NOAEL Studies Cosmetic Ingredient

Glyoxylic Acid NOAEL Studies

INCI: GLYOXYLIC ACID

CAS: 298-12-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_skin_sensitization 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization EC3 5.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13288; Record_ID=skin_sensitization_invivo_3384; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021594; Assay=LLNA; Endpoint=EC3; Response=5.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Anderson et al. 2008; 18569377; 10.1080/15476910802085681; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021594
NTP_ICE_skin_sensitization EC3 5.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13288; Record_ID=skin_sensitization_invivo_3384; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021594; Assay=LLNA; Endpoint=EC3; Response=5.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Anderson et al. 2008; 18569377; 10.1080/15476910802085681; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021594
NTP_ICE_skin_sensitization EC3 5.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13288; Record_ID=skin_sensitization_invivo_3384; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021594; Assay=LLNA; Endpoint=EC3; Response=5.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Anderson et al. 2008; 18569377; 10.1080/15476910802085681; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021594
NTP_ICE_skin_sensitization EC3 5.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13288; Record_ID=skin_sensitization_invivo_3384; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021594; Assay=LLNA; Endpoint=EC3; Response=5.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Anderson et al. 2008; 18569377; 10.1080/15476910802085681; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021594
ToxValDB_ECHA_IUCLID 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =18000 ppm Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1cfe4b0a7c65d2303d1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6904/7/9/3?documentUUID=77e2fa46-1cd2-4842-a40f-e63a46e17e8e; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15821567:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed7a712db96463cd918db3a33e493931
ToxValDB_ECHA_IUCLID NOAEL =6000 ppm Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8e9e4b0a7c65d21ab9e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6904/7/9/2?documentUUID=77e2fa46-1cd2-4842-a40f-e63a46e17e8e; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15856719:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1888f4f9e31ad06d1a7268c411b319ff
ToxValDB_ECHA_IUCLID NOAEL >=1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaae0e4b0a7c65d1b7e9e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6904/7/9/2?documentUUID=77e2fa46-1cd2-4842-a40f-e63a46e17e8e; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=ECHA IUCLID:15857045:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ea4b2567c60aadbf8acd40d78a71aa1
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =9.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632422:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_20e3be52329f3a1ec874cab3b744ca8d
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier JQ39C92HH6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JQ39C92HH6"}
openFDA substances FDA UNII substance identifier JQ39C92HH6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JQ39C92HH6"}
openFDA substances FDA UNII substance identifier JQ39C92HH6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JQ39C92HH6"}
openFDA substances FDA UNII substance identifier JQ39C92HH6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JQ39C92HH6"}