NOAEL Studies
Colorant
Ferric Ferrocyanide NOAEL Studies
INCI: CI 77510
CAS: 14038-43-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z | NOAEL | =25 | mg/kg bw/day | rat (2207; male/female) | oral: feed | 90 days | repeated dose toxicity oral | 3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z - RepeatedDoseToxicityOral - Short-term feeding study of sodium ferrocyanide in rats_1 - fdaf0434-b660-48be-bc1d-45b78f482c7c/66996ab1-a2bf-419c-aed6-47a85e4e0125 |
| FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z | NOAEL | =25 | mg/kg bw/day | rat (2207; male/female) | oral: feed | 90 days | repeated dose toxicity oral | 3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z - RepeatedDoseToxicityOral - Short-term feeding study of sodium ferrocyanide in rats_1 - fdaf0434-b660-48be-bc1d-45b78f482c7c/66996ab1-a2bf-419c-aed6-47a85e4e0125 |
| FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z | NOAEL | =25 | mg/kg bw/day | rat (2207; male/female) | oral: feed | 90 days | repeated dose toxicity oral | 3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z - RepeatedDoseToxicityOral - Short-term feeding study of sodium ferrocyanide in rats_1 - fdaf0434-b660-48be-bc1d-45b78f482c7c/66996ab1-a2bf-419c-aed6-47a85e4e0125 |
| FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z | NOAEL | =25 | mg/kg bw/day | rat (2207; male/female) | oral: feed | 90 days | repeated dose toxicity oral | 3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z - RepeatedDoseToxicityOral - Short-term feeding study of sodium ferrocyanide in rats_1 - fdaf0434-b660-48be-bc1d-45b78f482c7c/66996ab1-a2bf-419c-aed6-47a85e4e0125 |
| FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z | NOEL | <=2500 | mg/kg bw/day | rat (2207; male/female) | oral: feed | 90 days | repeated dose toxicity oral | 3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z - RepeatedDoseToxicityOral - Short-term feeding study of sodium ferrocyanide in rats_1 - fdaf0434-b660-48be-bc1d-45b78f482c7c/66996ab1-a2bf-419c-aed6-47a85e4e0125 - basis: clinical biochemistry: no abnormal phenotype detected |
| FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z | NOEL | <=2500 | mg/kg bw/day | rat (2207; male/female) | oral: feed | 90 days | repeated dose toxicity oral | 3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z - RepeatedDoseToxicityOral - Short-term feeding study of sodium ferrocyanide in rats_1 - fdaf0434-b660-48be-bc1d-45b78f482c7c/66996ab1-a2bf-419c-aed6-47a85e4e0125 - basis: clinical biochemistry: no abnormal phenotype detected |
| FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z | NOEL | <=2500 | mg/kg bw/day | rat (2207; male/female) | oral: feed | 90 days | repeated dose toxicity oral | 3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z - RepeatedDoseToxicityOral - Short-term feeding study of sodium ferrocyanide in rats_1 - fdaf0434-b660-48be-bc1d-45b78f482c7c/66996ab1-a2bf-419c-aed6-47a85e4e0125 - basis: clinical biochemistry: no abnormal phenotype detected |
| FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z | NOEL | <=2500 | mg/kg bw/day | rat (2207; male/female) | oral: feed | 90 days | repeated dose toxicity oral | 3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z - RepeatedDoseToxicityOral - Short-term feeding study of sodium ferrocyanide in rats_1 - fdaf0434-b660-48be-bc1d-45b78f482c7c/66996ab1-a2bf-419c-aed6-47a85e4e0125 - basis: clinical biochemistry: no abnormal phenotype detected |
ToxValDB_ECHA_IUCLID 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =2500 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3d08; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=66996ab1-a2bf-419c-aed6-47a85e4e0125; TOXICOLOGICAL_EFFECT=food consumption and compound intake: abnormal food intake|haematology: decreased hematocrit|haematology: decreased hemoglobin concentration|histopathology: non-neoplastic: discoloration of kidney|histopathology: non-neoplastic: hydronephrosis|histopathology: non-neoplastic: kidney calculi|histopathology: non-neoplastic: renal cast; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|gross pathology|hematology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846592_15846595_15846596:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6722b0ed6ab7ea29178c6235eefa8786 |
| ToxValDB_ECHA_IUCLID | LEL | >=250 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3d08; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=66996ab1-a2bf-419c-aed6-47a85e4e0125; TOXICOLOGICAL_EFFECT=gross pathology: enlarged kidney; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846594_15846597:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_295f6cc8f7f02f1df8a0077bfdea3c8f |
| ToxValDB_ECHA_IUCLID | NOAEL | =25 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead59e4b0a7c65d1c3d08; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=66996ab1-a2bf-419c-aed6-47a85e4e0125; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846592_15846595_15846596:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_24ed06786153fd3d94f3e2ba261bb690 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | TLE294X33A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"18CN.7Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TLE294X33A"} |
| openFDA substances | FDA UNII substance identifier | TLE294X33A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"18CN.7Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TLE294X33A"} |
| openFDA substances | FDA UNII substance identifier | TLE294X33A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"18CN.7Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TLE294X33A"} |
| openFDA substances | FDA UNII substance identifier | TLE294X33A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"18CN.7Fe","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"TLE294X33A"} |