NOAEL Studies
Cosmetic Ingredient
L-Tryptophan NOAEL Studies
INCI: TRYPTOPHAN
CAS: 73-22-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 1250 | mg/kg bw/day | rat | oral | 546 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 3750 | mg/kg bw/day | mouse | oral | 546 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 5000 | mg/kg bw/day | rat | oral | 45 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 7500 | mg/kg bw/day | mouse | oral | 45 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 400 | mg/kg bw/day | swine | oral | 40 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1600 | mg/kg bw/day | swine | oral | 16 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2000 | mg/kg bw/day | rat | oral | 42 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1153 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 84 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 1 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 200 | mg/kg bw/day | rat | oral | 7 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP_ICE_acute_inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >5.17 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2821; Record_ID=acute_inhalation_931; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021419; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.17; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10835/7/3/3/?documentUUID=ea4468c1-18d2-4b2a-b691-45e810f90e54; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021419; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021419 |
| NTP_ICE_acute_inhalation | LC50 | >5.75 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2822; Record_ID=acute_inhalation_934; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021419; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.75; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10835/7/3/3/?documentUUID=f84ee25e-3f30-46c9-bd85-11fc61540115; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021419; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021419 |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_9787; row=8631; data_type=In Vivo; mixture=Chemical; chemical_name=l-Tryptophan; preferred_name=L-Tryptophan; dtxsid=DTXSID5021419; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021419; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021419; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >16000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_9791; row=8632; data_type=In Vivo; mixture=Chemical; chemical_name=l-Tryptophan; preferred_name=L-Tryptophan; dtxsid=DTXSID5021419; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021419; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021419; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2150 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_9789; row=8633; data_type=In Vivo; mixture=Chemical; chemical_name=l-Tryptophan; preferred_name=L-Tryptophan; dtxsid=DTXSID5021419; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021419; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021419; source_file=acute_oral.xlsx |
NTP_ICE_cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | Top dose | 50000 | ppm | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=5795; Record_ID=cancer_3532; Data_Type=In Vivo; Formulation_Name=L-tryptophan; Mixture=Chemical; DTXSID=DTXSID5021419; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=50000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-071; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr071/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021419; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021419 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=11100; RecordID=ARPathway2016_1518; DatasetName=ARPathway2016; DTXSID=DTXSID5021419; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021419; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021419 |
ToxRefDB_ToxRefDB_v3_pod.csv 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >2500 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 78 week | CHR | study_id=5837; toxval_study_source_id=studyid5837_Adult_F0_F_NA; dose_level=2; study_year=1978; study_citation=NTP_1978_BIOASSAY OF L-TRYPTOPHAN FOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Rats; dsstox_substance_id=DTXSID5021419; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1250 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 78 week | CHR | study_id=5837; toxval_study_source_id=studyid5837_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1978; study_citation=NTP_1978_BIOASSAY OF L-TRYPTOPHAN FOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Rats; dsstox_substance_id=DTXSID5021419; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =3750 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 78 week | CHR | study_id=5839; toxval_study_source_id=studyid5839_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1978; study_citation=NTP_1978_BIOASSAY OF L-TRYPTOPHAN FOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Mice; dsstox_substance_id=DTXSID5021419; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 78 week | CHR | study_id=5837; toxval_study_source_id=studyid5837_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=0; study_year=1978; study_citation=NTP_1978_BIOASSAY OF L-TRYPTOPHAN FOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Rats; dsstox_substance_id=DTXSID5021419; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =2000 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15595366:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1c4af0a268d653a774e05302984d23ec |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =664 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635624:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc396d5704ac4a1262667a41aef55b40 |
ToxValDB_ToxRefDB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | >2500 | mg/kg bw/day | Rat | oral | chronic; 78 weeks | chronic | LONG_REF=NTP_1978_BIOASSAY OF L-TRYPTOPHAN\nFOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Rats; TITLE=BIOASSAY OF L-TRYPTOPHAN\nFOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5837; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ToxRefDB_dup_-_15710060_15710061_15710062_15710063:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_538e9c5c4bd80355505f6dab806de333 |
| ToxValDB_ToxRefDB | LEL | =1250 | mg/kg bw/day | Rat | oral | chronic; 78 weeks | chronic | LONG_REF=NTP_1978_BIOASSAY OF L-TRYPTOPHAN\nFOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Rats; TITLE=BIOASSAY OF L-TRYPTOPHAN\nFOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5837; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710064_15710065_15710066:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_411c22b52323c12b3ae95125c91f2b86 |
| ToxValDB_ToxRefDB | LEL | =3750 | mg/kg bw/day | Mouse | oral | chronic; 78 weeks | chronic | LONG_REF=NTP_1978_BIOASSAY OF L-TRYPTOPHAN\nFOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Mice; TITLE=BIOASSAY OF L-TRYPTOPHAN\nFOR POSSIBLE CARCINOGENICITY CAS No. 73-22-3_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5839; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710067_15710068:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b061ffbd09b8a2a59480f6f0fc6a2357 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 8DUH1N11BX | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H12N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8DUH1N11BX"} |
| openFDA substances | FDA UNII substance identifier | 8DUH1N11BX | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H12N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8DUH1N11BX"} |
| openFDA substances | FDA UNII substance identifier | 8DUH1N11BX | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H12N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8DUH1N11BX"} |
| openFDA substances | FDA UNII substance identifier | 8DUH1N11BX | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H12N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8DUH1N11BX"} |