NOAEL Studies Cosmetic Ingredient

L-Serine NOAEL Studies

INCI: SERINE

CAS: 56-45-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =2765 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c9366; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5558/7/6/2?documentUUID=b8f95adc-97a2-464e-84cc-711ec8a5b0f9; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15847593:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_36ca2f6a74fd62e5076e9d5d728271b8
ToxValDB_ECHA_IUCLID NOAEL =2905.1 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c9366; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5558/7/6/2?documentUUID=b8f95adc-97a2-464e-84cc-711ec8a5b0f9; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15849039:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f1a36eebc6d169c3cd7fc31eb741c272
ToxValDB_ECHA_IUCLID NOEL =799.9 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c9357; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5558/7/6/2?documentUUID=b8f95adc-97a2-464e-84cc-711ec8a5b0f9; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15849563:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cc909bfa7888b3b2421c282a0b1f3ca9
ToxValDB_ECHA_IUCLID NOEL =903.9 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c9357; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5558/7/6/2?documentUUID=b8f95adc-97a2-464e-84cc-711ec8a5b0f9; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15849564:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c5811dc9515bd7fa763b2e8788aafd07
ToxValDB_ECHA_IUCLID NOEL =3000 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c9360; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5558/7/6/2?documentUUID=b8f95adc-97a2-464e-84cc-711ec8a5b0f9; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15849565:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f8b32d1e7e68818f8a58bc3f7d95c4d5
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =529 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634612:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_20c44ec36326beb1c05472cd3bf30a66
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 452VLY9402 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H7NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"452VLY9402"}
openFDA substances FDA UNII substance identifier 452VLY9402 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H7NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"452VLY9402"}
openFDA substances FDA UNII substance identifier 452VLY9402 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H7NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"452VLY9402"}
openFDA substances FDA UNII substance identifier 452VLY9402 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H7NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"452VLY9402"}