NOAEL Studies
Cosmetic Ingredient
Furfural NOAEL Studies
INCI: FURFURAL
CAS: 98-01-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | LOAEL | 30 | mg/kg bw/day | rat | oral | 2 year | Chronic | PAFA; NTP TR 382 (NIH PBL 90-2837) |
| COSMOS_DB | LOAEL | 90 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH |
| COSMOS_DB | LOAEL | 11 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH |
| COSMOS_DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 25 | mg/kg bw/day | rat | oral | 35 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 240 | mg/kg bw/day | rat | oral | 16 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 400 | mg/kg bw/day | mouse | oral | 16 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 180 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 600 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 60 | mg/kg bw/day | rat | oral | 721 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 175 | mg/kg bw/day | mouse | oral | 721 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 120 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOEL | =54 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA AFC - 2004 - OutputID 2248 - haematology - hepatotoxicity - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Furfural and Furfural Diethylacetal - doi:10.2903/j.efsa.2004.67 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOEL | =53 | mg/kg bw/day | Rat | oral: feed | 91 days | subchronic | EFSA AFC - 2009 - OutputID 2265 - Flavouring Group Evaluation 66 (FGE.66)1: Consideration of furfuryl alcohol and related flavouring substances evaluated by JECFA (55th meeting) structurally related to Furfuryl and furan derivatives with and without additional side chain substituents and heteroatoms evaluated by EFSA in FGE.13 (2005) - doi:10.2903/j.efsa.2009.752 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOEL | =54 | mg/kg bw/day | Rat | oral: feed | 90 days | subchronic | EFSA AFC - 2004 - OutputID 2248 - haematology - hepatotoxicity - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Furfural and Furfural Diethylacetal - doi:10.2903/j.efsa.2004.67 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOEL | =53 | mg/kg bw/day | Rat | oral: feed | 91 days | subchronic | EFSA AFC - 2009 - OutputID 2265 - Flavouring Group Evaluation 66 (FGE.66)1: Consideration of furfuryl alcohol and related flavouring substances evaluated by JECFA (55th meeting) structurally related to Furfuryl and furan derivatives with and without additional side chain substituents and heteroatoms evaluated by EFSA in FGE.13 (2005) - doi:10.2903/j.efsa.2009.752 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =0.5 | mg/kg bw/day | Consumers | - | - | ADI | EFSA AFC - 2004 - OutputID 2248 - Consumers - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Furfural and Furfural Diethylacetal - doi:10.2903/j.efsa.2004.67 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =0.5 | mg/kg bw/day | Consumers | - | - | ADI | EFSA AFC - 2004 - OutputID 2248 - Consumers - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Furfural and Furfural Diethylacetal - doi:10.2903/j.efsa.2004.67 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | =0.5 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA FEEDAP - 2016 - OutputID 2768 - Consumers - Safety and efficacy of furfuryl and furan derivatives belonging to chemical group 14 when used as flavourings for all animal species and categories - doi:10.2903/j.efsa.2016.4389 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | =0.5 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA FEEDAP - 2016 - OutputID 2768 - Consumers - Safety and efficacy of furfuryl and furan derivatives belonging to chemical group 14 when used as flavourings for all animal species and categories - doi:10.2903/j.efsa.2016.4389 |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | LOAEL | =7.9 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=fc76ac3fad8a3d09; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LOAEL : 7.9 mg/kg-day; system=Hepatic; basis=Mild hepatocellular vacuolization; point_of_departure=LOAEL : 7.9 mg/kg-day; composite_uf=3000; confidence=Low; dtxsid=DTXSID1020647; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=317; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0317_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =0.003 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=cd9dbe8d86e92c1b; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-3; system=Hepatic; basis=Mild hepatocellular vacuolization; point_of_departure=LOAEL : 7.9 mg/kg-day; composite_uf=3000; confidence=Low; dtxsid=DTXSID1020647; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=317; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0317_summary.pdf |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1995 | IARC Monographs | {"additional_info":"volume_publication_year=1995","evaluation_year":1995,"source_table":"iarc_classifications","volume":"63"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1995 | IARC Monographs | {"additional_info":"volume_publication_year=1995","evaluation_year":1995,"source_table":"iarc_classifications","volume":"63"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1995 | IARC Monographs | {"additional_info":"volume_publication_year=1995","evaluation_year":1995,"source_table":"iarc_classifications","volume":"63"} |
INCHEM_WHO_cicads_cicads_cicad_21 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_cicads_cicads_cicad_21 | NOAEL | =208 | mg/m3 | Rat; Rabbit | - | - | Toxicology study | document_id=cicads_cicads_cicad_21; title=Furaldehyde, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad_21.htm; row_hash=9d2216f384720877; raw_unit=mg/m 3; context=A NOAEL of 208 mg/m 3 (52 ppm) was identified in rabbits; a NOAEL was not identified for rats. |
| INCHEM_WHO_cicads_cicads_cicad_21 | NOAEL | =80 | mg/m3 | - | - | - | Toxicology study | document_id=cicads_cicads_cicad_21; title=Furaldehyde, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad_21.htm; row_hash=ddd6c60daebd289c; raw_unit=mg/m 3; context=A NOAEL of 80 mg/m 3 (20 ppm) was identified. |
| INCHEM_WHO_cicads_cicads_cicad_21 | NOAEL | =208 | mg/m3 | Rat; Rabbit | - | - | Toxicology study | document_id=cicads_cicads_cicad_21; title=Furaldehyde, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad_21.htm; row_hash=9d2216f384720877; raw_unit=mg/m 3; context=A NOAEL of 208 mg/m 3 (52 ppm) was identified in rabbits; a NOAEL was not identified for rats. |
| INCHEM_WHO_cicads_cicads_cicad_21 | NOAEL | =80 | mg/m3 | - | - | - | Toxicology study | document_id=cicads_cicads_cicad_21; title=Furaldehyde, 2- (CICADS); path=mirror/documents/cicads/cicads/cicad_21.htm; row_hash=ddd6c60daebd289c; raw_unit=mg/m 3; context=A NOAEL of 80 mg/m 3 (20 ppm) was identified. |
INCHEM_WHO_jecfa_jecmono_v042je03 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v042je03 | NOEL | =77 | mg/m3 | - | - | - | Reproductive toxicity | document_id=jecfa_jecmono_v042je03; title=929. Furfural (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je03.htm; row_hash=b162fa93e5d8c39b; raw_unit=mg/m 3; context=The NOEL was 77 mg/m 3 , since mild nasal epithelial degeneration was observed at 448 mg/m 3 (Feron & Kruysse, 1978). |
| INCHEM_WHO_jecfa_jecmono_v042je03 | NOEL | =77 | mg/m3 | - | - | - | Reproductive toxicity | document_id=jecfa_jecmono_v042je03; title=929. Furfural (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je03.htm; row_hash=b162fa93e5d8c39b; raw_unit=mg/m 3; context=The NOEL was 77 mg/m 3 , since mild nasal epithelial degeneration was observed at 448 mg/m 3 (Feron & Kruysse, 1978). |
INCHEM_WHO_jecfa_jecmono_v46je08 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v46je08 | ADI | =0.5 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v46je08; title=FURFURYL ALCOHOL AND RELATED SUBSTANCES; path=mirror/documents/jecfa/jecmono/v46je08.htm; row_hash=18a4557f251bc76a; raw_unit=mg/kg bw; context=All intake values are expressed in ug/day. c A group ADI of 00.5 mg/kg bw was established by the Committee at its present meeting for furfural, furfuryl alcohol, furfuryl acetate, furfuryl propionate, furfuryl pentanoate, furfuryl octanoate, furfuryl 3-methylbutanoate, methyl 2-furoate, propyl 2-furoate, amyl 2-furoate, hexyl 2-fur |
| INCHEM_WHO_jecfa_jecmono_v46je08 | ADI | =0.5 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v46je08; title=FURFURYL ALCOHOL AND RELATED SUBSTANCES; path=mirror/documents/jecfa/jecmono/v46je08.htm; row_hash=18a4557f251bc76a; raw_unit=mg/kg bw; context=All intake values are expressed in ug/day. c A group ADI of 00.5 mg/kg bw was established by the Committee at its present meeting for furfural, furfuryl alcohol, furfuryl acetate, furfuryl propionate, furfuryl pentanoate, furfuryl octanoate, furfuryl 3-methylbutanoate, methyl 2-furoate, propyl 2-furoate, amyl 2-furoate, hexyl 2-fur |
| INCHEM_WHO_jecfa_jecmono_v46je08 | NOEL | =53 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je08; title=FURFURYL ALCOHOL AND RELATED SUBSTANCES; path=mirror/documents/jecfa/jecmono/v46je08.htm; row_hash=5c86cae7150009d7; raw_unit=mg/kg bw per day; context=The NOEL of 53 mg/kg bw per day for the related substance, furfural (Jonker, 2000), is > 10 000 times the estimated daily intake of furfuryl alcohol when used as a flavouring agent. |
| INCHEM_WHO_jecfa_jecmono_v46je08 | NOEL | =25 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je08; title=FURFURYL ALCOHOL AND RELATED SUBSTANCES; path=mirror/documents/jecfa/jecmono/v46je08.htm; row_hash=25af60ed4e06c254; raw_unit=mg/kg bw per day; context=The NOEL of 25 mg/kg bw per day (Posternak et al., 1969) is > 100 million times the estimated daily intake of 2-benzofuran- carboxaldehyde when used as a flavouring agent. |
| INCHEM_WHO_jecfa_jecmono_v46je08 | NOEL | =13 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je08; title=FURFURYL ALCOHOL AND RELATED SUBSTANCES; path=mirror/documents/jecfa/jecmono/v46je08.htm; row_hash=34d5cb2dab1b2bbe; raw_unit=mg/kg bw per day; context=The NOEL of 13 mg/kg bw per day (Posternak et al., 1969) is > 400 times the estimated daily intake of 2-phenyl-3-carbeth- oxyfuran when used as a flavouring substance. |
| INCHEM_WHO_jecfa_jecmono_v46je08 | NOEL | =53 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je08; title=FURFURYL ALCOHOL AND RELATED SUBSTANCES; path=mirror/documents/jecfa/jecmono/v46je08.htm; row_hash=5c86cae7150009d7; raw_unit=mg/kg bw per day; context=The NOEL of 53 mg/kg bw per day for the related substance, furfural (Jonker, 2000), is > 10 000 times the estimated daily intake of furfuryl alcohol when used as a flavouring agent. |
| INCHEM_WHO_jecfa_jecmono_v46je08 | NOEL | =25 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je08; title=FURFURYL ALCOHOL AND RELATED SUBSTANCES; path=mirror/documents/jecfa/jecmono/v46je08.htm; row_hash=25af60ed4e06c254; raw_unit=mg/kg bw per day; context=The NOEL of 25 mg/kg bw per day (Posternak et al., 1969) is > 100 million times the estimated daily intake of 2-benzofuran- carboxaldehyde when used as a flavouring agent. |
| INCHEM_WHO_jecfa_jecmono_v46je08 | NOEL | =13 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je08; title=FURFURYL ALCOHOL AND RELATED SUBSTANCES; path=mirror/documents/jecfa/jecmono/v46je08.htm; row_hash=34d5cb2dab1b2bbe; raw_unit=mg/kg bw per day; context=The NOEL of 13 mg/kg bw per day (Posternak et al., 1969) is > 400 times the estimated daily intake of 2-phenyl-3-carbeth- oxyfuran when used as a flavouring substance. |
NTP_ICE_acute_inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 0.6873 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=781; Record_ID=acute_inhalation_1053; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.6873; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
| NTP_ICE_acute_inhalation | LC50 | 12.2 | mg/L | - | Inhalation | Duration=2 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=782; Record_ID=acute_inhalation_1787; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=12.2; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
NTP_ICE_acute_oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =127 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11895; row=2073; data_type=In Vivo; mixture=Chemical; chemical_name=Furfural; preferred_name=Furfural; dtxsid=DTXSID1020647; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020647; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =108 | mg/kg bw | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Pesticide Active Ingredients Database (undated); record_id=acute_oral_11894; row=2074; data_type=In Vivo; mixture=Chemical; chemical_name=Furfural; preferred_name=Furfural; dtxsid=DTXSID1020647; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020647; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =105 | mg/kg bw | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Pesticide Active Ingredients Database (undated); record_id=acute_oral_11893; row=2075; data_type=In Vivo; mixture=Chemical; chemical_name=Furfural; preferred_name=Furfural; dtxsid=DTXSID1020647; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020647; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =65 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_11891; row=2076; data_type=In Vivo; mixture=Chemical; chemical_name=Furfural; preferred_name=Furfural; dtxsid=DTXSID1020647; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020647; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =100 | mg/kg bw | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Pesticide Active Ingredients Database (undated); record_id=acute_oral_11892; row=2077; data_type=In Vivo; mixture=Chemical; chemical_name=Furfural; preferred_name=Furfural; dtxsid=DTXSID1020647; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020647; source_file=acute_oral.xlsx |
NTP_ICE_cancer 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=1317; Record_ID=cancer_5323; Data_Type=WOE; Formulation_Name=Furfural; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/81; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
| NTP_ICE_cancer | POLY-3 lowest dose | 175 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=1318; Record_ID=cancer_5322; Data_Type=In Vivo; Formulation_Name=Furfural; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=175; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Level_of_Evidence=Some evidence; Tissue=Liver; Lesion=Hepatocellular adenoma; Reference=TR-382; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr382/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
| NTP_ICE_cancer | POLY-3 lowest dose | 60 | mg/kg bw/day | Rat | Gavage | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=1327; Record_ID=cancer_5321; Data_Type=In Vivo; Formulation_Name=Furfural; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=60; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Level_of_Evidence=Some evidence; Tissue=Liver; Lesion=Cholangiocarcinoma; Reference=TR-382; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr382/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
| NTP_ICE_cancer | Top dose | 175 | mg/kg | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1319; Record_ID=cancer_5322; Data_Type=In Vivo; Formulation_Name=Furfural; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=175; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Reference=TR-382; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr382/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
| NTP_ICE_cancer | Top dose | 60 | mg/kg | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=1321; Record_ID=cancer_5321; Data_Type=In Vivo; Formulation_Name=Furfural; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=60; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-382; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr382/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=9864; RecordID=ARPathway2016_1795; DatasetName=ARPathway2016; DTXSID=DTXSID1020647; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11534; Record_ID=skin_sensitization_invivo_2506; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80105-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 1350 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11532; Record_ID=skin_sensitization_invivo_2506; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1350; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80105-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=11538; Record_ID=skin_sensitization_invivo_2506; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020647; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1975: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80105-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020647; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020647 |
ToxRefDB_ToxRefDB_v3_pod.csv 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =120 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 16 day | SAC | study_id=5410; toxval_study_source_id=studyid5410_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-reduced activity|in life observation-clinical signs-labored respiration|in life observation-mortality-mortality; dose_level=4; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Rats; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =400 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 16 day | SAC | study_id=5411; toxval_study_source_id=studyid5411_Adult_F0_M_systemic; toxval_effect_list=in life observation-mortality-mortality; dose_level=5; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Mice; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =90 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5412; toxval_study_source_id=studyid5412_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality; dose_level=4; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Rats; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =11 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5412; toxval_study_source_id=studyid5412_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-vacuolization cytoplasmic|organ weight-liver-relative to body weight|organ weight-kidney-relative to body weight|organ weight-kidney-absolute|organ weight-liver-absolute|in life observation-mortality-mortality; dose_level=1; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Rats; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =75 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5413; toxval_study_source_id=studyid5413_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|in life observation-mortality-mortality|in life observation-body weight-body weight|pathology microscopic-liver-necrosis|pathology microscopic-liver-inflammation; dose_level=1; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Mice; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =150 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5413; toxval_study_source_id=studyid5413_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-inflammation|in life observation-body weight-body weight|pathology microscopic-liver-necrosis|organ weight-liver-relative to body weight|in life observation-mortality-mortality; dose_level=2; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Mice; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =60 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=5414; toxval_study_source_id=studyid5414_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-lung-foreign body|in life observation-mortality-mortality|pathology microscopic-lung-congestion; dose_level=2; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_2-year study_Rats; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =50 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5416; toxval_study_source_id=studyid5416_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-squamous cell papilloma|pathology microscopic-liver-pigmentation|pathology microscopic-liver-hepatocellular adenoma|pathology microscopic-liver-inflammation; dose_level=1; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_2-year study_Mice; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =100 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=5416; toxval_study_source_id=studyid5416_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-pigmentation|pathology microscopic-liver-inflammation; dose_level=2; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_2-year study_Mice; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =60 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 16 day | SAC | study_id=5410; toxval_study_source_id=studyid5410_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-labored respiration|in life observation-mortality-mortality|in life observation-clinical signs-reduced activity; dose_level=3; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Rats; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =200 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 16 day | SAC | study_id=5411; toxval_study_source_id=studyid5411_Adult_F0_M_systemic; toxval_effect_list=in life observation-mortality-mortality; dose_level=4; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Mice; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =45 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5412; toxval_study_source_id=studyid5412_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality; dose_level=3; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Rats; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5412; toxval_study_source_id=studyid5412_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-kidney-relative to body weight|pathology microscopic-liver-vacuolization cytoplasmic|organ weight-liver-absolute|in life observation-mortality-mortality|organ weight-kidney-absolute; dose_level=0; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Rats; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =30 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=5414; toxval_study_source_id=studyid5414_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-lung-congestion|pathology microscopic-lung-foreign body|in life observation-mortality-mortality; dose_level=1; study_year=1990; study_citation=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_2-year study_Rats; dsstox_substance_id=DTXSID1020647; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =82527.4 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=DOE Protective Action Criteria:15515727:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_928d0b04c772becec8e510b4f0ae210a |
ToxValDB_ECHA_IUCLID 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =60 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c849e4b0a7c65d217cac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/8?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15817672:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_02ba6333a9f7514a41c0ccbbd7f2c371 |
| ToxValDB_ECHA_IUCLID | LOAEL | =30 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c849e4b0a7c65d217cac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/8?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15817674:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c57954a43cf5e86bcd41d95b80a659ce |
| ToxValDB_ECHA_IUCLID | LOAEL | =175 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c849e4b0a7c65d217cb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/8?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818201_15818202_15818203:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_49e5fd70fdb131f63dd8f67bc948f34a |
| ToxValDB_ECHA_IUCLID | NOAEC | =97 | mg/m3 | Hamster | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c849e4b0a7c65d217cb2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/8?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15818483:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_feb07938f2dde2bc7496be35bc6f49dd |
| ToxValDB_ECHA_IUCLID | NOAEC | =20 | mg/m3 | Rat | inhalation | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/6/3?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828883_15828884:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0b547c554e9dac7bd1af9e72a441225c |
| ToxValDB_ECHA_IUCLID | NOAEC | =8 | mg/m3 | Rat | inhalation | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/6/3?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828883_15828884:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9389d7b051ede1dd72198d0585670450 |
| ToxValDB_ECHA_IUCLID | NOAEC | =320 | mg/m3 | Rat | inhalation | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/6/3?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829205_15829206:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_955af7bb2172975371aa20b15168c030 |
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c849e4b0a7c65d217cb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/8?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818201_15818202_15818203:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4f76014ab49bae7f93885b725bd750e2 |
| ToxValDB_ECHA_IUCLID | NOAEL | =50 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c849e4b0a7c65d217cb0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/8?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818201_15818202_15818203:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c0378dd5812d737af14b2d54b5fd091 |
| ToxValDB_ECHA_IUCLID | NOAEL | =250 | mg/kg bw/day | Rat | dermal | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f8fe4b096bca877e102; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/6/4?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826784_15826895_15826896:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_232b4c4a7040dcbc3aa9f748eb688fe1 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | dermal | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f8fe4b096bca877e102; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/6/4?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826784_15826895_15826896:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e57ddf9c04fb25f8ab04296425341eb7 |
| ToxValDB_ECHA_IUCLID | NOAEL | =96 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc35e4b0a7c65d229737; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/6/2?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15838084:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0f1339e82b76d31534aced835a452754 |
| ToxValDB_ECHA_IUCLID | NOAEL | <11 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc35e4b0a7c65d22973b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/6/2?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15841756:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ca85cafe06418016e3d0873385fab217 |
| ToxValDB_ECHA_IUCLID | NOAEL | =75 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc35e4b0a7c65d22974c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/6/2?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15844642:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5577d08871be8267eb2ac5700fe4d5aa |
| ToxValDB_ECHA_IUCLID | NOAEL | =53 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc35e4b0a7c65d229755; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/6/2?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15846634:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b5d5c270db09b05cd1520fd4f8717a69 |
| ToxValDB_ECHA_IUCLID | NOAEL | =60 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c96ee4b0a7c65d21cf9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23020/7/9/2?documentUUID=c9433e67-d9cc-4c53-8bcf-190fa8dfc6a6; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: urinalysis|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: neuropathology|P0: histopathology: non-neoplastic|P0: histopathology: neoplastic|P0: reproductive function (oestrous cycle)|P0: reproductive function (sperm measures)|P0: reproductive performance|P0: |P0: mortality|P0: dermal irritation|P0: body weight and weight gain|P0: food consumption and compound intake|P0: food efficiency|P0: water consumption and compound intake|P0: ophthalmological examination|P0: haematology|P0: clinical biochemistry; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction|urinalysis; STUDY_GROUP=ECHA IUCLID:15857866:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d163774f526a3b61d31395480a939542 |
ToxValDB_ECOTOX 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =20 | mL/kg | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Acta Pathol. Jpn.36(7): 1027-1038 Shimizu,A., and M. Kanisawa Experimental Studies on Hepatic Cirrhosis and Hepatocarcinogenesis I. Production of Hepatic Cirrhosis by Furfural Administration 1986; TITLE=Experimental Studies on Hepatic Cirrhosis and Hepatocarcinogenesis I. Production of Hepatic Cirrhosis by Furfural Administration; AUTHOR=Shimizu,A., and M. Kanisawa; DOI=10.1111/j.1440-1827.1986.tb00212.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75970; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX:15594610:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c14a207be9449bb40e8bb7a54a238340 |
| ToxValDB_ECOTOX | LOEL | =50 | mg/kg bw/day | Mouse | oral | acute; 0.0833 days | acute | LONG_REF=Food Chem. Toxicol.39(10): 999-1011 Lake,B.G., A.J. Edwards, R.J. Price, B.J. Phillips, A.B. Renwick, J.A. Beamand, and T.B. Adams Lack of Effect of Furfural on Unscheduled DNA Synthesis in the In Vivo Rat and Mouse Hepatocyte DNA Repair Assays and in Precision-Cut Human Liver Slices 2001; TITLE=Lack of Effect of Furfural on Unscheduled DNA Synthesis in the In Vivo Rat and Mouse Hepatocyte DNA Repair Assays and in Precision-Cut Human Liver Slices; AUTHOR=Lake,B.G., A.J. Edwards, R.J. Price, B.J. Phillips, A.B. Renwick, J.A. Beamand, and T.B. Adams; DOI=10.1016/s0278-6915(01)00050-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=75972; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Cell changes; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15597436:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1adb7400b86261d8ee97f32ecad0d023 |
| ToxValDB_ECOTOX | LOEL | =5 | mg/kg bw/day | Rat | oral | acute; 0.0833 days | acute | LONG_REF=Food Chem. Toxicol.39(10): 999-1011 Lake,B.G., A.J. Edwards, R.J. Price, B.J. Phillips, A.B. Renwick, J.A. Beamand, and T.B. Adams Lack of Effect of Furfural on Unscheduled DNA Synthesis in the In Vivo Rat and Mouse Hepatocyte DNA Repair Assays and in Precision-Cut Human Liver Slices 2001; TITLE=Lack of Effect of Furfural on Unscheduled DNA Synthesis in the In Vivo Rat and Mouse Hepatocyte DNA Repair Assays and in Precision-Cut Human Liver Slices; AUTHOR=Lake,B.G., A.J. Edwards, R.J. Price, B.J. Phillips, A.B. Renwick, J.A. Beamand, and T.B. Adams; DOI=10.1016/s0278-6915(01)00050-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=75972; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Cell(s): Cell changes; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15608482:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a2cd6e50028926e1f95bd6ffef9795f7 |
| ToxValDB_ECOTOX | NOEL | =13 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin|Enzyme(s): beta-N-Acetylhexosaminidase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15604217:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1ec982a26e7f234073c5bbd5cef549be |
| ToxValDB_ECOTOX | NOEL | =200 | mg/kg bw/day | Mouse | oral | short-term; 2 days | short-term | LONG_REF=Mutat. Res.343(2/3): 157-183 Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens 1995; TITLE=The In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test with Hepatocytes Prepared from Male B6C3F1 Mice as an Early Prediction Assay for Putative Nongenotoxic (Ames-Negative) Mouse Hepatocarcinogens; AUTHOR=Miyagawa,M., H. Takasawa, A. Sugiyama, Y. Inoue, T. Murata, Y. Uno, and K. Yoshikawa; DOI=10.1016/0165-1218(95)90082-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75052; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15605568:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9267b56753d872d9d5855d4fd44a82d7 |
| ToxValDB_ECOTOX | NOEL | =48 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=Food Chem. Toxicol.42(9): 1389-1399 Arts,J.H.E., H. Muijser, M.J. Appel, C. Frieke Kuper, J.G.M. Bessems, and R.A. Woutersen Subacute (28-Day) Toxicity of Furfural in Fischer 344 Rats: A Comparison of the Oral and Inhalation Route 2004; TITLE=Subacute (28-Day) Toxicity of Furfural in Fischer 344 Rats: A Comparison of the Oral and Inhalation Route; AUTHOR=Arts,J.H.E., H. Muijser, M.J. Appel, C. Frieke Kuper, J.G.M. Bessems, and R.A. Woutersen; DOI=10.1016/j.fct.2004.03.014; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=75766; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX:15612833:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ec743217275a41593d6227d43bc84d81 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOEL | =54 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA AFC (2004). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Furfural and Furfural Diethylacetal. doi:10.2903/j.efsa.2004.67.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to Furfural and Furfural Diethylacetal; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2004.67; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15621083:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fcc6c4d898c03b1b543de54aa7a05c12 |
ToxValDB_EPA_OPP 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_OPP | PAD (RfD) | =0.8 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15789598_15789600:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e763b80e873d8428155a9b878a8d247c |
| ToxValDB_EPA_OPP | PAD (RfD) | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15789598_15789600:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7c1379e1a3e811152841fcab5491a4e |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =8 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632354_15632355:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b40dd99168e1c0c2a1e7148bcef52092 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =4.26 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632354_15632355:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c84e5dffb303175af0b7d0feede914aa |
ToxValDB_IRIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LOAEL (ADJ) | =7.9 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=NTP (National Toxicology Program). 1981a. 90-day Rat Report. Unpublished study performed by Southern Research Institute.; TITLE=90-day Rat Report; AUTHOR=NTP (National Toxicology Program); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5738; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=317; TOXICOLOGICAL_EFFECT=hepatocellular vacuolization; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15645334_15645335:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c05cdfbb8e0702dbc459965111acd3c2 |
| ToxValDB_IRIS | RfD | =0.003 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=NTP, 1981a; AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a5738; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=317; TOXICOLOGICAL_EFFECT=Mild hepatocellular vacuolization in male/female rats; STUDY_GROUP=IRIS:15644891:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_81fb175002e42ac1a5bbb0293559c28e |
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfC | =0.05 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650140:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_787f37b154d1ee8c2567d368d184078f |
ToxValDB_RSL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_RSL | RfC | =0.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_HEAST_15656537_15663478:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d7f969fa0f94cdc3eaacefea986f640 |
| ToxValDB_RSL | RfD | =0.03 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663477:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e53c12483f8b8fa255193fb8fe469ec |
ToxValDB_ToxRefDB 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =120 | mg/kg bw/day | Rat | oral | short-term; 16 days | short-term | LONG_REF=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5410; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-reduced activity|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-labored respiration; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15709168_15709169:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5422aca005dba7180314918ec1d64bbf |
| ToxValDB_ToxRefDB | LEL | =400 | mg/kg bw/day | Mouse | oral | short-term; 16 days | short-term | LONG_REF=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5411; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15709172_15709173:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1733012267dcb0b7d80f8c39b12d3019 |
| ToxValDB_ToxRefDB | LEL | =90 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5412; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15709174_15709175:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1654fb102da0a8a4a19d3cdad8546a2e |
| ToxValDB_ToxRefDB | LEL | =150 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Mice; TITLE=Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5413; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-inflammation|systemic: pathology microscopic-liver-necrosis|systemic: in life observation-body weight-body weight|systemic: organ weight-liver-relative to body weight|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709178_15709179_15709180_15709181:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_07113588c75f149702c80a8c2dabc896 |
| ToxValDB_ToxRefDB | NEL | =60 | mg/kg bw/day | Rat | oral | short-term; 16 days | short-term | LONG_REF=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_16-day study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5410; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-reduced activity|systemic: in life observation-clinical signs-labored respiration; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15709168_15709169:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eaceee5f85e8783e73dcae1a163dbf73 |
| ToxValDB_ToxRefDB | NEL | =45 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1990_Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Rats; TITLE=Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)_13-week study_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5412; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15709174_15709175:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6ec2c4a1079185587446523d2d813463 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | DJ1HGI319P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DJ1HGI319P"} |
| openFDA substances | FDA UNII substance identifier | DJ1HGI319P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DJ1HGI319P"} |
| openFDA substances | FDA UNII substance identifier | DJ1HGI319P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DJ1HGI319P"} |
| openFDA substances | FDA UNII substance identifier | DJ1HGI319P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C5H4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DJ1HGI319P"} |