NOAEL Studies Cosmetic Ingredient

HEMA Acetoacetate NOAEL Studies

INCI: HEMA ACETOACETATE

CAS: 21282-97-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_4000; row=12461; data_type=In Vivo; mixture=Chemical; chemical_name=2-[Methacryloyloxy]ethyl acetoacetate; preferred_name=2-(Methacryloyloxy)ethyl acetoacetate; dtxsid=DTXSID7041388; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7041388; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce3c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12402/7/9/3?documentUUID=baaabcc0-1ab8-4746-8be4-09d435246ca1; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823397_15823772:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e342c3bf3a457cbd74ee158407178264
ToxValDB_ECHA_IUCLID NOEL =500 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c6296; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12402/7/6/2?documentUUID=baaabcc0-1ab8-4746-8be4-09d435246ca1; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850941:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_72a652b41bf609e1eb23528f01e4825d
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =35 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629471_15629472:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1bec6ab6e56ff89b1eed9bb84718fc1b
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6L3EW3HZF2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6L3EW3HZF2"}
openFDA substances FDA UNII substance identifier 6L3EW3HZF2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6L3EW3HZF2"}
openFDA substances FDA UNII substance identifier 6L3EW3HZF2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6L3EW3HZF2"}
openFDA substances FDA UNII substance identifier 6L3EW3HZF2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H14O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6L3EW3HZF2"}