NOAEL Studies Cosmetic Ingredient

Ethyl Pyrrolidone NOAEL Studies

INCI: ETHYL PYRROLIDONE

CAS: 2687-91-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1350 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_4890; row=6294; data_type=In Vivo; mixture=Chemical; chemical_name=1-Ethyl-2-pyrrolidinone; preferred_name=1-Ethyl-2-pyrrolidinone; dtxsid=DTXSID3044413; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3044413; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEC =200 mg/m3 Rat inhalation short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/6/3?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827215_15827216:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5a51a759142783d573658edea1c58fde
ToxValDB_ECHA_IUCLID LOAEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd28f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/9/3?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15824691:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cd2ef1a36537b56a8ff40074ecb986db
ToxValDB_ECHA_IUCLID LOAEL =100 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6dc1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/6/2?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15848339:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_11707db2ca43ab2475e5878ceb98b5d9
ToxValDB_ECHA_IUCLID LOAEL =220 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd293; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/9/3?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=fetus: changes in litter size and weights|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824692:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6bf8bd1f0e5f2cb94c8be08260f08497
ToxValDB_ECHA_IUCLID LOAEL =300 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6dc1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/6/2?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=kidney: body weight and weight gain|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833797_15848956:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8750b3b60237e4bce6089abd3446688a
ToxValDB_ECHA_IUCLID NOAEC =60 mg/m3 Rat inhalation subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/6/3?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=nasal cavity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15828647_15828648:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_517baf6f144bd2514686fb47d19e11c6
ToxValDB_ECHA_IUCLID NOAEC =80 mg/m3 Rat inhalation short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/6/3?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827215_15827216:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dbed83d8eb9355cc27b61087c54b6a98
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6dcf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/6/2?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15849358:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5135cfa1a7e04d3c486b99ade1cefde3
ToxValDB_ECHA_IUCLID NOEL =5 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6dcf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/6/2?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15849357:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3bbfd40f731936f8f01a4a7058acae4a
ToxValDB_ECHA_IUCLID NOEL =50 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadf9e4b0a7c65d1c6dcf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13618/7/6/2?documentUUID=0fe5e106-8f73-4e18-badf-cb8163614825; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15849356:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd18f1e0c581fe4c0e0a39077d0d51ab
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =10.05 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632086_15632087:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d7b1dd7ba157290cc8211bf094a1a1d8
ToxValDB_GESTIS_DNEL DNEL systemic =16.75 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632086_15632087:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44252d248e352ca98d05f8a81c81a70d
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier H0229SX1CW UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H11NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H0229SX1CW"}
openFDA substances FDA UNII substance identifier H0229SX1CW UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H11NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H0229SX1CW"}
openFDA substances FDA UNII substance identifier H0229SX1CW UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H11NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H0229SX1CW"}
openFDA substances FDA UNII substance identifier H0229SX1CW UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H11NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"H0229SX1CW"}