NOAEL Studies
Cosmetic Ingredient
Ethyl Acetate NOAEL Studies
INCI: ETHYL ACETATE
CAS: 141-78-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =900 | mg/kg bw/day | Rat | oral: gavage | 90 days | subchronic | EFSA FEEDAP - 2013 - OutputID 2209 - body weight - systemic - Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3169 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | <=25 | mg/kg bw/day | Consumers | - | - | ADI | EFSA CONTAM - 2011 - OutputID 586 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part I of III - doi:10.2903/j.efsa.2011.2482 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | <=25 | mg/kg bw/day | Consumers | - | - | ADI | EFSA CONTAM - 2011 - OutputID 586 - Consumers - Scientific Opinion on the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part I of III - doi:10.2903/j.efsa.2011.2482 |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | NOEL | =900 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=e13e04f952b10650; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOEL : 9.00e2 mg/kg-day; system=Other; basis=Mortality and body weight loss; point_of_departure=NOEL : 9.00e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID1022001; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=157; rfd_last_updated=03/01/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0157_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =0.9 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=7bc3894bf00d9008; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=9e-1; system=Other; basis=Mortality and body weight loss; point_of_departure=NOEL : 9.00e2 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID1022001; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=157; rfd_last_updated=03/01/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0157_summary.pdf |
NTP_ICE_acute_inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 200 | mg/L | - | Inhalation | - | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=865; Record_ID=acute_inhalation_1193; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=200; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
| NTP_ICE_acute_inhalation | LC50 | 5.762 | mg/L | - | Inhalation | Duration=8 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=866; Record_ID=acute_inhalation_1667; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=5.762; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
| NTP_ICE_acute_inhalation | LC50 | >21.6077 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=867; Record_ID=acute_inhalation_1669; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=21.6077; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
NTP_ICE_eye_irritation 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 18 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=465; Record_ID=eye_irritation_201; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=18; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=467; Record_ID=eye_irritation_201; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
| NTP_ICE_eye_irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=468; Record_ID=eye_irritation_201; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
| NTP_ICE_eye_irritation | Intensity | 0.29 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=466; Record_ID=eye_irritation_1267; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Vitrigel; Endpoint=Intensity; Response=0.29; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=471; Record_ID=eye_irritation_1267; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
| NTP_ICE_eye_irritation | Plateau level | 52 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=469; Record_ID=eye_irritation_1267; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Vitrigel; Endpoint=Plateau level; Response=52; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5414; Record_ID=skin_sensitization_invivo_1259; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90246-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 6480 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5413; Record_ID=skin_sensitization_invivo_1259; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6480; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90246-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5418; Record_ID=skin_sensitization_invivo_1259; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1022001; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90246-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022001; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1022001 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =72070.7 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15515279:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_609134c422f2aa460983f02457dbd7dd |
ToxValDB_DOE_Wildlife_Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Wildlife_Benchmarks | LOAEL | =360 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511628_15511629:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06f2b9e5d2cd27bf43808228a8905746 |
| ToxValDB_DOE_Wildlife_Benchmarks | NOAEL | =90 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511628_15511629:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ea93e39a4e2a625e7c4104d1cc07309 |
ToxValDB_ECHA_IUCLID 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =57700 | mg/m3 | Rat | inhalation | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/3/3?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15796719:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_871a968ec460cf7c185ce4dc16e6a198 |
| ToxValDB_ECHA_IUCLID | LEL | =36000 | mg/m3 | Mouse | inhalation | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/3/3?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15795798_15795799_15797659_15797660:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bec34880c1204d83fa5d622b2011fc31 |
| ToxValDB_ECHA_IUCLID | LEL | =2140.5 | mg/m3 | Mouse | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d21845d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/10/1?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825577_15825578_15825579:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b914db37dcb58b8303e5f3f5ef84e8cc |
| ToxValDB_ECHA_IUCLID | LEL | =4493 | mg/kg bw/day | Rabbit | oral | - | repeat dose other | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4eec; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/10/1?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15825644:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f8e447ae04f5d4017d71ccf6b9904f6e |
| ToxValDB_ECHA_IUCLID | LOAEL | =3600 | mg/kg bw/day | Rat | oral | chronic; 92 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead64e4b0a7c65d1c3f35; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/6/2?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833805_15833806:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_63ab4b4f5e8cc8809df295901f3ab690 |
| ToxValDB_ECHA_IUCLID | LOEC | =2017.98 | mg/m3 | Mouse | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d21845d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/10/1?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825577_15825578_15825579:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ce6488d46ec9782bc964af3c92075d7 |
| ToxValDB_ECHA_IUCLID | LOEC | =1261.24 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/6/3?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827700_15827703:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4a92170bb47a63bc43920198e235c054 |
| ToxValDB_ECHA_IUCLID | NOAEC | =2702.65 | mg/m3 | Rat | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d218465; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/10/1?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825916_15825918:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_642202196cc92c0362e98522f0cc43cf |
| ToxValDB_ECHA_IUCLID | NOAEL | =900 | mg/kg bw/day | Rat | oral | chronic; 92 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead64e4b0a7c65d1c3f35; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/6/2?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833805_15833806:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3389707eb8351fcd4e1c8cb76dc25b2d |
| ToxValDB_ECHA_IUCLID | NOAEL | =5405.3 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8cbe4b0a7c65d21a1dd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/9/2?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15857220:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_646cea57892caf7786ab7ebec4024adf |
| ToxValDB_ECHA_IUCLID | NOAEL | >57656.6 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8cbe4b0a7c65d21a1e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/9/2?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15857511:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf07e9606c3820cb6500c20b2ea610fc |
| ToxValDB_ECHA_IUCLID | NOEC | =1081.06 | mg/m3 | Mouse | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d21845d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/10/1?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825577_15825578_15825579:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d4b5e7502901f994b7021917bd874c9 |
| ToxValDB_ECHA_IUCLID | NOEC | >5405.3 | mg/m3 | Rat | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d21845f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/10/1?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15825679:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_87d7381b58c52e08d23d93462e2c4d73 |
| ToxValDB_ECHA_IUCLID | NOEC | =1261.24 | mg/m3 | Rat | inhalation | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c863e4b0a7c65d218465; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/10/1?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825916_15825918:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc5fac55b1d867af6f8f36cd1218cd9a |
| ToxValDB_ECHA_IUCLID | NOEC | =2702.65 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6312/7/6/3?documentUUID=46072429-5c11-4dc3-899d-22fb8f123a78; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827701_15827702:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f6687bb402a416e0296b4938a358841d |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =900 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA FEEDAP (2013). Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species. doi:10.2903/j.efsa.2013.3169.; TITLE=Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2013.3169; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614453:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1473bd1d4544139f4fe6854713224305 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =734 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631923_15631924:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb54c8c410b085542903d0f95f0fdbc8 |
ToxValDB_IRIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LOAEL | =3600 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=U.S. EPA. 1986. Rat oral subchronic study with ethyl acetate. Office of Solid Waste, Washington, DC.; TITLE=Rat oral subchronic study with ethyl acetate; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a5088; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=157; TOXICOLOGICAL_EFFECT=mortality and body weight loss; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15645328_15645329:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d98efa2f1483d3adc31c68702eabbf51 |
| ToxValDB_IRIS | RfD | =0.9 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=U.S. EPA, 1986; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a5088; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=157; TOXICOLOGICAL_EFFECT=Mortality and body weight loss in male/female rats; STUDY_GROUP=IRIS:15644795:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9d55d3fc07cd802046b24c720a4501f9 |
ToxValDB_PPRTV_(CPHEA) 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | NOAEL (HEC) | =209 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Christoph et al., 2003; AUTHOR=Christoph et al.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1742; TOXICOLOGICAL_EFFECT=reduced body weight, body weight gain, food efficiency, startle response (both sexes), and reduced food consumption (males); TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=PPRTV (CPHEA):15653595:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5bda270872b38f8a02d7766e7ccc0d0e |
| ToxValDB_PPRTV_(CPHEA) | NOAEL (HED) | =216 | mg/kg bw/day | Rat | oral | chronic; 93 days | chronic | LONG_REF=American Biogenics Corp., 1986; AUTHOR=American Biogenics Corp.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1742; TOXICOLOGICAL_EFFECT=increased salivation, irregular breathing, and lethargy in both sexes; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=PPRTV (CPHEA):15654068:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_21f2981c2a591f3389e2abfa0e6cd530 |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =0.7 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Christoph et al., 2003; AUTHOR=Christoph et al.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1742; TOXICOLOGICAL_EFFECT=Decreased body weights, body-weight gains, food efficiency, startle response (both sexes), and decreased food consumption (males) in male/female rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653593_15653594:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b154c9aeb169b587e2ac610dc7913b01 |
| ToxValDB_PPRTV_(CPHEA) | RfD (provisional) | =0.7 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=American Biogenics Corp., 1986; AUTHOR=American Biogenics Corp.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b7b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1742; TOXICOLOGICAL_EFFECT=Increased salivation, irregular breathing, and lethargy in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653734:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c0ff49bec3cfdaa3887d7632450a7362 |
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfC | =0.07 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650103:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b4d4b8a7133da0307bb1e4a514782b01 |
ToxValDB_WHO_JECFA_ADI 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | <=25 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af689e4b0d99f5a8754e6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/2357; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=WHO JECFA ADI:15715298:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09add1a2aa5b66b2cd9d88673a94e846 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 76845O8NMZ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"76845O8NMZ"} |
| openFDA substances | FDA UNII substance identifier | 76845O8NMZ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"76845O8NMZ"} |
| openFDA substances | FDA UNII substance identifier | 76845O8NMZ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"76845O8NMZ"} |
| openFDA substances | FDA UNII substance identifier | 76845O8NMZ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"76845O8NMZ"} |