Is Hexapeptide-9 safe in cosmetics?
Hexapeptide-9 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexapeptide-9
INCI: HEXAPEPTIDE-9
Hexapeptide-9 (CAS 1228371-11-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning — anti-aging; stimulates collagen I, III, IV synthesis;. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1228371-11-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning — anti-aging; stimulates collagen I, III, IV synthesis; boosts laminin-5, integrins; strengthens dermal-epidermal junction (DEJ)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S)-5-amino-2-[[(2S)-1-[2-[[(2S)-5-amino-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid
InChIKey
OGNHOGPWQTWKGQ-VGWMRTNUSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not restricted under 21 CFR; no dedicated CIR review published
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-9.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "firming, collagen-boosting", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "12-20", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept Re…
anti_pollution
{"cas_number": "223749-132-9", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhib…
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-9.
Frequently Asked Questions
Is Hexapeptide-9 allowed in the EU?
Hexapeptide-9 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-9 do in cosmetics?
Hexapeptide-9 functions as: Skin conditioning — anti-aging; stimulates collagen I, III, IV synthesis; boosts laminin-5, integrins; strengthens dermal-epidermal junction (DEJ). It is classified as a cosmetic ingredient in our database. CAS number: 1228371-11-6.
Compliance Tools
Check Hexapeptide-9 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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