Is Isopropylacrylamide safe in cosmetics?
Isopropylacrylamide has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Isopropylacrylamide
Also known as: 4-04-00-00517, BRN 1744926, EINECS 218-638-5, Isopropyl acrylamide, Isopropylamid kyseliny akrylove (+1 more)
INCI: ISOPROPYLACRYLAMIDE
Isopropylacrylamide (CAS 2210-25-5) is a cosmetic cosmetic ingredient functioning as Monomer / film-forming / hair-fixing (used as building block for poly(NIPAM). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2210-25-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isopropylacrylamide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H318, H319, H312, H373).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Monomer / film-forming / hair-fixing (used as building block for poly(NIPAM) polymers)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
N-propan-2-ylprop-2-enamide
InChIKey
QNILTEGFHQSKFF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Allowed as a cosmetic ingredient; FDA does not specifically prohibit it but residual acrylamide monomer concerns apply
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropylacrylamide.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Isopropylacrylamide.
Known Synonyms
4-04-00-00517
BRN 1744926
EINECS 218-638-5
Isopropyl acrylamide
Isopropylamid kyseliny akrylove
UNII-B7GFF17L9U
Chemical Function
No specific technical function
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1527236
Frequently Asked Questions
Is Isopropylacrylamide allowed in the EU?
Isopropylacrylamide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropylacrylamide do in cosmetics?
Isopropylacrylamide functions as: Monomer / film-forming / hair-fixing (used as building block for poly(NIPAM) polymers). It is classified as a cosmetic ingredient in our database. CAS number: 2210-25-5.
Is Isopropylacrylamide used outside cosmetics?
Isopropylacrylamide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isopropylacrylamide have different safety status in cosmetics vs industrial chemicals?
Isopropylacrylamide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H318, H319, H312, H373).
Compliance Tools
Check Isopropylacrylamide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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