Is Ethyl Ether safe in cosmetics?
Ethyl Ether has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Ethyl Ether
Also known as: Ethane, 1,1'-oxybis-, EINECS 200-467-2, Ethyl ether, tech., RCRA waste number U117, Solvent ether (+9 more)
INCI: ETHYL ETHER
Ethyl Ether (CAS 60-29-7) is a cosmetic cosmetic ingredient functioning as Solvent. NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 60-29-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethyl Ether is prohibited in EU cosmetics but has active industrial GHS classifications (H224, H302, H336, H305, H316, H320, H335, H361).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
ethoxyethane
InChIKey
RTZKZFJDLAIYFH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR cosmetic prohibition; regulated by OSHA for occupational exposure (PEL 400 ppm); cited by ACGIH, DOT, NFPA, EPA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Ether.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameExcl markWarn
Hazard Statements
Extremely flammable liquid and vapour Harmful if swallowed May cause drowsiness or dizziness
Short-term Exposure Effects
The substance is mildly irritating to the eyes and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system. This may result in narcosis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the central nervous system. May cause addiction.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Ether across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LEL | =57601 mg/m3 | Human | inhalation | - | DOE Protective Action Criteria |
| NOAEL | =500 mg/kg-day | Rat | oral | - | MN MDH HHBW |
| NOAEL | =303.163 mg/m3 | Human | inhalation | acute | EU SCOEL |
| OEL | =303.163 mg/m3 | Human | inhalation | - | EU SCOEL |
| LC50 | ~199481 mg/m3 | Mouse | inhalation | - | HPVIS |
| LC50 | =98224.8 mg/m3 | Mouse | inhalation | - | HPVIS |
| LC50 | =94890 mg/m3 | Mouse | inhalation | - | HPVIS |
| LC50 | ~181898 mg/m3 | Mouse | inhalation | - | HPVIS |
| LOAEL | =30 mg/L | Guinea Pig | inhalation | subchronic | HPVIS |
| LOAEL | =30 mg/L | Mouse | inhalation | subchronic | HPVIS |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 1; Acute Tox. 4 *; STOT SE 3
Hazard Statements
- H224 Extremely flammable liquid and vapour
- H302 Harmful if swallowed
- H336 May cause drowsiness or dizziness
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0355
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Repeated exposures in excess of 400 ppm may cause nasal irritation. | Causes a transitory smarting sensation if splashed in the eye or if a high vapor concn contacts the eye ... . | Complaints of nasal irritation ... began at 200 ppm, and ... 300 ppm was objectionable as a working atmosphere. | Irritating: 300 mg/cu m /From table/ | Moderately toxic to humans by ingestion. ... Mildly toxic by inha
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
DIETHYL ETHER | 1979 | NO ADI ALLOCATED | TRS 648-JECFA 23/21 | NOT PREPARED
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Ether.
Regulatory Flags
jecfa_concern
Known Synonyms
Ethane, 1,1'-oxybis-
EINECS 200-467-2
Ethyl ether, tech.
RCRA waste number U117
Solvent ether
Dwuetylowy eter
Etere etilico
Ether ethylique
Oxyde d'ethyle
UNII-0F5N573A2Y
Aether
Diethylaether
R-610
aether pro narcosi
Chemical Function
Solvent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Arts and crafts/Office supplies - fabric treatment and dye; Arts and crafts/Office supplies - home office - pens and markers; detected; Europe
Canada; pharmaceutical
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ETHER
ChEMBL ID
CHEMBL16264
Max Phase
2
Frequently Asked Questions
Is Ethyl Ether allowed in the EU?
Ethyl Ether EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Ether do in cosmetics?
Ethyl Ether functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 60-29-7.
Is Ethyl Ether classified as hazardous under GHS?
Ethyl Ether carries a GHS signal word of "DANGER". Hazard statements: Extremely flammable liquid and vapour Harmful if swallowed May cause drowsiness or dizziness. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Ethyl Ether used outside cosmetics?
Ethyl Ether also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethyl Ether have different safety status in cosmetics vs industrial chemicals?
Ethyl Ether is prohibited in EU cosmetics but has active industrial GHS classifications (H224, H302, H336, H305, H316, H320, H335, H361).
Compliance Tools
Check Ethyl Ether compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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