NOAEL Studies
Cosmetic Ingredient
ISOPHTHALIC ACID NOAEL Studies
CAS: 121-91-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >11.37 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1942; Record_ID=acute_inhalation_2498; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3021485; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=11.37; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15373/7/3/3/?documentUUID=e3bae00c-6609-41c9-9ed8-2194034b71f1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021485 |
NTP_ICE_acute_oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1705; row=5514; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Benzenedicarboxylic acid; preferred_name=1,3-Benzenedicarboxylic acid; dtxsid=DTXSID3021485; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021485; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =10400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1707; row=5515; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Benzenedicarboxylic acid; preferred_name=1,3-Benzenedicarboxylic acid; dtxsid=DTXSID3021485; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021485; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =12200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1711; row=5516; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Benzenedicarboxylic acid; preferred_name=1,3-Benzenedicarboxylic acid; dtxsid=DTXSID3021485; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021485; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =13000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1712; row=5517; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Benzenedicarboxylic acid; preferred_name=1,3-Benzenedicarboxylic acid; dtxsid=DTXSID3021485; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021485; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =10900 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1709; row=5518; data_type=In Vivo; mixture=Chemical; chemical_name=1,3-Benzenedicarboxylic acid; preferred_name=1,3-Benzenedicarboxylic acid; dtxsid=DTXSID3021485; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021485; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 1.44 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=1185; Record_ID=adme_parameters_1396; Data_Type=Measured; DTXSID=DTXSID3021485; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=1.44; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Black 2021; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021485 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=644; RecordID=ARPathway2016_693; DatasetName=ARPathway2016; DTXSID=DTXSID3021485; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021485 |
ToxValDB_ECHA_IUCLID 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEC | =9.07 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d199e4b0a7c65d22f44e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6788/7/9/3?documentUUID=4db89720-96ac-4d02-ac73-4139f0f235bb; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15821067:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58930c08cd18c96ba9ca194a458e434e |
| ToxValDB_ECHA_IUCLID | NOAEC | =9.59 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6788/7/6/3?documentUUID=4db89720-96ac-4d02-ac73-4139f0f235bb; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827931_15829156:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f4e383082004ec311ae6cda6098fd05 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =8.8 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632864:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2181e1a1b16bc489547a9229d7743a3e |
ToxValDB_HPVIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | NOAEL | >10 | mg/m3 | Rat | Inhalation | short-term; 10 days | developmental | LONG_REF=ITT Research Institute. 1991. A Segment II Inhalation Teratology Study of Isophthahlic Acid (IPA) in Rats. Study No. 1463.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: February 5, 2007.; QUALITY=1; EXTERNAL_SOURCE_ID=58400; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=HPVIS:15642444:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d5e665e5974f323f87a1a6d075a7ef96 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | X35216H9FJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X35216H9FJ"} |
| openFDA substances | FDA UNII substance identifier | X35216H9FJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X35216H9FJ"} |
| openFDA substances | FDA UNII substance identifier | X35216H9FJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X35216H9FJ"} |
| openFDA substances | FDA UNII substance identifier | X35216H9FJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X35216H9FJ"} |