Is Keratin Hydrolysate safe in cosmetics?
Keratin Hydrolysate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Keratin Hydrolysate
INCI: HYDROLYZED KERATIN
Keratin Hydrolysate (CAS 69430-36-0) is a cosmetic cosmetic ingredient functioning as Hair Conditioning, Skin Conditioning, Film Forming, Moisturizing. EU Regulation 1223/2009 status: permitted.
CAS Number
69430-36-0
Function
Hair Conditioning, Skin Conditioning, Film Forming, Moisturizing
Safety Rating
GOOD
Regulatory Status
🇪🇺 EU Status
permitted
🇺🇸 US Status
permitted
US Notes
CIR assessed as safe; animal-derived (wool, feather, porcine); human-hair origin restricted in EU unless hydrolyzed under specific acid conditions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Keratin Hydrolysate - available to Pro subscribers.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Keratin Hydrolysate, relevant to systemic exposure and MoS calculations.
Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
Variable Da
Log P
n/a
Systemic Absorption
minimal
Topical Bioavailability
0.5-2%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: CIR
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Conditioner | 0.5–2 | 5 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
amino_acid
{"cas_number": "69430-36-0", "ingredient_class": "keratin_derivative", "source_origin": "animal", "molecular_weight_range_Da": "1000-10000", "amino_acid_composition_key": "cysteine_rich_keratin", "isoelectric_point": "5.0", "charge_at_pH_5_5": "zwitterionic", "water_solubility": "soluble", "oil_solubility": "insoluble", "film_forming_ability": "excellent", "moisture_binding_capacity": "excellent",…
anti_pollution
{"cas_number": "69430-36-0", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibit…
baby_pediatric
{"cas_number": "69430-36-0", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "6", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Protein, hair/skin", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Protein fragments…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,dry,combination,normal", "acne_safe": "yes", "source": "Protein"}
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "10.0", "typical_concentration_pct": "5.0", "product_type": "Hair Mask", "function_at_concentration": "Intensive protein repair", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "35", "estimated_cost_per_kg_usd_high": "65", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "medium", "primary_source_region": "New Zealand/US", "bulk_discount_threshold_kg": "50", "seasonal_price_variation": "medium", "commodity_or_specialty": "specialty", "substitute_ingredients": "S…
dermal_absorption
{"molecular_weight_da": "Variable", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "1-3", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.5-2", "safety_margin_factor": "low", "source": "CIR"}
hair_care
{"hair_function": "protein-treatment", "hair_type_suitability": "medium/coarse", "curl_pattern_suitability": "all", "porosity_suitability": "high", "protein_sensitivity": "protein", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Binder
Film former
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Keratin Hydrolysate - available to Pro subscribers.
Regulatory Flags
animal-derived
film-forming
hair-repair
eu-source-restriction
Frequently Asked Questions
Is Keratin Hydrolysate allowed in the EU?
Keratin Hydrolysate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Keratin Hydrolysate do in cosmetics?
Keratin Hydrolysate functions as: Hair Conditioning, Skin Conditioning, Film Forming, Moisturizing. It is classified as a cosmetic ingredient in our database. CAS number: 69430-36-0.
Compliance Tools
Check Keratin Hydrolysate compliance across multiple jurisdictions:
🔬
🌸
🧪
🧮
⚗️
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
📱
Is Keratin Hydrolysate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Keratin Hydrolysate in your formulation.