NOAEL Studies Cosmetic Ingredient

Glucono Delta-Lactone NOAEL Studies

INCI: GLUCONOLACTONE

CAS: 90-80-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 182 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 695 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 594 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 560 mg/kg bw/day hamster oral 5 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 780 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_eye_irritation 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation Draize rabbit irritation score 2 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=167; Record_ID=eye_irritation_142; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0026549; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=2; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026549; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0026549
NTP_ICE_eye_irritation EPA Classification 4 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=173; Record_ID=eye_irritation_142; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0026549; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026549; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0026549
NTP_ICE_eye_irritation Lag time >180 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=172; Record_ID=eye_irritation_1219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0026549; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026549; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0026549
NTP_ICE_eye_irritation Plateau level 0 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=170; Record_ID=eye_irritation_1219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0026549; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0026549; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0026549
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =695 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf991; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19531/7/9/3?documentUUID=cd4cac46-b0a7-4c27-86e2-dfa85661d5f8; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15822016:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9836f6e7041d82b64a74d426572e3dc4
ToxValDB_ECHA_IUCLID NOAEL =560 mg/kg bw/day Hamster oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23ee4b0a7c65d2323eb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19531/7/9/3?documentUUID=cd4cac46-b0a7-4c27-86e2-dfa85661d5f8; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15822986:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d838ad79bc4d95ceefc1d2b03a1cd46
ToxValDB_ECHA_IUCLID NOAEL =594 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf9a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19531/7/9/3?documentUUID=cd4cac46-b0a7-4c27-86e2-dfa85661d5f8; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15823062:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_de5503fb2839277e73f614a14859490e
ToxValDB_ECHA_IUCLID NOEL =780 mg/kg bw/day Rabbit oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf999; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19531/7/9/3?documentUUID=cd4cac46-b0a7-4c27-86e2-dfa85661d5f8; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID:15822889:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_990fb5c3f921068e8e4a2fa061d3890e
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =59 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632388:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a02457c325707f4ac6c11ead40620d2
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier WQ29KQ9POT UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WQ29KQ9POT"}
openFDA substances FDA UNII substance identifier WQ29KQ9POT UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WQ29KQ9POT"}
openFDA substances FDA UNII substance identifier WQ29KQ9POT UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WQ29KQ9POT"}
openFDA substances FDA UNII substance identifier WQ29KQ9POT UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H10O6","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WQ29KQ9POT"}