NOAEL Studies Cosmetic Ingredient

Heptanoic Acid NOAEL Studies

INCI: HEPTANOIC ACID

CAS: 111-14-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =8370 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1522; row=3956; data_type=In Vivo; mixture=Chemical; chemical_name=Heptanoic acid; preferred_name=Heptanoic acid; dtxsid=DTXSID2021600; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021600; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021600; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =7000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1520; row=3957; data_type=In Vivo; mixture=Chemical; chemical_name=Heptanoic acid; preferred_name=Heptanoic acid; dtxsid=DTXSID2021600; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021600; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021600; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=10186; RecordID=ARPathway2016_559; DatasetName=ARPathway2016; DTXSID=DTXSID2021600; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021600; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021600
NTP_ICE_skin_irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Positive reaction 64.5 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=533; Record_ID=skin_irritation_invivo_14; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021600; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=64.5; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021600; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021600
ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL >1000 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb791; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15829/7/9/3?documentUUID=16ed7eea-4c07-4a2e-88f7-5a07970b1b59; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822572_15824004_15824005:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c62540f65d0f05207893dd4d019c851
ToxValDB_ECHA_IUCLID LOAEL =3500 mg/kg bw/day Rat oral short-term; 27 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d2203b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15829/7/6/2?documentUUID=16ed7eea-4c07-4a2e-88f7-5a07970b1b59; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837700_15850398:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ea64610a2e068aae0b04eb20ca83e107
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb791; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15829/7/9/3?documentUUID=16ed7eea-4c07-4a2e-88f7-5a07970b1b59; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824000_15824001_15824002:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_64e4cc4d6bf9fde5ccc18145bb775b9a
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rabbit oral - reproduction developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb799; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15829/7/9/3?documentUUID=16ed7eea-4c07-4a2e-88f7-5a07970b1b59; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822572_15824004_15824005:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_19699a5398ccc2309cccf083b195e9ff
ToxValDB_ECHA_IUCLID NOAEL =1750 mg/kg bw/day Rat oral short-term; 27 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d2203b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15829/7/6/2?documentUUID=16ed7eea-4c07-4a2e-88f7-5a07970b1b59; YEAR=2019; ORIGINAL_YEAR=2019; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837700_15850398:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4bd95bb776a7699961ace3ec94bfc204
ToxValDB_ECHA_IUCLID NOAEL <200 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b5994; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/34385/7/9/2?documentUUID=945cc522-249f-459b-904e-4ddc37e31878; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860538_15863160:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6233a137a600f360ff8489dddb8d5dcc
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =50 mg Mouse dermal chronic; 560 days chronic LONG_REF=EPA/OTS Doc #88-8400625:102 p. Celanese Corp. Summary of Results for a Chronic Dermal Application Study of N-Pentanoic Acid, Heptanoic Acid and Nonanoic Acid in C3H/HeJ Mice with Cover Letter 043084 1984; TITLE=Summary of Results for a Chronic Dermal Application Study of N-Pentanoic Acid, Heptanoic Acid and Nonanoic Acid in C3H/HeJ Mice with Cover Letter 043084; AUTHOR=Celanese Corp.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=119048; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15599442:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a99dd203cdac8636a0c3f37c98998b0a
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =98.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632441:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2926fcdfe57083fd5fb2b0fe46f75112
ToxValDB_HPVIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL =500 mg/kg bw/day Rabbit dermal short-term; 2 weeks short-term LONG_REF=Auletta C. (1981) A 28-day toxicity study in rabbits. Project No.6510-80. Unpublished report to FFHPVC.; TITLE=A 28-day toxicity study in rabbits; AUTHOR=Auletta, C. S; QUALITY=2; EXTERNAL_SOURCE_ID=63143; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS:15639367:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c6936aae2ef997b8f136587d61ef4bf3
ToxValDB_HPVIS NOAEL <=2000 mg/kg bw/day Rat oral - reproduction developmental LONG_REF=Vollmuth T.A., Bennett, M.B., Hoberman, A.M. and Christian, M.S. (1995) An Evaluation of Food Flavoring Ingredients Using an In Vivo Reproductive and Developmental Toxicity Screening Test. Teratology 41(5), 597.; TITLE=An Evaluation of Food Flavoring Ingredients Using an In Vivo Reproductive and Developmental Toxicity Screening Test; AUTHOR=Vollmuth T.A., Bennett, M.B., Hoberman, A.M. and Christian, M.S; QUALITY=1; EXTERNAL_SOURCE_ID=64418; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Reprotox_15643672_15643881:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2c9965b3d2d517b8304e62cc9c0b2f0c
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier THE3YNP39D UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"THE3YNP39D"}
openFDA substances FDA UNII substance identifier THE3YNP39D UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"THE3YNP39D"}
openFDA substances FDA UNII substance identifier THE3YNP39D UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"THE3YNP39D"}
openFDA substances FDA UNII substance identifier THE3YNP39D UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"THE3YNP39D"}