NOAEL Studies
Cosmetic Ingredient
Ethylbenzene NOAEL Studies
INCI: ETHYLBENZENE
CAS: 100-41-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ATSDR_toxval_ATSDR_MRLs.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ATSDR_toxval_ATSDR_MRLs.xlsx | LOAEL | =75.7726 | mg/m3 | Rat (F344/N; M/F) | inhalation | chronic; 104 weeks | chronic | ATSDR MRLs; row_hash=d27b4dc0522f43e8; source_hash=ToxValhc_cfdcf7a1e488d1ede29d4e093dcd2751; raw_endpoint_type=LOAEL (HEC); raw_endpoint_subtype=; raw_value=17.45; raw_unit=ppm; effect=renal; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=NTP. 1999. NTP technical report on the toxicology and carcinogenesis studies of ethylbenzene in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program, U.S. Department of Health and Human Services. NTP TR 466.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b |
| ATSDR_toxval_ATSDR_MRLs.xlsx | LOAEL | =325.67 | mg/m3 | Rat (F344/N; M/F) | inhalation | chronic; 104 weeks | chronic | ATSDR MRLs; row_hash=9443e8aed5a91b60; source_hash=ToxValhc_b3f7ad5be15fb6e88dc87efd255aa427; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=75; raw_unit=ppm; effect=renal; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=NTP. 1999. NTP technical report on the toxicology and carcinogenesis studies of ethylbenzene in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program, U.S. Department of Health and Human Services. NTP TR 466.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b |
California Proposition 65 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | ABinhalation=54; oral=41 | ug/day | - | - | 2004-06-11 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"2004-06-11","listing_mechanism":"AB","madl":null,"nsrl":"inhalation=54; oral=41","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | ABinhalation=54; oral=41 | ug/day | - | - | 2004-06-11 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"2004-06-11","listing_mechanism":"AB","madl":null,"nsrl":"inhalation=54; oral=41","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | ABinhalation=54; oral=41 | ug/day | - | - | 2004-06-11 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"2004-06-11","listing_mechanism":"AB","madl":null,"nsrl":"inhalation=54; oral=41","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | ABinhalation=54; oral=41 | ug/day | - | - | 2004-06-11 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"2004-06-11","listing_mechanism":"AB","madl":null,"nsrl":"inhalation=54; oral=41","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2004-06-11 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2004-06-11","listing_mechanism":"AB","madl":null,"nsrl":"inhalation=54; oral=41","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2004-06-11 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2004-06-11","listing_mechanism":"AB","madl":null,"nsrl":"inhalation=54; oral=41","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2004-06-11 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2004-06-11","listing_mechanism":"AB","madl":null,"nsrl":"inhalation=54; oral=41","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2004-06-11 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2004-06-11","listing_mechanism":"AB","madl":null,"nsrl":"inhalation=54; oral=41","source_table":"prop65_listings"} |
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 75 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=9f7b0c96-7de7-4b31-bdf2-f094cf46825b_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=9f7b0c96-7de7-4b31-bdf2-f094cf46825b/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=1e746f56-1e7c-48c9-80fa-769942c5491b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: sub-chronic oral | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=79b65dcd-e852-42c6-b2f3-d2b9f8a94dea_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=79b65dcd-e852-42c6-b2f3-d2b9f8a94dea/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=2006; basis=other:; key_result=false; entry_uuid=400b6ffc-2fef-4529-8469-1ed05838344d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 75 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=9f7b0c96-7de7-4b31-bdf2-f094cf46825b_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=9f7b0c96-7de7-4b31-bdf2-f094cf46825b/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=1e746f56-1e7c-48c9-80fa-769942c5491b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: sub-chronic oral | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=79b65dcd-e852-42c6-b2f3-d2b9f8a94dea_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=79b65dcd-e852-42c6-b2f3-d2b9f8a94dea/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=2006; basis=other:; key_result=false; entry_uuid=400b6ffc-2fef-4529-8469-1ed05838344d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 75 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=9f7b0c96-7de7-4b31-bdf2-f094cf46825b_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=9f7b0c96-7de7-4b31-bdf2-f094cf46825b/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2003; basis=other:; key_result=false; entry_uuid=1e746f56-1e7c-48c9-80fa-769942c5491b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: sub-chronic oral | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=79b65dcd-e852-42c6-b2f3-d2b9f8a94dea_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=79b65dcd-e852-42c6-b2f3-d2b9f8a94dea/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=2006; basis=other:; key_result=false; entry_uuid=400b6ffc-2fef-4529-8469-1ed05838344d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 136 | mg/kg bw/day | rat | oral: gavage | - | chronic toxicity: oral | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=6e8e92e8-5fc9-40c0-8664-3faa73449db1_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=6e8e92e8-5fc9-40c0-8664-3faa73449db1/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1956; basis=other:; key_result=false; entry_uuid=b362b2bd-a44b-4e37-939c-4d3e99b30de8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 750 | mg/kg bw/day | rat | oral: gavage | - | toxicity to reproduction: other studies | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=24ca70f9-9fbd-4364-9a68-219f912a6781_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=24ca70f9-9fbd-4364-9a68-219f912a6781/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=2003; key_result=false; entry_uuid=f2235af6-abde-432e-a9b6-8d0f13f2a175 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 136 | mg/kg bw/day | rat | oral: gavage | - | chronic toxicity: oral | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=6e8e92e8-5fc9-40c0-8664-3faa73449db1_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=6e8e92e8-5fc9-40c0-8664-3faa73449db1/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1956; basis=other:; key_result=false; entry_uuid=b362b2bd-a44b-4e37-939c-4d3e99b30de8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 750 | mg/kg bw/day | rat | oral: gavage | - | toxicity to reproduction: other studies | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=24ca70f9-9fbd-4364-9a68-219f912a6781_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=24ca70f9-9fbd-4364-9a68-219f912a6781/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=2003; key_result=false; entry_uuid=f2235af6-abde-432e-a9b6-8d0f13f2a175 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 136 | mg/kg bw/day | rat | oral: gavage | - | chronic toxicity: oral | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=6e8e92e8-5fc9-40c0-8664-3faa73449db1_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=6e8e92e8-5fc9-40c0-8664-3faa73449db1/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1956; basis=other:; key_result=false; entry_uuid=b362b2bd-a44b-4e37-939c-4d3e99b30de8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOEL | 750 | mg/kg bw/day | rat | oral: gavage | - | toxicity to reproduction: other studies | dossier=c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6z; document=24ca70f9-9fbd-4364-9a68-219f912a6781_c07cc2a4-0c69-4462-90d3-26b4e698d37a.i6d; document_key=24ca70f9-9fbd-4364-9a68-219f912a6781/c07cc2a4-0c69-4462-90d3-26b4e698d37a; document_subtype=ToxicityReproductionOther; literature=Name=Unnamed; ReferenceYear=2003; key_result=false; entry_uuid=f2235af6-abde-432e-a9b6-8d0f13f2a175 |
EPA_IRIS_iris_rfc_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfc_systems.csv | NOAEL (HEC) | =434 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=becbe39c4e9cba8e; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 4.34e2 mg/m^3; system=Developmental; basis=Developmental toxicity; point_of_departure=NOAEL (HEC): 4.34e2 mg/m^3; composite_uf=300; confidence=Low; dtxsid=DTXSID3020596; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=51; rfc_last_updated=03/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0051_summary.pdf |
| EPA_IRIS_iris_rfc_systems.csv | RfC | =1 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=8105e003a2b0691c; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=1; system=Developmental; basis=Developmental toxicity; point_of_departure=NOAEL (HEC): 4.34e2 mg/m^3; composite_uf=300; confidence=Low; dtxsid=DTXSID3020596; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=51; rfc_last_updated=03/01/1991; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0051_summary.pdf |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | NOEL | =97.1 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=a1b142b2293f5126; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOEL : 9.71e1 mg/kg-day; system=Hepatic, Urinary; basis=Liver and kidney toxicity; point_of_departure=NOEL : 9.71e1 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID3020596; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=51; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0051_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =0.1 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=af5d33af9bbc3b9e; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=1e-1; system=Hepatic, Urinary; basis=Liver and kidney toxicity; point_of_departure=NOEL : 9.71e1 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID3020596; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=51; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0051_summary.pdf |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2000 | IARC Monographs | {"additional_info":"volume_publication_year=2000","evaluation_year":2000,"source_table":"iarc_classifications","volume":"77"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2000 | IARC Monographs | {"additional_info":"volume_publication_year=2000","evaluation_year":2000,"source_table":"iarc_classifications","volume":"77"} |
| IARC Monographs | IARC carcinogenicity classification | 2B | IARC group | - | - | 2000 | IARC Monographs | {"additional_info":"volume_publication_year=2000","evaluation_year":2000,"source_table":"iarc_classifications","volume":"77"} |
INCHEM_WHO_ehc_ehc_ehc186 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_ehc_ehc_ehc186 | NOAEL | =4300 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc186; title=Ethylbenzene (EHC 186, 1996); path=mirror/documents/ehc/ehc/ehc186.htm; row_hash=af5b8cafacabfc66; raw_unit=mg/m 3; context=The no-observed-adverse-effect level would be higher than 4300 mg/m 3 (1000 ppm) (highest concentration used), since the increase in liver weight was not associated with any histopathological findings. |
| INCHEM_WHO_ehc_ehc_ehc186 | NOEL | =2150 | mg/m3 | Rat | - | - | Toxicology study | document_id=ehc_ehc_ehc186; title=Ethylbenzene (EHC 186, 1996); path=mirror/documents/ehc/ehc/ehc186.htm; row_hash=f0182440ad28ab9c; raw_unit=mg/m 3; context=The no-observed-effect level, based on increased liver weight in rats, was 2150 mg/m 3 (500 ppm). |
| INCHEM_WHO_ehc_ehc_ehc186 | NOEL | ~860 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc186; title=Ethylbenzene (EHC 186, 1996); path=mirror/documents/ehc/ehc/ehc186.htm; row_hash=4321d9adc856e704; raw_unit=mg/m 3; context=The no-observed-effect level (all four species) was considered to be about 860 mg/m 3 (200 ppm) (Wolf et al., 1956). |
| INCHEM_WHO_ehc_ehc_ehc186 | NOEL | =8.6 | mg/m3 | - | - | - | Toxicology study | document_id=ehc_ehc_ehc186; title=Ethylbenzene (EHC 186, 1996); path=mirror/documents/ehc/ehc/ehc186.htm; row_hash=4b91208768bd0d53; raw_unit=mg/m 3; context=From the medical surveillance study the NOEL could be estimated to be between 8.6 mg/m 3 (2 ppm) (mean value) and 86 mg/m 3 (20 ppm) (maximum value). |
NTP_ICE_acute_inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 55 | mg/L | - | Inhalation | Duration=2 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1902; Record_ID=acute_inhalation_1570; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3020596; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=55; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_acute_inhalation | LC50 | 17.3582 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1903; Record_ID=acute_inhalation_2273; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3020596; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=17.3582; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_acute_inhalation | LC50 | 57.9026 | mg/L | - | Inhalation | Duration=2 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1904; Record_ID=acute_inhalation_2274; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3020596; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=57.9026; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
NTP_ICE_adme_parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 54.85 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=1150; Record_ID=adme_parameters_1108; Data_Type=Measured; DTXSID=DTXSID3020596; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=54.85; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_adme_parameters | Clint | 10.12 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1151; Record_ID=adme_parameters_1108; Data_Type=Measured; DTXSID=DTXSID3020596; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=10.12; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_adme_parameters | Fu | 0.2568 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=1148; Record_ID=adme_parameters_1108; Data_Type=Measured; DTXSID=DTXSID3020596; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.2568; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_adme_parameters | Fu | 0.1676 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1149; Record_ID=adme_parameters_1108; Data_Type=Measured; DTXSID=DTXSID3020596; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.1676; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
NTP_ICE_cancer 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=3432; Record_ID=cancer_157; Data_Type=WOE; Formulation_Name=Ethylbenzene; Mixture=Chemical; DTXSID=DTXSID3020596; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2B; Response_Unit=Unitless; URL=http://publications.iarc.fr/95; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_cancer | POLY-3 lowest dose | 3256.68711656442 | mg/m3/day | Mouse | Inhalation | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=3419; Record_ID=cancer_160; Data_Type=In Vivo; Formulation_Name=Ethylbenzene; Mixture=Chemical; DTXSID=DTXSID3020596; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=3256.6871165644175; Response_Unit=mg/m3/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Inhalation; Level_of_Evidence=Some evidence; Tissue=Liver; Lesion=Hepatocellular carcinoma or hepatocellular adenoma; Reference=TR-466; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr466/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_cancer | Top dose | 750 | ppm | Rat | Inhalation | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3424; Record_ID=cancer_154; Data_Type=In Vivo; Formulation_Name=Ethylbenzene; Mixture=Chemical; DTXSID=DTXSID3020596; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=750; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Inhalation; Reference=TR-466; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr466/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_cancer | Top dose | 1000 | mg/kg bw/day | Mouse | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3425; Record_ID=cancer_5531; Data_Type=In Vivo; Formulation_ID=Cancer_PID_1057; Formulation_Name=Xylenes (Mixed); Percent_Active_Ingredient=17.0; Mixture=Mixture; DTXSID=DTXSID3020596; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1000; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-327; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr327/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_cancer | Top dose | 500 | mg/kg bw/day | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=3430; Record_ID=cancer_5529; Data_Type=In Vivo; Formulation_ID=Cancer_PID_1057; Formulation_Name=Xylenes (Mixed); Percent_Active_Ingredient=17.0; Mixture=Mixture; DTXSID=DTXSID3020596; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=500; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-327; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr327/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=1480; Record_ID=skin_sensitization_invivo_508; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3020596; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90228-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 6480 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=1477; Record_ID=skin_sensitization_invivo_508; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3020596; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6480; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90228-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=1484; Record_ID=skin_sensitization_invivo_508; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3020596; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90228-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID3020596 |
ToxValDB_ATSDR_MRLs 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ATSDR_MRLs | BMCL (1 SD HEC) | =669.839 | mg/m3 | Rat | inhalation | short-term; 5 days | short-term | LONG_REF=Cappaert NLM, Klis SFL, Baretta AB, et al. 2000. Ethyl benzene-induced ototoxicity in rats: A dose-dependent mid-frequency hearing loss. J Assoc Res Otolaryngol 1(4):292-299.; TITLE=Ethyl benzene-induced ototoxicity in rats: A dose-dependent mid-frequency hearing loss; AUTHOR=Cappaert NLM; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp110.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447595:unknown:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e7395b903d0fec2b3591e37ce485251a |
| ToxValDB_ATSDR_MRLs | BMCL (1 SD HEC) | =276.342 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Gagnaire F, Langlais C, Grossman S, et al. 2007. Ototoxicity in rats exposed to ethylbenzene and to two xylene vapors for 13 weeks. Arch Toxicol 81:127-143.; TITLE=Ototoxicity in rats exposed to ethylbenzene and to two xylene vapors for 13 weeks; AUTHOR=Gagnaire F; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp110.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447597:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a11fda5c5c4e4a62ff203a279870b44 |
| ToxValDB_ATSDR_MRLs | BMCL (1SD) | =8.61022 | mg/L | Rat | inhalation | short-term; 5 days | short-term | LONG_REF=Cappaert NLM, Klis SFL, Baretta AB, et al. 2000. Ethyl benzene-induced ototoxicity in rats: A dose-dependent mid-frequency hearing loss. J Assoc Res Otolaryngol 1(4):292-299.; TITLE=Ethyl benzene-induced ototoxicity in rats: A dose-dependent mid-frequency hearing loss; AUTHOR=Cappaert NLM; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp110.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447596:unknown:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9701a50e631ccb205c031c2bfd13fb87 |
| ToxValDB_ATSDR_MRLs | BMCL (1SD) | =2.11699 | mg/L | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Gagnaire F, Langlais C, Grossman S, et al. 2007. Ototoxicity in rats exposed to ethylbenzene and to two xylene vapors for 13 weeks. Arch Toxicol 81:127-143.; TITLE=Ototoxicity in rats exposed to ethylbenzene and to two xylene vapors for 13 weeks; AUTHOR=Gagnaire F; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp110.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447598:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2b763ec9cd36d8c8c2a774f8f173c2b6 |
| ToxValDB_ATSDR_MRLs | BMDL | =0.70177 | mg/L | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Mellert W, Deckardt K, Kauffmann W, et al. 2007. Ethylbenzene: 4- and 13-week rat oral toxicity. Arch Toxicol 81:361-370; TITLE=Ethylbenzene: 4- and 13-week rat oral toxicity; AUTHOR=Mellert W; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp110.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447602:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f53383828b4d9f86237b0d8ef0b7fe15 |
| ToxValDB_ATSDR_MRLs | BMDL (HED) | =10.68 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Mellert W, Deckardt K, Kauffmann W, et al. 2007. Ethylbenzene: 4- and 13-week rat oral toxicity. Arch Toxicol 81:361-370; TITLE=Ethylbenzene: 4- and 13-week rat oral toxicity; AUTHOR=Mellert W; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp110.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447601:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_30ab953fa0d0458f517d23ad4abfb984 |
| ToxValDB_ATSDR_MRLs | LOAEL | =325.67 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=NTP. 1999. NTP technical report on the toxicology and carcinogenesis studies of ethylbenzene in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program, U.S. Department of Health and Human Services. NTP TR 466.; TITLE=NTP technical report on the toxicology and carcinogenesis studies of ethylbenzene in F344/N rats and B6C3F1 mice (inhalation studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp110.pdf; TOXICOLOGICAL_EFFECT=renal; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs_dup_-_15447599_15447600:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b3f7ad5be15fb6e88dc87efd255aa427 |
| ToxValDB_ATSDR_MRLs | LOAEL (HEC) | =75.7726 | mg/m3 | Rat | inhalation | chronic; 104 weeks | chronic | LONG_REF=NTP. 1999. NTP technical report on the toxicology and carcinogenesis studies of ethylbenzene in F344/N rats and B6C3F1 mice (inhalation studies). Research Triangle Park, NC: National Toxicology Program, U.S. Department of Health and Human Services. NTP TR 466.; TITLE=NTP technical report on the toxicology and carcinogenesis studies of ethylbenzene in F344/N rats and B6C3F1 mice (inhalation studies); AUTHOR=NTP; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d58575b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp110.pdf; TOXICOLOGICAL_EFFECT=renal; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs_dup_-_15447599_15447600:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cfdcf7a1e488d1ede29d4e093dcd2751 |
| ToxValDB_ATSDR_MRLs | MRL | =21.7114 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=neurological in sex not reported rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447069_15447070_15447071:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5e822cf70e959d7e4c806b9a6fdcb096 |
| ToxValDB_ATSDR_MRLs | MRL | =8.68454 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=neurological in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447069_15447070_15447071:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_54aae8a3f8d1d3475d14a98dde945fa6 |
| ToxValDB_ATSDR_MRLs | MRL | =0.260536 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=renal in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447069_15447070_15447071:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6edf20ab76590b73c5389c4b5fcefd36 |
| ToxValDB_ATSDR_MRLs | MRL | =0.4 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=hepatic in male/female rats; STUDY_GROUP=ATSDR MRLs:15447072:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1de73a1ff6743a11e893a5fe2f65aa7a |
ToxValDB_AU_DWG 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_AU_DWG | NEL | =75 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | LONG_REF=Mellert W., Deckhardt K., Kaufmann W and van Ranvenzwaay B. (2007) Ethylbenzene: 4- and 13-week rat oral toxicity. Arch Toxicology 81: 361-3; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c82db5e4b02565fc7d237c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nhmrc.gov.au; SUBSOURCE_URL=https://www.nhmrc.gov.au/sites/default/files/documents/attachments/publications/Australian_Drinking_Water_Guidelines_ADWG_V3-8_Sep2022.pdf; TOXICOLOGICAL_EFFECT=liver and kidney related impacts in addition to hepatocyte hypertrophy; STUDY_GROUP=AU DWG:15951634:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd78f1c10a6f7c378a1f7be5c6e46cf7 |
ToxValDB_Alaska_DEC 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Alaska_DEC | RfC | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445717:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=7818e0a758344808680f665480e946f7 |
| ToxValDB_Alaska_DEC | RfC | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445717:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=7818e0a758344808680f665480e946f7 |
| ToxValDB_Alaska_DEC | RfD | =0.097 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445713:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=092b99daf3ea1931dfa25c8858217809 |
| ToxValDB_Alaska_DEC | RfD | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445714:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=3656ae98623eb1495fd75ddebad0fbb1 |
| ToxValDB_Alaska_DEC | RfD | =0.286 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445716:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=429ae9a724a9c6c08fa01dd1cbd74aa9 |
| ToxValDB_Alaska_DEC | RfD | =0.097 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445713:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=092b99daf3ea1931dfa25c8858217809 |
| ToxValDB_Alaska_DEC | RfD | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445714:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=3656ae98623eb1495fd75ddebad0fbb1 |
| ToxValDB_Alaska_DEC | RfD | =0.286 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445716:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=429ae9a724a9c6c08fa01dd1cbd74aa9 |
ToxValDB_Cal_OEHHA_REL_derivations 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Cal_OEHHA_REL_derivations | NOAEL | =325.67 | mg/m3 | Mouse | inhalation | chronic; 103 weeks | chronic | LONG_REF=Chan PC, Haseman JK, Mahleri J, Aranyi C. 1998. Tumor induction in F344/N r. NTP. 1999. National Toxicology Program. Toxicology and Carcinogenesis Studies of Ethylbenzene (CAS No. 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR466.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=hyperplasia of the pituitary gland; liver cellular alterations and necrosis; STUDY_GROUP=Cal OEHHA REL derivations:15952054:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1e8d78f53b9554eacec6badaf576741f |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =34738.2 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15515295:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d18ae87a6afe22d45c701ea936ab8564 |
ToxValDB_ECHA_IUCLID 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =250 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbb9e4b0a7c65d227501; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/30824?documentUUID=dc4299f1-32e8-4cec-99ad-3fdefa7f5121; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15829932_15829933_15830501_15830502_15831093_15831094_15831729_15831730_15833625_15833626_15835856_15835857_15836292_15836293_15836874_15836875_15837824_15837825_15838644_15838645_15839622_15839623_15839652_15839653_15841873_15841874_15845462_15845463:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a4907b73ae8175e2a33f6e2d67a2350b |
| ToxValDB_ECHA_IUCLID | NOAEC | >=2171.14 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d206e4b0a7c65d23127b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/2095?documentUUID=40867009-ac4b-49ef-ac97-2a1a903b7a1b; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821108_15821408:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2992968a6d41a6feca31282f2ddfb545 |
| ToxValDB_ECHA_IUCLID | NOAEC | >=8684.54 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d23de4b0a7c65d23222c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2186/7/9/3?documentUUID=214a0124-1fa4-4e14-a46d-c63e69cb5534; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821289_15821459_15821509_15821901:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_101b04f8ba8388315c74032d2339d63c |
ToxValDB_ECOTOX 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =10 | mmol/kg | Rat | injection | short-term; 3 days | short-term | LONG_REF=Biochim. Biophys. Acta1207(2): 179-186 Sequeira,D.J., G.F. Cawley, C.S. Eyer, and W.L. Backes Temporal Changes in P-450 2E1 Expression with Continued Ethylbenzene Exposure 1994; TITLE=Temporal Changes in P-450 2E1 Expression with Continued Ethylbenzene Exposure; AUTHOR=Sequeira,D.J., G.F. Cawley, C.S. Eyer, and W.L. Backes; DOI=10.1016/0167-4838(94)00070-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=77944; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Enzyme(s): NADPH cytochrome C reductase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15607621:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4704406568d8977d85163db4414ae524 |
| ToxValDB_ECOTOX | NOEL | =750 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601965_15605534:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8d761bff6369271f05b839e5739ed58a |
| ToxValDB_ECOTOX | NOEL | =350 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin|Enzyme(s): beta-N-Acetylhexosaminidase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601965_15605534:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=978520ca1f44a642531c9b945f68d859 |
ToxValDB_EPA_TSCA_8e 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_TSCA_8e | LEL | =100 | ppm | Rat | oral | subchronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88030000023_100414_BFC7C8A296EC543F85256D2C005EE18B.pdf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=F1: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EPA TSCA 8e_dup_-_15957181_15957183:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_49538e8e560ad4c5e97499cc3e386f8e |
| ToxValDB_EPA_TSCA_8e | LEL | =90 | mg/kg bw/day | Rat | oral | subchronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88030000023_100414_BFC7C8A296EC543F85256D2C005EE18B.pdf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=F1: mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EPA TSCA 8e_dup_-_15957182_15957184:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3896c6663eff6901b5ed556155c039aa |
| ToxValDB_EPA_TSCA_8e | LEL | =1000 | ppm | Rat | oral | subchronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88030000023_100414_BFC7C8A296EC543F85256D2C005EE18B.pdf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=F1: clinical signs, reduced body weight; STUDY_GROUP=EPA TSCA 8e_dup_-_15957181_15957183:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6fe311b37c6edcc31cff442060e2c82a |
| ToxValDB_EPA_TSCA_8e | LEL | =621 | mg/kg bw/day | Rat | oral | subchronic (developmental) | reproduction developmental | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88030000023_100414_BFC7C8A296EC543F85256D2C005EE18B.pdf; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=F1: reduced body weight; STUDY_GROUP=EPA TSCA 8e_dup_-_15957182_15957184:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2697fe07a31bddd4ff20ec95f3c3bb48 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =77 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631933:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_26574b5c0382ec4b8bf22e9a93c04245 |
ToxValDB_Health_Canada 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Health_Canada | NOAEL | =136 | mg/kg bw/day | Rat | oral | chronic; 182 days | chronic | LONG_REF=CSQG: CCME, 1996b (summarized in CCME, 2004) from U.S. EPA/ (based on Wolf et al., 1956)/ (reaffirmed 2005); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=histopathologic liver and kidney; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=Health Canada_dup_-_15637541_15637542:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9dc67e9ffa34301b03418731a74e40da |
| ToxValDB_Health_Canada | NOAEL | =434 | mg/m3 | Rabbit | inhalation | short-term (developmental); 19 days | developmental | LONG_REF=CSQG: CCME, 1996b (summarized in CCME, 2004), from U.S. EPA (IRIS), 1991 (based on Andrew et al., 1981; Hardin et al., 1981); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=increased relative liver, kidney, and spleen weights of dams|reduced litter size|skeletal variations; TOXICOLOGICAL_EFFECT_CATEGORY=development|organ weight|reproduction; STUDY_GROUP=Health Canada:15637543:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c988e40fc224b3e2ed55fb8eaa6007da |
| ToxValDB_Health_Canada | NOAEL (ADJ) | =97.1 | mg/kg bw/day | Rat | oral | chronic; 182 days | chronic | LONG_REF=CSQG: CCME, 1996b (summarized in CCME, 2004) from U.S. EPA/ (based on Wolf et al., 1956)/ (reaffirmed 2005); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=histopathologic liver and kidney; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=Health Canada_dup_-_15637541_15637542:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d8a8dd9ed384c64b12796514cfd153fc |
ToxValDB_IRIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LOAEL | =4340 | mg/m3 | Rat | inhalation | - | developmental | LONG_REF=Andrew, F.D., R.L. Buschbom, W.C. Cannon, R.A. Miller, L.F. Montgomery, D.W. Phelps, et al. 1981. Teratologic assessment of ethylbenzene and 2- ethoxyethanol. Battelle Pacific Northwest Laboratory, Richland, WA. PB 83- 208074., 108. ; Hardin, B.D., G.P. Bond, M.R. Sikov, F.D. Andrew, R.P. Beliles and R.W. Niemeier. 1981. Testing of selected workplace chemicals for teratogenic potential. Scand. J. Work Environ. Health. 7(suppl 4): 66-75.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d06; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=51; TOXICOLOGICAL_EFFECT=developmental toxicity; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=IRIS_dup_IRIS Summary_15644824_15644825_15644826:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_be423398d23317213964467f5466d77b |
| ToxValDB_IRIS | LOAEL | =408 | mg/kg bw/day | Rat | oral | chronic; 182 days | chronic | LONG_REF=Wolf, M.A., V.K. Rowe, D.D. McCollister, R.L. Hollingsworth and F. Oyen. 1956. Toxicological studies of certain alkylated benzenes and benzene. Arch. Ind. Health. 14: 387-398.; TITLE=Toxicological studies of certain alkylated benzenes and benzen; AUTHOR=Wolf, M.A., V.K. Rowe, D.D. McCollister, R.L. Hollingsworth and F. Oyen; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d06; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=51; TOXICOLOGICAL_EFFECT=liver and kidney toxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15645577_15645578_15645579_15645590:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fdb7cfb21f8ca2b7deb8daf36a10cfe1 |
| ToxValDB_IRIS | LOAEL (ADJ) | =291 | mg/kg bw/day | Rat | oral | chronic; 182 days | chronic | LONG_REF=Wolf, M.A., V.K. Rowe, D.D. McCollister, R.L. Hollingsworth and F. Oyen. 1956. Toxicological studies of certain alkylated benzenes and benzene. Arch. Ind. Health. 14: 387-398.; TITLE=Toxicological studies of certain alkylated benzenes and benzen; AUTHOR=Wolf, M.A., V.K. Rowe, D.D. McCollister, R.L. Hollingsworth and F. Oyen; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d06; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=51; TOXICOLOGICAL_EFFECT=liver and kidney toxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15645577_15645578_15645579_15645590:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b1ad2acfabd7cec2088cb76da0c98036 |
ToxValDB_PPRTV_(CPHEA) 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | BMDL (10) | =48 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=Mellert et al. 2007; AUTHOR=Mellert et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1746; TOXICOLOGICAL_EFFECT=centrilobular hepatocyte hypertrophy; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=PPRTV (CPHEA):15653944:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0063986d815c96a908105575079c6bbc |
| ToxValDB_PPRTV_(CPHEA) | LOAEL (HEC) | =868 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Gagnaire et al. 2007; AUTHOR=Gagnaire et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1746; TOXICOLOGICAL_EFFECT=histopathological evidence of ototoxicity without functional audiometric threshold; STUDY_GROUP=PPRTV (CPHEA):15653611:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_823ef0fd450df2c6af28c794972a39ef |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =9 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Gagnaire et al. 2007; AUTHOR=Gagnaire et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1746; TOXICOLOGICAL_EFFECT=Histopathological evidence of ototoxicity without functional changes in male rats; STUDY_GROUP=PPRTV (CPHEA):15653610:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9af8b63c9cc848fd02162e7bf2ac8655 |
| ToxValDB_PPRTV_(CPHEA) | RfD (provisional) | =0.05 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Mellert et al. 2007; AUTHOR=Mellert et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7c3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1746; TOXICOLOGICAL_EFFECT=Centrilobular hepatocyte hypertrophy in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653567:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_46c3b42cf4f67a8b8c8c29b81798f8f2 |
ToxValDB_TX_TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_TX_TCEQ | NOAEL | =2605.36 | mg/m3 | Rat | inhalation | short-term; 5 days | short-term | LONG_REF=Cappaert NM, SL Klis, AB Baretta, H Muijser, et al. 2000. Ethyl benzene-induced ototoxicity in rats: A dose-dependent mid-frequency hearing loss. J Assoc Res Otolaryngol 1:292-299.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b07; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/ethylbenzene.pdf; YEAR=2010 Accessible 2013; ORIGINAL_YEAR=2010 Accessible 2013; TOXICOLOGICAL_EFFECT=ototoxicity; STUDY_GROUP=TX TCEQ:15954425:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f008b732f49af5cfb33945cd167f8133 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | L5I45M5G0O | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L5I45M5G0O"} |
| openFDA substances | FDA UNII substance identifier | L5I45M5G0O | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L5I45M5G0O"} |
| openFDA substances | FDA UNII substance identifier | L5I45M5G0O | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L5I45M5G0O"} |
| openFDA substances | FDA UNII substance identifier | L5I45M5G0O | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"L5I45M5G0O"} |