NOAEL Studies Emollient

Isopropyl Palmitate NOAEL Studies

INCI: ISOPROPYL PALMITATE

CAS: 142-91-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_skin_irritation 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Positive reaction 0 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=1864; Record_ID=skin_irritation_invivo_39; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9027104; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027104
NTP_ICE_skin_irritation Viability 97.4 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=6006; Record_ID=skin_irritation_invitro_641; Data_Type=In Vitro; Formulation_Name=Isopropyl palmitate; Concentration=99.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9027104; Assay=EpiDerm Irritation; Endpoint=Viability; Response=97.4; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027104
NTP_ICE_skin_irritation Viability 103.6 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=6003; Record_ID=skin_irritation_invitro_646; Data_Type=In Vitro; Formulation_Name=Isopropyl palmitate; Concentration=99.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9027104; Assay=EpiDerm Irritation; Endpoint=Viability; Response=103.6; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027104
NTP_ICE_skin_irritation Viability 104.32 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=6002; Record_ID=skin_irritation_invitro_639; Data_Type=In Vitro; Formulation_Name=Isopropyl palmitate; Concentration=90; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9027104; Assay=EpiSkin Irritation; Endpoint=Viability; Response=104.32; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027104
NTP_ICE_skin_irritation Viability 104.83 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=6005; Record_ID=skin_irritation_invitro_640; Data_Type=In Vitro; Formulation_Name=Isopropyl palmitate; Concentration=90; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9027104; Assay=EpiSkin Irritation; Endpoint=Viability; Response=104.83; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027104
NTP_ICE_skin_irritation Viability 122.3 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=6004; Record_ID=skin_irritation_invitro_648; Data_Type=In Vitro; Formulation_Name=Isopropyl palmitate; Concentration=99.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9027104; Assay=EpiDerm Irritation; Endpoint=Viability; Response=122.3; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027104
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5471; Record_ID=skin_sensitization_invivo_1273; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9027104; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1978: report to RIFM|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027104
NTP_ICE_skin_sensitization Induction dose per skin area 5400 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5469; Record_ID=skin_sensitization_invivo_1273; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9027104; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5400; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1978: report to RIFM|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027104
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5475; Record_ID=skin_sensitization_invivo_1273; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9027104; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1978: report to RIFM|Anonymous 1982; Not available; 10.1016/S0015-6264(82)80217-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027104
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =25.85 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632911:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_777c5d4ba1398e026289196cb2e85ba9
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8CRQ2TH63M UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H38O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8CRQ2TH63M"}
openFDA substances FDA UNII substance identifier 8CRQ2TH63M UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H38O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8CRQ2TH63M"}
openFDA substances FDA UNII substance identifier 8CRQ2TH63M UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H38O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8CRQ2TH63M"}
openFDA substances FDA UNII substance identifier 8CRQ2TH63M UNII - - - chemical {"approval_status":null,"molecular_formula":"C19H38O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8CRQ2TH63M"}