Is Fluorescent Brightener 393 safe in cosmetics?
Fluorescent Brightener 393 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Fluorescent Brightener 393
Also known as: Benzoxazole, 2,2'-(1,2-ethenediyldi-4,1-phenylene)bis-, Benzoxazole, 2,2'-(vinylenedi-p-phenylene)bis-, 2,2'-(1,2-Ethenediyldi-4,1-phenylene)bis[benzoxazole], 2,2'-(Vinylenedi-4-phenylene)bis(benzoxazole), 2,2'-(Vinylenedi-p-phenylene)bisbenzoxazole (+12 more)
INCI: FLUORESCENT BRIGHTENER 393
Fluorescent Brightener 393 (CAS 1533-45-5) is a cosmetic cosmetic ingredient functioning as Colorant (fluorescent whitening agent — absorbs UV and re-emits as blue visible. NOAEL 190 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1533-45-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Fluorescent Brightener 393 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Colorant (fluorescent whitening agent — absorbs UV and re-emits as blue visible light)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[4-[2-[4-(1,3-benzoxazol-2-yl)phenyl]ethenyl]phenyl]-1,3-benzoxazole
InChIKey
ORACIQIJMCYPHQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR prohibition; subject to general safety requirements under FD&C Act
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Fluorescent Brightener 393.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Fluorescent Brightener 393 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Brightener
Dye
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Fluorescent Brightener 393.
Regulatory Flags
colorant
Known Synonyms
Benzoxazole, 2,2'-(1,2-ethenediyldi-4,1-phenylene)bis-
Benzoxazole, 2,2'-(vinylenedi-p-phenylene)bis-
2,2'-(1,2-Ethenediyldi-4,1-phenylene)bis[benzoxazole]
2,2'-(Vinylenedi-4-phenylene)bis(benzoxazole)
2,2'-(Vinylenedi-p-phenylene)bisbenzoxazole
4,4'-Di(benzoxazol-2-yl)stilbene
Benetex OB 1
C.I. 40674
C.I. Fluorescent Brightener 393
Eastobrite OB 1
Eastobrite OB 3
Optical Brightener 1
TM (UV stabilizer)
Uvitex OB 1
Uvitex OB-ONE
p,p'-Bis(2-benzoxazolyl)stilbene
2,2'-(Vinylenedi-p-phenylene)dibenzoxazole
Chemical Function
Dye
Brightener
Regulatory Lists
Indirect additives food contact (10/2018)
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Fluorescent Brightener 393 allowed in the EU?
Fluorescent Brightener 393 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Fluorescent Brightener 393 do in cosmetics?
Fluorescent Brightener 393 functions as: Colorant (fluorescent whitening agent — absorbs UV and re-emits as blue visible light). It is classified as a cosmetic ingredient in our database. CAS number: 1533-45-5.
Is Fluorescent Brightener 393 used outside cosmetics?
Fluorescent Brightener 393 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Fluorescent Brightener 393 have different safety status in cosmetics vs industrial chemicals?
Fluorescent Brightener 393 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335, H411).
Compliance Tools
Check Fluorescent Brightener 393 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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