NOAEL Studies Cosmetic Ingredient

Ferrous Fumarate NOAEL Studies

INCI: FERROUS FUMARATE

CAS: 141-01-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 1.8 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 16 mg/kg bw/day horse oral 14 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 50 mg/kg bw/day rabbit oral 147 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 152 mg/kg bw/day rat oral 84 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 800 mg/kg bw/day dog oral NA Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1369 mg/kg bw/day rabbit oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =50 mg/kg bw/day Rat oral subchronic; 12 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead64e4b0a7c65d1c3f18; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19585/7/6/2?documentUUID=bd204308-e382-4ed8-a80b-05a0c2d6bf07; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=body weight and weight gain|gross pathology|haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15850744:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0a32ff3c35a1c839728138d47683bba9
ECHA NOAEL =160 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa99e4b0a7c65d1b6a47; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19585/7/9/2?documentUUID=bd204308-e382-4ed8-a80b-05a0c2d6bf07; YEAR=2020; ORIGINAL_YEAR=2020; STUDY_GROUP=ECHA IUCLID:15861438:-:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a6f1dfb0922a404afcae83c5ee4a3943
ECHA NOAEL =200 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa99e4b0a7c65d1b6a3f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19585/7/9/2?documentUUID=bd204308-e382-4ed8-a80b-05a0c2d6bf07; YEAR=2020; ORIGINAL_YEAR=2020; STUDY_GROUP=ECHA IUCLID:15862334:-:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e82a3386dccce5ecac2ee0a481c40488
ECHA NOAEL =400 mg/kg bw/day Guinea Pig oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8cbe4b0a7c65d21a1d9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19585/7/9/2?documentUUID=bd204308-e382-4ed8-a80b-05a0c2d6bf07; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|reproduction; STUDY_GROUP=ECHA IUCLID:15857926:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_18d221793ad21d176936fbe26e2c13e7
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.822 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632803:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf838857ff2d366c4610e13340cfcfda
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier R5L488RY0Q UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H2O4.Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R5L488RY0Q"}
openFDA substances FDA UNII substance identifier R5L488RY0Q UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H2O4.Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R5L488RY0Q"}
openFDA substances FDA UNII substance identifier R5L488RY0Q UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H2O4.Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R5L488RY0Q"}
openFDA substances FDA UNII substance identifier R5L488RY0Q UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H2O4.Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"R5L488RY0Q"}