INCI: HYDROXYETHYL-P-PHENYLENEDIAMINE SULFATE
Hydroxyethyl-p-Phenylenediamine Sulfate (CAS 93841-25-9) is a cosmetic cosmetic ingredient functioning as Oxidative hair dye primary intermediate. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 2.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 93841-25-9 →
Hydroxyethyl-p-Phenylenediamine Sulfate is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H301, H317, H373, H411, H319).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxyethyl-p-Phenylenediamine Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Hydroxyethyl-p-Phenylenediamine Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.035 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.035 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.035 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.035 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =25 mg/kg bw | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =25 mg/kg bw/day | - | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =25 mg/kg bw | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =25 mg/kg bw/day | - | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =25 mg/kg bw | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =25 mg/kg bw/day | - | rat | repeated dose toxicity | SCCS_vision_codex |
Pre-calculated NOAEL → SED → MoS audit trail for Hydroxyethyl-p-Phenylenediamine Sulfate across SCCS product categories, with measured dermal absorption where available.
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: CosmEur database; DPRA: Cosmetics Europe; KS: Cosmetics Europe; hCLAT: Cosmetics Europe
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_hair_dye | - | Oxidative hair dye |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.097% | - | - | SCCP/0000 |
| measured | 0.006% | - | - | SCCP/0000 |
| measured | 0.005% | - | - | SCCP/0000 |
| measured | 0.023% | - | - | SCCP/0000 |
| measured | 0.091% | - | - | SCCP/0000 |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for Hydroxyethyl-p-Phenylenediamine Sulfate.
Public NOAEL study rows linked to Hydroxyethyl-p-Phenylenediamine Sulfate by CAS number or substance name.
Units vary across source rows: mg/kg bw, mg/kg bw/day, mg/kg/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.097% | - | - |
| 0.006% | - | - |
| 0.005% | - | - |
| 0.023% | - | - |
| 0.091% | - | - |
Hydroxyethyl-p-Phenylenediamine Sulfate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Hydroxyethyl-p-Phenylenediamine Sulfate EU regulatory status: prohibited. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
Hydroxyethyl-p-Phenylenediamine Sulfate functions as: Oxidative hair dye primary intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 93841-25-9.
The NOAEL (No Observed Adverse Effect Level) for Hydroxyethyl-p-Phenylenediamine Sulfate is =0.035 mg/kg bw based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Hydroxyethyl-p-Phenylenediamine Sulfate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Hydroxyethyl-p-Phenylenediamine Sulfate is prohibited in EU cosmetics at max 2.0% but has active industrial GHS classifications (H301, H317, H373, H411, H319).
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