Is L-Tyrosine safe in cosmetics?
L-Tyrosine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
L-Tyrosine
Also known as: (S)-alpha-Amino-4-hydroxybenzenepropanoic acid, alpha-Amino-4-hydroxybenzenepropanoic acid, (S)-, alpha-Amino-p-hydroxyhydrocinnamic acid, (-)-, L-2-Amino-3-p-hydroxyphenylpropanoic acid, 2-Amino-3-(4-hydroxyphenyl)propanoic acid, (S)- (+14 more)
INCI: TYROSINE
L-Tyrosine (CAS 60-18-4) is a cosmetic cosmetic ingredient functioning as Antistatic, Hair conditioning, Skin conditioning, Masking, Fragrance. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 60-18-4 →
Auto-generated CPSR Part A draft with source citations
Function
Antistatic, Hair conditioning, Skin conditioning, Masking, Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
InChIKey
OUYCCCASQSFEME-QMMMGPOBSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA cosmetic restrictions; used in suntan accelerators and skin-bronzing products; standard amino acid
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for L-Tyrosine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for L-Tyrosine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Neurotoxicity | COSMOS_DB |
| NOAEL | 618 mg/kg bw/day | oral | rat | Neurotoxicity | COSMOS_DB |
| NOAEL | =200 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =600 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for L-Tyrosine across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
4 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >618 mg/kg | Rat | oral | - | ECHA IUCLID |
| NOAEL | =200 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =600 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"cas_number": "60-18-4", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_ac…
anti_aging
{"anti_aging_claim": "brightening precursor", "mechanism_of_action": "Building block for proteins, NMF component", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "4-8", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Int J Cosmet Sci", "impro…
self_tanning
{"cas_number": "60-18-4", "ingredient_class": "tan_accelerator", "tanning_mechanism": "melanin_stimulation", "color_development_onset_hours": "48.0", "full_color_development_hours": "168", "color_duration_days": "14", "color_depth": "adjustable", "undertone": "natural", "color_uniformity": "excellent", "fade_pattern": "even", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_p…
sensory
{"silky": "powdery", "smooth, glides easily": "smooth, melanin precursor", "dry-touch, non-greasy": "protected, even", "instant": "moderate", "low": "low", "w/o": "o/w", "very-high": "moderate", "no": "no", "yes": "no", "1.40": "1.46", "transparent": "opaque", "colorless": "white", "excellent": "fair", "light": "light", "synthetic": "biotechnology"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (2)
JECFA Number
1434
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
L-TYROSINE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | Not evaluated using the Procedure for the Safety Evaluation of Flavouring Agents; the substance is a macronutrient and a normal component of protein and, as such, human exposure through food is orders of magnitude higher than the anticipated level of exposure from use as a flavouring agent | TRS 928
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Deodorizer
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for L-Tyrosine.
Regulatory Flags
amino-acid
skin-conditioning
antistatic
hair-conditioning
melanin-modulator
tanning
brightening
eu_children_restricted
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to L-Tyrosine by CAS number or substance name.
Studies
10
Lowest NOAEL
200 mg/kg bw/day
Highest NOAEL
618 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
(S)-alpha-Amino-4-hydroxybenzenepropanoic acid
alpha-Amino-4-hydroxybenzenepropanoic acid, (S)-
alpha-Amino-p-hydroxyhydrocinnamic acid, (-)-
L-2-Amino-3-p-hydroxyphenylpropanoic acid
2-Amino-3-(4-hydroxyphenyl)propanoic acid, (S)-
alpha-Amino-beta-(4-hydroxyphenyl)propionic acid
Benzenepropanoic acid, alpha-amino-4-hydroxy-, (S)-
EINECS 200-460-4
FEMA No. 3736
beta-(p-Hydroxyphenyl)alanine
Tyrosinum
UNII-42HK56048U
(-)-a-Amino-p-hydroxyhydrocinnamate
(-)-a-Amino-p-hydroxyhydrocinnamic acid
(-)-alpha-Amino-p-hydroxyhydrocinnamate
(-)-alpha-amino-p-hydroxyhydrocinnamic acid
(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
(S)-(-)-Tyrosine
(S)-2-Amino-3-(p-hydroxyphenyl)propionate
Chemical Function
Anti-static agent
Deodorizer
Softener and conditioner
Fragrance
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
children; Europe; Personal care
children; Europe; Personal care
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TYROSINE
ChEMBL ID
CHEMBL925
Max Phase
4
Adverse Event Associations
8
Frequently Asked Questions
Is L-Tyrosine allowed in the EU?
L-Tyrosine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Tyrosine do in cosmetics?
L-Tyrosine functions as: Antistatic, Hair conditioning, Skin conditioning, Masking, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 60-18-4.
What is the NOAEL for L-Tyrosine?
The NOAEL (No Observed Adverse Effect Level) for L-Tyrosine is 500 mg/kg bw/day based on a Neurotoxicity study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Is L-Tyrosine used outside cosmetics?
L-Tyrosine also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check L-Tyrosine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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