Is Hexapeptide-1 safe in cosmetics?
Hexapeptide-1 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexapeptide-1
INCI: HEXAPEPTIDE-1
Hexapeptide-1 (CAS Not assigned for base peptide (Acetyl Hexapeptide-1: CAS 448944-47-6)) is a cosmetic cosmetic ingredient functioning as Skin Conditioning — α-MSH biomimetic peptide; promotes melanin transfer,. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
Not assigned for base peptide (Acetyl Hexapeptide-1: CAS 448944-47-6)
View industrial chemical safety profile →
Function
Skin Conditioning — α-MSH biomimetic peptide; promotes melanin transfer, photoprotection, tan acceleration
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR prohibition; however, biological claims (melanogenesis) may trigger drug classification if overclaimed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-1.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-1.
Frequently Asked Questions
Is Hexapeptide-1 allowed in the EU?
Hexapeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-1 do in cosmetics?
Hexapeptide-1 functions as: Skin Conditioning — α-MSH biomimetic peptide; promotes melanin transfer, photoprotection, tan acceleration. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned for base peptide (Acetyl Hexapeptide-1: CAS 448944-47-6).
Compliance Tools
Check Hexapeptide-1 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Is Hexapeptide-1 in Your Products?
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Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hexapeptide-1 in your formulation.