Is Ginsenoside Rg1 safe in cosmetics?
Ginsenoside Rg1 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Ginsenoside Rg1
INCI: GINSENOSIDE RG1
Ginsenoside Rg1 (CAS 22427-39-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning, antioxidant (major protopanaxatriol-type ginsenoside). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 22427-39-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, antioxidant (major protopanaxatriol-type ginsenoside)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
InChIKey
YURJSTAIMNSZAE-HHNZYBFYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not prohibited or restricted under 21 CFR; covered under CIR Panax spp. assessment (safe as used, 2015)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ginsenoside Rg1.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Ginsenoside Rg1.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GINSENOSIDE RG1
ChEMBL ID
CHEMBL501637
Frequently Asked Questions
Is Ginsenoside Rg1 allowed in the EU?
Ginsenoside Rg1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ginsenoside Rg1 do in cosmetics?
Ginsenoside Rg1 functions as: Skin conditioning, antioxidant (major protopanaxatriol-type ginsenoside). It is classified as a cosmetic ingredient in our database. CAS number: 22427-39-0.
Is Ginsenoside Rg1 used outside cosmetics?
Ginsenoside Rg1 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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