Is Guanazole safe in cosmetics?
Guanazole has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Guanazole
Also known as: 1H-1,2,4-Triazole-3,5-diamine, 3,5-Diamino-1,2,4-triazole, EINECS 215-937-2, NCI-C04819, NSC 1895 (+4 more)
INCI: GUANAZOLE
Guanazole (CAS 1455-77-2) is a cosmetic cosmetic ingredient functioning as Historically investigated as an antineoplastic (3,5-diamino-1,2,4-triazole);. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1455-77-2 →
Auto-generated CPSR Part A draft with source citations
Function
Historically investigated as an antineoplastic (3,5-diamino-1,2,4-triazole); not reported in CosIng or COSMILE
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1H-1,2,4-triazole-3,5-diamine
InChIKey
PKWIYNIDEDLDCJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically addressed in 21 CFR Parts 700–740; permitted by default
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guanazole.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Guanazole.
Known Synonyms
1H-1,2,4-Triazole-3,5-diamine
3,5-Diamino-1,2,4-triazole
EINECS 215-937-2
NCI-C04819
NSC 1895
1,2,4-Triazolidine, 3,5-diimino-
UNII-I01TWM5267
3,5-Diamino-1H-1,2,4-triazole
3,5-Diamino-s-triazole
Chemical Function
No specific technical function
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GUANAZOLE
ChEMBL ID
CHEMBL56973
Frequently Asked Questions
Is Guanazole allowed in the EU?
Guanazole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guanazole do in cosmetics?
Guanazole functions as: Historically investigated as an antineoplastic (3,5-diamino-1,2,4-triazole); not reported in CosIng or COSMILE. It is classified as a cosmetic ingredient in our database. CAS number: 1455-77-2.
Is Guanazole used outside cosmetics?
Guanazole also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Guanazole compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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