NOAEL Studies
Cosmetic Ingredient
Ethylhexanol (2-Ethyl-1-hexanol) NOAEL Studies
INCI: ETHYLHEXANOL
CAS: 104-76-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 21 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | LOAEL | 1525 | mg/kg bw/day | mouse | oral | 6-13 Gestation day | Reproductive | PAFA |
| COSMOS_DB | LOAEL | 150 | mg/kg bw/day | rat | oral | 730 day | Chronic | PAFA |
| COSMOS_DB | LOAEL | 500 | mg/kg bw/day | mouse | oral | 13 week | Subchronic | REACH |
| COSMOS_DB | LOAEL | 250 | mg/kg bw/day | rat | oral | 13 week | Subchronic | REACH; study report |
| COSMOS_DB | NOAEL | 1525 | mg/kg bw/day | mouse | oral | 8 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2344 | mg/kg bw/day | rat | oral | 5 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1628 | mg/kg bw/day | rat | oral | 1 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 521 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 755 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 350 | mg/kg bw/day | rat | oral | 14 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 140 | mg/kg bw/day | mouse | oral | 14 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 191 | mg/kg bw/day | mouse | oral | 18 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 275 | mg/kg bw/day | rat | oral | 9 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 150 | mg/kg bw/day | rat | oral | 9 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 11 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 250 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 750 | mg/kg bw/day | mouse | oral | 540 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 320 | mg/kg bw/day | rat | oral | 21 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 50 | mg/kg bw/day | rat | oral | 730 day | Chronic | PAFA |
| COSMOS_DB | NOAEL | 125 | mg/kg bw/day | rat | oral | 13 week | Subchronic | REACH; study report |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =50 | mg/kg bw/day | Rat | oral: gavage | 730 days | chronic/long term toxicity | EFSA AFC - 2009 - OutputID 2303 - histopathology neoplastic - systemic - Flavouring Group Evaluation 4: 2-Ethylhexyl derivatives from chemical group 2 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) - doi:10.2903/j.efsa.2009.929 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =0.5 | mg/kg bw/day | Consumers | - | - | ADI | EFSA AFC - 2009 - OutputID 2306 - Consumers - Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1) Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - doi:10.2903/j.efsa.2009.934 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =0.5 | mg/kg bw/day | Consumers | - | - | ADI | EFSA AFC - 2009 - OutputID 2306 - Consumers - Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1) Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - doi:10.2903/j.efsa.2009.934 |
INCHEM_WHO_jecfa_jecmono_v32je04 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v32je04 | ADI | range:0-0.50.5 | mg/kg bw/day | Rat | - | long-term | Health guidance value | document_id=jecfa_jecmono_v32je04; title=786. Ethyl-1-hexanol, 2- (WHO Food Additives Series 32); path=mirror/documents/jecfa/jecmono/v32je04.htm; row_hash=7a134e6d6768c6e6; raw_unit=mg/kg bw; context=EVALUATION On the basis of a NOEL of 50 mg/kg bw/day from the long-term study in rats and using a safety factor of 100, the Committee established an ADI of 0-0.5 mg/kg bw for 2-ethyl-1-hexanol. |
| INCHEM_WHO_jecfa_jecmono_v32je04 | ADI | range:0-0.50.5 | mg/kg bw/day | Rat | - | long-term | Health guidance value | document_id=jecfa_jecmono_v32je04; title=786. Ethyl-1-hexanol, 2- (WHO Food Additives Series 32); path=mirror/documents/jecfa/jecmono/v32je04.htm; row_hash=7a134e6d6768c6e6; raw_unit=mg/kg bw; context=EVALUATION On the basis of a NOEL of 50 mg/kg bw/day from the long-term study in rats and using a safety factor of 100, the Committee established an ADI of 0-0.5 mg/kg bw for 2-ethyl-1-hexanol. |
| INCHEM_WHO_jecfa_jecmono_v32je04 | NOEL | =50 | mg/kg bw/day | Rat | - | long-term | Toxicology study | document_id=jecfa_jecmono_v32je04; title=786. Ethyl-1-hexanol, 2- (WHO Food Additives Series 32); path=mirror/documents/jecfa/jecmono/v32je04.htm; row_hash=22ad1a3e5ff368dc; raw_unit=mg/kg bw/day; context=EVALUATION On the basis of a NOEL of 50 mg/kg bw/day from the long-term study in rats and using a safety factor of 100, the Committee established an ADI of 0-0.5 mg/kg bw for 2-ethyl-1-hexanol. |
| INCHEM_WHO_jecfa_jecmono_v32je04 | NOEL | =50 | mg/kg bw/day | Rat | - | long-term | Toxicology study | document_id=jecfa_jecmono_v32je04; title=786. Ethyl-1-hexanol, 2- (WHO Food Additives Series 32); path=mirror/documents/jecfa/jecmono/v32je04.htm; row_hash=22ad1a3e5ff368dc; raw_unit=mg/kg bw/day; context=EVALUATION On the basis of a NOEL of 50 mg/kg bw/day from the long-term study in rats and using a safety factor of 100, the Committee established an ADI of 0-0.5 mg/kg bw for 2-ethyl-1-hexanol. |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =2053 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_390; row=8518; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethyl-1-hexanol; preferred_name=2-Ethyl-1-hexanol; dtxsid=DTXSID5020605; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020605; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2047 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_388; row=8519; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethyl-1-hexanol; preferred_name=2-Ethyl-1-hexanol; dtxsid=DTXSID5020605; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020605; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3730 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_392; row=8520; data_type=In Vivo; mixture=Chemical; chemical_name=2-Ethyl-1-hexanol; preferred_name=2-Ethyl-1-hexanol; dtxsid=DTXSID5020605; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020605; source_file=acute_oral.xlsx |
NTP_ICE_dart 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_dart | LOEL | 840 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, In life observation | sheet=Data; excel_row=74418; Record_ID=dart_20377; Data_Type=In Vivo; DTXSID=DTXSID5020605; Assay=DART, In life observation; Endpoint=LOEL; Response=840; Response_Unit=mg/kg/day; Species=Rat; Strain=Fischer 344; Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0041834;CUI;Erythema; Reference=ToxRefDB v2 , ID = 5106; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
| NTP_ICE_dart | LOEL | 840 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, In life observation | sheet=Data; excel_row=74419; Record_ID=dart_20378; Data_Type=In Vivo; DTXSID=DTXSID5020605; Assay=DART, In life observation; Endpoint=LOEL; Response=840; Response_Unit=mg/kg/day; Species=Rat; Strain=Fischer 344; Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0205204;CUI;Scab; Reference=ToxRefDB v2 , ID = 5106; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
| NTP_ICE_dart | LOEL | 840 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, In life observation | sheet=Data; excel_row=74420; Record_ID=dart_20379; Data_Type=In Vivo; DTXSID=DTXSID5020605; Assay=DART, In life observation; Endpoint=LOEL; Response=840; Response_Unit=mg/kg/day; Species=Rat; Strain=Fischer 344; Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0205204;CUI;Scab; Reference=ToxRefDB v2 , ID = 5106; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
| NTP_ICE_dart | LOEL | 2520 | mg/kg bw/day | Rat | Dermal | - | In Vivo; DART, In life observation | sheet=Data; excel_row=74421; Record_ID=dart_20407; Data_Type=In Vivo; DTXSID=DTXSID5020605; Assay=DART, In life observation; Endpoint=LOEL; Response=2520; Response_Unit=mg/kg/day; Species=Rat; Strain=Fischer 344; Sex=Female; Life_Stage=Adult; Route=Dermal; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 5106; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2320; RecordID=ARPathway2016_452; DatasetName=ARPathway2016; DTXSID=DTXSID5020605; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
NTP_ICE_eye_irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 51.3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1483; Record_ID=eye_irritation_151; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5020605; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=51.3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
| NTP_ICE_eye_irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1478; Record_ID=eye_irritation_16; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020605; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2A; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
| NTP_ICE_eye_irritation | Intensity | 0.23 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1477; Record_ID=eye_irritation_1291; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5020605; Assay=Vitrigel; Endpoint=Intensity; Response=0.23; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1479; Record_ID=eye_irritation_1291; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5020605; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
| NTP_ICE_eye_irritation | Plateau level | 41 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=1480; Record_ID=eye_irritation_1291; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5020605; Assay=Vitrigel; Endpoint=Plateau level; Response=41; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=2713; Record_ID=skin_sensitization_invivo_723; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020605; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80032-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 2700 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=2711; Record_ID=skin_sensitization_invivo_723; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020605; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80032-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=2717; Record_ID=skin_sensitization_invivo_723; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5020605; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|RIFM 1976; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80032-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020605; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020605 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =46872.7 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=DOE Protective Action Criteria:15515374:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a4a1f97ff8e61afa1317310a0320c43 |
ToxValDB_ECHA_IUCLID 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =234.364 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61b74e4b096bca876e2cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/3/3?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15795800:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d6ea15285e438e749ae97b757e344269 |
| ToxValDB_ECHA_IUCLID | LOAEL | =250 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeb0e4b0a7c65d1ca707; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16134/7/6/2?documentUUID=de73ed82-0106-464f-ab58-6318bde47a9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834951_15834952:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_362ba7f3c972b76a2cf9ef095b8541a5 |
| ToxValDB_ECHA_IUCLID | NOAEC | >=850 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231cce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14220/7/9/3?documentUUID=61ab35cd-8026-4a8f-b25b-5dc2399a5673; YEAR=1998; ORIGINAL_YEAR=1998; STUDY_GROUP=ECHA IUCLID:15820611:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f0ef9067c225e489844fe0074661131a |
| ToxValDB_ECHA_IUCLID | NOAEC | =639.174 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/6/3?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828347_15828348:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_365a7b77f5f51efd50bc362c23c2110e |
| ToxValDB_ECHA_IUCLID | NOAEC | =638.4 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/6/3?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828347_15828348:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2308e101322c97132da4c41db5016846 |
| ToxValDB_ECHA_IUCLID | NOAEL | =500 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c98; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/8?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816995_15816996_15816997:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_864daedbd4918fe0d055ebb4ef2cfeb9 |
| ToxValDB_ECHA_IUCLID | NOAEL | =150 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c98; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/8?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816995_15816996_15816997:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_08091e6566c0a889572976199caca07a |
| ToxValDB_ECHA_IUCLID | NOAEL | =750 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/8?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819588_15819589_15819590:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f773209aecc0f071be168784d515fc9 |
| ToxValDB_ECHA_IUCLID | NOAEL | =200 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cde4b0a7c65d1b2c9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/8?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819588_15819589_15819590:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2082693dc24a3d352c089b760934ef68 |
| ToxValDB_ECHA_IUCLID | NOAEL | =191 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb39f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/9/3?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820778_15821338_15821370:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_979357639a9c03074b40c863d7d3009b |
| ToxValDB_ECHA_IUCLID | NOAEL | =2520 | mg/kg bw/day | Rat | dermal | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d17de4b0a7c65d22ec0c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/9/3?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15821331:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dd519bf30c1ec52cfd1e03acfe5ef070 |
| ToxValDB_ECHA_IUCLID | NOAEL | =650 | mg/kg bw/day | Rat | oral | - | reproduction developmental | GUIDELINE=other:; QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3a4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/9/3?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15823064:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f96b6b27e09264ed11b100f07cdb0950 |
| ToxValDB_ECHA_IUCLID | NOAEL | =125 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaeb0e4b0a7c65d1ca707; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16134/7/6/2?documentUUID=de73ed82-0106-464f-ab58-6318bde47a9a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834951_15834952:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_41f2d8926e2abc5d54c5f58b783dff81 |
| ToxValDB_ECHA_IUCLID | NOAEL | =250 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c09ca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/6/2?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840437_15840438:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_74387b08b630bc61729d173b2546d2fd |
| ToxValDB_ECHA_IUCLID | NOEL | =125 | mg/kg bw/day | Mouse | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c09ca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7949/7/6/2?documentUUID=d20fa9f0-dda5-4090-9019-29a177204b52; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840437_15840438:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_de74295eb3f73ddf70a3c7c666dcea71 |
ToxValDB_ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =9.38 | mmol/kg | Rat | oral | acute; 0.75 days | reproduction developmental | LONG_REF=Toxicology126:9-21 Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid 1998; TITLE=Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid; AUTHOR=Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen; DOI=10.1016/s0300-483x(97)00171-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=67778; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein|Biochemistry: Zinc content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597813_15603720_15603721:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cef7e63448234196687c69a1c34bd37c |
| ToxValDB_ECOTOX | LOEL | =1525 | mg/kg bw/day | Mouse | oral | short-term (developmental); 8 days | reproduction developmental | LONG_REF=Teratog. Carcinog. Mutagen.7:29-48 Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test 1987; TITLE=Evaluation of 60 Chemicals in a Preliminary Developmental Toxicity Test; AUTHOR=Hardin,B.D., R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=49969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Mortality: Survival|Growth: Weight|Reproduction: Progeny counts/numbers|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|reproduction; STUDY_GROUP=ECOTOX:15611585:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=4dc9f4b842dbaccb8f61dcae401a583a |
| ToxValDB_ECOTOX | NOEL | =12.5 | mmol/kg | Rat | oral | acute; 0.75 days | reproduction developmental | LONG_REF=Toxicology126:9-21 Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid 1998; TITLE=Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid; AUTHOR=Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen; DOI=10.1016/s0300-483x(97)00171-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=67778; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Zinc content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597813_15603720_15603721:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d21c1edd971402af161db7682b875460 |
| ToxValDB_ECOTOX | NOEL | =6.25 | mmol/kg | Rat | oral | acute; 0.75 days | reproduction developmental | LONG_REF=Toxicology126:9-21 Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid 1998; TITLE=Altered Zinc Metabolism Contributes to the Developmental Toxicity of 2-Ethylhexanoic Acid, 2-Ethylhexanol and Valproic Acid; AUTHOR=Bui,L.M., M.W. Taubeneck, J.F. Commisso, J.Y. Uriu-Hare, W.D. Faber, and C.L. Keen; DOI=10.1016/s0300-483x(97)00171-6; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=67778; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein|Biochemistry: Zinc content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597813_15603720_15603721:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9de65e89440fcb210b14642b46737920 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =50 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2927.; TITLE=Scientific Opinion on the safety and efficacy of branched-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing branched-chain alcohols and acetals containing branched-chain aldehydes (chemical group 2) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2927; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614311:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70660eb848bb3e0978b33fa68b674c33 |
ToxValDB_EU_SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EU_SCOEL | NOAEL | =7.98967 | mg/m3 | Human | inhalation | acute; 4 hours | clinical | LONG_REF=van Thriel, C., E. Kiesswetter, et al. (2007). "From neurotoxic to chemosensory effects: new insights on acute solvent neurotoxicity exemplified by acute effects of 2ethylhexanol." Neurotoxicology 28(2): 347-55. van Thriel, C., E. Kiesswetter, et al. (2005). "An integrative approach considering acute symptoms and intensity ratings of chemosensory sensations during experimental exposures." Environmental Toxicology and Pharmacology 19(3): 589-598. van Thriel, C., A. Seeber, et al. (2003). "Physiological and psychological approaches to chemosensory effects of solvents." Toxicology Letters 140-141: 261-71. Kiesswetter, E., C. v. Thriel, et al. (2005). "Eye blinks as indicator for sensory irritation during constant and peak exposures to 2-ethylhexanol." Environmental Toxicology and Pharmacology 19(3): 531-541.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d3573; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/117_2-ethylhexan-1-ol_oel_en.pdf; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=irritation of the eyes and airways.; STUDY_GROUP=EU SCOEL:15952274:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3ea9a06536996c4b4f199325949c218b |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =53.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632020_15632021:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4202cc50db6d7ade2b7f67d02eb04a8 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =12.8 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632020_15632021:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1d84fc2b6933da8e042a96acb20e0d4a |
ToxValDB_HPVIS 26 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | LOAEL | =0.46 | % diet | Rat | oral | short-term; 11 days | short-term | LONG_REF=EPA Document No. 86-910000912, Michrofische No. OTS0529878 (1991).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=60686; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639640_15639719_15639969_15640088_15640121:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6ee7f36d175c0330583419f0c547950c |
| ToxValDB_HPVIS | LOAEL | =330 | mg/kg bw/day | Rat | oral | short-term; 11 days | short-term | LONG_REF=EPA Document No. 86-910000909, Microfiche No. OTS0529875 (1991)Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=60932; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639604_15639639_15639685_15639718_15639721_15639793_15639903_15639972_15640049_15640089_15640152_15643478_15643485_15643687_15643694:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5c6f89c8bbbc2edaa96519ac5a2de69 |
| ToxValDB_HPVIS | LOAEL | =0.25 | % diet | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=EPA Document No 86-870001426, Microfiche No. 0515588 (1980).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=61992; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640233_15640255:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f5462cc492b4c6f6e3f8d3acb6cef03b |
| ToxValDB_HPVIS | LOAEL | >=0.66 | % diet | Mouse | oral | short-term; 11 days | short-term | LONG_REF=EPA Document No. 86-910000913, Microfiche No. OTS0529879 (1991).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=62784; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643479_15643481_15643484_15643486_15643488_15643688_15643690_15643693_15643695_15643697:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f5c6b659729aba88af0fd24c20eb6dd7 |
| ToxValDB_HPVIS | LOAEL | <=1500 | mg/kg bw/day | Mouse | oral | short-term; 11 days | short-term | LONG_REF=EPA Document No. 86-910000908, Microfiche No. OTS0529874 (1991).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=60684; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643473_15643482_15643483_15643682_15643691_15643692:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ac8c2847f5ea04e8fcb0cb5058ed30b |
| ToxValDB_HPVIS | LOAEL | <=1.32 | % diet | Mouse | oral | short-term; 11 days | short-term | LONG_REF=EPA Document No. 86-910000913, Microfiche No. OTS0529879 (1991).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=62784; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643479_15643481_15643484_15643486_15643488_15643688_15643690_15643693_15643695_15643697:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_caec2dba201596cf11ec8caeaebbc310 |
| ToxValDB_HPVIS | LOAEL | <=500 | mg/kg bw/day | Mouse | oral | subchronic; 3 months | subchronic | LONG_REF=BASF AG (1991). Report on the oral toxicity of 2-Ethylhexanol in mice after administration by gavage (aqueous emulsion) for three months. Project No36CO631/87085 (Cited in EPA OTSO529876). Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=61983; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643492_15643493_15643494_15643701_15643702_15643703:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ccbef1ef52f7d76d67376b6b4507efd3 |
| ToxValDB_HPVIS | NOAEL | =100 | mg/kg bw/day | Rat | oral | short-term; 11 days | short-term | LONG_REF=BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung, Project No. 11C0631/87102, 26.03.1991Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=60430; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639604_15639639_15639685_15639718_15639721_15639793_15639903_15639972_15640049_15640089_15640152_15643478_15643485_15643687_15643694:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b94c8b6e7155aaa1d8862ceffe0cb15 |
| ToxValDB_HPVIS | NOAEL | =2650 | mg/kg bw/day | Mouse | oral | short-term; 11 days | short-term | LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 21st March, 2006.Reference: EPA Document No. 86-910000913, Microfiche No. OTS0529879 (1991).Source: Neste 0x0 AB Stenungsund ECB -Existing Chemicals Ispra (VA) Hoechst AG Frankfurt/Main Celanese GmbH Frankfurt am Main; EXTERNAL_SOURCE_ID=60687; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639641_15640050:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8de0a13f472bc7e9902c9e8c0a6d6e44 |
| ToxValDB_HPVIS | NOAEL | =0.32 | mg/L | Rat | inhalation | short-term; 14 days | short-term | LONG_REF=BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung, Project No. 3610044/89001, 17.10.1990Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=60930; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639683:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5aea3be5652803e2119f20b423a71500 |
| ToxValDB_HPVIS | NOAEL | =330 | mg/kg bw/day | Mouse | oral | short-term; 11 days | short-term | LONG_REF=EPA Document No. 86-910000908, Microfiche No. OTS0529874 (1991).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=60931; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639684_15639796_15640051:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e1c429d7001bcfd964fc6608ab4c72ef |
| ToxValDB_HPVIS | NOAEL | =83 | mg/kg bw/day | Rat | oral | short-term; 9 days | short-term | LONG_REF=EPA Document No. 86-8870000331, Microfiche No. OTS0516482 (1988).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=61209; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639717_15639720_15639794:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_707b5b1d56e2be29e937d4c874922069 |
| ToxValDB_HPVIS | NOAEL | =636 | ppm | Rat | oral | short-term; 9 days | short-term | LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 21st March, 2006.Reference: BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung, Project No. 10C0321/88022, 26.03.1991Source: Neste 0xo AB StenungsundECB -Existing Chemicals Ispra (VA)Hoechst AG Frankfurt/MainCelanese GmbH Frankfurt am Main; EXTERNAL_SOURCE_ID=61497; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1983; ORIGINAL_YEAR=1983; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639760_15639970:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4242f69df7a53190e51b41796aa3eb91 |
| ToxValDB_HPVIS | NOAEL | =0.648 | mg/L | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung, Project No. 5010044/89022, 16.04.1992Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=61980; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15639829:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_16797539a0c7bb42117cfd65c2f96c9a |
| ToxValDB_HPVIS | NOAEL | =1000 | mg/kg bw/day | Mouse | oral | short-term; 11 days | short-term | LONG_REF=EPA Document No. 86-910000908, Microfiche No. OTS0529874 (1991).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=63557; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639641_15640050:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_818703e20684555b4dfcf4d21d28e1c3 |
| ToxValDB_HPVIS | NOAEL | =1150 | mg/kg bw/day | Mouse | oral | short-term; 11 days | short-term | LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 21st March, 2006.Reference: EPA Document No. 86-910000913, Microfiche No. OTS0529879 (1991).Source: Neste 0x0 AB Stenungsund ECB -Existing Chemicals Ispra (VA) Hoechst AG Frankfurt/Main Celanese GmbH Frankfurt am Main; EXTERNAL_SOURCE_ID=63560; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639684_15639796_15640051:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_43ebcc9736e402799ebe5aaf68b88c3c |
| ToxValDB_HPVIS | NOAEL | =0.05 | % diet | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=EPA Document No 86-870001426, Microfiche No. 0515588 (1980).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=60681; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640233_15640255:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aa4a5e3824e5a4325661a886887e49b0 |
| ToxValDB_HPVIS | NOAEL | =0.46 | % diet | Rat | oral | - | repeat dose other | LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 21st March, 2006.Reference: BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung, Project No. 10C0321/88022, 26.03.1991Source: BASF AG Ludwigshafen; EXTERNAL_SOURCE_ID=61989; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15640352:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b8883e26e4474e6c4cabdb1450fde839 |
| ToxValDB_HPVIS | NOAEL | =650 | mg/kg bw/day | Rat | oral | - | developmental | LONG_REF=BASF (1991). Study of prenatal toxicity of Isodecanol, 2-Ethylhexanol and 711 Alcohol (T.C.) in rats after oral administration (gavage). Project No. 92RO753188069. EPA Document No. 88-90000082, Microfiche No. OTS0524015 (1990)EPA Document No. 8EHQ-0491-OSIOS, Microfiche No. OTS0524015-2 (1991).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=57872; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15642280:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58f555901a55955d9f111a75665f098d |
| ToxValDB_HPVIS | NOAEL | =130 | mg/kg bw/day | Rat | oral | short-term; 10 days | reproduction developmental | LONG_REF=Posting dates of document from HPV Challenge website frm which data have been added into the HPVIS: 14th December, 2001; 21st March, 2006.Reference:BASF (1991). Study of prenatal toxicity of Isodecanol, 2-Ethylhexanol and 711 Alcohol (T.C.) in rats after oral administration (gavage). Project No. 92R0753/88069.EPA Document No. 88-90000082, Microfiche No. OTS0524015 (1990) EPA Document No. 8EHQ-0491-0910S, Microfiche No. OTS0524015-2 (1991)Source:Neste 0x0 AB Stenungsund ECB -Existing Chemicals Ispra (VA) Hoechst AG Frankfurt/Main Celanese GmbH Frankfurt am Main; EXTERNAL_SOURCE_ID=58754; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15642552:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef5b6cf556a1d1ba16f3180d89047b36 |
| ToxValDB_HPVIS | NOAEL | >=0.44 | % diet | Mouse | oral | short-term; 11 days | short-term | LONG_REF=EPA Document No. 86-910000913, Microfiche No. OTS0529879 (1991).Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=61750; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643479_15643481_15643484_15643486_15643488_15643688_15643690_15643693_15643695_15643697:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_27255ba6cedba3b3da768a32f4915ba8 |
| ToxValDB_HPVIS | NOAEL | >=125 | mg/kg bw/day | Rat | oral | - | repeat dose other | LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 21st March, 2006.Reference: BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung, Project No. 31C0631/87077, 26.03.1991BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung, Project No. 31C0631/87082, 26.03.1991Source: BASF AG Ludwigshafen; EXTERNAL_SOURCE_ID=61991; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640177_15640194_15640367_15643498_15643499_15643500_15643707_15643708_15643709:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_04a80b9a4773c3623348d9d62fee832a |
| ToxValDB_HPVIS | NOAEL | >=252 | mg/kg bw/day | Rat | dermal | short-term; 10 days | reproduction developmental | LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 14th December, 2001; 21st March, 2006.Reference:Tyl RW, et al. (1992). The developmental toxicity of 2-ethylhexanol applied dermally to pregnant Fischer 344 rats. Fund Appl Toxicol 19, 176-185.Source:Neste 0x0 AB StenungsundECB -Existing Chemicals Ispra (VA) Hoechst AG Frankfurt/Main Celanese GmbH Frankfurt am Main; EXTERNAL_SOURCE_ID=58353; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15643670_15643879:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bd27fc61bc37efb35a739e84ccee6715 |
| ToxValDB_HPVIS | NOAEL | <=0.66 | % diet | Mouse | oral | - | repeat dose other | LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 21st March, 2006.Reference: BASF AG: BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung,Project No. 15C0321/88023, 26.03.1991Source: BASF AG Ludwigshafen; EXTERNAL_SOURCE_ID=60432; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643495_15643704:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_58d86f4d70015d18911878e80ad5f2bf |
| ToxValDB_HPVIS | NOAEL | <=250 | mg/kg bw/day | Rat | oral | - | repeat dose other | LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 21st March, 2006.Reference: BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung, Project No. 31C0631/87077, 26.03.1991BASF AG: Abt. Toxikologie, unveroeffentlichte Untersuchung, Project No. 31C0631/87082, 26.03.1991Source: BASF AG Ludwigshafen; EXTERNAL_SOURCE_ID=61991; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640177_15640194_15640367_15643498_15643499_15643500_15643707_15643708_15643709:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c1e562e5379e768286f88eb9e59c8aa |
| ToxValDB_HPVIS | NOAEL | <=840 | mg/kg bw/day | Rat | dermal | short-term; 10 days | reproduction developmental | LONG_REF=Posting dates of document from HPV Challenge website from which data have been entered into the HPVIS: 14th December, 2001; 21st March, 2006.Reference:Tyl RW, et al. (1992). The developmental toxicity of 2-ethylhexanol applied dermally to pregnant Fischer 344 rats. Fund Appl Toxicol 19, 176-185.Source:Neste 0x0 AB StenungsundECB -Existing Chemicals Ispra (VA) Hoechst AG Frankfurt/Main Celanese GmbH Frankfurt am Main; EXTERNAL_SOURCE_ID=58353; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15643670_15643879:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3d594171a483721967a436516aef0ac |
ToxValDB_PPRTV_(CPHEA) 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | BMCL (HEC) | =1.11 | mg/m3 | Mouse | inhalation | - | repeat dose other | LONG_REF=Miyake et al. (2016); AUTHOR=Miyake et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=2005; TOXICOLOGICAL_EFFECT=increased diameter of bowman's gland in the olfactory epithelium of the nasal cavity; STUDY_GROUP=PPRTV (CPHEA):15653296:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0da96d4d9fa1faf105b95b363106234e |
| ToxValDB_PPRTV_(CPHEA) | BMDL (05 HED) | =7.37 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Hellwig and Jackh (1997); Confidential (1991); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=2005; TOXICOLOGICAL_EFFECT=increased fetal skeletal variations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=PPRTV (CPHEA):15653867:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3e9f5f3316abd0eb3484d8755ffd0d84 |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =0.0004 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Miyake et al. (2016); AUTHOR=Miyake et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=2005; TOXICOLOGICAL_EFFECT=Increased diameter of Bowman's glands in male mice; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653294_15653295:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_44aa00cbe17c525416f9b19520270836 |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =0.004 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Miyake et al. (2016); AUTHOR=Miyake et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=2005; TOXICOLOGICAL_EFFECT=Increased diameter of Bowman's glands in male mice; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653294_15653295:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_10ceb99b535e3b62a7176097fd3c7358 |
| ToxValDB_PPRTV_(CPHEA) | RfD (provisional) | =0.07 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Hellwig and Jackh (1997); Confidential (1991); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754a4e4b08a6b3934aefd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=2005; TOXICOLOGICAL_EFFECT=Increased fetal skeletal variations in female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653581_15653582:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_912e90f4ec2c296eb34dc2ab73a5832c |
ToxValDB_WHO_JECFA_ADI 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | <=0.5 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af2dae4b0d99f5a86ffe9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/3239; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=WHO JECFA ADI:15715251:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_23ffbffeab1ab8856c736d174b071507 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | XZV7TAA77P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XZV7TAA77P"} |
| openFDA substances | FDA UNII substance identifier | XZV7TAA77P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XZV7TAA77P"} |
| openFDA substances | FDA UNII substance identifier | XZV7TAA77P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XZV7TAA77P"} |
| openFDA substances | FDA UNII substance identifier | XZV7TAA77P | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"XZV7TAA77P"} |