Is Histidine HCl safe in cosmetics?
Histidine HCl has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Histidine HCl
INCI: HISTIDINE HCL
Histidine HCl (CAS 645-35-2 (anhydrous); 5934-29-2 (monohydrate)) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Hair Conditioning, Antistatic. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 645-35-2 (anhydrous); 5934-29-2 (monohydrate) →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Hair Conditioning, Antistatic
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR found α-amino acids safe as used; L-Histidine HCl is also GRAS (21 CFR 172.320)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Histidine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Histidine HCl.
Frequently Asked Questions
Is Histidine HCl allowed in the EU?
Histidine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Histidine HCl do in cosmetics?
Histidine HCl functions as: Skin Conditioning, Hair Conditioning, Antistatic. It is classified as a cosmetic ingredient in our database. CAS number: 645-35-2 (anhydrous); 5934-29-2 (monohydrate).
Compliance Tools
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MoS Calculator
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Heavy Metal Limits
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