Is Hexapeptide-48 safe in cosmetics?
Hexapeptide-48 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexapeptide-48
INCI: HEXAPEPTIDE-48
Hexapeptide-48 (CAS Not publicly assigned for free base) is a cosmetic cosmetic ingredient functioning as Skin conditioning; acts on delta-opioid receptors (DOR) to modulate inflammation. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS Not publicly assigned for free base →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; acts on delta-opioid receptors (DOR) to modulate inflammation
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not prohibited or restricted under 21 CFR; no CIR monograph
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-48.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-48.
Frequently Asked Questions
Is Hexapeptide-48 allowed in the EU?
Hexapeptide-48 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-48 do in cosmetics?
Hexapeptide-48 functions as: Skin conditioning; acts on delta-opioid receptors (DOR) to modulate inflammation. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned for free base.
Compliance Tools
Check Hexapeptide-48 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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