Is Hexapeptide-20 safe in cosmetics?
Hexapeptide-20 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexapeptide-20
INCI: HEXAPEPTIDE-20
Hexapeptide-20 (CAS Not publicly available) is a cosmetic cosmetic ingredient functioning as Skin conditioning (acetyl derivative: MMP inhibition, TEWL reduction, firming). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS Not publicly available →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (acetyl derivative: MMP inhibition, TEWL reduction, firming)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-20.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-20.
Frequently Asked Questions
Is Hexapeptide-20 allowed in the EU?
Hexapeptide-20 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-20 do in cosmetics?
Hexapeptide-20 functions as: Skin conditioning (acetyl derivative: MMP inhibition, TEWL reduction, firming). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly available.
Compliance Tools
Check Hexapeptide-20 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Same category
Skin conditioning (skin brightening/l...
4-Amino-3-Hydroxybutyric Acid
Excellent
Same category
Skin Conditioning
Acetyl Glycyl Beta-Alanine
Excellent
Same category
Skin conditioning agent with melanin ...
Acetyl Tripeptide-1
Excellent
Same category
Skin Conditioning
Acetylneuraminic Acid
Excellent
Same category
Skin Conditioning, Skin Protecting
Acetylphytosphingosine
Excellent
Same category
Skin Conditioning, Hair Conditioning;...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
1,2,3,4,4a,7,8,8a-Octahydro-2,4a,5,8a-Tetramethyl-Naphthyl Formate
Moderate
Similar safety
Fragrance ingredient
HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE
Good
Browse nearby
Perfuming
HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE-8-METHANOL
Good
Browse nearby
Perfuming
HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE-8-METHYL ACETATE
Good
Browse nearby
Perfuming
Is Hexapeptide-20 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hexapeptide-20 in your formulation.