Is Hesperidinase safe in cosmetics?
Hesperidinase has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hesperidinase
Also known as: EINECS 253-402-5
INCI: HESPERIDINASE
Hesperidinase (CAS 37213-47-1) is a cosmetic cosmetic ingredient functioning as Skin conditioning (enzyme); hydrolyzes hesperidin glycosidic bonds. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 37213-47-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (enzyme); hydrolyzes hesperidin glycosidic bonds
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — enzyme with food-processing GRAS precedent; no cosmetic-specific restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hesperidinase.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Hesperidinase.
Regulatory Flags
potential-allergen
Known Synonyms
EINECS 253-402-5
Chemical Function
Softener and conditioner
Frequently Asked Questions
Is Hesperidinase allowed in the EU?
Hesperidinase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hesperidinase do in cosmetics?
Hesperidinase functions as: Skin conditioning (enzyme); hydrolyzes hesperidin glycosidic bonds. It is classified as a cosmetic ingredient in our database. CAS number: 37213-47-1.
Compliance Tools
Check Hesperidinase compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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