NOAEL Studies Cosmetic Ingredient

Hydroxylamine Sulfate NOAEL Studies

INCI: HYDROXYLAMINE SULFATE

CAS: 10039-54-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_skin_irritation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Breakthrough Time 210 min - Dermal - In Vitro; Corrositex sheet=Data_invitro; excel_row=1800; Record_ID=skin_irritation_invitro_103; Data_Type=In Vitro; Concentration=97; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2025424; Assay=Corrositex; Endpoint=Breakthrough Time; Response=210; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025424; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025424
NTP_ICE_skin_irritation GHS classification 1 unitless Rabbit Dermal - In Vivo; Draize Skin Irritation/Corrosion Test sheet=Data_invivo; excel_row=547; Record_ID=skin_irritation_invivo_94; Data_Type=In Vivo; Concentration=>97; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2025424; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=GHS classification; Response=1C; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2002; Not available; https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025424; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025424
ToxValDB_ECHA_IUCLID 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =0.2 mg/kg bw/day Rat oral - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b47cc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16246/7/8?documentUUID=e98b2413-9207-4114-9f2a-76cb82a08f04; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15820226:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b549c48334873f31923aae13c15772c9
ToxValDB_ECHA_IUCLID NOAEL =0.4 mg/kg bw/day Rat oral - chronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b47cc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16246/7/8?documentUUID=e98b2413-9207-4114-9f2a-76cb82a08f04; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15820225:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c6e2100864ead101f9b9865d902b63a6
ToxValDB_ECHA_IUCLID NOAEL >0.9 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc288; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16246/7/6/2?documentUUID=e98b2413-9207-4114-9f2a-76cb82a08f04; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843131_15849892:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3bcd64006eaa448fd306cd5070a67f10
ToxValDB_ECHA_IUCLID NOAEL =3 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf17e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16246/7/9/3?documentUUID=e98b2413-9207-4114-9f2a-76cb82a08f04; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15825204:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5f94d8d28c67fe53419baa4fe449146e
ToxValDB_ECHA_IUCLID NOAEL >=20 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf17e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16246/7/9/3?documentUUID=e98b2413-9207-4114-9f2a-76cb82a08f04; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15825203:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0bcc62605d76d99e605b38f0f7486216
ToxValDB_ECHA_IUCLID NOAEL >=21 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc288; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16246/7/6/2?documentUUID=e98b2413-9207-4114-9f2a-76cb82a08f04; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843131_15849892:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2c28760a7365e8caf2fe1c703d66644d
ToxValDB_ECHA_IUCLID NOAEL =25 ppm Rat oral short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc27f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16246/7/6/2?documentUUID=e98b2413-9207-4114-9f2a-76cb82a08f04; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15842774:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa286b9fadd49dcdb3fc52fdf1d33709
ToxValDB_ECHA_IUCLID NOAEL =100 ppm Rat oral short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc27f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16246/7/6/2?documentUUID=e98b2413-9207-4114-9f2a-76cb82a08f04; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=ECHA IUCLID:15842775:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5fc306b1d0291e6328352036c421e201
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.008 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630218:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_29073cf1e45e337dfdeb6d1d3ee924c1
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 49KP498D4O UNII - - - chemical {"approval_status":null,"molecular_formula":"O4S.2H4NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"49KP498D4O"}
openFDA substances FDA UNII substance identifier 49KP498D4O UNII - - - chemical {"approval_status":null,"molecular_formula":"O4S.2H4NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"49KP498D4O"}
openFDA substances FDA UNII substance identifier 49KP498D4O UNII - - - chemical {"approval_status":null,"molecular_formula":"O4S.2H4NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"49KP498D4O"}
openFDA substances FDA UNII substance identifier 49KP498D4O UNII - - - chemical {"approval_status":null,"molecular_formula":"O4S.2H4NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"49KP498D4O"}