NOAEL Studies Cosmetic Ingredient

Gellan Gum NOAEL Studies

INCI: GELLAN GUM

CAS: 71010-52-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 6000 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3000 mg/kg bw/day monkey oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4900 mg/kg bw/day mouse oral 672 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =3627 mg/kg bw/day Mouse oral: feed 672 days chronic/long term toxicity EFSA ANS - 2018 - OutputID 3055 - no adverse effect observed at single/highest dose - Re-evaluation of gellan gum (E 418) as food additive - doi:10.2903/j.efsa.2018.5296
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1460 mg/kg bw/day Rat oral: feed 728 days chronic/long term toxicity EFSA ANS - 2018 - OutputID 3055 - no adverse effect observed at single/highest dose - Re-evaluation of gellan gum (E 418) as food additive - doi:10.2903/j.efsa.2018.5296
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =3627 mg/kg bw/day Mouse oral: feed 672 days chronic/long term toxicity EFSA ANS - 2018 - OutputID 3055 - no adverse effect observed at single/highest dose - Re-evaluation of gellan gum (E 418) as food additive - doi:10.2903/j.efsa.2018.5296
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1460 mg/kg bw/day Rat oral: feed 728 days chronic/long term toxicity EFSA ANS - 2018 - OutputID 3055 - no adverse effect observed at single/highest dose - Re-evaluation of gellan gum (E 418) as food additive - doi:10.2903/j.efsa.2018.5296
ToxValDB_EFSA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA LEL =200 mg/kg bw/day Human oral short-term; 3 weeks clinical LONG_REF=EFSA ANS (2018). Re-evaluation of gellan gum (E 418) as food additive. doi:10.2903/j.efsa.2018.5296.; TITLE=Re-evaluation of gellan gum (E 418) as food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2018.5296; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625425:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6fe8fbbf6bdf59b2f26ac54d159407eb
ToxValDB_EFSA NOAEL =3627 mg/kg bw/day Mouse oral chronic; 96 weeks chronic LONG_REF=EFSA ANS (2018). Re-evaluation of gellan gum (E 418) as food additive. doi:10.2903/j.efsa.2018.5296.; TITLE=Re-evaluation of gellan gum (E 418) as food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2018.5296; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625423:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d6fa2a75b0c8ae6e09178e14df731f0f
ToxValDB_EFSA NOAEL =1460 mg/kg bw/day Rat oral chronic; 104 weeks chronic LONG_REF=EFSA ANS (2018). Re-evaluation of gellan gum (E 418) as food additive. doi:10.2903/j.efsa.2018.5296.; TITLE=Re-evaluation of gellan gum (E 418) as food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2018.5296; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15625424:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6585ef72dfd7880ea222694083a86091
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 7593U09I4D UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"7593U09I4D"}
openFDA substances FDA UNII substance identifier 7593U09I4D UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"7593U09I4D"}
openFDA substances FDA UNII substance identifier 7593U09I4D UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"7593U09I4D"}
openFDA substances FDA UNII substance identifier 7593U09I4D UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"7593U09I4D"}