NOAEL Studies
Cosmetic Ingredient
Glutaral NOAEL Studies
INCI: GLUTARAL
CAS: 111-30-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =0.0122844 | mg/m3 | Rat (F344; M/F) | inhalation | acute; 1 days | acute | ATSDR MRLs; row_hash=69a5c77168cbd268; source_hash=ToxValhc_7519fd961bb37c2d87f52af206b3c6f0; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=0.003; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Gross EA, Mellick PW, Kari FW, et al. 1994. Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks. Fundam Appl Toxicol 23(3):348-362.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585776 |
| Regulatory source | NOAEL | =0.511848 | mg/m3 | Rat (F344; M/F) | inhalation | acute; 1 days | acute | ATSDR MRLs; row_hash=50480350af325e2a; source_hash=ToxValhc_be4c964a5744c3f652e202db7a8ed50f; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=0.125; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Gross EA, Mellick PW, Kari FW, et al. 1994. Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks. Fundam Appl Toxicol 23(3):348-362.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585776 |
| Regulatory source | NOAEL | =4 | mg/kg/day | Rat (Fischer 344; M) | oral | chronic; 2 years | chronic | ATSDR MRLs; row_hash=436106d14cf61bfb; source_hash=ToxValhc_784411d92447769d0fc569ddd7c105cc; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=4; raw_unit=mg/kg/day; method=drinking water; effect=gastric irritation (multifocal color change, mucosal thickening, nodules, and ulceration affecting primarily the nonglandular mucosa; effect_category=gross pathology; file=toxval_ATSDR_MRLs.xlsx; long_ref=van Miller JP, Hermansky SJ, Losco PE, et al. 2002. Chronic toxicity and oncogenicity study with glutaraldehyde dosed in the drinking water of Fischer 344 rats. Toxicology 175(1-3):177-189.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585776 |
CIR Safety Assessment 24 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =0.1 | % | rat | oral | 28-day | oral toxicity | {"citation":"66; 733; 28","dose":"The oral LD,,, of Glutaral for rats ranged from 66 mgikg up to 733 mg/kg.","effect":"ra- tion studies of Glutaral indicate low penetration through animal skin and even less through human skin. The oral LD,,, of Glutaral for rats ranged from 66 mgikg up to 733 mg/kg. A 28-day dermal toxicity study of Glutaral produced skin irritation and slight effects on weight and blood chemistry with concen- trations as low as SO mgikglday. Animal skin irritation was dose-dependant, with a no-effect concentration of I%. Ocular exposure to Glutaral caused severe irritation in rabbits at concentrations >I%, with a no-effect level of 0.1%. Glutaral was not embryotoxic, fetotoxic. or teratogenic at concentra- tions that did not cause severe maternal toxicity. The no observable adverse effects level for reproduction toxicity was > I.000 ppm. Bacterial mutagenesis tests produced mixed results. as would be expected for a preservative. In most mammalian system mutagenesis tests, Glutaral was not genotoxic. In a ?-year drinking water study in rats, there was an increase in large granular lympho- cytic leukemia (LGLL), but only in females administered 50-l ,000 ppm Glut- aral. The respons...","page":1,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_001"} |
| CIR Safety Assessment | NOAEL | =2 | % | rat | dermal | 7 days | NOAEL study | {"citation":"0; 1, 0; 48","dose":"At the largest Glutaral dose, body weight gain in males and females was decreased and the absolute kidney and liver weights in males were decreased.","effect":"igh-dose group. No other clinical signs of toxicity, alter- ations in serum chemistry and hematology. effects on organ weights, or micro- scopic changes were observed (Union Carbide Corporation, 1993). Groups of five male and five female Harlow-Wistar albino rats were fed diets containing 0.1, 0.48, I .02, and 1.63 g/kg/day of Glutaral for 7 days. No animals died. At the largest Glutaral dose, body weight gain in males and females was decreased and the absolute kidney and liver weights in males were decreased. The no-effect level for Glutaral was I .O g/kg/day (Union Carbide Corporation, 1986). Dermal A 0.5-ml dose of a 2% alkaline Glutaral solution was applied daily for 6 weeks to the closely clipped skin of albino rabbits. The solution was spread with a brush J Am Cd Tmkd. Vol. 15. No. 2. 1996","page":12,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_002"} |
| CIR Safety Assessment | NOAEL | =100 | ppm | dog | oral | 6-week | NOAEL study | {"citation":"1; 6; 1,000","dose":"t group and for males and females in the 1 ,OOO-ppm group, as well as increases in urine osmolality for both sexes in the 1 ,OOO-ppm groups.","effect":"t group and for males and females in the 1 ,OOO-ppm group, as well as increases in urine osmolality for both sexes in the 1 ,OOO-ppm groups. The mean kidney weight relative to body weight was increased for females in the l,OOO-ppm treatment group. All parameters that were altered during the study returned to control values during the 6-week recovery period. The investigators concluded that 1,000 ppm Glutaral was a minimal toxic dose and that 250 ppm Glutaral may have produced a marginal physiological response. The no observable-adverse effect level (NOAEL) for this ingredient was considered to be 100 ppm. In a study with beagle dogs, groups of four dogs of each sex were administered 50, 150, or 250 ppm Glutaral in drinking water for 13 weeks. The mean daily uptake was calculated to be 3.3, 9.6, and 14.1 mgikglday for male dogs and 3.2, 9.9, and 15.1 mglkgiday for female dogs. A control group of dogs was given untreated drinking water. The dogs were monitored for clinical signs of toxicity and measurements of various biological parameters were made. All of the dogs were killed for...","page":16,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_003"} |
| CIR Safety Assessment | NOAEL | =50 | mg/kg/day | rat | inhalation | 4-week | repeated dose toxicity | {"citation":"4; 50; 10","dose":"Both gross and micro- scopic lesions were found in the skin, even at the lowest dose tested.","effect":"these conditions were resolved during the second to fourth weeks of the treatment period, and most of these clinical findings were resolved during the 4-week recovery period. Slight effects on body weight, body weight gain, food consumption, clinical chemistry (blood urea nitrogen in males), and hematology (platelet and reticulo- cyte counts in females) were observed during the study. Both gross and micro- scopic lesions were found in the skin, even at the lowest dose tested. The inves- tigators concluded that the NOAEL had not been determined, even though effects on the rats treated with 50 mg/kg/day Glutaral were marginal (Bushy Run Re- search Center, 1994a). Inhalation In a subchronic inhalation study (Kari, 1993) using F344/N rats and B6C3F, mice, groups of 10 males and 10 females of each species were exposed to vapor- ized Glutaral at concentrations of 0,62.5, 125,250,500, and 1,000 ppb. Exposures were to the whole body for 6.5 h/day, 5 days a week for 13 weeks. The animals were observed regularly for clinical signs of toxicity and body weights were mon- itored weekly. Necrop...","page":17,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_004"} |
| CIR Safety Assessment | NOAEL | =1 | ppm | rat | inhalation | subchronic | repeated dose toxicity | {"citation":"1,000; 250; 500","dose":"Reduced food consumption was also observed in the high-dose females (F, and F,) near the end of gestation.","effect":"dose groups. Reduced food consumption was also observed in the high-dose females (F, and F,) near the end of gestation. No effects on mating, fertility, or gestational factors were observed. There were no adverse effects on litter size or sex ratio in the F, or FZ litters. The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups. However. this did not affect the viability or survival of these pups. The investigators concluded that the NOAEL for adult and offspring toxicity was SO ppm and 250 ppm Glutaral, respectively. The NOAEL for reproductive effects was > 1,000 ppm Glutaral (Bushy Run Research Center, 1994b). In the subchronic inhalation study by Kari (1993), described earlier in this report, no adverse effects on sperm morphology or vaginal cytology was observed in F344/N rats whole-body exposed to vaporized Glutaral at concentrations of 1,000 ppb and lower. However, in studies with B6C3F, mice, there were changes in the amount of time spent in estrous stages for females of the 250- and 500-ppb g...","page":23,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_005"} |
| CIR Safety Assessment | NOAEL | >1000 | ppm | rat | inhalation | subchronic | repeated dose toxicity | {"citation":"1,000; 250; 500","dose":"The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups.","effect":",) near the end of gestation. No effects on mating, fertility, or gestational factors were observed. There were no adverse effects on litter size or sex ratio in the F, or FZ litters. The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups. However. this did not affect the viability or survival of these pups. The investigators concluded that the NOAEL for adult and offspring toxicity was SO ppm and 250 ppm Glutaral, respectively. The NOAEL for reproductive effects was > 1,000 ppm Glutaral (Bushy Run Research Center, 1994b). In the subchronic inhalation study by Kari (1993), described earlier in this report, no adverse effects on sperm morphology or vaginal cytology was observed in F344/N rats whole-body exposed to vaporized Glutaral at concentrations of 1,000 ppb and lower. However, in studies with B6C3F, mice, there were changes in the amount of time spent in estrous stages for females of the 250- and 500-ppb groups as compared with controls. More time was spent in estrus and diestrus and less time...","page":23,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_006"} |
| CIR Safety Assessment | NOAEL | =0.1 | % | rat | oral | 28-day | oral toxicity | {"citation":"66; 733; 28","dose":"The oral LD,,, of Glutaral for rats ranged from 66 mgikg up to 733 mg/kg.","effect":"ra- tion studies of Glutaral indicate low penetration through animal skin and even less through human skin. The oral LD,,, of Glutaral for rats ranged from 66 mgikg up to 733 mg/kg. A 28-day dermal toxicity study of Glutaral produced skin irritation and slight effects on weight and blood chemistry with concen- trations as low as SO mgikglday. Animal skin irritation was dose-dependant, with a no-effect concentration of I%. Ocular exposure to Glutaral caused severe irritation in rabbits at concentrations >I%, with a no-effect level of 0.1%. Glutaral was not embryotoxic, fetotoxic. or teratogenic at concentra- tions that did not cause severe maternal toxicity. The no observable adverse effects level for reproduction toxicity was > I.000 ppm. Bacterial mutagenesis tests produced mixed results. as would be expected for a preservative. In most mammalian system mutagenesis tests, Glutaral was not genotoxic. In a ?-year drinking water study in rats, there was an increase in large granular lympho- cytic leukemia (LGLL), but only in females administered 50-l ,000 ppm Glut- aral. The respons...","page":1,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_001"} |
| CIR Safety Assessment | NOAEL | =2 | % | rat | dermal | 7 days | NOAEL study | {"citation":"0; 1, 0; 48","dose":"At the largest Glutaral dose, body weight gain in males and females was decreased and the absolute kidney and liver weights in males were decreased.","effect":"igh-dose group. No other clinical signs of toxicity, alter- ations in serum chemistry and hematology. effects on organ weights, or micro- scopic changes were observed (Union Carbide Corporation, 1993). Groups of five male and five female Harlow-Wistar albino rats were fed diets containing 0.1, 0.48, I .02, and 1.63 g/kg/day of Glutaral for 7 days. No animals died. At the largest Glutaral dose, body weight gain in males and females was decreased and the absolute kidney and liver weights in males were decreased. The no-effect level for Glutaral was I .O g/kg/day (Union Carbide Corporation, 1986). Dermal A 0.5-ml dose of a 2% alkaline Glutaral solution was applied daily for 6 weeks to the closely clipped skin of albino rabbits. The solution was spread with a brush J Am Cd Tmkd. Vol. 15. No. 2. 1996","page":12,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_002"} |
| CIR Safety Assessment | NOAEL | =100 | ppm | dog | oral | 6-week | NOAEL study | {"citation":"1; 6; 1,000","dose":"t group and for males and females in the 1 ,OOO-ppm group, as well as increases in urine osmolality for both sexes in the 1 ,OOO-ppm groups.","effect":"t group and for males and females in the 1 ,OOO-ppm group, as well as increases in urine osmolality for both sexes in the 1 ,OOO-ppm groups. The mean kidney weight relative to body weight was increased for females in the l,OOO-ppm treatment group. All parameters that were altered during the study returned to control values during the 6-week recovery period. The investigators concluded that 1,000 ppm Glutaral was a minimal toxic dose and that 250 ppm Glutaral may have produced a marginal physiological response. The no observable-adverse effect level (NOAEL) for this ingredient was considered to be 100 ppm. In a study with beagle dogs, groups of four dogs of each sex were administered 50, 150, or 250 ppm Glutaral in drinking water for 13 weeks. The mean daily uptake was calculated to be 3.3, 9.6, and 14.1 mgikglday for male dogs and 3.2, 9.9, and 15.1 mglkgiday for female dogs. A control group of dogs was given untreated drinking water. The dogs were monitored for clinical signs of toxicity and measurements of various biological parameters were made. All of the dogs were killed for...","page":16,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_003"} |
| CIR Safety Assessment | NOAEL | =50 | mg/kg/day | rat | inhalation | 4-week | repeated dose toxicity | {"citation":"4; 50; 10","dose":"Both gross and micro- scopic lesions were found in the skin, even at the lowest dose tested.","effect":"these conditions were resolved during the second to fourth weeks of the treatment period, and most of these clinical findings were resolved during the 4-week recovery period. Slight effects on body weight, body weight gain, food consumption, clinical chemistry (blood urea nitrogen in males), and hematology (platelet and reticulo- cyte counts in females) were observed during the study. Both gross and micro- scopic lesions were found in the skin, even at the lowest dose tested. The inves- tigators concluded that the NOAEL had not been determined, even though effects on the rats treated with 50 mg/kg/day Glutaral were marginal (Bushy Run Re- search Center, 1994a). Inhalation In a subchronic inhalation study (Kari, 1993) using F344/N rats and B6C3F, mice, groups of 10 males and 10 females of each species were exposed to vapor- ized Glutaral at concentrations of 0,62.5, 125,250,500, and 1,000 ppb. Exposures were to the whole body for 6.5 h/day, 5 days a week for 13 weeks. The animals were observed regularly for clinical signs of toxicity and body weights were mon- itored weekly. Necrop...","page":17,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_004"} |
| CIR Safety Assessment | NOAEL | =1 | ppm | rat | inhalation | subchronic | repeated dose toxicity | {"citation":"1,000; 250; 500","dose":"Reduced food consumption was also observed in the high-dose females (F, and F,) near the end of gestation.","effect":"dose groups. Reduced food consumption was also observed in the high-dose females (F, and F,) near the end of gestation. No effects on mating, fertility, or gestational factors were observed. There were no adverse effects on litter size or sex ratio in the F, or FZ litters. The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups. However. this did not affect the viability or survival of these pups. The investigators concluded that the NOAEL for adult and offspring toxicity was SO ppm and 250 ppm Glutaral, respectively. The NOAEL for reproductive effects was > 1,000 ppm Glutaral (Bushy Run Research Center, 1994b). In the subchronic inhalation study by Kari (1993), described earlier in this report, no adverse effects on sperm morphology or vaginal cytology was observed in F344/N rats whole-body exposed to vaporized Glutaral at concentrations of 1,000 ppb and lower. However, in studies with B6C3F, mice, there were changes in the amount of time spent in estrous stages for females of the 250- and 500-ppb g...","page":23,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_005"} |
| CIR Safety Assessment | NOAEL | >1000 | ppm | rat | inhalation | subchronic | repeated dose toxicity | {"citation":"1,000; 250; 500","dose":"The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups.","effect":",) near the end of gestation. No effects on mating, fertility, or gestational factors were observed. There were no adverse effects on litter size or sex ratio in the F, or FZ litters. The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups. However. this did not affect the viability or survival of these pups. The investigators concluded that the NOAEL for adult and offspring toxicity was SO ppm and 250 ppm Glutaral, respectively. The NOAEL for reproductive effects was > 1,000 ppm Glutaral (Bushy Run Research Center, 1994b). In the subchronic inhalation study by Kari (1993), described earlier in this report, no adverse effects on sperm morphology or vaginal cytology was observed in F344/N rats whole-body exposed to vaporized Glutaral at concentrations of 1,000 ppb and lower. However, in studies with B6C3F, mice, there were changes in the amount of time spent in estrous stages for females of the 250- and 500-ppb groups as compared with controls. More time was spent in estrus and diestrus and less time...","page":23,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_006"} |
| CIR Safety Assessment | NOAEL | =0.1 | % | rat | oral | 28-day | oral toxicity | {"citation":"66; 733; 28","dose":"The oral LD,,, of Glutaral for rats ranged from 66 mgikg up to 733 mg/kg.","effect":"ra- tion studies of Glutaral indicate low penetration through animal skin and even less through human skin. The oral LD,,, of Glutaral for rats ranged from 66 mgikg up to 733 mg/kg. A 28-day dermal toxicity study of Glutaral produced skin irritation and slight effects on weight and blood chemistry with concen- trations as low as SO mgikglday. Animal skin irritation was dose-dependant, with a no-effect concentration of I%. Ocular exposure to Glutaral caused severe irritation in rabbits at concentrations >I%, with a no-effect level of 0.1%. Glutaral was not embryotoxic, fetotoxic. or teratogenic at concentra- tions that did not cause severe maternal toxicity. The no observable adverse effects level for reproduction toxicity was > I.000 ppm. Bacterial mutagenesis tests produced mixed results. as would be expected for a preservative. In most mammalian system mutagenesis tests, Glutaral was not genotoxic. In a ?-year drinking water study in rats, there was an increase in large granular lympho- cytic leukemia (LGLL), but only in females administered 50-l ,000 ppm Glut- aral. The respons...","page":1,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_001"} |
| CIR Safety Assessment | NOAEL | =2 | % | rat | dermal | 7 days | NOAEL study | {"citation":"0; 1, 0; 48","dose":"At the largest Glutaral dose, body weight gain in males and females was decreased and the absolute kidney and liver weights in males were decreased.","effect":"igh-dose group. No other clinical signs of toxicity, alter- ations in serum chemistry and hematology. effects on organ weights, or micro- scopic changes were observed (Union Carbide Corporation, 1993). Groups of five male and five female Harlow-Wistar albino rats were fed diets containing 0.1, 0.48, I .02, and 1.63 g/kg/day of Glutaral for 7 days. No animals died. At the largest Glutaral dose, body weight gain in males and females was decreased and the absolute kidney and liver weights in males were decreased. The no-effect level for Glutaral was I .O g/kg/day (Union Carbide Corporation, 1986). Dermal A 0.5-ml dose of a 2% alkaline Glutaral solution was applied daily for 6 weeks to the closely clipped skin of albino rabbits. The solution was spread with a brush J Am Cd Tmkd. Vol. 15. No. 2. 1996","page":12,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_002"} |
| CIR Safety Assessment | NOAEL | =100 | ppm | dog | oral | 6-week | NOAEL study | {"citation":"1; 6; 1,000","dose":"t group and for males and females in the 1 ,OOO-ppm group, as well as increases in urine osmolality for both sexes in the 1 ,OOO-ppm groups.","effect":"t group and for males and females in the 1 ,OOO-ppm group, as well as increases in urine osmolality for both sexes in the 1 ,OOO-ppm groups. The mean kidney weight relative to body weight was increased for females in the l,OOO-ppm treatment group. All parameters that were altered during the study returned to control values during the 6-week recovery period. The investigators concluded that 1,000 ppm Glutaral was a minimal toxic dose and that 250 ppm Glutaral may have produced a marginal physiological response. The no observable-adverse effect level (NOAEL) for this ingredient was considered to be 100 ppm. In a study with beagle dogs, groups of four dogs of each sex were administered 50, 150, or 250 ppm Glutaral in drinking water for 13 weeks. The mean daily uptake was calculated to be 3.3, 9.6, and 14.1 mgikglday for male dogs and 3.2, 9.9, and 15.1 mglkgiday for female dogs. A control group of dogs was given untreated drinking water. The dogs were monitored for clinical signs of toxicity and measurements of various biological parameters were made. All of the dogs were killed for...","page":16,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_003"} |
| CIR Safety Assessment | NOAEL | =50 | mg/kg/day | rat | inhalation | 4-week | repeated dose toxicity | {"citation":"4; 50; 10","dose":"Both gross and micro- scopic lesions were found in the skin, even at the lowest dose tested.","effect":"these conditions were resolved during the second to fourth weeks of the treatment period, and most of these clinical findings were resolved during the 4-week recovery period. Slight effects on body weight, body weight gain, food consumption, clinical chemistry (blood urea nitrogen in males), and hematology (platelet and reticulo- cyte counts in females) were observed during the study. Both gross and micro- scopic lesions were found in the skin, even at the lowest dose tested. The inves- tigators concluded that the NOAEL had not been determined, even though effects on the rats treated with 50 mg/kg/day Glutaral were marginal (Bushy Run Re- search Center, 1994a). Inhalation In a subchronic inhalation study (Kari, 1993) using F344/N rats and B6C3F, mice, groups of 10 males and 10 females of each species were exposed to vapor- ized Glutaral at concentrations of 0,62.5, 125,250,500, and 1,000 ppb. Exposures were to the whole body for 6.5 h/day, 5 days a week for 13 weeks. The animals were observed regularly for clinical signs of toxicity and body weights were mon- itored weekly. Necrop...","page":17,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_004"} |
| CIR Safety Assessment | NOAEL | =1 | ppm | rat | inhalation | subchronic | repeated dose toxicity | {"citation":"1,000; 250; 500","dose":"Reduced food consumption was also observed in the high-dose females (F, and F,) near the end of gestation.","effect":"dose groups. Reduced food consumption was also observed in the high-dose females (F, and F,) near the end of gestation. No effects on mating, fertility, or gestational factors were observed. There were no adverse effects on litter size or sex ratio in the F, or FZ litters. The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups. However. this did not affect the viability or survival of these pups. The investigators concluded that the NOAEL for adult and offspring toxicity was SO ppm and 250 ppm Glutaral, respectively. The NOAEL for reproductive effects was > 1,000 ppm Glutaral (Bushy Run Research Center, 1994b). In the subchronic inhalation study by Kari (1993), described earlier in this report, no adverse effects on sperm morphology or vaginal cytology was observed in F344/N rats whole-body exposed to vaporized Glutaral at concentrations of 1,000 ppb and lower. However, in studies with B6C3F, mice, there were changes in the amount of time spent in estrous stages for females of the 250- and 500-ppb g...","page":23,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_005"} |
| CIR Safety Assessment | NOAEL | >1000 | ppm | rat | inhalation | subchronic | repeated dose toxicity | {"citation":"1,000; 250; 500","dose":"The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups.","effect":",) near the end of gestation. No effects on mating, fertility, or gestational factors were observed. There were no adverse effects on litter size or sex ratio in the F, or FZ litters. The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups. However. this did not affect the viability or survival of these pups. The investigators concluded that the NOAEL for adult and offspring toxicity was SO ppm and 250 ppm Glutaral, respectively. The NOAEL for reproductive effects was > 1,000 ppm Glutaral (Bushy Run Research Center, 1994b). In the subchronic inhalation study by Kari (1993), described earlier in this report, no adverse effects on sperm morphology or vaginal cytology was observed in F344/N rats whole-body exposed to vaporized Glutaral at concentrations of 1,000 ppb and lower. However, in studies with B6C3F, mice, there were changes in the amount of time spent in estrous stages for females of the 250- and 500-ppb groups as compared with controls. More time was spent in estrus and diestrus and less time...","page":23,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_006"} |
| CIR Safety Assessment | NOAEL | =0.1 | % | rat | oral | 28-day | oral toxicity | {"citation":"66; 733; 28","dose":"The oral LD,,, of Glutaral for rats ranged from 66 mgikg up to 733 mg/kg.","effect":"ra- tion studies of Glutaral indicate low penetration through animal skin and even less through human skin. The oral LD,,, of Glutaral for rats ranged from 66 mgikg up to 733 mg/kg. A 28-day dermal toxicity study of Glutaral produced skin irritation and slight effects on weight and blood chemistry with concen- trations as low as SO mgikglday. Animal skin irritation was dose-dependant, with a no-effect concentration of I%. Ocular exposure to Glutaral caused severe irritation in rabbits at concentrations >I%, with a no-effect level of 0.1%. Glutaral was not embryotoxic, fetotoxic. or teratogenic at concentra- tions that did not cause severe maternal toxicity. The no observable adverse effects level for reproduction toxicity was > I.000 ppm. Bacterial mutagenesis tests produced mixed results. as would be expected for a preservative. In most mammalian system mutagenesis tests, Glutaral was not genotoxic. In a ?-year drinking water study in rats, there was an increase in large granular lympho- cytic leukemia (LGLL), but only in females administered 50-l ,000 ppm Glut- aral. The respons...","page":1,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_001"} |
| CIR Safety Assessment | NOAEL | =2 | % | rat | dermal | 7 days | NOAEL study | {"citation":"0; 1, 0; 48","dose":"At the largest Glutaral dose, body weight gain in males and females was decreased and the absolute kidney and liver weights in males were decreased.","effect":"igh-dose group. No other clinical signs of toxicity, alter- ations in serum chemistry and hematology. effects on organ weights, or micro- scopic changes were observed (Union Carbide Corporation, 1993). Groups of five male and five female Harlow-Wistar albino rats were fed diets containing 0.1, 0.48, I .02, and 1.63 g/kg/day of Glutaral for 7 days. No animals died. At the largest Glutaral dose, body weight gain in males and females was decreased and the absolute kidney and liver weights in males were decreased. The no-effect level for Glutaral was I .O g/kg/day (Union Carbide Corporation, 1986). Dermal A 0.5-ml dose of a 2% alkaline Glutaral solution was applied daily for 6 weeks to the closely clipped skin of albino rabbits. The solution was spread with a brush J Am Cd Tmkd. Vol. 15. No. 2. 1996","page":12,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_002"} |
| CIR Safety Assessment | NOAEL | =100 | ppm | dog | oral | 6-week | NOAEL study | {"citation":"1; 6; 1,000","dose":"t group and for males and females in the 1 ,OOO-ppm group, as well as increases in urine osmolality for both sexes in the 1 ,OOO-ppm groups.","effect":"t group and for males and females in the 1 ,OOO-ppm group, as well as increases in urine osmolality for both sexes in the 1 ,OOO-ppm groups. The mean kidney weight relative to body weight was increased for females in the l,OOO-ppm treatment group. All parameters that were altered during the study returned to control values during the 6-week recovery period. The investigators concluded that 1,000 ppm Glutaral was a minimal toxic dose and that 250 ppm Glutaral may have produced a marginal physiological response. The no observable-adverse effect level (NOAEL) for this ingredient was considered to be 100 ppm. In a study with beagle dogs, groups of four dogs of each sex were administered 50, 150, or 250 ppm Glutaral in drinking water for 13 weeks. The mean daily uptake was calculated to be 3.3, 9.6, and 14.1 mgikglday for male dogs and 3.2, 9.9, and 15.1 mglkgiday for female dogs. A control group of dogs was given untreated drinking water. The dogs were monitored for clinical signs of toxicity and measurements of various biological parameters were made. All of the dogs were killed for...","page":16,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_003"} |
| CIR Safety Assessment | NOAEL | =50 | mg/kg/day | rat | inhalation | 4-week | repeated dose toxicity | {"citation":"4; 50; 10","dose":"Both gross and micro- scopic lesions were found in the skin, even at the lowest dose tested.","effect":"these conditions were resolved during the second to fourth weeks of the treatment period, and most of these clinical findings were resolved during the 4-week recovery period. Slight effects on body weight, body weight gain, food consumption, clinical chemistry (blood urea nitrogen in males), and hematology (platelet and reticulo- cyte counts in females) were observed during the study. Both gross and micro- scopic lesions were found in the skin, even at the lowest dose tested. The inves- tigators concluded that the NOAEL had not been determined, even though effects on the rats treated with 50 mg/kg/day Glutaral were marginal (Bushy Run Re- search Center, 1994a). Inhalation In a subchronic inhalation study (Kari, 1993) using F344/N rats and B6C3F, mice, groups of 10 males and 10 females of each species were exposed to vapor- ized Glutaral at concentrations of 0,62.5, 125,250,500, and 1,000 ppb. Exposures were to the whole body for 6.5 h/day, 5 days a week for 13 weeks. The animals were observed regularly for clinical signs of toxicity and body weights were mon- itored weekly. Necrop...","page":17,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_004"} |
| CIR Safety Assessment | NOAEL | =1 | ppm | rat | inhalation | subchronic | repeated dose toxicity | {"citation":"1,000; 250; 500","dose":"Reduced food consumption was also observed in the high-dose females (F, and F,) near the end of gestation.","effect":"dose groups. Reduced food consumption was also observed in the high-dose females (F, and F,) near the end of gestation. No effects on mating, fertility, or gestational factors were observed. There were no adverse effects on litter size or sex ratio in the F, or FZ litters. The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups. However. this did not affect the viability or survival of these pups. The investigators concluded that the NOAEL for adult and offspring toxicity was SO ppm and 250 ppm Glutaral, respectively. The NOAEL for reproductive effects was > 1,000 ppm Glutaral (Bushy Run Research Center, 1994b). In the subchronic inhalation study by Kari (1993), described earlier in this report, no adverse effects on sperm morphology or vaginal cytology was observed in F344/N rats whole-body exposed to vaporized Glutaral at concentrations of 1,000 ppb and lower. However, in studies with B6C3F, mice, there were changes in the amount of time spent in estrous stages for females of the 250- and 500-ppb g...","page":23,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_005"} |
| CIR Safety Assessment | NOAEL | >1000 | ppm | rat | inhalation | subchronic | repeated dose toxicity | {"citation":"1,000; 250; 500","dose":"The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups.","effect":",) near the end of gestation. No effects on mating, fertility, or gestational factors were observed. There were no adverse effects on litter size or sex ratio in the F, or FZ litters. The investigators noted that the pup body weights and weight gains were reduced in both the F, and F, 1,000 ppm Glutaral treatment groups. However. this did not affect the viability or survival of these pups. The investigators concluded that the NOAEL for adult and offspring toxicity was SO ppm and 250 ppm Glutaral, respectively. The NOAEL for reproductive effects was > 1,000 ppm Glutaral (Bushy Run Research Center, 1994b). In the subchronic inhalation study by Kari (1993), described earlier in this report, no adverse effects on sperm morphology or vaginal cytology was observed in F344/N rats whole-body exposed to vaporized Glutaral at concentrations of 1,000 ppb and lower. However, in studies with B6C3F, mice, there were changes in the amount of time spent in estrous stages for females of the 250- and 500-ppb groups as compared with controls. More time was spent in estrus and diestrus and less time...","page":23,"pdf":"pr14.pdf","row_type":"noael_study","study_id":"pr14_noael_006"} |
COSMOS DB 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 150 | ppm | dog | oral | 13 week | Subchronic | PAFA; FAP |
| COSMOS DB | LOAEL | 250 | ppm | rat | oral | 13 week | Subchronic | REACH |
| COSMOS DB | NOAEL | 6 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 9 | mg/kg bw/day | dog | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 13.5 | mg/kg bw/day | dog | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 45 | mg/kg bw/day | rabbit | oral | 13 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 50 | ppm | dog | oral | 13 week | Subchronic | PAFA; FAP |
| COSMOS DB | NOAEL | 68 | mg/kg bw/day | rat | oral | 11 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 103 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 120 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 200 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ECHA 158 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 106.9 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=body weight and weight gain; key_result=false; entry_uuid=638fa19a-de0e-4ace-a942-9155dd68b80f |
| ECHA | LOAEL | 144.4 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=body weight and weight gain; key_result=false; entry_uuid=a1d6fe2c-560f-46c9-8e99-8dd655c92fb5 |
| ECHA | LOAEL | 17 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=body weight and weight gain; key_result=false; entry_uuid=550ab055-29dc-4803-a648-d956ee89aa54 |
| ECHA | LOAEL | 25 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=body weight and weight gain; key_result=false; entry_uuid=0d3d3b82-dee0-40c0-82f9-c7345d89141b |
| ECHA | LOAEL | 45 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=50979983-f2db-43fe-baa9-6a503f2dade2_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=50979983-f2db-43fe-baa9-6a503f2dade2/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-11; basis=body weight and weight gain; key_result=false; entry_uuid=3729d328-b7b5-4cf2-8f26-38d01583865d |
| ECHA | LOAEL | 50 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=4c84fa09-5085-4579-92c2-e9b473017fd8_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=4c84fa09-5085-4579-92c2-e9b473017fd8/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-05-26; basis=dermal irritation; key_result=false; entry_uuid=a01aa7bf-3c16-44ec-b111-bdcde0598185 |
| ECHA | LOAEL | 100.7 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=food consumption and compound intake; key_result=false; entry_uuid=1fad3ad8-29aa-4569-863e-5160f69047a3 |
| ECHA | LOAEL | 105.5 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=body weight and weight gain; key_result=false; entry_uuid=3d85e9c2-b14f-403a-8b78-7bc557694cc8 |
| ECHA | LOAEL | 35 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=76a6b4d6-f962-44a8-9d3f-d9e012b8c361_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=76a6b4d6-f962-44a8-9d3f-d9e012b8c361/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=organ weights and organ / body weight ratios; key_result=false; entry_uuid=9bb30df5-5edb-451b-bec3-b0f95fd08550 |
| ECHA | LOAEL | 180 | mg/kg bw/day | rat | oral: drinking water | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=9af6594a-10fd-46be-b524-3a3ef9ad1655_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=9af6594a-10fd-46be-b524-3a3ef9ad1655/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-01-30; basis=body weight and weight gain; key_result=false; entry_uuid=9ac5a065-6f11-4184-a2b3-e84486ff129d |
| ECHA | LOAEL | 1630 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=beaf9a00-ccd5-4b32-8cdf-97893530cf9b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=beaf9a00-ccd5-4b32-8cdf-97893530cf9b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-08-29; basis=body weight and weight gain; key_result=false; entry_uuid=52d3084d-8686-4c79-a6e9-e767dcdfeee8 |
| ECHA | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=103ad70d-f295-457b-9bbd-20bbeba491f6_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=103ad70d-f295-457b-9bbd-20bbeba491f6/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=body weight and weight gain; key_result=false; entry_uuid=92836d12-fa02-4449-94e7-e509b469132f |
| ECHA | LOAEL | 16 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=7fd6b346-f558-41b5-82d3-dffe8d82c110_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=7fd6b346-f558-41b5-82d3-dffe8d82c110/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1980; basis=body weight and weight gain; key_result=false; entry_uuid=158117e7-690f-4c25-b7ab-89e351235177 |
| ECHA | LOAEL | 116.6 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=body weight and weight gain; key_result=false; entry_uuid=f218d938-987c-467d-ab62-fb99ce73a7f2 |
| ECHA | LOAEL | 153.2 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=body weight and weight gain; key_result=false; entry_uuid=7d8dd2f1-9ff0-407f-9464-b82eabd8af78 |
| ECHA | LOAEL | 106.9 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=body weight and weight gain; key_result=false; entry_uuid=638fa19a-de0e-4ace-a942-9155dd68b80f |
| ECHA | LOAEL | 144.4 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=body weight and weight gain; key_result=false; entry_uuid=a1d6fe2c-560f-46c9-8e99-8dd655c92fb5 |
| ECHA | LOAEL | 17 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=body weight and weight gain; key_result=false; entry_uuid=550ab055-29dc-4803-a648-d956ee89aa54 |
| ECHA | LOAEL | 25 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=body weight and weight gain; key_result=false; entry_uuid=0d3d3b82-dee0-40c0-82f9-c7345d89141b |
| ECHA | LOAEL | 45 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=50979983-f2db-43fe-baa9-6a503f2dade2_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=50979983-f2db-43fe-baa9-6a503f2dade2/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-11; basis=body weight and weight gain; key_result=false; entry_uuid=3729d328-b7b5-4cf2-8f26-38d01583865d |
| ECHA | LOAEL | 50 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=4c84fa09-5085-4579-92c2-e9b473017fd8_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=4c84fa09-5085-4579-92c2-e9b473017fd8/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-05-26; basis=dermal irritation; key_result=false; entry_uuid=a01aa7bf-3c16-44ec-b111-bdcde0598185 |
| ECHA | LOAEL | 100.7 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=food consumption and compound intake; key_result=false; entry_uuid=1fad3ad8-29aa-4569-863e-5160f69047a3 |
| ECHA | LOAEL | 105.5 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=body weight and weight gain; key_result=false; entry_uuid=3d85e9c2-b14f-403a-8b78-7bc557694cc8 |
| ECHA | LOAEL | 35 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=76a6b4d6-f962-44a8-9d3f-d9e012b8c361_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=76a6b4d6-f962-44a8-9d3f-d9e012b8c361/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=organ weights and organ / body weight ratios; key_result=false; entry_uuid=9bb30df5-5edb-451b-bec3-b0f95fd08550 |
| ECHA | LOAEL | 180 | mg/kg bw/day | rat | oral: drinking water | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=9af6594a-10fd-46be-b524-3a3ef9ad1655_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=9af6594a-10fd-46be-b524-3a3ef9ad1655/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-01-30; basis=body weight and weight gain; key_result=false; entry_uuid=9ac5a065-6f11-4184-a2b3-e84486ff129d |
| ECHA | LOAEL | 1630 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=beaf9a00-ccd5-4b32-8cdf-97893530cf9b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=beaf9a00-ccd5-4b32-8cdf-97893530cf9b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-08-29; basis=body weight and weight gain; key_result=false; entry_uuid=52d3084d-8686-4c79-a6e9-e767dcdfeee8 |
| ECHA | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=103ad70d-f295-457b-9bbd-20bbeba491f6_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=103ad70d-f295-457b-9bbd-20bbeba491f6/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=body weight and weight gain; key_result=false; entry_uuid=92836d12-fa02-4449-94e7-e509b469132f |
| ECHA | LOAEL | 16 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=7fd6b346-f558-41b5-82d3-dffe8d82c110_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=7fd6b346-f558-41b5-82d3-dffe8d82c110/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1980; basis=body weight and weight gain; key_result=false; entry_uuid=158117e7-690f-4c25-b7ab-89e351235177 |
| ECHA | LOAEL | 116.6 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=body weight and weight gain; key_result=false; entry_uuid=f218d938-987c-467d-ab62-fb99ce73a7f2 |
| ECHA | LOAEL | 153.2 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=body weight and weight gain; key_result=false; entry_uuid=7d8dd2f1-9ff0-407f-9464-b82eabd8af78 |
| ECHA | LOAEL | 106.9 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=body weight and weight gain; key_result=false; entry_uuid=638fa19a-de0e-4ace-a942-9155dd68b80f |
| ECHA | LOAEL | 144.4 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=body weight and weight gain; key_result=false; entry_uuid=a1d6fe2c-560f-46c9-8e99-8dd655c92fb5 |
| ECHA | LOAEL | 17 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=body weight and weight gain; key_result=false; entry_uuid=550ab055-29dc-4803-a648-d956ee89aa54 |
| ECHA | LOAEL | 25 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=body weight and weight gain; key_result=false; entry_uuid=0d3d3b82-dee0-40c0-82f9-c7345d89141b |
| ECHA | LOAEL | 45 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=50979983-f2db-43fe-baa9-6a503f2dade2_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=50979983-f2db-43fe-baa9-6a503f2dade2/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-11; basis=body weight and weight gain; key_result=false; entry_uuid=3729d328-b7b5-4cf2-8f26-38d01583865d |
| ECHA | LOAEL | 50 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=4c84fa09-5085-4579-92c2-e9b473017fd8_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=4c84fa09-5085-4579-92c2-e9b473017fd8/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1994; ReportDate=1994-05-26; basis=dermal irritation; key_result=false; entry_uuid=a01aa7bf-3c16-44ec-b111-bdcde0598185 |
| ECHA | LOAEL | 100.7 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=food consumption and compound intake; key_result=false; entry_uuid=1fad3ad8-29aa-4569-863e-5160f69047a3 |
| ECHA | LOAEL | 105.5 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=body weight and weight gain; key_result=false; entry_uuid=3d85e9c2-b14f-403a-8b78-7bc557694cc8 |
| ECHA | LOAEL | 35 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=76a6b4d6-f962-44a8-9d3f-d9e012b8c361_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=76a6b4d6-f962-44a8-9d3f-d9e012b8c361/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=organ weights and organ / body weight ratios; key_result=false; entry_uuid=9bb30df5-5edb-451b-bec3-b0f95fd08550 |
| ECHA | LOAEL | 180 | mg/kg bw/day | rat | oral: drinking water | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=9af6594a-10fd-46be-b524-3a3ef9ad1655_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=9af6594a-10fd-46be-b524-3a3ef9ad1655/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1976; ReportDate=1976-01-30; basis=body weight and weight gain; key_result=false; entry_uuid=9ac5a065-6f11-4184-a2b3-e84486ff129d |
| ECHA | LOAEL | 1630 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=beaf9a00-ccd5-4b32-8cdf-97893530cf9b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=beaf9a00-ccd5-4b32-8cdf-97893530cf9b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-08-29; basis=body weight and weight gain; key_result=false; entry_uuid=52d3084d-8686-4c79-a6e9-e767dcdfeee8 |
| ECHA | LOAEL | 100 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=103ad70d-f295-457b-9bbd-20bbeba491f6_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=103ad70d-f295-457b-9bbd-20bbeba491f6/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; basis=body weight and weight gain; key_result=false; entry_uuid=92836d12-fa02-4449-94e7-e509b469132f |
| ECHA | LOAEL | 16 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=7fd6b346-f558-41b5-82d3-dffe8d82c110_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=7fd6b346-f558-41b5-82d3-dffe8d82c110/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1980; basis=body weight and weight gain; key_result=false; entry_uuid=158117e7-690f-4c25-b7ab-89e351235177 |
| ECHA | LOAEL | 116.6 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=body weight and weight gain; key_result=false; entry_uuid=f218d938-987c-467d-ab62-fb99ce73a7f2 |
| ECHA | LOAEL | 153.2 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=body weight and weight gain; key_result=false; entry_uuid=7d8dd2f1-9ff0-407f-9464-b82eabd8af78 |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=62f9f24c-c4f1-4540-9b4e-a54f1e32f076_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=62f9f24c-c4f1-4540-9b4e-a54f1e32f076/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-05-19; basis=other:; key_result=false; entry_uuid=e8a9672e-288e-453f-88fa-b5c1cbc40e1c |
| ECHA | NOAEL | 29.9 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=other:; key_result=false; entry_uuid=a75f0eeb-1e70-4d77-a08d-561a4c370343 |
| ECHA | NOAEL | 38.5 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=other:; key_result=false; entry_uuid=f30a9e62-60af-402b-bf46-f61f205be77f |
| ECHA | NOAEL | 4 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=7d4c8d11-9c74-46be-b780-a2e8024cbd5e |
| ECHA | NOAEL | 6 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=31050d2f-6f60-4433-924c-250240393ead |
| ECHA | NOAEL | 15 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=50979983-f2db-43fe-baa9-6a503f2dade2_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=50979983-f2db-43fe-baa9-6a503f2dade2/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-11; basis=other:; key_result=false; entry_uuid=84735400-7fad-4460-854c-48872d12e4c5 |
| ECHA | NOAEL | 12.8 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=other:; key_result=false; entry_uuid=63c5f7d3-55ab-406c-8439-b78fc6ea88f8 |
| ECHA | NOAEL | 13.6 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=other:; key_result=false; entry_uuid=395b335f-f25b-4b34-9ca5-6bb15307b24f |
| ECHA | NOAEL | 10 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=00b5d57f-766c-4f4b-8884-3b6b1b5f8dbf_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=00b5d57f-766c-4f4b-8884-3b6b1b5f8dbf/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-11; basis=other:; key_result=false; entry_uuid=a3143f3e-6475-4a7c-8578-d34c0598e4ef |
| ECHA | NOAEL | 5 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=76a6b4d6-f962-44a8-9d3f-d9e012b8c361_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=76a6b4d6-f962-44a8-9d3f-d9e012b8c361/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=false; entry_uuid=038faad0-8b14-472b-951b-b59c14004fad |
| ECHA | NOAEL | 7 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=76a6b4d6-f962-44a8-9d3f-d9e012b8c361_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=76a6b4d6-f962-44a8-9d3f-d9e012b8c361/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=false; entry_uuid=d2e88bca-6275-479a-8aaf-a59e1a8a65c4 |
| ECHA | NOAEL | 1020 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=beaf9a00-ccd5-4b32-8cdf-97893530cf9b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=beaf9a00-ccd5-4b32-8cdf-97893530cf9b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-08-29; basis=other:; key_result=false; entry_uuid=2fc9291b-20d1-4b48-a6cf-7059ffff25eb |
| ECHA | NOAEL | 50 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=7fd6b346-f558-41b5-82d3-dffe8d82c110_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=7fd6b346-f558-41b5-82d3-dffe8d82c110/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1980; basis=other:; key_result=false; entry_uuid=bebdb427-b1a8-4329-af5a-1285e48169c8 |
| ECHA | NOAEL | 14 | mg/kg bw/day | dog | other: | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=ea2d3c3e-b270-4683-b002-51e72a98c770_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=ea2d3c3e-b270-4683-b002-51e72a98c770/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-03; basis=other:; key_result=false; entry_uuid=cd3a6ff0-156c-4666-98d7-98048dfd8879 |
| ECHA | NOAEL | 13 | mg/kg bw/day | dog | other: | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=ea2d3c3e-b270-4683-b002-51e72a98c770_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=ea2d3c3e-b270-4683-b002-51e72a98c770/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-03; basis=other:; key_result=false; entry_uuid=728f46d2-473b-44d5-9e5c-0e2b6c66e362 |
| ECHA | NOAEL | >14.1 | mg/kg bw/day | dog | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=6dc8db5d-2f95-4fc6-b3db-277640ef45f8_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=6dc8db5d-2f95-4fc6-b3db-277640ef45f8/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-29; basis=other:; key_result=false; entry_uuid=6ee8c896-ef7d-4e53-b036-60e70df1f547 |
| ECHA | NOAEL | >15.1 | mg/kg bw/day | dog | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=6dc8db5d-2f95-4fc6-b3db-277640ef45f8_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=6dc8db5d-2f95-4fc6-b3db-277640ef45f8/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-29; basis=other:; key_result=false; entry_uuid=1b41828d-aaaa-4caa-9e0e-fb1dbcc2ea41 |
| ECHA | NOAEL | 30.5 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=other:; key_result=false; entry_uuid=b88dfa3c-f790-4653-bdf4-1febd6c19798 |
| ECHA | NOAEL | 46 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=other:; key_result=false; entry_uuid=e4d46f1b-9ccf-4a6d-ba7f-3a6b0770be9f |
| ECHA | NOAEL | 29.1 | mg/kg bw/day | dog | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=f1de3cfe-d716-4cba-8ca5-69799a238064_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=f1de3cfe-d716-4cba-8ca5-69799a238064/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-21; basis=other:; key_result=false; entry_uuid=711cb64d-f961-4635-b1ec-2f64130b54bb |
| ECHA | NOAEL | 33.2 | mg/kg bw/day | dog | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=f1de3cfe-d716-4cba-8ca5-69799a238064_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=f1de3cfe-d716-4cba-8ca5-69799a238064/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-21; basis=other:; key_result=false; entry_uuid=9d553900-4694-4ba3-bfbf-b2f41f1aa6fb |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=62f9f24c-c4f1-4540-9b4e-a54f1e32f076_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=62f9f24c-c4f1-4540-9b4e-a54f1e32f076/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-05-19; basis=other:; key_result=false; entry_uuid=e8a9672e-288e-453f-88fa-b5c1cbc40e1c |
| ECHA | NOAEL | 29.9 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=other:; key_result=false; entry_uuid=a75f0eeb-1e70-4d77-a08d-561a4c370343 |
| ECHA | NOAEL | 38.5 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=other:; key_result=false; entry_uuid=f30a9e62-60af-402b-bf46-f61f205be77f |
| ECHA | NOAEL | 4 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=7d4c8d11-9c74-46be-b780-a2e8024cbd5e |
| ECHA | NOAEL | 6 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=31050d2f-6f60-4433-924c-250240393ead |
| ECHA | NOAEL | 15 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=50979983-f2db-43fe-baa9-6a503f2dade2_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=50979983-f2db-43fe-baa9-6a503f2dade2/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-11; basis=other:; key_result=false; entry_uuid=84735400-7fad-4460-854c-48872d12e4c5 |
| ECHA | NOAEL | 12.8 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=other:; key_result=false; entry_uuid=63c5f7d3-55ab-406c-8439-b78fc6ea88f8 |
| ECHA | NOAEL | 13.6 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=other:; key_result=false; entry_uuid=395b335f-f25b-4b34-9ca5-6bb15307b24f |
| ECHA | NOAEL | 10 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=00b5d57f-766c-4f4b-8884-3b6b1b5f8dbf_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=00b5d57f-766c-4f4b-8884-3b6b1b5f8dbf/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-11; basis=other:; key_result=false; entry_uuid=a3143f3e-6475-4a7c-8578-d34c0598e4ef |
| ECHA | NOAEL | 5 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=76a6b4d6-f962-44a8-9d3f-d9e012b8c361_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=76a6b4d6-f962-44a8-9d3f-d9e012b8c361/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=false; entry_uuid=038faad0-8b14-472b-951b-b59c14004fad |
| ECHA | NOAEL | 7 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=76a6b4d6-f962-44a8-9d3f-d9e012b8c361_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=76a6b4d6-f962-44a8-9d3f-d9e012b8c361/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=false; entry_uuid=d2e88bca-6275-479a-8aaf-a59e1a8a65c4 |
| ECHA | NOAEL | 1020 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=beaf9a00-ccd5-4b32-8cdf-97893530cf9b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=beaf9a00-ccd5-4b32-8cdf-97893530cf9b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-08-29; basis=other:; key_result=false; entry_uuid=2fc9291b-20d1-4b48-a6cf-7059ffff25eb |
| ECHA | NOAEL | 50 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=7fd6b346-f558-41b5-82d3-dffe8d82c110_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=7fd6b346-f558-41b5-82d3-dffe8d82c110/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1980; basis=other:; key_result=false; entry_uuid=bebdb427-b1a8-4329-af5a-1285e48169c8 |
| ECHA | NOAEL | 14 | mg/kg bw/day | dog | other: | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=ea2d3c3e-b270-4683-b002-51e72a98c770_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=ea2d3c3e-b270-4683-b002-51e72a98c770/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-03; basis=other:; key_result=false; entry_uuid=cd3a6ff0-156c-4666-98d7-98048dfd8879 |
| ECHA | NOAEL | 13 | mg/kg bw/day | dog | other: | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=ea2d3c3e-b270-4683-b002-51e72a98c770_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=ea2d3c3e-b270-4683-b002-51e72a98c770/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-03; basis=other:; key_result=false; entry_uuid=728f46d2-473b-44d5-9e5c-0e2b6c66e362 |
| ECHA | NOAEL | >14.1 | mg/kg bw/day | dog | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=6dc8db5d-2f95-4fc6-b3db-277640ef45f8_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=6dc8db5d-2f95-4fc6-b3db-277640ef45f8/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-29; basis=other:; key_result=false; entry_uuid=6ee8c896-ef7d-4e53-b036-60e70df1f547 |
| ECHA | NOAEL | >15.1 | mg/kg bw/day | dog | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=6dc8db5d-2f95-4fc6-b3db-277640ef45f8_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=6dc8db5d-2f95-4fc6-b3db-277640ef45f8/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-29; basis=other:; key_result=false; entry_uuid=1b41828d-aaaa-4caa-9e0e-fb1dbcc2ea41 |
| ECHA | NOAEL | 30.5 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=other:; key_result=false; entry_uuid=b88dfa3c-f790-4653-bdf4-1febd6c19798 |
| ECHA | NOAEL | 46 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=other:; key_result=false; entry_uuid=e4d46f1b-9ccf-4a6d-ba7f-3a6b0770be9f |
| ECHA | NOAEL | 29.1 | mg/kg bw/day | dog | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=f1de3cfe-d716-4cba-8ca5-69799a238064_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=f1de3cfe-d716-4cba-8ca5-69799a238064/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-21; basis=other:; key_result=false; entry_uuid=711cb64d-f961-4635-b1ec-2f64130b54bb |
| ECHA | NOAEL | 33.2 | mg/kg bw/day | dog | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=f1de3cfe-d716-4cba-8ca5-69799a238064_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=f1de3cfe-d716-4cba-8ca5-69799a238064/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-21; basis=other:; key_result=false; entry_uuid=9d553900-4694-4ba3-bfbf-b2f41f1aa6fb |
| ECHA | NOAEL | 150 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=62f9f24c-c4f1-4540-9b4e-a54f1e32f076_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=62f9f24c-c4f1-4540-9b4e-a54f1e32f076/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=2000; ReportDate=2000-05-19; basis=other:; key_result=false; entry_uuid=e8a9672e-288e-453f-88fa-b5c1cbc40e1c |
| ECHA | NOAEL | 29.9 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=other:; key_result=false; entry_uuid=a75f0eeb-1e70-4d77-a08d-561a4c370343 |
| ECHA | NOAEL | 38.5 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=338f6ce7-b440-41aa-89c0-33bd3b1c2689_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=338f6ce7-b440-41aa-89c0-33bd3b1c2689/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-10; basis=other:; key_result=false; entry_uuid=f30a9e62-60af-402b-bf46-f61f205be77f |
| ECHA | NOAEL | 4 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=7d4c8d11-9c74-46be-b780-a2e8024cbd5e |
| ECHA | NOAEL | 6 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=73795bd1-bc08-4d46-b598-8e2af488749b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=73795bd1-bc08-4d46-b598-8e2af488749b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=31050d2f-6f60-4433-924c-250240393ead |
| ECHA | NOAEL | 15 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=50979983-f2db-43fe-baa9-6a503f2dade2_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=50979983-f2db-43fe-baa9-6a503f2dade2/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-11; basis=other:; key_result=false; entry_uuid=84735400-7fad-4460-854c-48872d12e4c5 |
| ECHA | NOAEL | 12.8 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=other:; key_result=false; entry_uuid=63c5f7d3-55ab-406c-8439-b78fc6ea88f8 |
| ECHA | NOAEL | 13.6 | mg/kg bw/day | rat | oral: drinking water | - | repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=a7cb8ce2-7978-4702-995b-b257ed74ab74_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=a7cb8ce2-7978-4702-995b-b257ed74ab74/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; ReportDate=1985-03-19; basis=other:; key_result=false; entry_uuid=395b335f-f25b-4b34-9ca5-6bb15307b24f |
| ECHA | NOAEL | 10 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=00b5d57f-766c-4f4b-8884-3b6b1b5f8dbf_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=00b5d57f-766c-4f4b-8884-3b6b1b5f8dbf/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1991; ReportDate=1991-02-11; basis=other:; key_result=false; entry_uuid=a3143f3e-6475-4a7c-8578-d34c0598e4ef |
| ECHA | NOAEL | 5 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=76a6b4d6-f962-44a8-9d3f-d9e012b8c361_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=76a6b4d6-f962-44a8-9d3f-d9e012b8c361/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=false; entry_uuid=038faad0-8b14-472b-951b-b59c14004fad |
| ECHA | NOAEL | 7 | mg/kg bw/day | rat | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=76a6b4d6-f962-44a8-9d3f-d9e012b8c361_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=76a6b4d6-f962-44a8-9d3f-d9e012b8c361/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1985; basis=other:; key_result=false; entry_uuid=d2e88bca-6275-479a-8aaf-a59e1a8a65c4 |
| ECHA | NOAEL | 1020 | mg/kg bw/day | rat | oral: feed | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=beaf9a00-ccd5-4b32-8cdf-97893530cf9b_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=beaf9a00-ccd5-4b32-8cdf-97893530cf9b/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1975; ReportDate=1975-08-29; basis=other:; key_result=false; entry_uuid=2fc9291b-20d1-4b48-a6cf-7059ffff25eb |
| ECHA | NOAEL | 50 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=7fd6b346-f558-41b5-82d3-dffe8d82c110_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=7fd6b346-f558-41b5-82d3-dffe8d82c110/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1980; basis=other:; key_result=false; entry_uuid=bebdb427-b1a8-4329-af5a-1285e48169c8 |
| ECHA | NOAEL | 14 | mg/kg bw/day | dog | other: | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=ea2d3c3e-b270-4683-b002-51e72a98c770_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=ea2d3c3e-b270-4683-b002-51e72a98c770/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-03; basis=other:; key_result=false; entry_uuid=cd3a6ff0-156c-4666-98d7-98048dfd8879 |
| ECHA | NOAEL | 13 | mg/kg bw/day | dog | other: | - | short-term repeated dose toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=ea2d3c3e-b270-4683-b002-51e72a98c770_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=ea2d3c3e-b270-4683-b002-51e72a98c770/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-03; basis=other:; key_result=false; entry_uuid=728f46d2-473b-44d5-9e5c-0e2b6c66e362 |
| ECHA | NOAEL | >14.1 | mg/kg bw/day | dog | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=6dc8db5d-2f95-4fc6-b3db-277640ef45f8_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=6dc8db5d-2f95-4fc6-b3db-277640ef45f8/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-29; basis=other:; key_result=false; entry_uuid=6ee8c896-ef7d-4e53-b036-60e70df1f547 |
| ECHA | NOAEL | >15.1 | mg/kg bw/day | dog | oral: drinking water | - | sub-chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=6dc8db5d-2f95-4fc6-b3db-277640ef45f8_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=6dc8db5d-2f95-4fc6-b3db-277640ef45f8/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-29; basis=other:; key_result=false; entry_uuid=1b41828d-aaaa-4caa-9e0e-fb1dbcc2ea41 |
| ECHA | NOAEL | 30.5 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=other:; key_result=false; entry_uuid=b88dfa3c-f790-4653-bdf4-1febd6c19798 |
| ECHA | NOAEL | 46 | mg/kg bw/day | rat | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=af5dfb56-82d6-4439-9a50-dc4a10ae5f30_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=af5dfb56-82d6-4439-9a50-dc4a10ae5f30/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2002; ReportDate=2002-11-26; basis=other:; key_result=false; entry_uuid=e4d46f1b-9ccf-4a6d-ba7f-3a6b0770be9f |
| ECHA | NOAEL | 29.1 | mg/kg bw/day | dog | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=f1de3cfe-d716-4cba-8ca5-69799a238064_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=f1de3cfe-d716-4cba-8ca5-69799a238064/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-21; basis=other:; key_result=false; entry_uuid=711cb64d-f961-4635-b1ec-2f64130b54bb |
| ECHA | NOAEL | 33.2 | mg/kg bw/day | dog | oral: drinking water | - | chronic toxicity: oral | dossier=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6z; document=f1de3cfe-d716-4cba-8ca5-69799a238064_7d4c4213-bd6f-40a2-bf4c-978aed4fdffe.i6d; document_key=f1de3cfe-d716-4cba-8ca5-69799a238064/7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-05-21; basis=other:; key_result=false; entry_uuid=9d553900-4694-4ba3-bfbf-b2f41f1aa6fb |
| ECHA | LEL | =10.6464 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/3/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15797831:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_78aeb878577b4606621368af351b4340 |
| ECHA | LOAEC | =0.204739 | mg/m3 | Rat | inhalation | chronic; 14 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828469_15828470:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_57642d5b2f1f2fde98b2bfa8d90c5dff |
| ECHA | LOAEC | =0.253877 | mg/m3 | Mouse | inhalation | short-term; 1 weeks | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828861_15828862_15828863:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_43c556ba027e8bdf487f4efb5d2f1d65 |
| ECHA | LOAEC | =0.511848 | mg/m3 | Mouse | inhalation | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828310_15828311_15828312_15828313:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_73552b810d62bbfcc8ccbf47c72a69c2 |
| ECHA | LOAEC | =0.818957 | mg/m3 | Rat | inhalation | short-term; 9 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15829370:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce14787eb6833e53628a4b879cbf386a |
| ECHA | LOAEC | =1.0237 | mg/m3 | Rat | inhalation | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827719_15827720_15827721:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_de61b4cce017cbaa80b30488175592e3 |
| ECHA | LOAEC | =2.04739 | mg/m3 | Rat | inhalation | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827719_15827720_15827721:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_943b6e9eeb97cfbc4caf94c49508cb38 |
| ECHA | LOAEL | =16 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb7c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/9/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15822594:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d155338795203468743a27eecee99dc3 |
| ECHA | LOAEL | =17 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1230; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|gross pathology|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837295_15837297:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64f93e3672c4f4ccedf7ce9acbc380ce |
| ECHA | LOAEL | =25 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1230; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|gross pathology|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837296_15837298:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b7d494c2291ef1d13f4754b8ee73a9f |
| ECHA | LOAEL | =35 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1232; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=organ weight and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837471_15837473:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c230b54b4dd35a0ad32b07e235dd1d6e |
| ECHA | LOAEL | =50 | mg/kg bw/day | Rat | dermal | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61df8e4b096bca8777cc1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/4?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15826359:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26361a0258aa7bf1e7530076fbc09205 |
| ECHA | LOAEL | =100 | ppm | Rabbit | oral | - | reproduction developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f0c5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/9/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=maternal: food consumption and compound intake|maternal: water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15822491:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_320031a0b7b47693adc0d6e69d025f06 |
| ECHA | LOAEL | =100.7 | mg/kg bw/day | Rat | oral | short-term; 2 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d22045f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=food consumption and compound intake|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840811_15840813:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af9045fb3bcbf941fdd99ab83d413345 |
| ECHA | LOAEL | =105.5 | mg/kg bw/day | Rat | oral | short-term; 2 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d22045f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840812_15840814:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9407e6b55fac3dcfdef79589af6d42f4 |
| ECHA | LOAEL | =106.9 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c122c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833127_15833129:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64e09da0a74493d815c81fd23e9d6fa5 |
| ECHA | LOAEL | =111.5 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3009; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/8?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818843_15818844:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44a53cd722faef29707ec831ef20e8d9 |
| ECHA | LOAEL | =116.6 | mg/kg bw/day | Rat | oral | chronic; 12 months | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1236; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|histopathology: non-neoplastic|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841385_15841387:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c61c86726c14356186e0ea88755fe90c |
| ECHA | LOAEL | =144.4 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c122c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833128_15833130:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9fe8e6cc6ed54f5e4764401188672955 |
| ECHA | LOAEL | =153.2 | mg/kg bw/day | Rat | oral | chronic; 12 months | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1236; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|histopathology: non-neoplastic|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841386_15841388:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_08ee22f93304b5f6b44a418f29f3a598 |
| ECHA | LOAEL | =180 | mg/kg bw/day | Rat | oral | short-term; 4 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d22045c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15839932:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_55edbff3229ad06b1bbedf927974212b |
| ECHA | LOAEL | =250 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c892e4b0a7c65d21931c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/9/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=P1: body weight and weight gain|P1: food consumption and compound intake|P1: water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858026_15858099_15858137:M/F:P1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bb94d3d0fb13ce8669c7f6f221a231fa |
| ECHA | LOAEL | =1630 | mg/kg bw/day | Rat | oral | short-term; 7 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d220476; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=body weight and weight gain|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842291_15842292:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f2ae925c3bfaa77776be1aadadf7dc6 |
| ECHA | NOAEC | =0.0818957 | mg/m3 | Rat | inhalation | chronic; 14 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828469_15828470:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02f2851c80a2b46bb6439829f4f4e47f |
| ECHA | NOAEC | =0.253877 | mg/m3 | Mouse | inhalation | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828310_15828311_15828312_15828313:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1167b43500a91ff4d37d445b30db1aae |
| ECHA | NOAEC | =0.511848 | mg/m3 | Rat | inhalation | short-term; 1 weeks | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828415_15828416_15828417:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fa84f1385cdef90b6588bc375470823 |
| ECHA | NOAEC | >4.09479 | mg/m3 | Rat | inhalation | short-term; 1 weeks | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/3?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828415_15828416_15828417:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c1aa8229ff4209103c518db860a0745d |
| ECHA | NOAEL | =5 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1232; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837470_15837472:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1ba4a22fcf150877ed252cf53c598eb1 |
| ECHA | NOAEL | =6 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1230; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837296_15837298:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a9f1396ead78b31c88ea797f12234e81 |
| ECHA | NOAEL | =7 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1232; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837471_15837473:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1b309e42ae5ad9b96b66e1cc2932821e |
| ECHA | NOAEL | =12.8 | mg/kg bw/day | Rat | oral | short-term; 2 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d22045f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840811_15840813:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_35cd2cd5952b11533229d110bb13dace |
| ECHA | NOAEL | =13 | mg/kg bw/day | Dog | oral | short-term; 2 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d220487; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15845209:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e02382a2a10f1c27f0e624d50acaab9 |
| ECHA | NOAEL | =13.6 | mg/kg bw/day | Rat | oral | short-term; 2 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d22045f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840812_15840814:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_39e638d9025058275af71579d2f9fe0e |
| ECHA | NOAEL | =14 | mg/kg bw/day | Dog | oral | short-term; 2 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d220487; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15845208:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_833ebaf9ff62bd10fd0c1bec17bde180 |
| ECHA | NOAEL | >14.1 | mg/kg bw/day | Dog | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c122e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15836941:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4afa19dccd5aa58bbc9a0a2676d61d15 |
| ECHA | NOAEL | >15.1 | mg/kg bw/day | Dog | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c122e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15836942:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_761e03d7eb117b9ebbbd54f7b1ebf3f2 |
| ECHA | NOAEL | =22.3 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3009; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/8?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818843_15818844:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_15b31e318f3fd30b3849ef9cb2518156 |
| ECHA | NOAEL | =29.1 | mg/kg bw/day | Dog | oral | chronic; 12 months | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c123c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845725_15845726:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9b51ac5ffeb6e63efb263f082adcfe38 |
| ECHA | NOAEL | =29.9 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c122c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833127_15833129:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5b4e07d359d4bde46652f792f2b67b9f |
| ECHA | NOAEL | =30.5 | mg/kg bw/day | Rat | oral | chronic; 12 months | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1236; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841385_15841387:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e214c3862002748a26e3d2be6accd6f6 |
| ECHA | NOAEL | =33.2 | mg/kg bw/day | Dog | oral | chronic; 12 months | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c123c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15845725_15845726:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0ea90f83ff1b38814e5fb93fa9ca7a65 |
| ECHA | NOAEL | =38.5 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c122c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833128_15833130:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_269a7c709cc4659e07fa80d2174fdb7f |
| ECHA | NOAEL | =46 | mg/kg bw/day | Rat | oral | chronic; 12 months | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1236; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841386_15841388:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_94375e5e087c04c9088b2fff40a7be97 |
| ECHA | NOAEL | =50 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c892e4b0a7c65d21931c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/9/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858026_15858099_15858137:M/F:P1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_01c89564636db5c1c4dadf01c646e09b |
| ECHA | NOAEL | =150 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | GUIDELINE=OECD Guideline 411 (Subchronic Dermal Toxicity: 90-Day Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e2ae4b096bca877895d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/4?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15826421:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8d883d926057dc142bc98ef6fbbfe962 |
| ECHA | NOAEL | =500 | ppm | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c892e4b0a7c65d21931a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/9/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855006_15855905_15856634:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0461cec02901c04befb29edce33c0ba3 |
| ECHA | NOAEL | =1000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c892e4b0a7c65d21931c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/9/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15858026_15858099_15858137:M/F:P1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b55d48e30a94b9247762d2eba813cc78 |
| ECHA | NOAEL | =1020 | mg/kg bw/day | Rat | oral | short-term; 7 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca1ae4b0a7c65d220476; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/6/2?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15842291_15842292:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0dd5ec8bea94b20c3c7744ad0c8cd6a |
| ECHA | NOAEL | =2000 | ppm | Rat | oral | - | repeat dose other | GUIDELINE=other:; QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218107; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/10/1?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15825772:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76a5ddb5ed64b09bc2ff527f6b833d43 |
| ECHA | NOEL | <11.15 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9d8e4b0a7c65d1b3007; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23371/7/8?documentUUID=7d4c4213-bd6f-40a2-bf4c-978aed4fdffe; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=histopathology: neoplastic|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15818073:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_25c56324ec8717792813c628f5422f1e |
WHO/JECFA 31 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =50 | mg/kg bw/day | - | - | 56-day | Chronic toxicity | document_id=harmproj_harmproj_harmproj4; title=Harmonization Project Document No. 4; path=mirror/documents/harmproj/harmproj/harmproj4.pdf; row_hash=8754ceccb8be778d; raw_unit=mg/kg bw per day; context=Effect NOAEL/LOAEL Liver Induction of UGT 15/50 mg/kg bw per day (56-day study) Increase in T4 biliary elimination <150/150 mg/kg bw per day (only dose tested in 56-day study) Increase in liver weight 5/15 mg/kg bw per day (56-day study) 44.2/136.4 mg/kg bw per day (2-year study) Hepatocellular hypertrophy 4.4/44.2 mg/kg b |
| WHO/JECFA | LOAEL | ~90 | mg/kg bw/day | - | - | - | Toxicology study | document_id=harmproj_harmproj_harmproj4; title=Harmonization Project Document No. 4; path=mirror/documents/harmproj/harmproj/harmproj4.pdf; row_hash=bed6098cb6b63440; raw_unit=mg/kg bw per day; context=These doses would have been at least 2-fold higher than those that were readily available (so the real LOAEL for neoplasia would have been about 90 mg/kg bw per day). |
| WHO/JECFA | NOAEL | =50 | mg/kg bw/day | Rat | - | 2-year | Carcinogenicity | document_id=harmproj_harmproj_harmproj4; title=Harmonization Project Document No. 4; path=mirror/documents/harmproj/harmproj/harmproj4.pdf; row_hash=52a3d9e208d47dc1; raw_unit=mg/kg bw per day; context=f thiazopyr producing a statistically significant (P < 0.05) increase in thyroid follicular cell tumours in male SD rats was 44.2 mg/kg bw per day in the 2-year study, whereas the NOAEL for effects on T4 and TSH was 50 mg/kg bw per day in the 56-day study (Table 2). |
| WHO/JECFA | LOEL | =0.2 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=79c9e6428939e0f6; raw_unit=ppm; context=The LOEL (lowest observed effect level) for the irritative effects is below 0.2 ppm which is comparable to animal data. |
| WHO/JECFA | LOEL | =0.2 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=79c9e6428939e0f6; raw_unit=ppm; context=The LOEL (lowest observed effect level) for the irritative effects is below 0.2 ppm which is comparable to animal data. |
| WHO/JECFA | LOEL | =0.2 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=79c9e6428939e0f6; raw_unit=ppm; context=The LOEL (lowest observed effect level) for the irritative effects is below 0.2 ppm which is comparable to animal data. |
| WHO/JECFA | LOEL | =0.2 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=79c9e6428939e0f6; raw_unit=ppm; context=The LOEL (lowest observed effect level) for the irritative effects is below 0.2 ppm which is comparable to animal data. |
| WHO/JECFA | NOAEL | =0.0625 | ppm | Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=4634e746e6f81b10; raw_unit=ppm; context=6h/d;5d/w;13w NOAEL for respiratory lesions 71 mouse BCF 0.0625 ppm; |
| WHO/JECFA | NOAEL | =0.0625 | ppm | Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=4634e746e6f81b10; raw_unit=ppm; context=6h/d;5d/w;13w NOAEL for respiratory lesions 71 mouse BCF 0.0625 ppm; |
| WHO/JECFA | NOAEL | =0.0625 | ppm | Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=4634e746e6f81b10; raw_unit=ppm; context=6h/d;5d/w;13w NOAEL for respiratory lesions 71 mouse BCF 0.0625 ppm; |
| WHO/JECFA | NOAEL | =0.0625 | ppm | Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=4634e746e6f81b10; raw_unit=ppm; context=6h/d;5d/w;13w NOAEL for respiratory lesions 71 mouse BCF 0.0625 ppm; |
| WHO/JECFA | NOAEL | =50 | ppm | - | oral | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=e8c7f9866005369e; raw_unit=ppm; context=The investigators concluded that the NOAEL for adult and offspring toxicity was 50 ppm and 250 ppm glutaraldehyde in drinking water, respectively. |
| WHO/JECFA | NOAEL | =50 | ppm | - | oral | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=e8c7f9866005369e; raw_unit=ppm; context=The investigators concluded that the NOAEL for adult and offspring toxicity was 50 ppm and 250 ppm glutaraldehyde in drinking water, respectively. |
| WHO/JECFA | NOAEL | =50 | ppm | - | oral | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=e8c7f9866005369e; raw_unit=ppm; context=The investigators concluded that the NOAEL for adult and offspring toxicity was 50 ppm and 250 ppm glutaraldehyde in drinking water, respectively. |
| WHO/JECFA | NOAEL | =50 | ppm | - | oral | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=e8c7f9866005369e; raw_unit=ppm; context=The investigators concluded that the NOAEL for adult and offspring toxicity was 50 ppm and 250 ppm glutaraldehyde in drinking water, respectively. |
| WHO/JECFA | NOAEL | =62.5 | ppb | Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=5cb4e331c09e26d9; raw_unit=ppb; context=No NOAEL was reached in mice as inflammation was found in the anterior nasal passage at concentrations as low as 62.5 ppb. |
| WHO/JECFA | NOAEL | =62.5 | ppb | Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=5cb4e331c09e26d9; raw_unit=ppb; context=No NOAEL was reached in mice as inflammation was found in the anterior nasal passage at concentrations as low as 62.5 ppb. |
| WHO/JECFA | NOAEL | =62.5 | ppb | Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=5cb4e331c09e26d9; raw_unit=ppb; context=No NOAEL was reached in mice as inflammation was found in the anterior nasal passage at concentrations as low as 62.5 ppb. |
| WHO/JECFA | NOAEL | =62.5 | ppb | Mouse | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=5cb4e331c09e26d9; raw_unit=ppb; context=No NOAEL was reached in mice as inflammation was found in the anterior nasal passage at concentrations as low as 62.5 ppb. |
| WHO/JECFA | NOAEL | =125 | ppb | Rat | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=f56dba833837e6c3; raw_unit=ppb; context=A NOAEL for respiratory lesions was decided to be 125 ppb in rats. |
| WHO/JECFA | NOAEL | =125 | ppb | Rat | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=f56dba833837e6c3; raw_unit=ppb; context=A NOAEL for respiratory lesions was decided to be 125 ppb in rats. |
| WHO/JECFA | NOAEL | =125 | ppb | Rat | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=f56dba833837e6c3; raw_unit=ppb; context=A NOAEL for respiratory lesions was decided to be 125 ppb in rats. |
| WHO/JECFA | NOAEL | =125 | ppb | Rat | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=f56dba833837e6c3; raw_unit=ppb; context=A NOAEL for respiratory lesions was decided to be 125 ppb in rats. |
| WHO/JECFA | NOAEL | >1000 | ppm | - | oral | - | Reproductive toxicity | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=f89e11a7075d4850; raw_unit=ppm; context=The NOAEL for reproductive effects was > 1000 ppm in drinking water] 10.7. |
| WHO/JECFA | NOAEL | >1000 | ppm | - | oral | - | Reproductive toxicity | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=f89e11a7075d4850; raw_unit=ppm; context=The NOAEL for reproductive effects was > 1000 ppm in drinking water] 10.7. |
| WHO/JECFA | NOAEL | >1000 | ppm | - | oral | - | Reproductive toxicity | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=f89e11a7075d4850; raw_unit=ppm; context=The NOAEL for reproductive effects was > 1000 ppm in drinking water] 10.7. |
| WHO/JECFA | NOAEL | >1000 | ppm | - | oral | - | Reproductive toxicity | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=f89e11a7075d4850; raw_unit=ppm; context=The NOAEL for reproductive effects was > 1000 ppm in drinking water] 10.7. |
| WHO/JECFA | NOEL | =0.16 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=aad2577f14d98412; raw_unit=ppm; context=The NOEL in this study appears to be 0.16 ppm (71). |
| WHO/JECFA | NOEL | =0.16 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=aad2577f14d98412; raw_unit=ppm; context=The NOEL in this study appears to be 0.16 ppm (71). |
| WHO/JECFA | NOEL | =0.16 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=aad2577f14d98412; raw_unit=ppm; context=The NOEL in this study appears to be 0.16 ppm (71). |
| WHO/JECFA | NOEL | =0.16 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah1997_20; title=DECOS and NEG Basis for an Occupational Standard. Glutaraldehyde; path=mirror/documents/kemi/kemi/ah1997_20.pdf; row_hash=aad2577f14d98412; raw_unit=ppm; context=The NOEL in this study appears to be 0.16 ppm (71). |
NTP ICE acute dermal 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1554; Record_ID=acute_dermal_42; Data_Type=In Vivo; Formulation_ID=MIX41; Formulation_Name=Bactron K-139; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute dermal | GHS classification | 1 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1555; Record_ID=acute_dermal_541; Data_Type=In Vivo; Formulation_ID=MIX534; Formulation_Name=Ucarcide SB 130 Antimicrobial; Percent_Active_Ingredient=30.0; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=1.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1557; Record_ID=acute_dermal_42; Data_Type=In Vivo; Formulation_ID=MIX41; Formulation_Name=Bactron K-139; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute dermal | LD50 | 10.928 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1558; Record_ID=acute_dermal_541; Data_Type=In Vivo; Formulation_ID=MIX534; Formulation_Name=Ucarcide SB 130 Antimicrobial; Percent_Active_Ingredient=30.0; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response=10.928; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute dermal | LD50 | >2020 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1559; Record_ID=acute_dermal_42; Data_Type=In Vivo; Formulation_ID=MIX41; Formulation_Name=Bactron K-139; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2020.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
NTP ICE acute inhalation 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | EPA Classification | 3 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3482; Record_ID=acute_inhalation_50; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX41; Formulation_Name=Bactron K-139; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | GHS Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3485; Record_ID=acute_inhalation_50; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX41; Formulation_Name=Bactron K-139; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | range0 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3487; Record_ID=acute_inhalation_2924; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=range; Response=>0 and 0<; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=a26302d7-1c23-484e-b96f-1c18060f7f11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | >0.0123 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3497; Record_ID=acute_inhalation_2503; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.0123; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=e4ec57ed-becf-4a12-99db-4c06d13acc5c; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | >0.0201 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3492; Record_ID=acute_inhalation_2515; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.0201; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=2448d6a6-f92a-44ca-bd39-58ceb71525bb; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | >0.0331 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3491; Record_ID=acute_inhalation_2516; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.0331; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=1439c5c0-2d9a-40a5-8918-0dcb66529573; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | >0.0667 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3499; Record_ID=acute_inhalation_2500; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.0667; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=1f883c8f-f987-404a-9dab-ceef0a14bf00; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.083 | mg/L | - | Inhalation | Duration=3 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3493; Record_ID=acute_inhalation_2510; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.083; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=a244dddc-6ddc-4585-b8e8-64bf5e4cb115; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | >0.0908 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3483; Record_ID=acute_inhalation_2488; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.0908; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=a62fcf97-2b51-48f9-8d15-32edac8fdadb; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.0962 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3503; Record_ID=acute_inhalation_2489; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.0962; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=a4b97734-bc12-4747-bd57-97d584762dd0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.151 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3501; Record_ID=acute_inhalation_2494; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.151; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=a4b97734-bc12-4747-bd57-97d584762dd0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.1641 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3502; Record_ID=acute_inhalation_2493; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.1641; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=a4b97734-bc12-4747-bd57-97d584762dd0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.1817 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3490; Record_ID=acute_inhalation_2496; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.1817; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=a4b97734-bc12-4747-bd57-97d584762dd0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | >0.1968 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3498; Record_ID=acute_inhalation_2502; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.1968; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=31cd0949-70f6-4086-ad01-c964d2f9a4f8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.28 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3504; Record_ID=acute_inhalation_2487; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.28; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=a26302d7-1c23-484e-b96f-1c18060f7f11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.35 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3505; Record_ID=acute_inhalation_2486; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.35; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=a26302d7-1c23-484e-b96f-1c18060f7f11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.45 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3500; Record_ID=acute_inhalation_2506; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.45; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=c67e5aaf-5faf-434f-a475-6140527fd351; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.48 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3489; Record_ID=acute_inhalation_2594; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.48; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.52 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3496; Record_ID=acute_inhalation_2505; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.52; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=c67e5aaf-5faf-434f-a475-6140527fd351; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.77 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3484; Record_ID=acute_inhalation_2485; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.77; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=2180e3d4-647a-40fd-8d2f-f1467571ca06; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 0.8 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3486; Record_ID=acute_inhalation_2484; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.8; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=2180e3d4-647a-40fd-8d2f-f1467571ca06; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | range1 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3488; Record_ID=acute_inhalation_2922; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=range; Response=>1 and 1<; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=2180e3d4-647a-40fd-8d2f-f1467571ca06; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | 1.7 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3481; Record_ID=acute_inhalation_50; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX41; Formulation_Name=Bactron K-139; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.7; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | >12 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3495; Record_ID=acute_inhalation_2517; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=12; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=fe02ddb8-caa4-4650-a03d-f42a714e6161; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | >12.6 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3494; Record_ID=acute_inhalation_2509; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=12.6; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=e00844a4-2857-48da-bd01-658a95b21dfc; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE acute inhalation | LC50 | >40 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3506; Record_ID=acute_inhalation_2514; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=40; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1930/7/3/3/?documentUUID=8e1a710c-876a-4990-8789-e42911880fb2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
NTP ICE acute oral 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =2 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13159; row=10389; data_type=In Vivo; mixture=Mixture; formulation_id=MIX664; formulation_name=Aqucar GA 23 SB Water Treatment Microbiocide; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; percent_active_ingredient=23.0; dtxsid=DTXSID6025355; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12244; row=10390; data_type=In Vivo; mixture=Mixture; formulation_id=MIX41; formulation_name=Bactron K-139; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; percent_active_ingredient=5.0; dtxsid=DTXSID6025355; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =3 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13159; row=10382; data_type=In Vivo; mixture=Mixture; formulation_id=MIX664; formulation_name=Aqucar GA 23 SB Water Treatment Microbiocide; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; percent_active_ingredient=23.0; dtxsid=DTXSID6025355; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12244; row=10383; data_type=In Vivo; mixture=Mixture; formulation_id=MIX41; formulation_name=Bactron K-139; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; percent_active_ingredient=5.0; dtxsid=DTXSID6025355; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =96 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1012; row=10386; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =134 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1013; row=10385; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =154 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1014; row=10387; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =246 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1015; row=10388; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =252 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1016; row=10391; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =285 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1017; row=10392; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =315 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1018; row=10393; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =352 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1019; row=10394; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =418 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1020; row=10377; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =511 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12244; row=10384; data_type=In Vivo; mixture=Mixture; formulation_id=MIX41; formulation_name=Bactron K-139; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; percent_active_ingredient=5.0; dtxsid=DTXSID6025355; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =820 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1021; row=10378; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1330 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1022; row=10379; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1470 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1023; row=10380; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2380 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1024; row=10381; data_type=In Vivo; mixture=Chemical; chemical_name=Glutaraldehyde; preferred_name=Glutaraldehyde; dtxsid=DTXSID6025355; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID6025355; source_file=acute_oral.xlsx |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | Top dose | 250 | ppb | Mouse | Inhalation | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7072; Record_ID=cancer_5688; Data_Type=In Vivo; Formulation_Name=Glutaraldehyde; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=250; Response_Unit=ppb; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Inhalation; Reference=TR-490; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr490/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE cancer | Top dose | 750 | ppb | Rat | Inhalation | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=7065; Record_ID=cancer_5695; Data_Type=In Vivo; Formulation_Name=Glutaraldehyde; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=750; Response_Unit=ppb; Species=Rat; Strain=F344/N; Sex=Male; Route=Inhalation; Reference=TR-490; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr490/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
NTP ICE dart 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE dart | LOEL | 45 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=95817; Record_ID=dart_28233; Data_Type=In Vivo; DTXSID=DTXSID6025355; Assay=DART, In life observation; Endpoint=LOEL; Response=45; Response_Unit=mg/kg/day; Species=Rabbit; Strain=Himalayan; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0005910;CUI;Body Weight; Reference=ToxRefDB v2 , ID = 5999; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE dart | LOEL | 45 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=95818; Record_ID=dart_28248; Data_Type=In Vivo; DTXSID=DTXSID6025355; Assay=DART, In life observation; Endpoint=LOEL; Response=45; Response_Unit=mg/kg/day; Species=Rabbit; Strain=Himalayan; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 5999; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE dart | LOEL | 45 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=95819; Record_ID=dart_28240; Data_Type=In Vivo; DTXSID=DTXSID6025355; Assay=DART, In life observation; Endpoint=LOEL; Response=45; Response_Unit=mg/kg/day; Species=Rabbit; Strain=Himalayan; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0026565;CUI;Mortality Vital Statistics|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0026565;CUI;Mortality Vital Statistics; Reference=ToxRefDB v2 , ID = 5999; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE dart | LOEL | 45 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=95820; Record_ID=dart_28239; Data_Type=In Vivo; DTXSID=DTXSID6025355; Assay=DART, In life observation; Endpoint=LOEL; Response=45; Response_Unit=mg/kg/day; Species=Rabbit; Strain=Himalayan; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C2983605;CUI;Food Consumption|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C2983605;CUI;Food Consumption; Reference=ToxRefDB v2 , ID = 5999; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE dart | LOEL | 45 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=95821; Record_ID=dart_28238; Data_Type=In Vivo; DTXSID=DTXSID6025355; Assay=DART, In life observation; Endpoint=LOEL; Response=45; Response_Unit=mg/kg/day; Species=Rabbit; Strain=Himalayan; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0577115;CUI;Soft stool (finding); Reference=ToxRefDB v2 , ID = 5999; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE dart | LOEL | 45 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=95822; Record_ID=dart_28236; Data_Type=In Vivo; DTXSID=DTXSID6025355; Assay=DART, In life observation; Endpoint=LOEL; Response=45; Response_Unit=mg/kg/day; Species=Rabbit; Strain=Himalayan; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0011991;CUI;Diarrhea; Reference=ToxRefDB v2 , ID = 5999; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE dart | LOEL | 45 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=95823; Record_ID=dart_28235; Data_Type=In Vivo; DTXSID=DTXSID6025355; Assay=DART, In life observation; Endpoint=LOEL; Response=45; Response_Unit=mg/kg/day; Species=Rabbit; Strain=Himalayan; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0011135;CUI;Defecation; Reference=ToxRefDB v2 , ID = 5999; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE dart | LOEL | 45 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=95824; Record_ID=dart_28234; Data_Type=In Vivo; DTXSID=DTXSID6025355; Assay=DART, In life observation; Endpoint=LOEL; Response=45; Response_Unit=mg/kg/day; Species=Rabbit; Strain=Himalayan; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 5999; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 1.32366462832733 | uM | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=9999; RecordID=ARPathway2016_345; DatasetName=ARPathway2016; DTXSID=DTXSID6025355; Assay=AR Pathway Model, Antagonist; Endpoint=AC50; Response=1.32366462832733; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE endocrine | ACC | 0.849729331848536 | uM | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=9998; RecordID=ARPathway2016_345; DatasetName=ARPathway2016; DTXSID=DTXSID6025355; Assay=AR Pathway Model, Antagonist; Endpoint=ACC; Response=0.849729331848536; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10000; RecordID=ARPathway2016_345; DatasetName=ARPathway2016; DTXSID=DTXSID6025355; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE endocrine | Model Score | 0.0532 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=10001; RecordID=ARPathway2016_345; DatasetName=ARPathway2016; DTXSID=DTXSID6025355; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.0532; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1854; Record_ID=eye_irritation_324; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID110; Formulation_Name=Bactron K-139; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
NTP ICE skin irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | EPA classification | 3 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1215; Record_ID=skin_irritation_invivo_1021; Data_Type=In Vivo; Formulation_ID=MIX41; Formulation_Name=Bactron K-139; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID6025355; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand White; Strain=New Zealand White; Sex=Male/Female; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
NTP ICE skin sensitization 48 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 2.7 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1982; Record_ID=skin_sensitization_invitro_500; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=2.7; Reported_Response_Unit=ug/mL; Response=2.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | CD86, EC150 | 0.2 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8347; Record_ID=skin_sensitization_invitro_2314; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=1.997602877; Reported_Response_Unit=uM; Conversion_Factor_Value=100.117; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.2; Converted_Response_Unit=ug/mL; Response=0.2; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | CD86, EC150 | 2.78 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1984; Record_ID=skin_sensitization_invitro_500; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=2.78; Reported_Response_Unit=ug/mL; Response=2.78; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | CD86, EC150 | 83 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8558; Record_ID=skin_sensitization_invitro_2360; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=83; Reported_Response_Unit=ug/mL; Response=83; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8554; Record_ID=skin_sensitization_invitro_2360; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | CV75 | 5.3 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=1986; Record_ID=skin_sensitization_invitro_500; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=h-CLAT; Endpoint=CV75; Reported_Response=5.3; Reported_Response_Unit=ug/mL; Response=5.3; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 1.071 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3647; Record_ID=skin_sensitization_invivo_906; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.071; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Concentration, one positive response | 0.7143 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3643; Record_ID=skin_sensitization_invivo_906; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.7143; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Depletion Cys | 25.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=575; Record_ID=skin_sensitization_invitro_167; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=25.2; Reported_Response_Unit=%; Response=25.2; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Depletion Cys | 30.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=561; Record_ID=skin_sensitization_invitro_164; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=30.2; Reported_Response_Unit=%; Response=30.2; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Depletion Lys | 84.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=573; Record_ID=skin_sensitization_invitro_167; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=84.2; Reported_Response_Unit=%; Response=84.2; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Depletion Lys | 85.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=586; Record_ID=skin_sensitization_invitro_164; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=85.4; Reported_Response_Unit=%; Response=85.4; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 55 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=577; Record_ID=skin_sensitization_invitro_167; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=55; Reported_Response_Unit=%; Response=55; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 57.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=563; Record_ID=skin_sensitization_invitro_164; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=57.8; Reported_Response_Unit=%; Response=57.8; Response_Unit=%; Reference=Gerberick et al. 2004; 15254333; 10.1093/toxsci/kfh213|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC1.5 | 24.259 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4733; Record_ID=skin_sensitization_invitro_1094; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=24.259; Reported_Response_Unit=uM; Response=24.259; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC1.5 | <45.05 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7614; Record_ID=skin_sensitization_invitro_1856; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=45.05; Reported_Response_Unit=uM; Response=45.05; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.04 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13276; Record_ID=skin_sensitization_invivo_3362; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.04; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1998; 9471984; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.04 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13276; Record_ID=skin_sensitization_invivo_3362; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.04; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1998; 9471984; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.04 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13276; Record_ID=skin_sensitization_invivo_3362; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.04; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1998; 9471984; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.04 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13276; Record_ID=skin_sensitization_invivo_3362; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.04; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1998; 9471984; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.07 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13279; Record_ID=skin_sensitization_invivo_3366; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=7.00E-02; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Azadi et al. 2004; 15126069; 10.1016/j.taap.2004.01.017; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.07 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13279; Record_ID=skin_sensitization_invivo_3366; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=7.00E-02; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Azadi et al. 2004; 15126069; 10.1016/j.taap.2004.01.017; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.07 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13279; Record_ID=skin_sensitization_invivo_3366; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=7.00E-02; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Azadi et al. 2004; 15126069; 10.1016/j.taap.2004.01.017; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.07 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13279; Record_ID=skin_sensitization_invivo_3366; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=7.00E-02; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Azadi et al. 2004; 15126069; 10.1016/j.taap.2004.01.017; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.09 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13280; Record_ID=skin_sensitization_invivo_3369; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.09; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Azadi et al. 2004; 15126069; 10.1016/j.taap.2004.01.017; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.09 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13280; Record_ID=skin_sensitization_invivo_3369; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.09; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Azadi et al. 2004; 15126069; 10.1016/j.taap.2004.01.017; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.09 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13280; Record_ID=skin_sensitization_invivo_3369; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.09; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Azadi et al. 2004; 15126069; 10.1016/j.taap.2004.01.017; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.09 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13280; Record_ID=skin_sensitization_invivo_3369; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.09; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Azadi et al. 2004; 15126069; 10.1016/j.taap.2004.01.017; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13274; Record_ID=skin_sensitization_invivo_3360; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1998; 9471984; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13274; Record_ID=skin_sensitization_invivo_3360; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1998; 9471984; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13274; Record_ID=skin_sensitization_invivo_3360; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1998; 9471984; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 0.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13274; Record_ID=skin_sensitization_invivo_3360; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=0.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Hilton et al. 1998; 9471984; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 2.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13282; Record_ID=skin_sensitization_invivo_3371; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=2.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 1992; 1459374; 10.1016/0272-0590(92)90183-i; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 2.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13282; Record_ID=skin_sensitization_invivo_3371; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=2.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 1992; 1459374; 10.1016/0272-0590(92)90183-i; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 2.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13282; Record_ID=skin_sensitization_invivo_3371; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=2.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 1992; 1459374; 10.1016/0272-0590(92)90183-i; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 2.1 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13282; Record_ID=skin_sensitization_invivo_3371; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LLNA; Endpoint=EC3; Response=2.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 1992; 1459374; 10.1016/0272-0590(92)90183-i; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | EC3 | 69.43 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4735; Record_ID=skin_sensitization_invitro_1094; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=69.429000000000002; Reported_Response_Unit=uM; Response=69.43; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | IC50 | 104.2 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7683; Record_ID=skin_sensitization_invitro_1856; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LuSens; Endpoint=IC50; Reported_Response=104.2426999; Reported_Response_Unit=uM; Response=104.2; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | IC50 | 242.56 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4737; Record_ID=skin_sensitization_invitro_1094; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=242.56; Reported_Response_Unit=uM; Response=242.56; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Imax | 5.991 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7904; Record_ID=skin_sensitization_invitro_1856; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=LuSens; Endpoint=Imax; Reported_Response=5.990994846; Reported_Response_Unit=Unitless; Response=5.991; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Imax | 80.72 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4739; Record_ID=skin_sensitization_invitro_1094; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=80.72; Reported_Response_Unit=Unitless; Response=80.72; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3631; Record_ID=skin_sensitization_invivo_904; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Incidence of positive responses | 23.33 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3639; Record_ID=skin_sensitization_invivo_906; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=23.33; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Induction dose per skin area | 69.75 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3629; Record_ID=skin_sensitization_invivo_904; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=69.75; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Induction dose per skin area | 3488 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3637; Record_ID=skin_sensitization_invivo_906; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=3488; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 747.3 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3649; Record_ID=skin_sensitization_invivo_906; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=747.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 498.2 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3645; Record_ID=skin_sensitization_invivo_906; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=498.2; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=3635; Record_ID=skin_sensitization_invivo_904; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6025355; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6025355; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6025355 |
EPA ToxRefDB v3 48 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =0.009375 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | inhalation | 0 week to 13 week | SUB | study_id=6592; toxval_study_source_id=studyid6592_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-inflammation|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-nose-[other]|in life observation-clinical signs-emaciation|in life observation-clinical signs-respiration (dyspnea)|in life observation-mortality-mortality|in life observation-clinical signs-reduced activity|in life observation-clinical signs-abnormal posture|in life observation-clinical signs-fur (altered appearance)|pathology microscopic-larynx-metaplasia|in life observation-clinical signs-tachypnea; dose_level=1; study_year=1993; study_citation=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation 13-wk_B6C3F1 mice_Tox-25; dsstox_substance_id=DTXSID6025355; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =0.0125 | mg/kg bw/day | rat (fischer; Fischer 344) | inhalation | 0 week to 13 week | SUB | study_id=6591; toxval_study_source_id=studyid6591_Adult_F0_F_systemic; toxval_effect_list=hematology-neutrophils-neutrophils|pathology microscopic-nose-respiratory metaplasia|pathology microscopic-nose-hyperplasia|pathology microscopic-nose-[other]|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|organ weight-kidney-relative to body weight|in life observation-body weight-body weight gain|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|in life observation-clinical signs-fur (altered appearance)|organ weight-heart-relative to body weight|pathology microscopic-nose-degeneration|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|in life observation-body weight-body weight|in life observation-clinical signs-emaciation|pathology microscopic-nose-inflammation; dose_level=3; study_year=1993; study_citation=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation... 13-wk_F/334 Rat_Tox-25; dsstox_substance_id=DTXSID6025355; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =0.075 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | inhalation | 0 week to 13 week | SUB | study_id=6592; toxval_study_source_id=studyid6592_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal; dose_level=4; study_year=1993; study_citation=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation 13-wk_B6C3F1 mice_Tox-25; dsstox_substance_id=DTXSID6025355; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =0.15 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | inhalation | 0 week to 13 week | SUB | study_id=6592; toxval_study_source_id=studyid6592_Fetal_F0_M_developmental; toxval_effect_list=developmental malformation-penis-paraphimosis; dose_level=5; study_year=1993; study_citation=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation 13-wk_B6C3F1 mice_Tox-25; dsstox_substance_id=DTXSID6025355; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =5.3 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 24 month | CHR | study_id=6004; toxval_study_source_id=studyid6004_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-food consumption-food consumption|pathology gross-stomach-erosion|in life observation-body weight-body weight gain|pathology microscopic-larynx-metaplasia|in life observation-clinical signs-urine, discoloration|pathology gross-stomach-ulcer|pathology microscopic-stomach-erosion|in life observation-body weight-body weight|pathology microscopic-trachea-metaplasia|in life observation-clinical signs-abnormal respiratory sounds|pathology microscopic-stomach-ulcer; dose_level=1; study_year=2003; study_citation=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =6 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 104 week | CHR | study_id=4326; toxval_study_source_id=studyid4326_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-blood-leukemia lymphocytic|urinalysis-volume-volume|pathology microscopic-kidney-basophilia|urinalysis-specific gravity/osmolality-specific gravity/osmolality|in life observation-food consumption-food consumption|pathology microscopic-kidney-pigmentation|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-hemorrhage|organ weight-kidney-relative to body weight|in life observation-body weight-body weight gain|pathology microscopic-stomach-ulcer|pathology microscopic-kidney-inflammation|organ weight-kidney-absolute; dose_level=1; study_year=1994; study_citation=Hermansky SJ and Loughran KA. (1994) Glutaraldehyde: Combined Chronic Toxicity/Oncogenicity Study in the Drinking Water of Rats. Study No. 91U0012. Bushy Run Research Center, Export, PA. MRID 43191101.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =14.6 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=4323; toxval_study_source_id=studyid4323_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-vomitting; dose_level=3; study_year=1990; study_citation=Van Miller, JP. 1990. Glutaraldehyde: 13-week toxicity study in dogs with administration via the drinking water. Bushy Run Research Center, Project ID 52-93. MRID 41480501.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =16.1 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 24 month | CHR | study_id=6004; toxval_study_source_id=studyid6004_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-food consumption-food consumption|pathology gross-stomach-ulcer|pathology gross-stomach-erosion|in life observation-clinical signs-abnormal respiratory sounds|in life observation-body weight-body weight gain|pathology microscopic-larynx-metaplasia|in life observation-body weight-body weight|pathology microscopic-stomach-ulcer|pathology microscopic-stomach-erosion|in life observation-clinical signs-urine, discoloration; dose_level=2; study_year=2003; study_citation=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =17 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 104 week | CHR | study_id=4326; toxval_study_source_id=studyid4326_Adult_F0_M_systemic; toxval_effect_list=in life observation-food consumption-food consumption|pathology microscopic-blood-leukemia lymphocytic|urinalysis-volume-volume|urinalysis-specific gravity/osmolality-specific gravity/osmolality|pathology microscopic-epididymis-mesothelioma nos|pathology microscopic-testes-mesothelioma nos|in life observation-body weight-body weight gain|pathology microscopic-mesentery-mesothelioma nos|pathology microscopic-stomach-hyperplasia|organ weight-kidney-relative to body weight|organ weight-kidney-absolute|pathology microscopic-stomach-ulcer|pathology microscopic-stomach-hemorrhage|pathology microscopic-kidney-pigmentation|pathology microscopic-bone marrow-hyperplasia|pathology microscopic-stomach-keratin cyst; dose_level=2; study_year=1994; study_citation=Hermansky SJ and Loughran KA. (1994) Glutaraldehyde: Combined Chronic Toxicity/Oncogenicity Study in the Drinking Water of Rats. Study No. 91U0012. Bushy Run Research Center, Export, PA. MRID 43191101.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =19.5 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption; dose_level=2; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =20.95 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-lymph node-hyperplasia; dose_level=2; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =22.4 | mg/kg bw/day | rat (wistar; Wistar) | oral | 76 days (premating) to 2 generation | MGR | study_id=6000; toxval_study_source_id=studyid6000_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption; dose_level=2; study_year=2001; study_citation=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =23.2 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 12 month | CHR | study_id=6003; toxval_study_source_id=studyid6003_Adult_F0_F_systemic; toxval_effect_list=pathology gross-pituitary gland-enlarged|pathology gross-stomach-erosion|in life observation-clinical signs-abnormal respiratory sounds|pathology microscopic-stomach-lesion(s) (nos)|pathology gross-stomach-ulcer|in life observation-food consumption-food consumption|in life observation-water consumption-water consumption; dose_level=2; study_year=2002; study_citation=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =28.28 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Adult_F1_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption; dose_level=2; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =29.57 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Adult_F1_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption; dose_level=2; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =45 | mg/kg bw/day | rabbit (himalayan; Himalayan) | oral | 7 GD to 19 GD | DEV | study_id=5999; toxval_study_source_id=studyid5999_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-resorptions-resorptions|reproductive performance-postimplantation loss-postimplantation loss; dose_level=3; study_year=1991; study_citation=Hellwig, J and B Hildebrand. 1991. Study of the prenatal toxicity of glutaraldehyde in rabbits after oral administration (gavage). BASF Aktiengesellschaft, Study no. 40R0599/89026. MRID 42154001.; dsstox_substance_id=DTXSID6025355; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =50 | mg/kg bw/day | rat (sprague dawley; CD(SD)ICS BR) | dermal | 0 day to 90 day | SUB | study_id=5998; toxval_study_source_id=studyid5998_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-desquamation|pathology gross-skin-scabbing|in life observation-clinical signs-scabbing|pathology microscopic-skin-acanthosis|pathology microscopic-skin-ulcer|in life observation-clinical signs-erythema|pathology microscopic-skin-inflammation; dose_level=1; study_year=2000; study_citation=Manciaux, X. (2000). 13-Week Toxicity Study by Cutaneous Route in Rats. Centre International de Toxicologie (BP 563 - 27005 Evreux, France). Laboratory Study Number 19051 TCR, May 19, 2000. MRID 46046801. Unpublished.; dsstox_substance_id=DTXSID6025355; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =58.9 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 12 month | CHR | study_id=6003; toxval_study_source_id=studyid6003_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology gross-intestine small-thickened|in life observation-body weight-body weight gain|in life observation-clinical signs-abnormal respiratory sounds|pathology microscopic-liver-clear cell focus|in life observation-clinical signs-urine, discoloration|pathology gross-stomach-erosion|pathology microscopic-stomach-lesion(s) (nos)|pathology gross-stomach-ulcer|in life observation-food consumption-food consumption|in life observation-water consumption-water consumption; dose_level=3; study_year=2002; study_citation=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =95.6 | mg/kg bw/day | rat (wistar; Wistar) | oral | 76 days (premating) to 2 generation | MGR | study_id=6000; toxval_study_source_id=studyid6000_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=3; study_year=2001; study_citation=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =98.37 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Juvenile_F1_M_systemic; toxval_effect_list=in life observation-body weight-offspring (pup) weight gain; dose_level=3; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =99.56 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Juvenile_F1_F_systemic; toxval_effect_list=in life observation-body weight-offspring (pup) weight gain; dose_level=3; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =199.8 | mg/kg bw/day | mouse (cd1; Crl: CD-1) | oral | 0 day to 90 day | SUB | study_id=4324; toxval_study_source_id=studyid4324_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-stomach-inflammation|urinalysis-specific gravity/osmolality-specific gravity/osmolality|urinalysis-volume-volume|in life observation-water consumption-water consumption; dose_level=3; study_year=1989; study_citation=Gill, MW and JP Van Miller. 1989. Glutaraldehyde: 90-day drinking water toxicity study in mice. Bushy Run Research Center, Study no. 52-1. MRID 41773601.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =238.1 | mg/kg bw/day | mouse (cd1; Crl: CD-1) | oral | 0 day to 90 day | SUB | study_id=4324; toxval_study_source_id=studyid4324_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-inflammation|urinalysis-specific gravity/osmolality-specific gravity/osmolality|urinalysis-volume-volume; dose_level=3; study_year=1989; study_citation=Gill, MW and JP Van Miller. 1989. Glutaraldehyde: 90-day drinking water toxicity study in mice. Bushy Run Research Center, Study no. 52-1. MRID 41773601.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =25 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 104 week | CHR | study_id=4326; toxval_study_source_id=studyid4326_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption; dose_level=2; study_year=1994; study_citation=Hermansky SJ and Loughran KA. (1994) Glutaraldehyde: Combined Chronic Toxicity/Oncogenicity Study in the Drinking Water of Rats. Study No. 91U0012. Bushy Run Research Center, Export, PA. MRID 43191101.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =61 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 24 month | CHR | study_id=6004; toxval_study_source_id=studyid6004_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-larynx-metaplasia; dose_level=3; study_year=2003; study_citation=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =76 | mg/kg bw/day | rat (wistar; Wistar) | oral | 76 days (premating) to 2 generation | MGR | study_id=6000; toxval_study_source_id=studyid6000_Adult_F1_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-body weight-body weight|in life observation-food consumption-food consumption; dose_level=3; study_year=2001; study_citation=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =77.4 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 12 month | CHR | study_id=6003; toxval_study_source_id=studyid6003_Adult_F0_F_systemic; toxval_effect_list=pathology gross-stomach-erosion|pathology gross-stomach-ulcer; dose_level=3; study_year=2002; study_citation=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =87.6 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 24 month | CHR | study_id=6004; toxval_study_source_id=studyid6004_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-larynx-metaplasia|pathology microscopic-trachea-metaplasia; dose_level=3; study_year=2003; study_citation=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 104 week | CHR | study_id=4326; toxval_study_source_id=studyid4326_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hemorrhage|in life observation-food consumption-food consumption|pathology microscopic-stomach-hyperplasia|in life observation-body weight-body weight gain|organ weight-kidney-relative to body weight|pathology microscopic-kidney-pigmentation|pathology microscopic-blood-leukemia lymphocytic|organ weight-kidney-absolute|pathology microscopic-kidney-inflammation|urinalysis-volume-volume|pathology microscopic-kidney-basophilia|pathology microscopic-stomach-ulcer|urinalysis-specific gravity/osmolality-specific gravity/osmolality; dose_level=0; study_year=1994; study_citation=Hermansky SJ and Loughran KA. (1994) Glutaraldehyde: Combined Chronic Toxicity/Oncogenicity Study in the Drinking Water of Rats. Study No. 91U0012. Bushy Run Research Center, Export, PA. MRID 43191101.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =0.003125 | mg/kg bw/day | rat (fischer; Fischer 344) | inhalation | 0 week to 13 week | SUB | study_id=6591; toxval_study_source_id=studyid6591_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|pathology microscopic-nose-hyperplasia|in life observation-body weight-body weight|organ weight-lung-relative to body weight|pathology microscopic-nose-respiratory metaplasia|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|organ weight-testes-relative to body weight|in life observation-body weight-body weight gain|hematology-neutrophils-neutrophils|organ weight-heart-relative to body weight|in life observation-clinical signs-fur (altered appearance)|in life observation-clinical signs-emaciation|pathology microscopic-nose-erosion|pathology microscopic-nose-[other]|pathology microscopic-nose-inflammation|pathology microscopic-nose-degeneration; dose_level=1; study_year=1993; study_citation=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation... 13-wk_F/334 Rat_Tox-25; dsstox_substance_id=DTXSID6025355; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =0.00625 | mg/kg bw/day | rat (fischer; Fischer 344) | inhalation | 0 week to 13 week | SUB | study_id=6591; toxval_study_source_id=studyid6591_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-[other]|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|in life observation-clinical signs-fur (altered appearance)|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|organ weight-kidney-relative to body weight|pathology microscopic-nose-hyperplasia|organ weight-heart-relative to body weight|pathology microscopic-nose-degeneration|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|in life observation-body weight-body weight|in life observation-body weight-body weight gain|hematology-neutrophils-neutrophils|in life observation-clinical signs-emaciation|pathology microscopic-nose-respiratory metaplasia|pathology microscopic-nose-inflammation; dose_level=2; study_year=1993; study_citation=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation... 13-wk_F/334 Rat_Tox-25; dsstox_substance_id=DTXSID6025355; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =0.0375 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | inhalation | 0 week to 13 week | SUB | study_id=6592; toxval_study_source_id=studyid6592_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-abnormal; dose_level=3; study_year=1993; study_citation=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation 13-wk_B6C3F1 mice_Tox-25; dsstox_substance_id=DTXSID6025355; admin_method=Whole-Body; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =3.5 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 24 month | CHR | study_id=6004; toxval_study_source_id=studyid6004_Adult_F0_M_systemic; toxval_effect_list=in life observation-food consumption-food consumption|pathology microscopic-larynx-metaplasia|in life observation-body weight-body weight gain|in life observation-clinical signs-abnormal respiratory sounds|pathology gross-stomach-erosion|pathology gross-stomach-ulcer|in life observation-clinical signs-urine, discoloration|in life observation-water consumption-water consumption|pathology microscopic-stomach-erosion|in life observation-body weight-body weight|pathology microscopic-stomach-ulcer; dose_level=1; study_year=2003; study_citation=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =4 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 104 week | CHR | study_id=4326; toxval_study_source_id=studyid4326_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|urinalysis-volume-volume|pathology microscopic-stomach-hemorrhage|pathology microscopic-kidney-pigmentation|pathology microscopic-bone marrow-hyperplasia|pathology microscopic-stomach-keratin cyst|in life observation-food consumption-food consumption|pathology microscopic-blood-leukemia lymphocytic|pathology microscopic-testes-mesothelioma nos|pathology microscopic-epididymis-mesothelioma nos|pathology microscopic-mesentery-mesothelioma nos|pathology microscopic-stomach-hyperplasia|organ weight-kidney-absolute|pathology microscopic-stomach-ulcer|in life observation-body weight-body weight gain|urinalysis-specific gravity/osmolality-specific gravity/osmolality; dose_level=1; study_year=1994; study_citation=Hermansky SJ and Loughran KA. (1994) Glutaraldehyde: Combined Chronic Toxicity/Oncogenicity Study in the Drinking Water of Rats. Study No. 91U0012. Bushy Run Research Center, Export, PA. MRID 43191101.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =4.25 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption; dose_level=1; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =4.53 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-lymph node-hyperplasia; dose_level=1; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =4.7 | mg/kg bw/day | rat (wistar; Wistar) | oral | 76 days (premating) to 2 generation | MGR | study_id=6000; toxval_study_source_id=studyid6000_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption; dose_level=1; study_year=2001; study_citation=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =4.8 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 12 month | CHR | study_id=6003; toxval_study_source_id=studyid6003_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-clinical signs-abnormal respiratory sounds|pathology gross-stomach-erosion|pathology gross-stomach-ulcer|pathology microscopic-stomach-lesion(s) (nos)|in life observation-food consumption-food consumption|pathology gross-pituitary gland-enlarged; dose_level=1; study_year=2002; study_citation=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =6.1 | mg/kg bw/day | rat (wistar; Wistar) | oral | 76 days (premating) to 2 generation | MGR | study_id=6000; toxval_study_source_id=studyid6000_Adult_F1_F_systemic; toxval_effect_list=pathology gross-stomach-ulcer|pathology microscopic-stomach-erosion|in life observation-body weight-body weight gain|in life observation-water consumption-water consumption|pathology microscopic-stomach-edema|in life observation-food consumption-food consumption|pathology gross-stomach-erosion|in life observation-body weight-body weight; dose_level=1; study_year=2001; study_citation=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =6.68 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Adult_F1_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption; dose_level=1; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =6.72 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 10 weeks (premating) to 2 generation | MGR | study_id=4330; toxval_study_source_id=studyid4330_Adult_F1_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption; dose_level=1; study_year=1994; study_citation=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =9.8 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=4323; toxval_study_source_id=studyid4323_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-vomitting; dose_level=2; study_year=1990; study_citation=Van Miller, JP. 1990. Glutaraldehyde: 13-week toxicity study in dogs with administration via the drinking water. Bushy Run Research Center, Project ID 52-93. MRID 41480501.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =15 | mg/kg bw/day | rabbit (himalayan; Himalayan) | oral | 7 GD to 19 GD | DEV | study_id=5999; toxval_study_source_id=studyid5999_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-resorptions-resorptions|reproductive performance-postimplantation loss-postimplantation loss; dose_level=2; study_year=1991; study_citation=Hellwig, J and B Hildebrand. 1991. Study of the prenatal toxicity of glutaraldehyde in rabbits after oral administration (gavage). BASF Aktiengesellschaft, Study no. 40R0599/89026. MRID 42154001.; dsstox_substance_id=DTXSID6025355; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =15.4 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 12 month | CHR | study_id=6003; toxval_study_source_id=studyid6003_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|pathology gross-intestine small-thickened|in life observation-body weight-body weight|pathology gross-stomach-erosion|pathology microscopic-liver-clear cell focus|in life observation-clinical signs-urine, discoloration|in life observation-clinical signs-abnormal respiratory sounds|in life observation-food consumption-food consumption|pathology microscopic-stomach-lesion(s) (nos)|pathology gross-stomach-ulcer|in life observation-water consumption-water consumption; dose_level=2; study_year=2002; study_citation=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =28.7 | mg/kg bw/day | rat (wistar; Wistar) | oral | 76 days (premating) to 2 generation | MGR | study_id=6000; toxval_study_source_id=studyid6000_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-body weight-body weight gain|in life observation-water consumption-water consumption|in life observation-body weight-body weight; dose_level=2; study_year=2001; study_citation=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =60.8 | mg/kg bw/day | mouse (cd1; Crl: CD-1) | oral | 0 day to 90 day | SUB | study_id=4324; toxval_study_source_id=studyid4324_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|urinalysis-volume-volume|urinalysis-specific gravity/osmolality-specific gravity/osmolality|pathology microscopic-stomach-inflammation; dose_level=2; study_year=1989; study_citation=Gill, MW and JP Van Miller. 1989. Glutaraldehyde: 90-day drinking water toxicity study in mice. Bushy Run Research Center, Study no. 52-1. MRID 41773601.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =74.3 | mg/kg bw/day | mouse (cd1; Crl: CD-1) | oral | 0 day to 90 day | SUB | study_id=4324; toxval_study_source_id=studyid4324_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|urinalysis-specific gravity/osmolality-specific gravity/osmolality|pathology microscopic-stomach-inflammation|urinalysis-volume-volume; dose_level=2; study_year=1989; study_citation=Gill, MW and JP Van Miller. 1989. Glutaraldehyde: 90-day drinking water toxicity study in mice. Bushy Run Research Center, Study no. 52-1. MRID 41773601.; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =24.3 | mg/kg bw/day | rat (wistar; Wistar) | oral | 0 month to 24 month | CHR | study_id=6004; toxval_study_source_id=studyid6004_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-abnormal respiratory sounds|pathology microscopic-stomach-ulcer|pathology microscopic-trachea-metaplasia|in life observation-food consumption-food consumption|pathology gross-stomach-ulcer|pathology microscopic-stomach-erosion|in life observation-water consumption-water consumption|in life observation-body weight-body weight|pathology microscopic-larynx-metaplasia|in life observation-clinical signs-urine, discoloration|pathology gross-stomach-erosion|in life observation-body weight-body weight gain; dose_level=2; study_year=2003; study_citation=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; dsstox_substance_id=DTXSID6025355; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ATSDR MRLs 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | BMCL (10 HEC) | =0.000327583 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Gross EA, Mellick PW, Kari FW, et al. 1994. Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks. Fundam Appl Toxicol 23(3):348-362.; TITLE=Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks; AUTHOR=Gross EA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585776; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp208.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447622_15447623:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1a7408efed4ff36da936811cfcb96323 |
| ToxValDB ATSDR MRLs | BMCL (10) | =0.0139223 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Gross EA, Mellick PW, Kari FW, et al. 1994. Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks. Fundam Appl Toxicol 23(3):348-362.; TITLE=Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks; AUTHOR=Gross EA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585776; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp208.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447622_15447623:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d16c2c09e86b3a0540138ee05455776f |
| ToxValDB ATSDR MRLs | MRL | =0.000122844 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=respiratory in male/female mice; STUDY_GROUP=ATSDR MRLs_dup_-_15447088_15447089:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02a27d0c65e25ba56421f87f03beac86 |
| ToxValDB ATSDR MRLs | MRL | =0.00409479 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=respiratory in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447088_15447089:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b5a8559f12e6a1372c1fc46d67cddaf |
| ToxValDB ATSDR MRLs | MRL | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=gastrointestinal; STUDY_GROUP=ATSDR MRLs:15447090:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6825c22ca80a1b2e0f191422a70e1b7e |
| ToxValDB ATSDR MRLs | NOAEL | =0.511848 | mg/m3 | Rat | inhalation | acute; 1 days | acute | LONG_REF=Gross EA, Mellick PW, Kari FW, et al. 1994. Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks. Fundam Appl Toxicol 23(3):348-362.; TITLE=Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks; AUTHOR=Gross EA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585776; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp208.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447621:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_be4c964a5744c3f652e202db7a8ed50f |
| ToxValDB ATSDR MRLs | NOAEL | =4 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=van Miller JP, Hermansky SJ, Losco PE, et al. 2002. Chronic toxicity and oncogenicity study with glutaraldehyde dosed in the drinking water of Fischer 344 rats. Toxicology 175(1-3):177-189.; TITLE=Chronic toxicity and oncogenicity study with glutaraldehyde dosed in the drinking water of Fischer 344 rats; AUTHOR=van Miller JP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585776; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp208.pdf; TOXICOLOGICAL_EFFECT=gastric irritation (multifocal color change, mucosal thickening, nodules, and ulceration affecting primarily the nonglandular mucosa; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ATSDR MRLs:15447624:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_784411d92447769d0fc569ddd7c105cc |
| ToxValDB ATSDR MRLs | NOAEL (HEC) | =0.0122844 | mg/m3 | Rat | inhalation | acute; 1 days | acute | LONG_REF=Gross EA, Mellick PW, Kari FW, et al. 1994. Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks. Fundam Appl Toxicol 23(3):348-362.; TITLE=Histopathology and cell replication responses in the respiratory tract of rats and mice exposed by inhalation to glutaraldehyde for up to 13 weeks; AUTHOR=Gross EA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585776; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp208.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447620:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7519fd961bb37c2d87f52af206b3c6f0 |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | BMC (05) | =0.0839431 | mg/m3 | Mouse | inhalation | chronic; 104 weeks | chronic | LONG_REF=National Toxicology Program (NTP). 1998. Toxicology and Carcinogenesis Studies of Glutaraldehyde (CAS NO. 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR-490. Board Draft. National Toxicology Program (NTP). 1999. Toxicology and Carcinogenesis Studies of Glutaraldehyde (CAS NO. 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR-490. September 1999. NIH Publication No. 99-3980. Available online at http://ntp-server.niehs.nih.gov/htdocs/LT-studies/tr490.html; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Respiratory epithelium squamous metaplasia; STUDY_GROUP=Cal OEHHA REL derivations_dup_-_15952077_15952078:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ca9506a16fd17f1da482970f69b018d6 |
| ToxValDB Cal OEHHA REL derivations | LOAEL | =0.255924 | mg/m3 | Mouse | inhalation | chronic; 104 weeks | chronic | LONG_REF=National Toxicology Program (NTP). 1998. Toxicology and Carcinogenesis Studies of Glutaraldehyde (CAS NO. 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR-490. Board Draft. National Toxicology Program (NTP). 1999. Toxicology and Carcinogenesis Studies of Glutaraldehyde (CAS NO. 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR-490. September 1999. NIH Publication No. 99-3980. Available online at http://ntp-server.niehs.nih.gov/htdocs/LT-studies/tr490.html; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Respiratory epithelium squamous metaplasia; STUDY_GROUP=Cal OEHHA REL derivations_dup_-_15952077_15952078:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_56a8f6f32cf72d4a0d0ce88358524aeb |
ToxValDB ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =1 | % v/v | Mouse | dermal | short-term; 6 days | short-term | LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15611069:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=74061224ccd442bc125cf4ecccaa5520 |
| ToxValDB ECOTOX | LOEL | =3.75 | % w/v | Mouse | dermal | short-term; 3 days | short-term | LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597649_15597650_15597651_15597652:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6d9b309795a72bea6df95dbdda7e2da1 |
| ToxValDB ECOTOX | NOEL | =0.94 | % w/v | Mouse | dermal | short-term; 3 days | short-term | LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597649_15597650_15597651_15597652:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e57801536c3d6dc59899c9578ce6ab24 |
| ToxValDB ECOTOX | NOEL | =1.88 | % w/v | Mouse | dermal | short-term; 3 days | short-term | LONG_REF=Arch. Toxicol.74(12): 733-744 Ulrich,P., J. Streich, and W. Suter Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced 2001; TITLE=Intralaboratory Validation of Alternative Endpoints in the Murine Local Lymph Node Assay for the Identification of Contact Allergic Potential: Primary Ear Skin Irritation and Ear-Draining Lymph Node Hyperplasia Induced; AUTHOR=Ulrich,P., J. Streich, and W. Suter; DOI=10.1007/s002040000192; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112411; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597649_15597650_15597651_15597652:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ba6f123d2b2a78bc17bef62c25af197f |
ToxValDB RSL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfC | =0.00008 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15656567:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_18f9f9ef38c2dda04c4c3616b0d99f9e |
| ToxValDB RSL | RfC | =0.00012 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663480:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b8243eb053e3e13891520ead39a3dfa5 |
ToxValDB ToxRefDB 43 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =0.009375 | mg/kg bw/day | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalationa?| 13-wk_B6C3F1 mice_Tox-25; TITLE=Technical Report on Toxicity studies of Glutaraldehyde administered by inhalationa?| 13-wk_B6C3F1 mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=6592; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-nose-inflammation|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-nose-[other]|systemic: in life observation-clinical signs-respiration (dyspnea)|systemic: in life observation-clinical signs-emaciation|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-larynx-metaplasia|systemic: in life observation-clinical signs-reduced activity|systemic: in life observation-clinical signs-abnormal posture|systemic: in life observation-clinical signs-tachypnea; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15712347_15712348:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0254a78a49ff4467e43734197024219a |
| ToxValDB ToxRefDB | LEL | =0.0125 | mg/kg bw/day | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation... 13-wk_F/334 Rat_Tox-25; TITLE=Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation... 13-wk_F/334 Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=6591; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: hematology-neutrophils-neutrophils|systemic: pathology microscopic-nose-[other]|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: pathology microscopic-nose-respiratory metaplasia|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-nose-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: in life observation-clinical signs-emaciation|systemic: organ weight-heart-relative to body weight|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-nose-inflammation|systemic: pathology microscopic-nose-degeneration|systemic: in life observation-clinical signs-fur (altered appearance); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712339_15712340_15712341_15712342:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4fb996881ff6d899dd5e25b42cd9df1c |
| ToxValDB ToxRefDB | LEL | =0.075 | mg/kg bw/day | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalationa?| 13-wk_B6C3F1 mice_Tox-25; TITLE=Technical Report on Toxicity studies of Glutaraldehyde administered by inhalationa?| 13-wk_B6C3F1 mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=6592; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-abnormal; STUDY_GROUP=ToxRefDB_dup_-_15712345_15712346:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e05130eb3aa12144154d6b8337f331d |
| ToxValDB ToxRefDB | LEL | =0.15 | mg/kg bw/day | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalationa?| 13-wk_B6C3F1 mice_Tox-25; TITLE=Technical Report on Toxicity studies of Glutaraldehyde administered by inhalationa?| 13-wk_B6C3F1 mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=6592; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=developmental: developmental malformation-penis-paraphimosis; STUDY_GROUP=ToxRefDB_dup_-_15712350_15712351:M:F0fetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8142cfe727e449a0da38db76c429090e |
| ToxValDB ToxRefDB | LEL | =5.3 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; TITLE=PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months; AUTHOR=Kaspers, U, K Deckardt, C Gembardt et al; EXTERNAL_SOURCE_ID=6004; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-food consumption-food consumption|systemic: pathology gross-stomach-erosion|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-trachea-metaplasia|systemic: pathology gross-stomach-ulcer|systemic: pathology microscopic-stomach-erosion|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: pathology microscopic-stomach-ulcer|systemic: pathology microscopic-larynx-metaplasia|systemic: in life observation-clinical signs-urine, discoloration|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710488_15710489_15710490:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_54f7fac3f3d1cdb92e321171a5b3e0af |
| ToxValDB ToxRefDB | LEL | =14.6 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Van Miller, JP. 1990. Glutaraldehyde: 13-week toxicity study in dogs with administration via the drinking water. Bushy Run Research Center, Project ID 52-93. MRID 41480501.; TITLE=Glutaraldehyde: 13-week toxicity study in dogs with administration via the drinking water; AUTHOR=Van Miller, JP; EXTERNAL_SOURCE_ID=4323; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-vomitting; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15707355_15707356_15707357_15707358:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46683e1aca7d41e926d8f368d204adc3 |
| ToxValDB ToxRefDB | LEL | =16.1 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; TITLE=PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months; AUTHOR=Kaspers, U, K Deckardt, C Gembardt et al; EXTERNAL_SOURCE_ID=6004; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-urine, discoloration|systemic: pathology gross-stomach-ulcer|systemic: pathology gross-stomach-erosion|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-ulcer|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: pathology microscopic-stomach-erosion|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-larynx-metaplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710491_15710492_15710493_15710494:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_823387db064bffe6eab6d7d1b375407b |
| ToxValDB ToxRefDB | LEL | =19.5 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15707396_15707397:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b6b68a2d3e8f85cacefb5441f05eb6fa |
| ToxValDB ToxRefDB | LEL | =20.95 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-lymph node-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15707394_15707395:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c26ad1b74e1f9074c094290185d0d37f |
| ToxValDB ToxRefDB | LEL | =22.4 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; TITLE=Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water; AUTHOR=Kaufmann, W, K Deckardt, C Gembardt, et al; EXTERNAL_SOURCE_ID=6000; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710454_15710455:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_525b7670ff942cd0dab2c16300057c65 |
| ToxValDB ToxRefDB | LEL | =23.2 | mg/kg bw/day | Rat | oral | chronic; 12 months | chronic | LONG_REF=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; TITLE=Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology; AUTHOR=Kaspers, U, K Deckardt, B Kittel et al; EXTERNAL_SOURCE_ID=6003; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=systemic: pathology gross-pituitary gland-enlarged|systemic: pathology gross-stomach-erosion|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: in life observation-food consumption-food consumption|systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-lesion(s) (nos)|systemic: pathology gross-stomach-ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710480_15710481_15710482_15710483:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0715eabe108fbcbce1b1635d41b24898 |
| ToxValDB ToxRefDB | LEL | =28.28 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15707400_15707401:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f2889ce5b7b7ab9b0d42aba8e89915ac |
| ToxValDB ToxRefDB | LEL | =29.57 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15707398_15707399:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3288e253b6f18e80ca7c844c34d31f6 |
| ToxValDB ToxRefDB | LEL | =45 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Hellwig, J & B Hildebrand. 1991. Study of the prenatal toxicity of glutaraldehyde in rabbits after oral administration (gavage). BASF Aktiengesellschaft, Study no. 40R0599/89026. MRID 42154001.; TITLE=Study of the prenatal toxicity of glutaraldehyde in rabbits after oral administration (gavage); AUTHOR=Hellwig, J & B Hildebrand; EXTERNAL_SOURCE_ID=5999; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-postimplantation loss-postimplantation loss|reproductive: reproductive performance-resorptions-resorptions; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15710440_15710441:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50fe81df3e0d5e44d7ff0463e752e2d9 |
| ToxValDB ToxRefDB | LEL | =50 | mg/kg bw/day | Rat | dermal | subchronic; 90 days | subchronic | LONG_REF=Manciaux, X. (2000). 13-Week Toxicity Study by Cutaneous Route in Rats. Centre International de Toxicologie (BP 563 - 27005 Evreux, France). Laboratory Study Number 19051 TCR, May 19, 2000. MRID 46046801. Unpublished.; TITLE=13-Week Toxicity Study by Cutaneous Route in Rats; AUTHOR=Manciaux, X; EXTERNAL_SOURCE_ID=5998; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-erythema|systemic: in life observation-clinical signs-scabbing|systemic: pathology gross-skin-scabbing|systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-skin-ulcer|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-clinical signs-desquamation; STUDY_GROUP=ToxRefDB_dup_-_15710436_15710437:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d04c8863bddab6a34577be4420694198 |
| ToxValDB ToxRefDB | LEL | =58.9 | mg/kg bw/day | Rat | oral | chronic; 12 months | chronic | LONG_REF=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; TITLE=Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology; AUTHOR=Kaspers, U, K Deckardt, B Kittel et al; EXTERNAL_SOURCE_ID=6003; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: pathology microscopic-stomach-lesion(s) (nos)|systemic: pathology gross-stomach-ulcer|systemic: pathology microscopic-liver-clear cell focus|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-urine, discoloration|systemic: pathology gross-intestine small-thickened|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-stomach-erosion|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710484_15710485_15710486_15710487:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2f2bfa45df927e441b7aa2688d939271 |
| ToxValDB ToxRefDB | LEL | =95.6 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; TITLE=Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water; AUTHOR=Kaufmann, W, K Deckardt, C Gembardt, et al; EXTERNAL_SOURCE_ID=6000; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710450_15710451_15710452_15710453:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c12406d2214a58a598efccf3d3e41359 |
| ToxValDB ToxRefDB | LEL | =98.37 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-offspring (pup) weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15707406_15707407_15707408_15707409:M:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5a98cc20266e883ffeb2e15205e1ed3c |
| ToxValDB ToxRefDB | LEL | =99.56 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-offspring (pup) weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15707402_15707403_15707404_15707405:F:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_074f2f8e8b3287fd43efbe1e5a957cb3 |
| ToxValDB ToxRefDB | LEL | =199.8 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | LONG_REF=Gill, MW & JP Van Miller. 1989. Glutaraldehyde: 90-day drinking water toxicity study in mice. Bushy Run Research Center, Study no. 52-1. MRID 41773601.; TITLE=Glutaraldehyde: 90-day drinking water toxicity study in mice; AUTHOR=Gill, MW & JP Van Miller; EXTERNAL_SOURCE_ID=4324; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-inflammation|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: urinalysis-volume-volume|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15707367_15707368_15707369_15707370:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7033189e73870f1be5c4f5bbab35aaf7 |
| ToxValDB ToxRefDB | LEL | =238.1 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | LONG_REF=Gill, MW & JP Van Miller. 1989. Glutaraldehyde: 90-day drinking water toxicity study in mice. Bushy Run Research Center, Study no. 52-1. MRID 41773601.; TITLE=Glutaraldehyde: 90-day drinking water toxicity study in mice; AUTHOR=Gill, MW & JP Van Miller; EXTERNAL_SOURCE_ID=4324; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-inflammation|systemic: urinalysis-volume-volume|systemic: in life observation-water consumption-water consumption|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15707363_15707364_15707365_15707366:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ea36311b35192904baaf5c0bb02d2230 |
| ToxValDB ToxRefDB | LOAEL | =61 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; TITLE=PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months; AUTHOR=Kaspers, U, K Deckardt, C Gembardt et al; EXTERNAL_SOURCE_ID=6004; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-larynx-metaplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710491_15710492_15710493_15710494:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bded0aea9095c292c296c7f29dd4de08 |
| ToxValDB ToxRefDB | LOAEL | =76 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; TITLE=Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water; AUTHOR=Kaufmann, W, K Deckardt, C Gembardt, et al; EXTERNAL_SOURCE_ID=6000; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710460_15710461_15710462_15710463:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_839c9cfb58bdbec2e087cd5eb287041b |
| ToxValDB ToxRefDB | LOAEL | =77.4 | mg/kg bw/day | Rat | oral | chronic; 12 months | chronic | LONG_REF=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; TITLE=Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology; AUTHOR=Kaspers, U, K Deckardt, B Kittel et al; EXTERNAL_SOURCE_ID=6003; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=systemic: pathology gross-stomach-erosion|systemic: pathology gross-stomach-ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710480_15710481_15710482_15710483:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_db0d3e733c7896d621c58bec68adad86 |
| ToxValDB ToxRefDB | LOAEL | =87.6 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; TITLE=PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months; AUTHOR=Kaspers, U, K Deckardt, C Gembardt et al; EXTERNAL_SOURCE_ID=6004; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-trachea-metaplasia|systemic: pathology microscopic-larynx-metaplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710488_15710489_15710490:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e31c7c55fc94f48b2e9ec8b8ad7288c2 |
| ToxValDB ToxRefDB | NEL | =0.003125 | mg/kg bw/day | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation... 13-wk_F/334 Rat_Tox-25; TITLE=Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation... 13-wk_F/334 Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=6591; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: hematology-neutrophils-neutrophils|systemic: pathology microscopic-nose-erosion|systemic: pathology microscopic-nose-[other]|systemic: pathology microscopic-nose-respiratory metaplasia|systemic: organ weight-heart-relative to body weight|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: in life observation-clinical signs-emaciation|systemic: pathology microscopic-nose-hyperplasia|systemic: organ weight-testes-relative to body weight|systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-nose-inflammation|systemic: organ weight-lung-relative to body weight|systemic: pathology microscopic-nose-degeneration; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712343_15712344:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f887a9e6dd73f87049d090c7b3b71fe0 |
| ToxValDB ToxRefDB | NEL | =0.00625 | mg/kg bw/day | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation... 13-wk_F/334 Rat_Tox-25; TITLE=Technical Report on Toxicity studies of Glutaraldehyde administered by inhalation... 13-wk_F/334 Rat; AUTHOR=NTP; EXTERNAL_SOURCE_ID=6591; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-nose-[other]|systemic: pathology microscopic-nose-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: hematology-neutrophils-neutrophils|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: in life observation-clinical signs-emaciation|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight|systemic: organ weight-heart-relative to body weight|systemic: pathology microscopic-nose-respiratory metaplasia|systemic: pathology microscopic-nose-degeneration|systemic: pathology microscopic-nose-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712339_15712340_15712341_15712342:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a22bc411fd2bbc1a2159facfa6d30d79 |
| ToxValDB ToxRefDB | NEL | =0.0375 | mg/kg bw/day | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1993_Technical Report on Toxicity studies of Glutaraldehyde administered by inhalationa?| 13-wk_B6C3F1 mice_Tox-25; TITLE=Technical Report on Toxicity studies of Glutaraldehyde administered by inhalationa?| 13-wk_B6C3F1 mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=6592; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-abnormal; STUDY_GROUP=ToxRefDB_dup_-_15712345_15712346:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_89f768b69f6a6ae45928713a719c5b01 |
| ToxValDB ToxRefDB | NEL | =3.5 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; TITLE=PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months; AUTHOR=Kaspers, U, K Deckardt, C Gembardt et al; EXTERNAL_SOURCE_ID=6004; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-larynx-metaplasia|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-stomach-erosion|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-ulcer|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: pathology gross-stomach-erosion|systemic: pathology gross-stomach-ulcer|systemic: in life observation-clinical signs-urine, discoloration; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710491_15710492_15710493_15710494:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b24efa775d58a1cd6d94ab7d08830092 |
| ToxValDB ToxRefDB | NEL | =4.25 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15707396_15707397:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_03701f6b8d302fd68ab16ad13a49474d |
| ToxValDB ToxRefDB | NEL | =4.53 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-lymph node-hyperplasia|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15707394_15707395:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c8fd80f8698457971d513331c3da639 |
| ToxValDB ToxRefDB | NEL | =4.7 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; TITLE=Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water; AUTHOR=Kaufmann, W, K Deckardt, C Gembardt, et al; EXTERNAL_SOURCE_ID=6000; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710454_15710455:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a1228b287c05c109757fd0f6092f0232 |
| ToxValDB ToxRefDB | NEL | =4.8 | mg/kg bw/day | Rat | oral | chronic; 12 months | chronic | LONG_REF=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; TITLE=Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology; AUTHOR=Kaspers, U, K Deckardt, B Kittel et al; EXTERNAL_SOURCE_ID=6003; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: pathology gross-stomach-erosion|systemic: pathology gross-stomach-ulcer|systemic: pathology microscopic-stomach-lesion(s) (nos)|systemic: pathology gross-pituitary gland-enlarged|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710480_15710481_15710482_15710483:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d40293f120e41bfad17be723497a3d34 |
| ToxValDB ToxRefDB | NEL | =6.1 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; TITLE=Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water; AUTHOR=Kaufmann, W, K Deckardt, C Gembardt, et al; EXTERNAL_SOURCE_ID=6000; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-food consumption-food consumption|systemic: pathology gross-stomach-ulcer|systemic: pathology microscopic-stomach-erosion|systemic: pathology microscopic-stomach-edema|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-stomach-erosion|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710456_15710457_15710458_15710459:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed5839da3b3131d70aee431e05321663 |
| ToxValDB ToxRefDB | NEL | =6.68 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15707400_15707401:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ea5e20ec3a66a13441d8997bdb2a01ef |
| ToxValDB ToxRefDB | NEL | =6.72 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Chun, J.S. and Neeper-Bradley, T.L. (1994) Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats. Study performed by Bushy Run Research Center for Union Carbide Chemicals and Plastics Co. Laboratory Project No. 9201059.; TITLE=Gluteraldehyde: Two-Generation Reproduction Study in the Drinking Water of CD Rats; AUTHOR=Chun, J.S. and Neeper-Bradley, T.L; EXTERNAL_SOURCE_ID=4330; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15707398_15707399:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96671dbb236edae52dd4f0bfda4d6105 |
| ToxValDB ToxRefDB | NEL | =9.8 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Van Miller, JP. 1990. Glutaraldehyde: 13-week toxicity study in dogs with administration via the drinking water. Bushy Run Research Center, Project ID 52-93. MRID 41480501.; TITLE=Glutaraldehyde: 13-week toxicity study in dogs with administration via the drinking water; AUTHOR=Van Miller, JP; EXTERNAL_SOURCE_ID=4323; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-vomitting; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15707355_15707356_15707357_15707358:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e500c5667dc01b32e258620d0ea3592 |
| ToxValDB ToxRefDB | NEL | =15 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Hellwig, J & B Hildebrand. 1991. Study of the prenatal toxicity of glutaraldehyde in rabbits after oral administration (gavage). BASF Aktiengesellschaft, Study no. 40R0599/89026. MRID 42154001.; TITLE=Study of the prenatal toxicity of glutaraldehyde in rabbits after oral administration (gavage); AUTHOR=Hellwig, J & B Hildebrand; EXTERNAL_SOURCE_ID=5999; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-resorptions-resorptions|reproductive: reproductive performance-postimplantation loss-postimplantation loss; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15710440_15710441:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec533905fb8cb167551933b6d82dc3b7 |
| ToxValDB ToxRefDB | NEL | =15.4 | mg/kg bw/day | Rat | oral | chronic; 12 months | chronic | LONG_REF=Kaspers, U, K Deckardt, B Kittel et al. 2002. Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology. BASF. Aktiengesellschaft. Ludwigshafen/Rhein.; TITLE=Protectol GDA (50.5% a.i. Glutaraldehyde)-Chronic toxicity study in Wistar rats. Administration in the drinking water for 12 months. Experimental Tox and Ecology; AUTHOR=Kaspers, U, K Deckardt, B Kittel et al; EXTERNAL_SOURCE_ID=6003; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: pathology gross-stomach-erosion|systemic: in life observation-water consumption-water consumption|systemic: pathology gross-intestine small-thickened|systemic: pathology microscopic-liver-clear cell focus|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-urine, discoloration|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: pathology microscopic-stomach-lesion(s) (nos)|systemic: pathology gross-stomach-ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710484_15710485_15710486_15710487:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1eef16ee484e5ac62b109105d6337212 |
| ToxValDB ToxRefDB | NEL | =28.7 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Kaufmann, W, K Deckardt, C Gembardt, et al. (2001) Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water. BASF Aktiengesellschaft, Germany. Lab. Proj. No. 71R0447/97170.; TITLE=Protectol GDA (50% Glutaraldehyde)-2-generation reproduction toxicity study in Wistar rats-Continuous administration in the drinking water; AUTHOR=Kaufmann, W, K Deckardt, C Gembardt, et al; EXTERNAL_SOURCE_ID=6000; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight gain|systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710450_15710451_15710452_15710453:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ede9a83c864c7545c1b060915d38713 |
| ToxValDB ToxRefDB | NEL | =60.8 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | LONG_REF=Gill, MW & JP Van Miller. 1989. Glutaraldehyde: 90-day drinking water toxicity study in mice. Bushy Run Research Center, Study no. 52-1. MRID 41773601.; TITLE=Glutaraldehyde: 90-day drinking water toxicity study in mice; AUTHOR=Gill, MW & JP Van Miller; EXTERNAL_SOURCE_ID=4324; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: pathology microscopic-stomach-inflammation|systemic: in life observation-water consumption-water consumption|systemic: urinalysis-volume-volume; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15707367_15707368_15707369_15707370:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dcb4ad6a401db2ad6033ce277509ac56 |
| ToxValDB ToxRefDB | NEL | =74.3 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | LONG_REF=Gill, MW & JP Van Miller. 1989. Glutaraldehyde: 90-day drinking water toxicity study in mice. Bushy Run Research Center, Study no. 52-1. MRID 41773601.; TITLE=Glutaraldehyde: 90-day drinking water toxicity study in mice; AUTHOR=Gill, MW & JP Van Miller; EXTERNAL_SOURCE_ID=4324; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: in life observation-water consumption-water consumption|systemic: urinalysis-volume-volume|systemic: pathology microscopic-stomach-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15707363_15707364_15707365_15707366:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dfd98088937fccc51b42347a96b69e3d |
| ToxValDB ToxRefDB | NOAEL | =24.3 | mg/kg bw/day | Rat | oral | chronic; 24 months | chronic | LONG_REF=Kaspers, U, K Deckardt, C Gembardt et al. 2003. PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months. BASF. (Dept of Experimental Tox and Ecology, D-67056 Ludwigshafen/Rhein, Ge; TITLE=PROTECTOL GDA (50.5% a.i. Glutaraldehyde)-Carcinogenicity study in Wistar rats: Administration in the drinking water for 24 months; AUTHOR=Kaspers, U, K Deckardt, C Gembardt et al; EXTERNAL_SOURCE_ID=6004; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-abnormal respiratory sounds|systemic: pathology microscopic-stomach-ulcer|systemic: pathology microscopic-larynx-metaplasia|systemic: in life observation-clinical signs-urine, discoloration|systemic: pathology gross-stomach-erosion|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-trachea-metaplasia|systemic: pathology gross-stomach-ulcer|systemic: pathology microscopic-stomach-erosion|systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710488_15710489_15710490:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a709d837c19188d3e58e71daeb1950a1 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | T3C89M417N | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T3C89M417N"} |
| openFDA substances | FDA UNII substance identifier | T3C89M417N | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T3C89M417N"} |
| openFDA substances | FDA UNII substance identifier | T3C89M417N | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T3C89M417N"} |
| openFDA substances | FDA UNII substance identifier | T3C89M417N | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T3C89M417N"} |