Is Hexapeptide-4 safe in cosmetics?
Hexapeptide-4 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexapeptide-4
INCI: HEXAPEPTIDE-4
Hexapeptide-4 (CAS 112317-45-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning — stimulates collagen IV/VII, fibronectin, elastin synthesis;. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 112317-45-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning — stimulates collagen IV/VII, fibronectin, elastin synthesis; inhibits MMP-1
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
methyl (2S)-2-[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]propanoyl]amino]-3-phenylpropanoate
InChIKey
OHFBCDFWQFKELV-KNIQQNQGSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not listed as prohibited/restricted in 21 CFR; no CIR monograph
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-4.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-4.
Frequently Asked Questions
Is Hexapeptide-4 allowed in the EU?
Hexapeptide-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-4 do in cosmetics?
Hexapeptide-4 functions as: Skin conditioning — stimulates collagen IV/VII, fibronectin, elastin synthesis; inhibits MMP-1. It is classified as a cosmetic ingredient in our database. CAS number: 112317-45-0.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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