NOAEL Studies Cosmetic Ingredient

Imidazole NOAEL Studies

INCI: IMIDAZOLE

CAS: 288-32-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 24 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 150 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7e38df4a-ba11-44e5-950f-7feb5c49a956_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7e38df4a-ba11-44e5-950f-7feb5c49a956/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=25705657-913c-4269-82a3-8392bd3f0dde
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 500 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7e38df4a-ba11-44e5-950f-7feb5c49a956_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7e38df4a-ba11-44e5-950f-7feb5c49a956/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=06a02bd2-cfba-4d44-9596-fe37cc5bc185
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=a483e5da-2375-4a11-a66f-90ff48e99fad_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=a483e5da-2375-4a11-a66f-90ff48e99fad/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-09-05; basis=other:; key_result=false; entry_uuid=b1343f7d-0894-4446-a1a4-954cda1b673a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 1000 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=80ce8fb5-7553-435c-8986-ebddc3447c23_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=80ce8fb5-7553-435c-8986-ebddc3447c23/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2012; ReportDate=2012-12-10; basis=other:; key_result=false; entry_uuid=4a1ff9e1-5b2f-449d-b7b7-fbf3639fd08e
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 125 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=d29b8ed6-dc54-49ec-8faa-94388720cc48_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=d29b8ed6-dc54-49ec-8faa-94388720cc48/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=dff89e17-e6e3-450d-86a8-a94df0d7f5da
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 62.5 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=19f92c3c-fd2b-4e1a-9716-ffc0c92f9e99_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=19f92c3c-fd2b-4e1a-9716-ffc0c92f9e99/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-01-23; key_result=false; entry_uuid=4b143c8f-45da-4187-afcf-6cc7bacb3627
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 90 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=bac6103c-ca1d-4e12-842b-7f8cafe11e29_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=bac6103c-ca1d-4e12-842b-7f8cafe11e29/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; ReportDate=2016-06-20; basis=other:; key_result=false; entry_uuid=02cd87d2-53f0-4dc6-8a16-e19a98603020
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 30 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7ea0e201-ec81-466b-aa5b-e17b86fbbcdf_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7ea0e201-ec81-466b-aa5b-e17b86fbbcdf/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=b85a8906-fe74-4068-82cb-d616ea00215e
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 150 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7e38df4a-ba11-44e5-950f-7feb5c49a956_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7e38df4a-ba11-44e5-950f-7feb5c49a956/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=25705657-913c-4269-82a3-8392bd3f0dde
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 500 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7e38df4a-ba11-44e5-950f-7feb5c49a956_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7e38df4a-ba11-44e5-950f-7feb5c49a956/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=06a02bd2-cfba-4d44-9596-fe37cc5bc185
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=a483e5da-2375-4a11-a66f-90ff48e99fad_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=a483e5da-2375-4a11-a66f-90ff48e99fad/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-09-05; basis=other:; key_result=false; entry_uuid=b1343f7d-0894-4446-a1a4-954cda1b673a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 1000 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=80ce8fb5-7553-435c-8986-ebddc3447c23_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=80ce8fb5-7553-435c-8986-ebddc3447c23/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2012; ReportDate=2012-12-10; basis=other:; key_result=false; entry_uuid=4a1ff9e1-5b2f-449d-b7b7-fbf3639fd08e
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 125 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=d29b8ed6-dc54-49ec-8faa-94388720cc48_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=d29b8ed6-dc54-49ec-8faa-94388720cc48/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=dff89e17-e6e3-450d-86a8-a94df0d7f5da
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 62.5 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=19f92c3c-fd2b-4e1a-9716-ffc0c92f9e99_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=19f92c3c-fd2b-4e1a-9716-ffc0c92f9e99/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-01-23; key_result=false; entry_uuid=4b143c8f-45da-4187-afcf-6cc7bacb3627
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 90 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=bac6103c-ca1d-4e12-842b-7f8cafe11e29_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=bac6103c-ca1d-4e12-842b-7f8cafe11e29/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; ReportDate=2016-06-20; basis=other:; key_result=false; entry_uuid=02cd87d2-53f0-4dc6-8a16-e19a98603020
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 30 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7ea0e201-ec81-466b-aa5b-e17b86fbbcdf_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7ea0e201-ec81-466b-aa5b-e17b86fbbcdf/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=b85a8906-fe74-4068-82cb-d616ea00215e
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 150 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7e38df4a-ba11-44e5-950f-7feb5c49a956_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7e38df4a-ba11-44e5-950f-7feb5c49a956/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=25705657-913c-4269-82a3-8392bd3f0dde
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 500 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7e38df4a-ba11-44e5-950f-7feb5c49a956_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7e38df4a-ba11-44e5-950f-7feb5c49a956/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=06a02bd2-cfba-4d44-9596-fe37cc5bc185
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=a483e5da-2375-4a11-a66f-90ff48e99fad_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=a483e5da-2375-4a11-a66f-90ff48e99fad/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-09-05; basis=other:; key_result=false; entry_uuid=b1343f7d-0894-4446-a1a4-954cda1b673a
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 1000 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=80ce8fb5-7553-435c-8986-ebddc3447c23_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=80ce8fb5-7553-435c-8986-ebddc3447c23/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2012; ReportDate=2012-12-10; basis=other:; key_result=false; entry_uuid=4a1ff9e1-5b2f-449d-b7b7-fbf3639fd08e
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 125 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=d29b8ed6-dc54-49ec-8faa-94388720cc48_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=d29b8ed6-dc54-49ec-8faa-94388720cc48/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=dff89e17-e6e3-450d-86a8-a94df0d7f5da
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 62.5 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=19f92c3c-fd2b-4e1a-9716-ffc0c92f9e99_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=19f92c3c-fd2b-4e1a-9716-ffc0c92f9e99/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-01-23; key_result=false; entry_uuid=4b143c8f-45da-4187-afcf-6cc7bacb3627
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 90 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=bac6103c-ca1d-4e12-842b-7f8cafe11e29_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=bac6103c-ca1d-4e12-842b-7f8cafe11e29/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2016; ReportDate=2016-06-20; basis=other:; key_result=false; entry_uuid=02cd87d2-53f0-4dc6-8a16-e19a98603020
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 30 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=928b7f78-6701-4b13-8717-8a1aa88705a1.i6z; document=7ea0e201-ec81-466b-aa5b-e17b86fbbcdf_928b7f78-6701-4b13-8717-8a1aa88705a1.i6d; document_key=7ea0e201-ec81-466b-aa5b-e17b86fbbcdf/928b7f78-6701-4b13-8717-8a1aa88705a1; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2013; ReportDate=2013-05-29; basis=other:; key_result=false; entry_uuid=b85a8906-fe74-4068-82cb-d616ea00215e
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =220 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_5071; row=4296; data_type=In Vivo; mixture=Chemical; chemical_name=Imidazole; preferred_name=Imidazole; dtxsid=DTXSID2029616; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10568; RecordID=ARPathway2016_1104; DatasetName=ARPathway2016; DTXSID=DTXSID2029616; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616
NTP_ICE_eye_irritation 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation Draize rabbit irritation score 59.3 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=793; Record_ID=eye_irritation_155; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=59.3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616
NTP_ICE_eye_irritation EPA Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=787; Record_ID=eye_irritation_80; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616
NTP_ICE_eye_irritation Intensity 0.26 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=791; Record_ID=eye_irritation_1293; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Vitrigel; Endpoint=Intensity; Response=0.26; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616
NTP_ICE_eye_irritation Lag time 100 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=792; Record_ID=eye_irritation_1293; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Vitrigel; Endpoint=Lag time; Response=100; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616
NTP_ICE_eye_irritation Plateau level 22 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=789; Record_ID=eye_irritation_1293; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2029616; Assay=Vitrigel; Endpoint=Plateau level; Response=22; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029616
ToxValDB_ECOTOX 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =30 mg/L Mouse environmental short-term; 2 days reproduction developmental LONG_REF=Teratology40(6): 555-566 Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors 1989; TITLE=Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors; AUTHOR=Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer; DOI=10.1002/tera.1420400603; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92257; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX:15597694:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ebc5f218f7e6d2b1863d1a51a4649b40
ToxValDB_ECOTOX NOEL =30 mg/L Mouse environmental short-term; 2 days developmental LONG_REF=Teratology40(6): 555-566 Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors 1989; TITLE=Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors; AUTHOR=Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer; DOI=10.1002/tera.1420400603; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92257; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Development: Abnormal|Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX:15595387:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=86e965b6568e74e13d0f9dc880d353b6
ToxValDB_ECOTOX NOEL =210 mg/L Rat environmental short-term; 2 days developmental LONG_REF=Teratology40(6): 555-566 Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors 1989; TITLE=Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors; AUTHOR=Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer; DOI=10.1002/tera.1420400603; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92257; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Development: Abnormal|Morphology: Length|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601040_15601253:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=09f86fbe76aa62ed638a1a71c212211b
ToxValDB_ECOTOX NOEL =60 mg/L Rat environmental short-term; 2 days reproduction developmental LONG_REF=Teratology40(6): 555-566 Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors 1989; TITLE=Difference in Teratogenic Potency of Ethylenethiourea in Rats and Mice: Relative Contribution of Embryonic and Maternal Factors; AUTHOR=Daston,G.P., J.E. Yonker, J.F. Powers, and S.A. Heitmeyer; DOI=10.1002/tera.1420400603; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=92257; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15602124:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=183f2105cdc717bd83181f3c5e4cb1bf
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =10.6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632768:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5248fb6b594a6b0a120ce6ccdb65ce58
ToxValDB_HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HESS NOAEL =60 mg/kg bw/day Rat oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0ddce4b0a676289ddfd9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Deaths: There were no substance-related deaths.|Urinalysis: Transitional epithelial cells increase|Blood Chemistry: Cl decrease, Glob decrease, TP decrease, Alb decrease|Relative Organ Weight: Liver increase, Kidney increase|Histopathology: Liver: Centrilobular hypertrophy Kidney: a2u-microglobulin accumulation, proximal epithelial and luminal tubule, diffuse; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=HESS:15638554:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8d50bc9d7dc8ba0c5c281feb2e642a4f
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 7GBN705NH1 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H4N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7GBN705NH1"}
openFDA substances FDA UNII substance identifier 7GBN705NH1 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H4N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7GBN705NH1"}
openFDA substances FDA UNII substance identifier 7GBN705NH1 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H4N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7GBN705NH1"}
openFDA substances FDA UNII substance identifier 7GBN705NH1 UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H4N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7GBN705NH1"}