Is Horseradish Peroxidase safe in cosmetics?
Horseradish Peroxidase has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Horseradish Peroxidase
INCI: HORSERADISH PEROXIDASE
Horseradish Peroxidase (CAS 9003-99-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning; enzyme-catalyzed antioxidant and detoxifier. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 9003-99-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Horseradish Peroxidase is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning; enzyme-catalyzed antioxidant and detoxifier
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
InChIKey
HRNLUBSXIHFDHP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted and not specifically restricted under 21 CFR; no CIR monograph exists
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Horseradish Peroxidase.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Stabilizing agent
Regulatory List Membership (1)
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Horseradish Peroxidase.
Regulatory Flags
eu_children_restricted
Chemical Function
Antioxidant
Softener and conditioner
Stabilizing agent
Regulatory Lists
children; Europe; Personal care - dental care - toothpaste
children; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Lactoperoxidase
Food Category
preservative
Frequently Asked Questions
Is Horseradish Peroxidase allowed in the EU?
Horseradish Peroxidase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Horseradish Peroxidase do in cosmetics?
Horseradish Peroxidase functions as: Skin conditioning; enzyme-catalyzed antioxidant and detoxifier. It is classified as a cosmetic ingredient in our database. CAS number: 9003-99-0.
Is Horseradish Peroxidase used outside cosmetics?
Horseradish Peroxidase also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Horseradish Peroxidase have different safety status in cosmetics vs industrial chemicals?
Horseradish Peroxidase is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Horseradish Peroxidase compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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