Is Hexapeptide-3 safe in cosmetics?
Hexapeptide-3 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexapeptide-3
INCI: HEXAPEPTIDE-3
Hexapeptide-3 (CAS 1205679-02-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning — fibronectin-mimetic peptide (sequence:. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1205679-02-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning — fibronectin-mimetic peptide (sequence: Ala-Asp-Leu-Lys-Pro-Thr); promotes ECM protein synthesis and cell adhesion
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
InChIKey
RYBWAQANBURYGX-PXQJOHHUSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not prohibited or restricted under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-3.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-wrinkle, collagen-boosting", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "12-22", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pe…
synergy
{"inci_name_2": "Peptide Complex", "synergy_type": "efficacy-boost", "synergy_description": "Multi-peptide system for comprehensive skin rebuilding", "combined_benefit": "Enhanced collagen, elastin, and GAG synthesis, complete ECM renewal", "efficacy_multiplier": "2.8x", "mechanism_of_action": "Multiple peptides target different ECM components for synergistic rebuilding", "optimal_ratio": "1:1 (2%…
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-3.
Frequently Asked Questions
Is Hexapeptide-3 allowed in the EU?
Hexapeptide-3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-3 do in cosmetics?
Hexapeptide-3 functions as: Skin conditioning — fibronectin-mimetic peptide (sequence: Ala-Asp-Leu-Lys-Pro-Thr); promotes ECM protein synthesis and cell adhesion. It is classified as a cosmetic ingredient in our database. CAS number: 1205679-02-2.
Compliance Tools
Check Hexapeptide-3 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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