NOAEL Studies Cosmetic Ingredient

Glutamic Acid NOAEL Studies

INCI: GLUTAMIC ACID

CAS: 56-86-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 5000 mg/kg bw/day mouse oral NA Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 10000 mg/kg bw/day rat oral 8 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =3200 mg/kg bw/day Rat oral: feed - other EFSA ANS - 2017 - OutputID 2972 - behaviour - neurotoxicity - Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives - doi:10.2903/j.efsa.2017.4910
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =3200 mg/kg bw/day Rat oral: feed - other EFSA ANS - 2017 - OutputID 2972 - behaviour - neurotoxicity - Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives - doi:10.2903/j.efsa.2017.4910
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =30 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2017 - OutputID 2972 - Consumers - Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives - doi:10.2903/j.efsa.2017.4910
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI (group) =30 mg/kg bw/day Consumers - - ADI (group) EFSA ANS - 2017 - OutputID 2972 - Consumers - Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives - doi:10.2903/j.efsa.2017.4910
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =3200 mg/kg bw/day Rat oral - repeat dose other LONG_REF=EFSA ANS (2017). Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives. doi:10.2903/j.efsa.2017.4910.; TITLE=Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2017.4910; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=behavior; STUDY_GROUP=EFSA:15622588:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_847a1243a567da4cefd0e84f627f3c2a
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =10 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632396:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b8b6c0572560ca3d846390bf7acd080e
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3KX376GY7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KX376GY7L"}
openFDA substances FDA UNII substance identifier 3KX376GY7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KX376GY7L"}
openFDA substances FDA UNII substance identifier 3KX376GY7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KX376GY7L"}
openFDA substances FDA UNII substance identifier 3KX376GY7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KX376GY7L"}
openFDA substances FDA UNII substance identifier 3KX376GY7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KX376GY7L"}
openFDA substances FDA UNII substance identifier 3KX376GY7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KX376GY7L"}
openFDA substances FDA UNII substance identifier 3KX376GY7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KX376GY7L"}
openFDA substances FDA UNII substance identifier 3KX376GY7L UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H9NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KX376GY7L"}