Is Guanidine Phosphate safe in cosmetics?
Guanidine Phosphate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Guanidine Phosphate
INCI: GUANIDINE PHOSPHATE
Guanidine Phosphate (CAS 5423-22-3) is a cosmetic cosmetic ingredient functioning as Buffering agent. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 5423-22-3 →
Auto-generated CPSR Part A draft with source citations
Function
Buffering agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
guanidine;phosphoric acid
InChIKey
CEDDGDWODCGBFQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted by default — not restricted under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guanidine Phosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Guanidine Phosphate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expert Verdict
Expert safety assessment and concern-level summary for Guanidine Phosphate.
Frequently Asked Questions
Is Guanidine Phosphate allowed in the EU?
Guanidine Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guanidine Phosphate do in cosmetics?
Guanidine Phosphate functions as: Buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 5423-22-3.
Is Guanidine Phosphate used outside cosmetics?
Guanidine Phosphate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Guanidine Phosphate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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