Is Inositol Hexanicotinate safe in cosmetics?
Inositol Hexanicotinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Inositol Hexanicotinate
Also known as: 5-22-02-00067, BRN 0077649, Dilexpal, EINECS 229-485-9, Esantene (+14 more)
INCI: INOSITOL HEXANICOTINATE
Inositol Hexanicotinate (CAS 6556-11-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning (niacin derivative — vasodilation, barrier support). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
View industrial chemical safety profile for CAS 6556-11-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (niacin derivative — vasodilation, barrier support)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[2,3,4,5,6-pentakis(pyridine-3-carbonyloxy)cyclohexyl] pyridine-3-carboxylate
InChIKey
MFZCIDXOLLEMOO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — also used as a dietary supplement (flush-free niacin); EFSA has assessed oral safety
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Inositol Hexanicotinate.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Inositol Hexanicotinate.
Known Synonyms
5-22-02-00067
BRN 0077649
Dilexpal
EINECS 229-485-9
Esantene
Hexanicit
Hexanicotinoyl inositol
Hexanicotol
Hexopal
Linodil
Mesonex
Mesotal
myo-Inositol hexanicotinate
Palohex
Nicotinato de inositol
Inositoli nicotinas
Inositolo nicotinato
Nicotinate d'inositol
UNII-A99MK953KZ
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
INOSITOL NIACINATE
ChEMBL ID
CHEMBL1094982
Max Phase
2
Adverse Event Associations
3
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Vitamin B3 - Inositol Hexanicotinate
Food Category
vitamins_minerals
Frequently Asked Questions
Is Inositol Hexanicotinate allowed in the EU?
Inositol Hexanicotinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Inositol Hexanicotinate do in cosmetics?
Inositol Hexanicotinate functions as: Skin conditioning (niacin derivative — vasodilation, barrier support). It is classified as a cosmetic ingredient in our database. CAS number: 6556-11-2.
Is Inositol Hexanicotinate used outside cosmetics?
Inositol Hexanicotinate also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Inositol Hexanicotinate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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