NOAEL Studies Cosmetic Ingredient

Geranyl Butyrate NOAEL Studies

INCI: GERANYL BUTYRATE

CAS: 106-29-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =345 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =345 mg/kg bw/day Rat oral: feed 98 days subchronic EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =10660 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_549; row=3224; data_type=In Vivo; mixture=Chemical; chemical_name=Geranyl butyrate; preferred_name=Geranyl butyrate; dtxsid=DTXSID1047152; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047152; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3039; Record_ID=skin_sensitization_invivo_797; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1047152; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90169-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047152
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3038; Record_ID=skin_sensitization_invivo_797; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1047152; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90169-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047152
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3043; Record_ID=skin_sensitization_invivo_797; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1047152; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90169-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1047152
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =345 mg/kg bw/day Rat oral chronic; 14 weeks chronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4512.; TITLE=Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4512; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15622560:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_321ba82fd0dc50280faf91f703f59901
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 69AVH8L7KL UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"69AVH8L7KL"}
openFDA substances FDA UNII substance identifier 69AVH8L7KL UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"69AVH8L7KL"}
openFDA substances FDA UNII substance identifier 69AVH8L7KL UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"69AVH8L7KL"}
openFDA substances FDA UNII substance identifier 69AVH8L7KL UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"69AVH8L7KL"}