoflavin is 25 mg/kg bw/day based on a Subchronic study via oral route in dog. A total of 3 study endpoints are available. Source: COSMOS_DB.
Is Lactoflavin used outside cosmetics?
Lactoflavin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Lactoflavin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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