Is Glucosamine safe in cosmetics?
Glucosamine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by cir.
Glucosamine
Also known as: 4-04-00-02017, BRN 1724602, EINECS 222-311-2, Glucosaminum, UNII-N08U5BOQ1K
INCI: GLUCOSAMINE
Glucosamine (CAS 3416-24-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; promotes hyaluronic acid synthesis, skin hydration,. EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 3416-24-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent; promotes hyaluronic acid synthesis, skin hydration, wound healing
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
InChIKey
MSWZFWKMSRAUBD-IVMDWMLBSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted, not restricted under 21 CFR for cosmetics; also a dietary supplement under DSHEA 1994; CIR Panel (2021 Draft Report) concluded safe as used when formulated to be non-irritating
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glucosamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: safe
NOAEL: 5 % (oral)
and concluded that these glucosamine ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating. Keywords Safety, Cosmetics, Cosmetic Ingredient Review, Expert panel for Cosmetic Ingredient Safety,
Additional Ingredient Properties
3 property records from structured ingredient metadata.
acne
{"cas_number": "3416-24-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
microbiome_impact
{"microbiome_effect": "positive", "prebiotic": "yes", "probiotic_compatible": "yes", "preservative_effect_on_microbiome": "Amino sugar; prebiotic; barrier support; anti-inflammatory", "gut_microbiome_risk": "low", "microbiome_recovery_time": "<3 days", "selective_antimicrobial": "no", "beneficial_bacteria_support": "S. epidermidis, Lactobacillus spp", "biofilm_disruption": "low", "fermentation_der…
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "recommended", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "exfoliating", "skin_benefit_secondary": "brightening", …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
No specific technical function
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Glucosamine.
Regulatory Flags
potential-allergen
Known Synonyms
4-04-00-02017
BRN 1724602
EINECS 222-311-2
Glucosaminum
UNII-N08U5BOQ1K
Chemical Function
Anti-static agent
Softener and conditioner
No specific technical function
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Glucosamine allowed in the EU?
Glucosamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glucosamine do in cosmetics?
Glucosamine functions as: Skin conditioning agent; promotes hyaluronic acid synthesis, skin hydration, wound healing. It is classified as a cosmetic ingredient in our database. CAS number: 3416-24-8.
Is Glucosamine used outside cosmetics?
Glucosamine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glucosamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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