NOAEL Studies Cosmetic Ingredient

L-Hydroxyproline NOAEL Studies

INCI: HYDROXYPROLINE

CAS: 51-35-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL >4000 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae5ae4b0a7c65d1c8bf2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25734/7/6/2?documentUUID=2bed568f-434c-49b1-9c95-9cebc64ed219; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=kidney: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833491_15833492:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7515b27dc48740e9f7f88f74df0f9d1f
ToxValDB_ECHA_IUCLID NOAEL =200 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae5ae4b0a7c65d1c8bf2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25734/7/6/2?documentUUID=2bed568f-434c-49b1-9c95-9cebc64ed219; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=kidney: body weight and weight gain|food consumption and compound intake|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833491_15833492:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef5c8c39952ecf0eed7a1ecb8f829ab2
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier RMB44WO89X UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RMB44WO89X"}
openFDA substances FDA UNII substance identifier RMB44WO89X UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RMB44WO89X"}
openFDA substances FDA UNII substance identifier RMB44WO89X UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RMB44WO89X"}
openFDA substances FDA UNII substance identifier RMB44WO89X UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RMB44WO89X"}