Is Glucolactone safe in cosmetics?
Glucolactone has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Glucolactone
INCI: GLUCONOLACTONE
Glucolactone (CAS 90-80-2 (same as Gluconolactone)) is a cosmetic cosmetic ingredient functioning as Chelating agent, skin conditioning (PHA), antiacne agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 90-80-2 (same as Gluconolactone) →
Auto-generated CPSR Part A draft with source citations
Function
Chelating agent, skin conditioning (PHA), antiacne agent
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR concluded safe in present practices of use and concentration (Sept 2022); FDA GRAS as food ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glucolactone.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Glucolactone, relevant to systemic exposure and MoS calculations.
Absorption %
2-5%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
178.1 Da
Log P
-2.1
Systemic Absorption
minimal
Topical Bioavailability
1-3%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: Dermatol Surg 2004
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "90-80-2", "anti_acne_mechanism": "keratolytic/anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "non_inflammatory", "p_acnes_mic_ug_per_ml": "No direct antibacterial", "sebum_reduction_pct_clinical": "5-8", "keratolytic_strength": "mild", "exfoliation_mechanism": "chemical", "optimal_ph_for_efficacy": "3.5-4.5", "peel_depth": "superficial", "prescriptio…
concentration
{"min_concentration_pct": "2.0", "max_concentration_pct": "8.0", "typical_concentration_pct": "4.0", "product_type": "Moisturizer", "function_at_concentration": "Gentle exfoliation, hydration", "source": "Supplier TDS"}
dermal_absorption
{"molecular_weight_da": "178.1", "log_p_value": "-2.1", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "2-5", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "1-3", "safety_margin_factor": "minimal", "source": "De…
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "14-28", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "pa…
exfoliant
{"cas_number": "90-80-2", "ingredient_class": "PHA", "chemical_subclass": "polyhydroxy_acid", "molecular_weight_Da": "178.14", "pKa_value": "3.70", "pH_dependent_activity": "yes", "optimal_pH_range": "3.5-5.0", "penetration_depth": "stratum_corneum", "mechanism_of_action": "desmolysis", "target_bonds": "desmosomal", "onset_of_action": "hours", "peak_effect_timeline": "10-14 weeks", "cell_turnover_…
interactions
{"ingredient_2": "Preservatives (general)", "interaction_type": "synergistic", "severity": "beneficial", "effect": "PHA chelates metals, enhances preservative stability", "recommendation": "Compatible; gluconolactone acts as preservative booster", "data_source": "Formulation science literature, dermatological research, cosmetic chemistry best practices", "last_updated": "2026-03-05"}
microbiome_impact
{"microbiome_effect": "positive", "prebiotic": "yes", "probiotic_compatible": "yes", "antimicrobial_spectrum": "selective", "preservative_effect_on_microbiome": "Polyhydroxy acid; gentle preservative booster; supports beneficial bacteria", "gut_microbiome_risk": "low", "microbiome_recovery_time": "<3 days", "selective_antimicrobial": "yes", "beneficial_bacteria_support": "S. epidermidis, Lactobaci…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "10.0", "adult_max_concentration_pct": "10.0", "pediatric_dermal_absorption_factor": "normal", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "eye_irritation_risk": "low", "diaper_area_s…
Expert Verdict
Expert safety assessment and concern-level summary for Glucolactone.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Glucolactone by CAS number or substance name.
Studies
3
Lowest NOAEL
560 mg/kg bw/day
Highest NOAEL
695 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Frequently Asked Questions
Is Glucolactone allowed in the EU?
Glucolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glucolactone do in cosmetics?
Glucolactone functions as: Chelating agent, skin conditioning (PHA), antiacne agent. It is classified as a cosmetic ingredient in our database. CAS number: 90-80-2 (same as Gluconolactone).
Compliance Tools
Check Glucolactone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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