| ToxValDB_ECOTOX |
LOEL |
=5000 |
mg/kg bw/day |
Mouse |
oral |
acute; 0.1667 days |
acute |
LONG_REF=Toxicol. Appl. Pharmacol.74(2): 230-236 Waalkes,M.P., J.J. Hjelle, and C.D. Klaassen Transient Induction of Hepatic Metallothionein Following Oral Ethanol Administration 1984; TITLE=Transient Induction of Hepatic Metallothionein Following Oral Ethanol Administration; AUTHOR=Waalkes,M.P., J.J. Hjelle, and C.D. Klaassen; DOI=10.1016/0041-008x(84)90147-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=87717; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594096:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f1922bf8eb4325252dc8b2c5696b8598 |
| ToxValDB_ECOTOX |
LOEL |
=5 |
% |
Rat |
oral |
short-term; 11 days |
short-term |
LONG_REF=Exp. Pathol. (Jena)25(4): 205-213 Jones,W.L., and D.B. Stewart Effects of Orally-Administered Ethanol on Mammary Gland Morphology and Functional Efficiency in Lactating Rats 1984; TITLE=Effects of Orally-Administered Ethanol on Mammary Gland Morphology and Functional Efficiency in Lactating Rats; AUTHOR=Jones,W.L., and D.B. Stewart; DOI=10.1016/s0232-1513(84)80022-5; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113117; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Morphology: Length|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594613:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c9d31d2815ef397601a1faae98348529 |
| ToxValDB_ECOTOX |
LOEL |
=9 |
% w/v |
Dog |
oral |
acute; 0.0208 days |
acute |
LONG_REF=Am. J. Physiol. Gasterointest. Liver Physiol.269(3, Pt. 1): G363 - G369 Charles,F., and S.F. Phillips Effects of Ethanol, Xylose, and Glucose on Canine Jejunal Motility 1995; TITLE=Effects of Ethanol, Xylose, and Glucose on Canine Jejunal Motility; AUTHOR=Charles,F., and S.F. Phillips; DOI=10.1152/ajpgi.1995.269.3.G363; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113204; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Physiology: Contraction rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594709_15594710:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ae2bd5d82deade9a3fcbe5c93cff685a |
| ToxValDB_ECOTOX |
LOEL |
=6 |
% vol |
Rat |
oral |
acute (developmental); 1 days |
developmental |
LONG_REF=Alcohol Alcohol.28(6): 657-666 Fuseler,J.W. Maternal Ethanol Consumption Induces Transient Compensatory Hyperplasia of Developing Cardiac Tissue in the Neonatal Rat 1993; TITLE=Maternal Ethanol Consumption Induces Transient Compensatory Hyperplasia of Developing Cardiac Tissue in the Neonatal Rat; AUTHOR=Fuseler,J.W.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115289; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Genetics: Mitotic index (# mitoses/total cells)|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX:15594796:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a97616008b6011b4948acff4fc39f5cd |
| ToxValDB_ECOTOX |
LOEL |
=15 |
% v/v |
Mouse |
oral |
short-term; 8 days |
short-term |
LONG_REF=Can. J. Physiol. Pharmacol.64(7): 1032-1037 Kennedy,L.A., S. Mukerji, and M.J. Elliott The Ontogeny of Placental Na+-K+ Atpase in the Mouse and Its Impairment by Ethanol 1986; TITLE=The Ontogeny of Placental Na+-K+ Atpase in the Mouse and Its Impairment by Ethanol; AUTHOR=Kennedy,L.A., S. Mukerji, and M.J. Elliott; DOI=10.1139/y86-176; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112961; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Enzyme(s): Sodium potassium ATPase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595148_15595149_15604255:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c5db1fc821d4a22a8534080ad6ad9953 |
| ToxValDB_ECOTOX |
LOEL |
=5.202 |
g/org-day |
Rat |
oral |
short-term; 28 days |
short-term |
LONG_REF=Alcohol Alcohol.37(3): 213-221 Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, and M. Galazyn-Sidorczuk Cadmium Turnover and Changes of Zinc and Copper Body Status of Rats Continuously Exposed to Cadmium and Ethanol 2002; TITLE=Cadmium Turnover and Changes of Zinc and Copper Body Status of Rats Continuously Exposed to Cadmium and Ethanol; AUTHOR=Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, and M. Galazyn-Sidorczuk; DOI=10.1093/alcalc/37.3.213; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=82501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption|Physiology: Zinc excretion; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595265_15602781:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b0442229408ff68b4a8bfd555d4b1356 |
| ToxValDB_ECOTOX |
LOEL |
=20 |
% |
Rat |
oral |
short-term; 30 days |
reproduction developmental |
LONG_REF=www.unisa.it/Centri_e_Vari/pharmacologyonline3:862-876 Muche,A., E. Makonnen, Y. Kinfu, and M. Afework The Effect of Ethanol and Khat (Catha edulis Forsk) on the Cerebellar Cortex of Early Postnatal Rats 2006; TITLE=The Effect of Ethanol and Khat (Catha edulis Forsk) on the Cerebellar Cortex of Early Postnatal Rats; AUTHOR=Muche,A., E. Makonnen, Y. Kinfu, and M. Afework; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112936; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Cell(s): Diameter|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15595347:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3cb37372218a10fb573f897e82abb11a |
| ToxValDB_ECOTOX |
LOEL |
=6000 |
mg/kg bw/day |
Mouse |
oral |
acute; 0.0625 days |
acute |
LONG_REF=Am. J. Pathol.164(6): 1959-1966 Lambert,J.C., Z. Zhou, L. Wang, Z. Song, C.J. McClain, and Y.J. Kang Preservation of Intestinal Structural Integrity by Zinc is Independent of Metallothionein in Alcohol-Intoxicated Mice 2004; TITLE=Preservation of Intestinal Structural Integrity by Zinc is Independent of Metallothionein in Alcohol-Intoxicated Mice; AUTHOR=Lambert,J.C., Z. Zhou, L. Wang, Z. Song, C.J. McClain, and Y.J. Kang; DOI=10.1016/S0002-9440(10)63756-X; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100802; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Endotoxin|Biochemistry: Metallothionein|Biochemistry: Tumor necrosis factor-alpha|Enzyme(s): Alanine transaminase (ALT); TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595417_15597718:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fad87e109d5f459e5d79b73c15713922 |
| ToxValDB_ECOTOX |
LOEL |
=10 |
% v/v |
Mouse |
oral |
short-term; 21 days |
reproduction developmental |
LONG_REF=Physiol. Behav.30(3): 485-488 Perez,V.J., G.E.,Jr. Gonzalez, and C.J. Smith Exposure to Ethanol During Pregnancy in Mice: Potential Importance of Dose for the Development of Tolerance in Offspring 1983; TITLE=Exposure to Ethanol During Pregnancy in Mice: Potential Importance of Dose for the Development of Tolerance in Offspring; AUTHOR=Perez,V.J., G.E.,Jr. Gonzalez, and C.J. Smith; DOI=10.1016/0031-9384(83)90156-7; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=112740; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15595516:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5b444366bdfabf31f9e3199270943526 |
| ToxValDB_ECOTOX |
LOEL |
=3000 |
ppm |
Rat |
oral |
short-term; 6 days |
developmental |
LONG_REF=Alcohol41(4): 253-261 Oladehin,A., C.P. Margret, S.E. Maier, C.X. Li, T.A. Jan, T.D. Chappell, and R.S. Waters Early Postnatal Alcohol Exposure Reduced the Size of Vibrissal Barrel Field in Rat Somatosensory Cortex (SI) but did not Disrupt Barrel Field Organization 2007; TITLE=Early Postnatal Alcohol Exposure Reduced the Size of Vibrissal Barrel Field in Rat Somatosensory Cortex (SI) but did not Disrupt Barrel Field Organization; AUTHOR=Oladehin,A., C.P. Margret, S.E. Maier, C.X. Li, T.A. Jan, T.D. Chappell, and R.S. Waters; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113182; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15595691:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=252e9a4d72d57f50af9c9a8c18f694a6 |
| ToxValDB_ECOTOX |
LOEL |
=25 |
% v/v |
Mouse |
oral |
short-term; 4 days |
short-term |
LONG_REF=J. Reprod. Fertil.80(1): 49-57 Wiebold,J.L., and W.C. Becker In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos 1987; TITLE=In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos; AUTHOR=Wiebold,J.L., and W.C. Becker; DOI=10.1530/jrf.0.0800049; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113118; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595716_15601220:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=40df39ed6c45069667ee26747b27efec |
| ToxValDB_ECOTOX |
LOEL |
=130 |
mg/kg bw/day |
Dog |
oral |
acute; 0.0833 days |
acute |
LONG_REF=Dig. Dis. Sci.29(1): 12-18 Eysselein,V.E., M.V. Singer, H. Wentz, and H. Goebell Action of Ethanol on Gastrin Release in the Dog 1984; TITLE=Action of Ethanol on Gastrin Release in the Dog; AUTHOR=Eysselein,V.E., M.V. Singer, H. Wentz, and H. Goebell; DOI=10.1007/BF01296856; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113119; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Hormone(s): Gastrin; STUDY_GROUP=ECOTOX:15595717:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=80540d4c8435db175fced66dcbe93062 |
| ToxValDB_ECOTOX |
LOEL |
=10 |
% w/v |
Mouse |
oral |
short-term; 27 days |
developmental |
LONG_REF=Prostaglandins Leukot. Essent. Fatty Acids76(3): 141-151 Cebral,E., A. Faletti, A. Jawerbaum, and D. Paz Periconceptional Alcohol Consumption-Induced Changes in Embryonic Prostaglandin E Levels in Mouse Organogenesis: Modulation by Nitric Oxide 2007; TITLE=Periconceptional Alcohol Consumption-Induced Changes in Embryonic Prostaglandin E Levels in Mouse Organogenesis: Modulation by Nitric Oxide; AUTHOR=Cebral,E., A. Faletti, A. Jawerbaum, and D. Paz; DOI=10.1016/j.plefa.2006.12.001; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=113188; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Biochemistry: Prostaglandin E2|Development: Stage|Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|development|reproduction; STUDY_GROUP=ECOTOX:15595979:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f4ef5de0f8ce84c7332b4b6ec4ef3df7 |
| ToxValDB_ECOTOX |
LOEL |
=10 |
% |
Rat |
oral |
chronic; 365.28 days |
chronic |
LONG_REF=Jpn. J. Cancer Res.83:1267-1272 Watanabe,H., T. Okamoto, T. Takahashi, P.O. Ogundigie, and A. Ito The Effects of Sodium Chloride, Miso or Ethanol on Development of Intestinal Metaplasia After X-Irradiation of the Rat Glandular Stomach 1992; TITLE=The Effects of Sodium Chloride, Miso or Ethanol on Development of Intestinal Metaplasia After X-Irradiation of the Rat Glandular Stomach; AUTHOR=Watanabe,H., T. Okamoto, T. Takahashi, P.O. Ogundigie, and A. Ito; DOI=10.1111/j.1349-7006.1992.tb02757.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107468; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Height; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15596343:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a423b36bad0634fc94c9274033eedec8 |
| ToxValDB_ECOTOX |
LOEL |
=65.4 |
mL |
Rat |
oral |
short-term; 19 days |
developmental |
LONG_REF=Alcohol33(2): 83-89 Peres,W.A.F., M.G.T. Carmo, S. Zucoloto, A.C. Iglesias, and V.B. Braulio Ethanol Intake Inhibits Growth of the Epithelium in the Intestine of Pregnant Rats 2004; TITLE=Ethanol Intake Inhibits Growth of the Epithelium in the Intestine of Pregnant Rats; AUTHOR=Peres,W.A.F., M.G.T. Carmo, S. Zucoloto, A.C. Iglesias, and V.B. Braulio; DOI=10.1016/j.alcohol.2004.05.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113181; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15596543:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=71f9d8d7f5238948679b071e4e80be7f |
| ToxValDB_ECOTOX |
LOEL |
=7100000 |
ppm |
European Rabbit |
environmental |
short-term; 2 days |
developmental |
LONG_REF=Teratology59(2): 102-109 Pitt,J.A., and E.W. Carney Evaluation of Various Toxicants in Rabbit Whole-Embryo Culture Using a New Morphologically-Based Evaluation System 1999; TITLE=Evaluation of Various Toxicants in Rabbit Whole-Embryo Culture Using a New Morphologically-Based Evaluation System; AUTHOR=Pitt,J.A., and E.W. Carney; DOI=10.1002/(SICI)1096-9926(199902)59:2<102::AID-TERA4>3.0.CO;2-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117298; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Abnormal|Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=development|other|urinalysis; STUDY_GROUP=ECOTOX:15596563:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c6f3f755e08ea4239b4348fdd626f952 |
| ToxValDB_ECOTOX |
LOEL |
=0.57 |
g/100 g bw/day |
Rat |
oral |
subchronic; 84 days |
subchronic |
LONG_REF=Food Cosmet. Toxicol.17(4): 333-338 Antal,M., M. Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi Studies on the Interaction of Methomyl and Ethanol in Rats 1979; TITLE=Studies on the Interaction of Methomyl and Ethanol in Rats; AUTHOR=Antal,M., M. Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi; DOI=10.1016/0015-6264(79)90325-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74539; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Enzyme(s): Aniline hydrogenase|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity|organ weight; STUDY_GROUP=ECOTOX:15596633:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=86bff223307a6039014bbcd93ed2b1f2 |
| ToxValDB_ECOTOX |
LOEL |
=0.5 |
% |
Rat |
environmental |
short-term; 2 days |
developmental |
LONG_REF=Toxicology30(1): 45-57 Kitchin,K.T., and M.T. Ebron Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System 1984; TITLE=Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System; AUTHOR=Kitchin,K.T., and M.T. Ebron; DOI=10.1016/0300-483x(84)90061-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115431; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Development: Abnormal|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596656_15596657:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9637264c7bdb54aba883c47944f00bfe |
| ToxValDB_ECOTOX |
LOEL |
=21350 |
ppm |
Mouse |
oral |
short-term; 13 days |
reproduction developmental |
LONG_REF=Alcohol11(6): 517-522 Weathersby,R.T., H.C. Becker, and R.L. Hale Reduced Sensitivity to the Effects of Clonidine on Ethanol-Stimulated Locomotor Activity in Adult Mouse Offspring Prenatally Exposed to Ethanol 1994; TITLE=Reduced Sensitivity to the Effects of Clonidine on Ethanol-Stimulated Locomotor Activity in Adult Mouse Offspring Prenatally Exposed to Ethanol; AUTHOR=Weathersby,R.T., H.C. Becker, and R.L. Hale; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116714; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Growth: Weight|Growth: Weight gain|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596717_15604220_15609677:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3c53bf03f0e09ce21dbc9bcd1af46ef2 |
| ToxValDB_ECOTOX |
LOEL |
=4000 |
mg/kg bw/day |
Rat |
oral |
short-term; 11 days |
short-term |
LONG_REF=Teratology29(2): 251-258 Burns,E.M., T.W. Kruckeberg, H. Stibler, E. Cerven, and S. Borg The Effects of Ethanol Exposure During the Brain Growth Spurt in Rats 1984; TITLE=The Effects of Ethanol Exposure During the Brain Growth Spurt in Rats; AUTHOR=Burns,E.M., T.W. Kruckeberg, H. Stibler, E. Cerven, and S. Borg; DOI=10.1002/tera.1420290211; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116923; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Cell(s): Structural changes|Growth: Weight gain|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596897_15608154:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7bf4a5bdcacbf612d7c6f629f7086830 |
| ToxValDB_ECOTOX |
LOEL |
=4.49 |
% v/v |
Mouse |
oral |
short-term; 8 days |
developmental |
LONG_REF=J. Mol. Neurosci.24(2): 189-199 Zhou,F.C., Y. Sari, T.A. Powrozek, and C.Y. Spong A Neuroprotective Peptide Antagonizes Fetal Alcohol Exposure-Compromised Brain Growth 2004; TITLE=A Neuroprotective Peptide Antagonizes Fetal Alcohol Exposure-Compromised Brain Growth; AUTHOR=Zhou,F.C., Y. Sari, T.A. Powrozek, and C.Y. Spong; DOI=10.1385/JMN:24:2:189; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116870; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development|other; STUDY_GROUP=ECOTOX:15597123:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1804b9c289a01b8b673748c3ba799b01 |
| ToxValDB_ECOTOX |
LOEL |
=13000 |
ppm |
Rat |
oral |
short-term; 30.44 days |
short-term |
LONG_REF=Exp. Mol. Pathol.77(3): 210-213 Li,J., P. Fu, B.A. French, and S.W. French The Effect of Rotenone on the Urinary Ethanol Cycle in Rats Fed Ethanol Intragastrically 2004; TITLE=The Effect of Rotenone on the Urinary Ethanol Cycle in Rats Fed Ethanol Intragastrically; AUTHOR=Li,J., P. Fu, B.A. French, and S.W. French; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=76246; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Injury: Injury, general|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|other; STUDY_GROUP=ECOTOX:15597467:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e82a422f42dab49c22fd4b066660cb7d |
| ToxValDB_ECOTOX |
LOEL |
=6.36 |
% v/v |
Rat |
oral |
short-term; 21 days |
developmental |
LONG_REF=Pharmacol. Res.47(4): 341-347 Ren,J., Z.K. Roughead, L.E. Wold, F.L. Norby, S. Rakoczy, R.L. Mabey, and H.M. Brown-Borg Increases in Insulin-Like Growth Factor-1 Level and Peroxidative Damage After Gestational Ethanol Exposure in Rats 2003; TITLE=Increases in Insulin-Like Growth Factor-1 Level and Peroxidative Damage After Gestational Ethanol Exposure in Rats; AUTHOR=Ren,J., Z.K. Roughead, L.E. Wold, F.L. Norby, S. Rakoczy, R.L. Mabey, and H.M. Brown-Borg; DOI=10.1016/s1043-6618(03)00005-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112360; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15598160:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ab58e1f3d1aededaa67a6d9669eafba3 |
| ToxValDB_ECOTOX |
LOEL |
=9 |
% v/v |
Rat |
oral |
short-term; 18 days |
reproduction developmental |
LONG_REF=Nutr. Res.4(3): 469-475 Gordon,E.F., and M.B. Zemel Effects of Prenatal Ethanol Exposure on Iron Utilization in the Rat 1984; TITLE=Effects of Prenatal Ethanol Exposure on Iron Utilization in the Rat; AUTHOR=Gordon,E.F., and M.B. Zemel; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112737; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Feeding behavior: Water consumption|Growth: Weight|Physiology: Iron uptake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598310_15601527:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=881100eb01ff56b0a1c6f19ba0bc5424 |
| ToxValDB_ECOTOX |
LOEL |
=1 |
% v/v |
Mouse |
environmental |
short-term; 3 days |
developmental |
LONG_REF=J. Reprod. Fertil.80(1): 49-57 Wiebold,J.L., and W.C. Becker In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos 1987; TITLE=In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos; AUTHOR=Wiebold,J.L., and W.C. Becker; DOI=10.1530/jrf.0.0800049; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113118; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Development: Morula stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15598315:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=456f12e6a35a29ffe28e58f958c0cbdd |
| ToxValDB_ECOTOX |
LOEL |
=0.3 |
% w/v |
Mouse |
environmental |
acute; 1 days |
acute |
LONG_REF=Toxicology242(1-3): 109-122 Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts 2007; TITLE=Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts; AUTHOR=Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan; DOI=10.1016/j.tox.2007.09.015; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107979; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Genetics: Apoptosis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15598391:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7e0bbb7461db95e4154f58ad35590d72 |
| ToxValDB_ECOTOX |
LOEL |
=1000 |
mg/kg bw/day |
Dog |
oral |
acute; 0.0625 days |
acute |
LONG_REF=Acta Physiol. Scand.118(3): 209-214 Kettunen,R., J. Timisjaervi, P. Saukko, and M. Koskela Influence of Ethanol on Systemic and Pulmonary Hemodynamics in Anesthetized Dogs 1983; TITLE=Influence of Ethanol on Systemic and Pulmonary Hemodynamics in Anesthetized Dogs; AUTHOR=Kettunen,R., J. Timisjaervi, P. Saukko, and M. Koskela; DOI=10.1111/j.1748-1716.1983.tb07264.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112968; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Biochemistry: pH; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX:15598464:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=39c332e97192ad6abb68a3c8adcb9f98 |
| ToxValDB_ECOTOX |
LOEL |
=30 |
% |
Rat |
oral |
subchronic; 56 days |
subchronic |
LONG_REF=Biol. Trace Elem. Res.100(3): 247-257 Pathak,A., A. Mahmood, R. Pathak, and D. Dhawan Role of Zinc on Lipid Peroxidation and Antioxidative Enzymes in Intestines of Ethanol-Fed Rats 2004; TITLE=Role of Zinc on Lipid Peroxidation and Antioxidative Enzymes in Intestines of Ethanol-Fed Rats; AUTHOR=Pathak,A., A. Mahmood, R. Pathak, and D. Dhawan; DOI=10.1385/BTER:100:3:247; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100367; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Enzyme(s): Catalase|Enzyme(s): Glutathione peroxidase|Enzyme(s): Glutathione reductase|Enzyme(s): Superoxide dismutase (SOD) enzyme activity|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598593_15602311:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=db81ce643c68086b88bce3291a262ef6 |
| ToxValDB_ECOTOX |
LOEL |
=0.1 |
% v/v |
Mouse |
environmental |
short-term; 19.5 days |
short-term |
LONG_REF=J. Reprod. Fertil.80(1): 49-57 Wiebold,J.L., and W.C. Becker In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos 1987; TITLE=In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos; AUTHOR=Wiebold,J.L., and W.C. Becker; DOI=10.1530/jrf.0.0800049; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113118; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Reproduction: Number of implantations; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599262_15603809:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ab4bf5f45fb252f930f75b19b4b28ca9 |
| ToxValDB_ECOTOX |
LOEL |
=6.5 |
% v/v |
Rat |
oral |
short-term; 28 days |
short-term |
LONG_REF=Ph.D.Thesis, Vanderbilt Univ., Nashville, TN:174 p. Wu,T. Normal and Abnormal Development of Dendritic Spines in Tissue Culture 1998; TITLE=Normal and Abnormal Development of Dendritic Spines in Tissue Culture; AUTHOR=Wu,T.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113920; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Morphology: Abnormal|Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|other; STUDY_GROUP=ECOTOX:15599497:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2a035a34f99838337e90552f72e9ee79 |
| ToxValDB_ECOTOX |
LOEL |
=2 |
% w/v |
Mouse |
oral |
short-term; 5 days |
short-term |
LONG_REF=Toxicology242(1-3): 109-122 Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts 2007; TITLE=Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts; AUTHOR=Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan; DOI=10.1016/j.tox.2007.09.015; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107979; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Genetics: Apoptosis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15599907:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=33f6e375266b1007e84674750bd3b4f6 |
| ToxValDB_ECOTOX |
LOEL |
=2200 |
mg/kg bw/day |
Rat |
injection |
short-term; 7 days |
short-term |
LONG_REF=Acta Endocrinol.119(1): 99-105 Salonen,I., and I. Huhtaniemi Specific and Weight Loss-Associated Effects of One-Week Exposure to Ethanol on Pituitary-Gonadal Function of Male Rats 1988; TITLE=Specific and Weight Loss-Associated Effects of One-Week Exposure to Ethanol on Pituitary-Gonadal Function of Male Rats; AUTHOR=Salonen,I., and I. Huhtaniemi; DOI=10.1530/acta.0.1190099; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112953; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Weight|Hormone(s): Testosterone|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|other; STUDY_GROUP=ECOTOX:15599976:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dc71b90344114c852109741e16c7a876 |
| ToxValDB_ECOTOX |
LOEL |
=2.7 |
g/org-day |
Rat |
oral |
short-term; 21 days |
reproduction developmental |
LONG_REF=J. Lab. Clin. Med.104(2): 176-184 Singh,S.P., A.K. Snyder, and S.K. Singh Effects of Ethanol Ingestion on Maternal and Fetal Glucose Homeostasis 1984; TITLE=Effects of Ethanol Ingestion on Maternal and Fetal Glucose Homeostasis; AUTHOR=Singh,S.P., A.K. Snyder, and S.K. Singh; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112958; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Biochemistry: Glycogen|Feeding behavior: Food consumption|Growth: Weight|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|other; STUDY_GROUP=ECOTOX:15600030:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=21ee1148458f5e3cb021c347ccd8f230 |
| ToxValDB_ECOTOX |
LOEL |
=5 |
% v/v |
Mouse |
oral |
subchronic; 35 days |
subchronic |
LONG_REF=J. Pharmacol. Exp. Ther.225(2): 479-484 Anderson,R.A.,Jr., B.R. Willis, C. Oswald, and L.J.D. Zaneveld Ethanol-Induced Male Infertility: Impairment of Spermatozoa 1983; TITLE=Ethanol-Induced Male Infertility: Impairment of Spermatozoa; AUTHOR=Anderson,R.A.,Jr., B.R. Willis, C. Oswald, and L.J.D. Zaneveld; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117197; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Morphology: Abnormal|Reproduction: Velocity; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600583_15608732:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=111d6927c8d93161ebb73e5fd8176e91 |
| ToxValDB_ECOTOX |
LOEL |
=4 |
mg/mL |
Mouse |
environmental |
short-term; 2 days |
developmental |
LONG_REF=Toxicol. Lett.167(3): 167-172 Xu,Y., L. Li, Z. Zhang, and Y. Li Effects of Folinic Acid and Vitamin B12 on Ethanol-Induced Developmental Toxicity in Mouse 2006; TITLE=Effects of Folinic Acid and Vitamin B12 on Ethanol-Induced Developmental Toxicity in Mouse; AUTHOR=Xu,Y., L. Li, Z. Zhang, and Y. Li; DOI=10.1016/j.toxlet.2006.07.341; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113158; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Development: Abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15600829:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f9a6920a1d8fe5b1eed900d67ab5b869 |
| ToxValDB_ECOTOX |
LOEL |
=0.4 |
mL/kg |
Rat |
oral |
subchronic; 45 days |
subchronic |
LONG_REF=J. Toxicol. Environ. Health10:267-276 Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats 1982; TITLE=Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats; AUTHOR=Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham; DOI=10.1080/15287398209530249; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112708; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601198_15604950:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2d4d2cfb8e38ba67a545fbd94b58b1d5 |
| ToxValDB_ECOTOX |
LOEL |
=1500 |
mg/kg bw/day |
Dog |
oral |
acute; 0.0417 days |
acute |
LONG_REF=Digestion32(2): 77-85 Diaz,G.R., M.A. Devaux, and H. Sarles Effect of Acute and Chronic Oral Administration of Ethanol on Canine Exocrine Pancreatic Secretion 1985; TITLE=Effect of Acute and Chronic Oral Administration of Ethanol on Canine Exocrine Pancreatic Secretion; AUTHOR=Diaz,G.R., M.A. Devaux, and H. Sarles; DOI=10.1159/000199222; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113103; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: Bicarbonate (HCO3-) concentration|Physiology: Secretion; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15601279:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6541cd6c3ae2a0c2ecf80470bcd7cf95 |
| ToxValDB_ECOTOX |
LOEL |
=0.5 |
% w/v |
Mouse |
environmental |
acute; 1 days |
developmental |
LONG_REF=Toxicology242(1-3): 109-122 Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts 2007; TITLE=Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts; AUTHOR=Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan; DOI=10.1016/j.tox.2007.09.015; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107979; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Development: Normal; STUDY_GROUP=ECOTOX:15601293:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c899a51f224a6ed9ccc45c696295b999 |
| ToxValDB_ECOTOX |
LOEL |
=2.15 |
% w/v |
Rat |
oral |
short-term; 8.4 days |
reproduction developmental |
LONG_REF=Neurotoxicol. Teratol.12(1): 15-22 Meyer,L.S., L.E. Kotch, and E.P. Riley Neonatal Ethanol Exposure: Functional Alterations Associated with Cerebellar Growth Retardation 1990; TITLE=Neonatal Ethanol Exposure: Functional Alterations Associated with Cerebellar Growth Retardation; AUTHOR=Meyer,L.S., L.E. Kotch, and E.P. Riley; DOI=10.1016/0892-0362(90)90107-n; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116938; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Behavior: Head lift; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15601353:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=90628735945e743f988f356d4bbb5dba |
| ToxValDB_ECOTOX |
LOEL |
=3300 |
mg/kg bw/day |
Rat |
oral |
short-term; 6 days |
short-term |
LONG_REF=Alcohol12(4): 351-355 Chen,W.J.A., R.E.,Jr. McAlhany, and J.R. West 4-Methylpyrazole, an Alcohol Dehydrogenase Inhibitor, Exacerbates Alcohol-Induced Microencephaly During the Brain Growth Spurt 1995; TITLE=4-Methylpyrazole, an Alcohol Dehydrogenase Inhibitor, Exacerbates Alcohol-Induced Microencephaly During the Brain Growth Spurt; AUTHOR=Chen,W.J.A., R.E.,Jr. McAlhany, and J.R. West; DOI=10.1016/0741-8329(95)00017-l; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116696; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602323_15609201:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2210ea715b6b15f15c254e43c0b95dc6 |
| ToxValDB_ECOTOX |
LOEL |
=2.5 |
% |
Rat |
environmental |
short-term; 2 days |
short-term |
LONG_REF=Toxicology30(1): 45-57 Kitchin,K.T., and M.T. Ebron Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System 1984; TITLE=Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System; AUTHOR=Kitchin,K.T., and M.T. Ebron; DOI=10.1016/0300-483x(84)90061-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115431; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602437_15602438:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4cb04c2d335c35eb1655e9034bacbb24 |
| ToxValDB_ECOTOX |
LOEL |
=310 |
mg/kg bw/day |
Mouse |
oral |
short-term; 5 days |
short-term |
LONG_REF=Steroids23(6): 921-928 Badr,F.M., and A. Bartke Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice 1974; TITLE=Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice; AUTHOR=Badr,F.M., and A. Bartke; DOI=10.1016/0039-128x(74)90064-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112967; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601680_15602688_15602689:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=16916000aaa9e518d44fb1432760922b |
| ToxValDB_ECOTOX |
LOEL |
=0.46 |
g/100 g bw/day |
Rat |
oral |
subchronic; 84 days |
subchronic |
LONG_REF=Food Cosmet. Toxicol.17(4): 333-338 Antal,M., M. Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi Studies on the Interaction of Methomyl and Ethanol in Rats 1979; TITLE=Studies on the Interaction of Methomyl and Ethanol in Rats; AUTHOR=Antal,M., M. Bedo, G. Constantinovits, K. Nagy, and J. Szepvolgyi; DOI=10.1016/0015-6264(79)90325-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74539; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Enzyme(s): Aniline hydrogenase|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603185_15604830:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bc19d08b0f5965414d863eb611f63354 |
| ToxValDB_ECOTOX |
LOEL |
=174 |
mmol/kg |
Rat |
oral |
acute; 0.0556 days |
acute |
LONG_REF=Arch. Toxicol.61(1): 79-82 Hoffmann,P. Cardiotoxicity Testing of Organic Solvents by Coronary Artery Ligation in Closed-Chest Rats 1987; TITLE=Cardiotoxicity Testing of Organic Solvents by Coronary Artery Ligation in Closed-Chest Rats; AUTHOR=Hoffmann,P.; DOI=10.1007/BF00324553; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97720; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Mortality: Survival|Physiology: Heart rate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ECOTOX:15603593:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6fa2eeb31db394ed4eb2b335d1a2d404 |
| ToxValDB_ECOTOX |
LOEL |
=80 |
mg/kg bw/day |
Dog |
injection |
acute; 0.0042 days |
acute |
LONG_REF=Alcohol. Clin. Exp. Res.5(1): 56-63 Stratton,R., K.J. Dormer, and A.R. Zeiner The Cardiovascular Effects of Ethanol and Acetaldehyde in Exercising Dogs 1981; TITLE=The Cardiovascular Effects of Ethanol and Acetaldehyde in Exercising Dogs; AUTHOR=Stratton,R., K.J. Dormer, and A.R. Zeiner; DOI=10.1111/j.1530-0277.1981.tb04865.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112741; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Physiology: Heart rate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604075_15604076:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=72be9fd811977df9df5065a1b5a4029d |
| ToxValDB_ECOTOX |
LOEL |
=2000 |
mg/kg bw/day |
Rat |
injection |
acute; 0.0174 days |
acute |
LONG_REF=Neurotoxicol. Teratol.21(5): 551-557 Virgolini,M.B., L.M. Cancela, and S. Fulginiti Behavioral Responses to Ethanol in Rats Perinatally Exposed to Low Lead Levels 1999; TITLE=Behavioral Responses to Ethanol in Rats Perinatally Exposed to Low Lead Levels; AUTHOR=Virgolini,M.B., L.M. Cancela, and S. Fulginiti; DOI=10.1016/s0892-0362(99)00020-3; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113348; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605082_15605083:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=498a90d1bed4c591a0b6c286dd36f0b8 |
| ToxValDB_ECOTOX |
LOEL |
=2900 |
mg/kg bw/day |
Dog |
injection |
acute; 0.0021 days |
acute |
LONG_REF=Cardiovasc. Res.17(10): 604-607 Pescio,S., P. Macho, M. Penna, and R.J. Domenech Changes in Total and Transmural Coronary Blood Flow Induced by Ethanol 1983; TITLE=Changes in Total and Transmural Coronary Blood Flow Induced by Ethanol; AUTHOR=Pescio,S., P. Macho, M. Penna, and R.J. Domenech; DOI=10.1093/cvr/17.10.604; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=112971; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Physiology: Oxygen consumption; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15606751:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0ae08827e1b5767e10072d7b7e3e0b81 |
| ToxValDB_ECOTOX |
LOEL |
=2.5 |
mL/kg bw |
Mouse |
oral |
acute; 1 days |
acute |
LONG_REF=J. Toxicol. Environ. Health18(4): 575-587 Lin,S.C., H. Saito, T. Yohro, and J. Shiga Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus 1986; TITLE=Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus; AUTHOR=Lin,S.C., H. Saito, T. Yohro, and J. Shiga; DOI=10.1080/15287398609530895; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Enzyme(s): Glutamic-oxaloacetic transaminase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606994_15606995_15606996:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2aa4ca7cd91d2b9b7f303d61f8818cae |
| ToxValDB_ECOTOX |
LOEL |
=10 |
mL/kg bw |
Mouse |
oral |
acute; 1 days |
acute |
LONG_REF=J. Toxicol. Environ. Health18(4): 575-587 Lin,S.C., H. Saito, T. Yohro, and J. Shiga Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus 1986; TITLE=Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus; AUTHOR=Lin,S.C., H. Saito, T. Yohro, and J. Shiga; DOI=10.1080/15287398609530895; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT); TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606994_15606995_15606996:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=45a08ffef0281043bbcd08e31b0018eb |
| ToxValDB_ECOTOX |
LOEL |
=3720 |
mg/day |
Rat |
oral |
subchronic; 60 days |
subchronic |
LONG_REF=Alcohol11(5): 355-360 Gonzalez-Reimers,E., A. Martinez-Riera, F. Santolaria-Fernandez, A. Conde-Martel, H. Alvarez-Arguelles, C. Santana-Herr Relative and Combined Effects of Ethanol and Protein Deficiency on Gonadal Function and Histology 1994; TITLE=Relative and Combined Effects of Ethanol and Protein Deficiency on Gonadal Function and Histology; AUTHOR=Gonzalez-Reimers,E., A. Martinez-Riera, F. Santolaria-Fernandez, A. Conde-Martel, H. Alvarez-Arguelles, C. Santana-Herr; DOI=10.1016/0741-8329(94)90017-5; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116711; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596808_15598880_15607332:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2f49b725284eea44de0bc7f417ba34e6 |
| ToxValDB_ECOTOX |
LOEL |
=390 |
mg/100 mL |
Rat |
environmental |
short-term; 2 days |
short-term |
LONG_REF=Biochem. Pharmacol.31(22): 3641-3643 Priscott,P.K. The Effects of Ethanol on Rat Embryos Developing In Vitro 1982; TITLE=The Effects of Ethanol on Rat Embryos Developing In Vitro; AUTHOR=Priscott,P.K.; DOI=10.1016/0006-2952(82)90588-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607345_15607346:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=39f1bcf971d2cdc274e3cb00a14bf124 |
| ToxValDB_ECOTOX |
LOEL |
=3000 |
mg/kg bw/day |
Rat |
injection |
short-term; 14 days |
reproduction developmental |
LONG_REF=Biol. Pharm. Bull.17(2): 270-274 Okamura,N., K. Kobayashi, A. Akaike, and A. Yagi Protective Effect of Ginseng Saponins Against Impaired Brain Growth in Neonatal Rats Exposed to Ethanol 1994; TITLE=Protective Effect of Ginseng Saponins Against Impaired Brain Growth in Neonatal Rats Exposed to Ethanol; AUTHOR=Okamura,N., K. Kobayashi, A. Akaike, and A. Yagi; DOI=10.1248/bpb.17.270; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116189; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15607385:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0bc912b6de65a2aa2d8f8bc15317b9cf |
| ToxValDB_ECOTOX |
LOEL |
=590 |
mg/100 mL |
Rat |
environmental |
short-term; 2 days |
developmental |
LONG_REF=Biochem. Pharmacol.31(22): 3641-3643 Priscott,P.K. The Effects of Ethanol on Rat Embryos Developing In Vitro 1982; TITLE=The Effects of Ethanol on Rat Embryos Developing In Vitro; AUTHOR=Priscott,P.K.; DOI=10.1016/0006-2952(82)90588-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Development: Stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608138_15608139:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cb2c382bca6ea36f18fab357f73a3696 |
| ToxValDB_ECOTOX |
LOEL |
=6 |
% v/v |
Mouse |
oral |
subchronic; 35 days |
subchronic |
LONG_REF=J. Pharmacol. Exp. Ther.225(2): 479-484 Anderson,R.A.,Jr., B.R. Willis, C. Oswald, and L.J.D. Zaneveld Ethanol-Induced Male Infertility: Impairment of Spermatozoa 1983; TITLE=Ethanol-Induced Male Infertility: Impairment of Spermatozoa; AUTHOR=Anderson,R.A.,Jr., B.R. Willis, C. Oswald, and L.J.D. Zaneveld; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117197; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Reproduction: Velocity; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600583_15608732:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c68893d447cc9fd4e66cb5a8e3065cfe |
| ToxValDB_ECOTOX |
LOEL |
=200 |
uL |
Rat |
injection |
acute; 1 days |
acute |
LONG_REF=Biosci. Biotechnol. Biochem.58(1): 55-59 Ashida,H., K. Kanazawa, and G. Danno Hepatic Phosphoglucomutase Activity as a Marker of Oxidative Stress Induced by Pro-Oxidative Drugs 1994; TITLE=Hepatic Phosphoglucomutase Activity as a Marker of Oxidative Stress Induced by Pro-Oxidative Drugs; AUTHOR=Ashida,H., K. Kanazawa, and G. Danno; DOI=10.1271/bbb.58.55; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=95525; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Thiobarbituric acid|Enzyme(s): 6-Phosphogluconate dehydrogenase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15608822:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=49fbecab2fe9d9e391996f60b33d96d2 |
| ToxValDB_ECOTOX |
LOEL |
=1500 |
ppm |
Mouse |
oral |
short-term; 13 days |
reproduction developmental |
LONG_REF=Alcohol11(6): 517-522 Weathersby,R.T., H.C. Becker, and R.L. Hale Reduced Sensitivity to the Effects of Clonidine on Ethanol-Stimulated Locomotor Activity in Adult Mouse Offspring Prenatally Exposed to Ethanol 1994; TITLE=Reduced Sensitivity to the Effects of Clonidine on Ethanol-Stimulated Locomotor Activity in Adult Mouse Offspring Prenatally Exposed to Ethanol; AUTHOR=Weathersby,R.T., H.C. Becker, and R.L. Hale; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116714; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596717_15604220_15609677:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4eb0cae4e63c341fbeac30ddb1f1b780 |
| ToxValDB_ECOTOX |
LOEL |
=7.1 |
mL/kg bw |
Mouse |
oral |
short-term; 8 days |
developmental |
LONG_REF=Dev. Pharmacol. Ther.11(4): 237-242 Kennedy,L.A., S. Mukerji, and B. Bhaumick Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration 1988; TITLE=Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration; AUTHOR=Kennedy,L.A., S. Mukerji, and B. Bhaumick; DOI=10.1159/000457694; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112739; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610158_15610159:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=65861c047dc03af54a7bb08fd8cc603f |
| ToxValDB_ECOTOX |
LOEL |
=3 |
% v/v |
Mouse |
oral |
short-term; 30 days |
short-term |
LONG_REF=Reprod. Toxicol.3(2): 101-113 Anderson,R.A.,Jr., J.F. Phillips, S.H. Berryman, and L.J.D. Zaneveld Ethanol-Induced Delayed Male Puberty in Mice is not Due to Impaired Leydig Cell Function 1989; TITLE=Ethanol-Induced Delayed Male Puberty in Mice is not Due to Impaired Leydig Cell Function; AUTHOR=Anderson,R.A.,Jr., J.F. Phillips, S.H. Berryman, and L.J.D. Zaneveld; DOI=10.1016/0890-6238(89)90044-0; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116881; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Hormone(s): Androstenedione; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611043_15611133:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=05de28c9631243a349b100f970dea0b0 |
| ToxValDB_ECOTOX |
LOEL |
=3.32 |
g/org-day |
Rat |
oral |
short-term; 7 days |
reproduction developmental |
LONG_REF=J. Pharmacobio-Dyn.6(12): 913-921 Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats 1983; TITLE=Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats; AUTHOR=Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi; DOI=10.1248/bpb1978.6.913; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113098; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Enzyme(s): Aminopyrine n-demethylase|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity; STUDY_GROUP=ECOTOX:15611044:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7cde3024d4fac9741f912eaca7411916 |
| ToxValDB_ECOTOX |
LOEL |
=2.4 |
% v/v |
Mouse |
oral |
subchronic; 37 days |
developmental |
LONG_REF=Alcohol. Clin. Exp. Res.30(10): 1791-1798 Parnell,S.E., D.B. Dehart, T.A. Wills, S.Y. Chen, C.W. Hodge, J. Besheer, H.G. Waage-Baudet, M.E. Charness, and K.K. Su Maternal Oral Intake Mouse Model for Fetal Alcohol Spectrum Disorders: Ocular Defects as a Measure of Effect 2006; TITLE=Maternal Oral Intake Mouse Model for Fetal Alcohol Spectrum Disorders: Ocular Defects as a Measure of Effect; AUTHOR=Parnell,S.E., D.B. Dehart, T.A. Wills, S.Y. Chen, C.W. Hodge, J. Besheer, H.G. Waage-Baudet, M.E. Charness, and K.K. Su; DOI=10.1111/j.1530-0277.2006.00212.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113183; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Development: Weight|Morphology: Shape; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15611078:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9c3609257039f6b3b07732c854dd0280 |
| ToxValDB_ECOTOX |
LOEL |
=25000 |
mg/kg bw/day |
Mouse |
oral |
short-term; 11 days |
short-term |
LONG_REF=Biochem. Pharmacol.36(13): 2157-2167 Anderson,R.A.,Jr., B.R. Willis, J.F. Phillips, C. Oswald, and L.J.D. Zaneveld Delayed Pubertal Development of the Male Reproductive Tract Associated with Chronic Ethanol Ingestion 1987; TITLE=Delayed Pubertal Development of the Male Reproductive Tract Associated with Chronic Ethanol Ingestion; AUTHOR=Anderson,R.A.,Jr., B.R. Willis, J.F. Phillips, C. Oswald, and L.J.D. Zaneveld; DOI=10.1016/0006-2952(87)90145-6; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116882; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15611095:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6ca04de79808cead285fe1a497c2fb82 |
| ToxValDB_ECOTOX |
LOEL |
=3 |
mg/kg bw/day |
Rat |
oral |
subchronic; 8 weeks |
subchronic |
LONG_REF=- | Basic Clin. Pharmacol. Toxicol.96(6): 475-479 Verma,S.K., R. Dua, and K.D. Gill Impaired Energy Metabolism After Co-Exposure to Lead and Ethanol 2005; TITLE=Impaired Energy Metabolism After Co-Exposure to Lead and Ethanol; AUTHOR=Verma,S.K., R. Dua, and K.D. Gill; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Metabolism: Brain ATP (Adenosine triphosphate) levels|Metabolism: Brain cytochrome oxidase activity | Metabolism: Brain succinate dehydrogenase activity | Metabolism: NADH dehydrogenase activity | Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|other; STUDY_GROUP=ECOTOX:15612918:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=28f74482280184a27265d399d346cd5d |
| ToxValDB_ECOTOX |
LOEL |
=3500 |
mg/kg bw/day |
Rat |
oral |
short-term; 10 days |
reproduction developmental |
LONG_REF=- | Neurobehav. Toxicol. Teratol.7(3): 263-266 Abel,E.L., and B.A. Dintcheff Factors Affecting the Outcome of Maternal Alcohol Exposure: II. Maternal Age 1985; TITLE=Factors Affecting the Outcome of Maternal Alcohol Exposure: II. Maternal Age; AUTHOR=Abel,E.L., and B.A. Dintcheff; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116883; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain|Reproduction: Gestation time; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|reproduction; STUDY_GROUP=ECOTOX:15612989:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=4185d5a00c4ed2898eaaf5aa62f7aa1f |
| ToxValDB_ECOTOX |
LOEL |
=1600 |
mg/kg bw/day |
Mouse |
oral |
short-term; 4 weeks |
short-term |
LONG_REF=- | Indian J. Physiol. Pharmacol.49(4): 422-426 Maneesh,M., and H. Jayalekshmi Effect of Ascorbic Acid, alpha-Tocopherol, Lecithin and L-Ornithine-L-Aspartate on Ethanol Induced Hypoproteinemia and Hyperlipidemia in Rats 2005; TITLE=Effect of Ascorbic Acid, alpha-Tocopherol, Lecithin and L-Ornithine-L-Aspartate on Ethanol Induced Hypoproteinemia and Hyperlipidemia in Rats; AUTHOR=Maneesh,M., and H. Jayalekshmi; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117480; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Serum protein, albumin, globulin, A:G ratio | Serum cholesterol, triglyceride, LDLC; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15612992:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=c76856edd75c647e122283ad4210ff62 |
| ToxValDB_ECOTOX |
LOEL |
=2400 |
mg/kg bw/day |
Rat |
oral |
short-term; 6 days |
reproduction developmental |
LONG_REF=- | Alcohol14(6): 569-573 Addolorato,G., A. Gasbarrini, S. Marcoccia, M. Simoncini, P. Baccarini, G. Vagni, A. Grieco, A. Sbriccoli, A. Granato, Prenatal Exposure to Ethanol in Rats: Effects on Liver Energy Level and Antioxidant Status in Mothers, Fetuses, and Newborns 1997; TITLE=Prenatal Exposure to Ethanol in Rats: Effects on Liver Energy Level and Antioxidant Status in Mothers, Fetuses, and Newborns; AUTHOR=Addolorato,G., A. Gasbarrini, S. Marcoccia, M. Simoncini, P. Baccarini, G. Vagni, A. Grieco, A. Sbriccoli, A. Granato,; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116698; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Growth: decreased body Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15612998:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=262d85f7e693864725b8eee6a4a5f2e2 |
| ToxValDB_ECOTOX |
LOEL |
=5800 |
mg/kg bw/day |
Rat |
oral |
short-term; 4 days |
reproduction developmental |
LONG_REF=- | Neurotoxicol. Teratol.28(2): 229-237 Fakoya,F.A., and E.A. Caxton-Martins Neocortical Neurodegeneration in Young Adult Wistar Rats Prenatally Exposed to Ethanol 2006; TITLE=Neocortical Neurodegeneration in Young Adult Wistar Rats Prenatally Exposed to Ethanol; AUTHOR=Fakoya,F.A., and E.A. Caxton-Martins; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112978; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Cell(s): Density|Growth: Weight, brain weight|Morphology: Weight| Reproductive: birth weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|multiple|other; STUDY_GROUP=ECOTOX:15613108:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=435b64a7e7941b55298e1f0e45241a94 |
| ToxValDB_ECOTOX |
LOEL |
=2.23 |
mg/kg bw/day |
Rat |
oral |
chronic; 108 days |
chronic |
LONG_REF=- | J. Toxicol. Environ. Health10(21): 247-254 Messiha,F.S. Ethanol and Hypobarometric Simulated High Altitude: A Gonadal-Hepatic Toxicity Study in the Male Rat 1982; TITLE=Ethanol and Hypobarometric Simulated High Altitude: A Gonadal-Hepatic Toxicity Study in the Male Rat; AUTHOR=Messiha,F.S.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113112; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Enzyme(s): Aldehyde dehydrogenase (ALDH)|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX:15613334:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=144b4b7cae50bad99d94766c9d9fe483 |
| ToxValDB_ECOTOX |
LOEL |
=6600 |
mg/kg bw/day |
Rat |
oral |
short-term; 6 days |
reproduction developmental |
LONG_REF=- | Neurotoxicol. Teratol.11(2): 135-143 Bonthius,D.J., and J.R. West Aspirin Augments Alcohol in Restricting Brain Growth in the Neonatal Rat 1989; TITLE=Aspirin Augments Alcohol in Restricting Brain Growth in the Neonatal Rat; AUTHOR=Bonthius,D.J., and J.R. West; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116879; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Morphology: brain weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX:15613447:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=01da57cd936fd444b2c65b058d88f346 |
| ToxValDB_ECOTOX |
LOEL |
=7200 |
mg/kg bw/day |
Rat |
oral |
chronic; 98 days |
chronic |
LONG_REF=- | J. Toxicol. Environ. Health Part A68(10): 797-809 Morvai,V., E. Szakmary, and G. Ungvary The Effects of Carbon Disulfide and Ethanol on the Circulatory System of Rats 2005; TITLE=The Effects of Carbon Disulfide and Ethanol on the Circulatory System of Rats; AUTHOR=Morvai,V., E. Szakmary, and G. Ungvary; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=81806; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Daily food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX:15613454:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=8a8613121214b66eb3585b690df6ca21 |
| ToxValDB_ECOTOX |
LOEL |
=12950 |
mg/kg bw/day |
Rat |
oral |
short-term; 15 days |
reproduction developmental |
LONG_REF=- | Neurotoxicol. Teratol.15(2): 97-105 Hannigan,J.H., E.L. Abel, and M.L. Kruger \\\"Population\\\" Characteristics of Birthweight in an Animal Model of Alcohol-Related Developmental Effects 1993; TITLE="Population" Characteristics of Birthweight in an Animal Model of Alcohol-Related Developmental Effects; AUTHOR=Hannigan,J.H., E.L. Abel, and M.L. Kruger; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113329; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Progeny counts/numbers, gestational length, litter birth weights; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15613526:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=3299baab9eb488ff6426c18d3c0b41a6 |
| ToxValDB_ECOTOX |
LOEL |
=10000 |
mg/kg bw/day |
Mouse |
oral |
subchronic; 12 weeks |
subchronic |
LONG_REF=- | Am. J. Pathol.166(6): 1681-1690 Zhou,Z., L. Wang, Z. Song, J.T. Saari, C.J. McClain, and Y.J. Kang Zinc Supplementation Prevents Alcoholic Liver Injury in Mice Through Attenuation of Oxidative Stress 2005; TITLE=Zinc Supplementation Prevents Alcoholic Liver Injury in Mice Through Attenuation of Oxidative Stress; AUTHOR=Zhou,Z., L. Wang, Z. Song, J.T. Saari, C.J. McClain, and Y.J. Kang; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100803; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Decreased hepatic zinc concentrations in liver | Decreased hepatic MT concentrations in liver | Increased serum ALT levels | Increased hepatic TNF-a levels | Increased malondialdehyde in liver | Increased protein carbonyl concentrations in liver | Increased CYP2E1 and ALDH activity | Increased CYP2E1 and ALHD protein | Decreased cytosolic GHS, mitochondrial GHS, GPx concentration | Increased liver: body weight ratio, Ultrastructural changes: lipid droplet accumulation, Enlargement and degeneration of mitochondria, Disorganization of rough endoplasmic reticulum, Chromatin condensation; STUDY_GROUP=ECOTOX:15613596:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=cec6dd09177131d3b68e7fe6de9acd67 |
| ToxValDB_ECOTOX |
LOEL |
=7600 |
mg/kg bw/day |
Rat |
oral |
short-term; 4 days |
developmental |
LONG_REF=- | Neurobehav. Toxicol. Teratol.4(3): 315-321 Grant,K.A., and H.H. Samson Ethanol and Tertiary Butanol Induced Microcephaly in the Neonatal Rat: Comparison of Brain Growth Parameters 1982; TITLE=Ethanol and Tertiary Butanol Induced Microcephaly in the Neonatal Rat: Comparison of Brain Growth Parameters; AUTHOR=Grant,K.A., and H.H. Samson; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112931; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Behavior: Righting response and ability to cliff avoid, and abstinence syndrom|Biochemistry: Cholesterol reduction|Cell(s): Structural changes|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|neurobehavior|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECOTOX:15613597:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=192a31eaa91a865904fec63e6af7eb8d |
| ToxValDB_ECOTOX |
LOEL |
=9000 |
mg/kg bw/day |
Rat |
oral |
subchronic; 5 weeks |
subchronic |
LONG_REF=- | Toxicol. Sci.82(2): 656-660 Perrien,D.S., E.C. Wahl, W.R. Hogue, U. Feige, J. Aronson, M.J.J. Ronis, T.M. Badger, and C.K.,Jr. Lumpkin IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats 2004; TITLE=IL-1 and TNF Antagonists Prevent Inhibition of Fracture Healing by Ethanol in Rats; AUTHOR=Perrien,D.S., E.C. Wahl, W.R. Hogue, U. Feige, J. Aronson, M.J.J. Ronis, T.M. Badger, and C.K.,Jr. Lumpkin; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=80478; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Bone: mineral content | Fracture healing (callus analysis); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15613603:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=f2630ba7edaf3800c68278b3398e43c9 |
| ToxValDB_ECOTOX |
LOEL |
=36 |
% diet |
Rat |
oral |
short-term; 21 days |
reproduction developmental |
LONG_REF=- | J. Neuroendocrinol.18(9): 672-684 Lan,N., F. Yamashita, A.G. Halpert, L. Ellis, W.K. Yu, V. Viau, and J. Weinberg Prenatal Ethanol Exposure Alters the Effects of Gonadectomy on Hypothalamic-Pituitary-Adrenal Activity in Male Rats 2006; TITLE=Prenatal Ethanol Exposure Alters the Effects of Gonadectomy on Hypothalamic-Pituitary-Adrenal Activity in Male Rats; AUTHOR=Lan,N., F. Yamashita, A.G. Halpert, L. Ellis, W.K. Yu, V. Viau, and J. Weinberg; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112949; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Genetics: Messenger RNA levels of Gonadotrophin-releasing hormone|Growth: Body weight|Reproduction: Gestation time|Hormone(s): Adrenocorticotropic hormone; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|reproduction; STUDY_GROUP=ECOTOX:15613606:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=75827c0bde0129e05f8141e27e16d579 |
| ToxValDB_ECOTOX |
LOEL |
=12600 |
mg/kg bw/day |
Mouse |
oral |
short-term; 14 days |
reproduction developmental |
LONG_REF=- | Teratology30(1): 119-129 Uphoff,C., C. Nyquist-Battie, and R. Toth Cardiac Muscle Development in Mice Exposed to Ethanol In Utero 1984; TITLE=Cardiac Muscle Development in Mice Exposed to Ethanol In Utero; AUTHOR=Uphoff,C., C. Nyquist-Battie, and R. Toth; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112959; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Cell(s): Myocyte|Growth: Weight | Growth: length; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15613618:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=dc2c887f1856404a11ce8dede5fc2572 |
| ToxValDB_ECOTOX |
NOEL |
=7.1 |
mL/kg bw |
Mouse |
oral |
short-term; 8 days |
reproduction developmental |
LONG_REF=Dev. Pharmacol. Ther.11(4): 237-242 Kennedy,L.A., S. Mukerji, and B. Bhaumick Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration 1988; TITLE=Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration; AUTHOR=Kennedy,L.A., S. Mukerji, and B. Bhaumick; DOI=10.1159/000457694; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112739; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Weight|Hormone(s): Somatomedins|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival; STUDY_GROUP=ECOTOX:15594055:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d6c8471576434fde25105abe7c5b076e |
| ToxValDB_ECOTOX |
NOEL |
=14400 |
mg |
Mouse |
oral |
short-term; 28 days |
short-term |
LONG_REF=Alcohol Alcohol.32(5): 563-572 Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno Impaired Mouse Fertilization by Low Chronic Alcohol Treatment 1997; TITLE=Impaired Mouse Fertilization by Low Chronic Alcohol Treatment; AUTHOR=Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno; DOI=10.1093/oxfordjournals.alcalc.a008297; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116874; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Fertilization; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15594202:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=07fa83e16e343f8d316f592ef4b62731 |
| ToxValDB_ECOTOX |
NOEL |
=6 |
% w/v |
Rat |
oral |
short-term; 17 days |
reproduction developmental |
LONG_REF=Neuropharmacology22(7): 931-933 Thadani,P.V. Effect of Maternal Ethanol Administration on Synaptic Vesicles Development in Heart of Rat Offspring 1983; TITLE=Effect of Maternal Ethanol Administration on Synaptic Vesicles Development in Heart of Rat Offspring; AUTHOR=Thadani,P.V.; DOI=10.1016/0028-3908(83)90144-2; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112928; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Hormone(s): Norepinephrine|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=neurotransmitter|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594237_15610219:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7a8e83d0defeab31ad22ac45f15a9ce6 |
| ToxValDB_ECOTOX |
NOEL |
=42200 |
ppm |
Rat |
oral |
short-term (developmental); 22 days |
developmental |
LONG_REF=Metab. Clin. Exp.38(2): 149-152 Snyder,A.K., and S.P. Singh Effects of Ethanol on Glucose Turnover in Pregnant Rats 1989; TITLE=Effects of Ethanol on Glucose Turnover in Pregnant Rats; AUTHOR=Snyder,A.K., and S.P. Singh; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112955; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594300_15601480:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a686486f033bfff4e7f5cf6b9fd9f92a |
| ToxValDB_ECOTOX |
NOEL |
=20 |
% w/v |
Mouse |
oral |
chronic; 140 days |
chronic |
LONG_REF=Ann. Nutr. Metab.53(3-4): 252-259 Smith,R.R., J. Hong, A.E. Harvey, T. Lewis, D. Diaz, and N.P. Nunez Ethanol Consumption does Not Promote Weight Gain in Female Mice 2008; TITLE=Ethanol Consumption does Not Promote Weight Gain in Female Mice; AUTHOR=Smith,R.R., J. Hong, A.E. Harvey, T. Lewis, D. Diaz, and N.P. Nunez; DOI=10.1159/000189128; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116707; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Calcium weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594310_15597888:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ea9d4514378afdf35ce6830d2e78271d |
| ToxValDB_ECOTOX |
NOEL |
=10 |
% v/v |
Rat |
oral |
subchronic; 70 days |
subchronic |
LONG_REF=Arch. Environ. Health28(4): 217-222 Mahaffey,K.R., R.A. Goyer, and M.H. Wilson Influence of Ethanol Ingestion on Lead Toxicity in Rats Fed Isocaloric Diets 1974; TITLE=Influence of Ethanol Ingestion on Lead Toxicity in Rats Fed Isocaloric Diets; AUTHOR=Mahaffey,K.R., R.A. Goyer, and M.H. Wilson; DOI=10.1080/00039896.1974.10666471; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=51799; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Biochemistry: Hematocrit (anemia)|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX:15594312:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7d41806ffa50e6c6b1b676b48338b622 |
| ToxValDB_ECOTOX |
NOEL |
=20 |
% v/v |
Mouse |
oral |
short-term; 17 days |
developmental |
LONG_REF=Toxicol. Lett.4:79-82 Hood,R.D., J.M. Lary, and J.B. Blacklock Lack of Prenatal Effects of Maternal Ethanol Consumption in CD-1 Mice 1979; TITLE=Lack of Prenatal Effects of Maternal Ethanol Consumption in CD-1 Mice; AUTHOR=Hood,R.D., J.M. Lary, and J.B. Blacklock; DOI=10.1016/0378-4274(79)90077-8; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=37177; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Weight|Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development|reproduction; STUDY_GROUP=ECOTOX:15594595:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5b5b5d54e7e47bbf65dc030ae779c6c0 |
| ToxValDB_ECOTOX |
NOEL |
=4.5 |
% w/v |
Dog |
oral |
acute; 0.0208 days |
acute |
LONG_REF=Am. J. Physiol. Gasterointest. Liver Physiol.269(3, Pt. 1): G363 - G369 Charles,F., and S.F. Phillips Effects of Ethanol, Xylose, and Glucose on Canine Jejunal Motility 1995; TITLE=Effects of Ethanol, Xylose, and Glucose on Canine Jejunal Motility; AUTHOR=Charles,F., and S.F. Phillips; DOI=10.1152/ajpgi.1995.269.3.G363; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113204; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Physiology: Contraction rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594709_15594710:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=23b134d21522150b1a1eff791cc7dded |
| ToxValDB_ECOTOX |
NOEL |
=5 |
% v/v |
Rat |
oral |
subchronic; 56 days |
subchronic |
LONG_REF=Biol. Trace Elem. Res.28(2): 157-164 Flora,S.J.S., D. Kumar, S.R.S. Sachan, and S. Das Gupta Combined Exposure to Lead and Ethanol on Tissue Concentration of Essential Metals and Some Biochemical Indices in Rat 1991; TITLE=Combined Exposure to Lead and Ethanol on Tissue Concentration of Essential Metals and Some Biochemical Indices in Rat; AUTHOR=Flora,S.J.S., D. Kumar, S.R.S. Sachan, and S. Das Gupta; DOI=10.1007/BF02863081; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=86414; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Calcium content|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594732_15594733_15597153:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2b668d79bf20c25216a67761d9c67c8a |
| ToxValDB_ECOTOX |
NOEL |
=13900 |
mg |
Mouse |
oral |
short-term; 28 days |
short-term |
LONG_REF=Alcohol Alcohol.32(5): 563-572 Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno Impaired Mouse Fertilization by Low Chronic Alcohol Treatment 1997; TITLE=Impaired Mouse Fertilization by Low Chronic Alcohol Treatment; AUTHOR=Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno; DOI=10.1093/oxfordjournals.alcalc.a008297; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116874; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595538_15598190_15600014:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b81cdee36add8330adfbee5e60a5935d |
| ToxValDB_ECOTOX |
NOEL |
=30 |
% |
Rat |
oral |
short-term; 14 days |
short-term |
LONG_REF=Biol. Trace Elem. Res.100(3): 247-257 Pathak,A., A. Mahmood, R. Pathak, and D. Dhawan Role of Zinc on Lipid Peroxidation and Antioxidative Enzymes in Intestines of Ethanol-Fed Rats 2004; TITLE=Role of Zinc on Lipid Peroxidation and Antioxidative Enzymes in Intestines of Ethanol-Fed Rats; AUTHOR=Pathak,A., A. Mahmood, R. Pathak, and D. Dhawan; DOI=10.1385/BTER:100:3:247; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100367; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Enzyme(s): Glutathione reductase|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595694_15596875:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8c333ec9188c0394d72819ab5fa77e69 |
| ToxValDB_ECOTOX |
NOEL |
=0.4 |
mL/kg |
Rat |
oral |
short-term; 27 days |
short-term |
LONG_REF=J. Toxicol. Environ. Health10:267-276 Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats 1982; TITLE=Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats; AUTHOR=Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham; DOI=10.1080/15287398209530249; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112708; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Growth: Weight|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival; STUDY_GROUP=ECOTOX:15596085:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=96b7aa003325c258d7c1015b9b16fbf8 |
| ToxValDB_ECOTOX |
NOEL |
=5 |
% w/v |
Rat |
oral |
chronic; 119 days |
chronic |
LONG_REF=Pharmacol. Biochem. Behav.19(4): 583-585 Krueger,W.A., W.J. Bo, and P.K. Rudeen Estrous Cyclicity in Rats Fed an Ethanol Diet for Four Months 1983; TITLE=Estrous Cyclicity in Rats Fed an Ethanol Diet for Four Months; AUTHOR=Krueger,W.A., W.J. Bo, and P.K. Rudeen; DOI=10.1016/0091-3057(83)90331-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115198; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596244_15597376:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3a39ddf18558bf8578459ad18c97b504 |
| ToxValDB_ECOTOX |
NOEL |
=15 |
% v/v |
Mouse |
oral |
short-term; 8 days |
developmental |
LONG_REF=Can. J. Physiol. Pharmacol.64(7): 1032-1037 Kennedy,L.A., S. Mukerji, and M.J. Elliott The Ontogeny of Placental Na+-K+ Atpase in the Mouse and Its Impairment by Ethanol 1986; TITLE=The Ontogeny of Placental Na+-K+ Atpase in the Mouse and Its Impairment by Ethanol; AUTHOR=Kennedy,L.A., S. Mukerji, and M.J. Elliott; DOI=10.1139/y86-176; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112961; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Development: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596371_15596372:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8b088535a6064cb24a4f419613b9415d |
| ToxValDB_ECOTOX |
NOEL |
=0.1 |
% |
Rat |
environmental |
short-term; 2 days |
developmental |
LONG_REF=Toxicology30(1): 45-57 Kitchin,K.T., and M.T. Ebron Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System 1984; TITLE=Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System; AUTHOR=Kitchin,K.T., and M.T. Ebron; DOI=10.1016/0300-483x(84)90061-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115431; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Development: Abnormal|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596656_15596657:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fbb537b38511f705710c616cc63c4bc7 |
| ToxValDB_ECOTOX |
NOEL |
=3790 |
mg/day |
Rat |
oral |
subchronic; 60 days |
subchronic |
LONG_REF=Alcohol11(5): 355-360 Gonzalez-Reimers,E., A. Martinez-Riera, F. Santolaria-Fernandez, A. Conde-Martel, H. Alvarez-Arguelles, C. Santana-Herr Relative and Combined Effects of Ethanol and Protein Deficiency on Gonadal Function and Histology 1994; TITLE=Relative and Combined Effects of Ethanol and Protein Deficiency on Gonadal Function and Histology; AUTHOR=Gonzalez-Reimers,E., A. Martinez-Riera, F. Santolaria-Fernandez, A. Conde-Martel, H. Alvarez-Arguelles, C. Santana-Herr; DOI=10.1016/0741-8329(94)90017-5; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116711; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596808_15598880_15607332:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f0979b8516fcd2ac98ced94b01fca9b1 |
| ToxValDB_ECOTOX |
NOEL |
=2400 |
mg/kg bw/day |
Rat |
oral |
acute; 0.1667 days |
acute |
LONG_REF=Food Chem.99(2): 305-314 Yao,P., K. Li, Y. Jin, F. Song, S. Zhou, X. Sun, A.K. Nussler, and L. Liu Oxidative Damage After Chronic Ethanol Intake in Rat Tissues: Prophylaxis of Ginkgo biloba Extract 2006; TITLE=Oxidative Damage After Chronic Ethanol Intake in Rat Tissues: Prophylaxis of Ginkgo biloba Extract; AUTHOR=Yao,P., K. Li, Y. Jin, F. Song, S. Zhou, X. Sun, A.K. Nussler, and L. Liu; DOI=10.1016/j.foodchem.2005.07.047; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=114291; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597022_15598079:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=06ff942cb5fb46590c04ada118696a7a |
| ToxValDB_ECOTOX |
NOEL |
=25 |
% v/v |
Mouse |
injection |
subchronic; 51 days |
developmental |
LONG_REF=Behav. Brain Res.186(2): 230-238 Summers,B.L., C.M.A. Henry, A.M. Rofe, and P. Coyle Dietary Zinc Supplementation During Pregnancy Prevents Spatial and Object Recognition Memory Impairments Caused by Early Prenatal Ethanol Exposure 2008; TITLE=Dietary Zinc Supplementation During Pregnancy Prevents Spatial and Object Recognition Memory Impairments Caused by Early Prenatal Ethanol Exposure; AUTHOR=Summers,B.L., C.M.A. Henry, A.M. Rofe, and P. Coyle; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101711; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15597309:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=391b8267421eafe5fa087c83bd771328 |
| ToxValDB_ECOTOX |
NOEL |
=6 |
% v/v |
Rat |
oral |
short-term; 14 days |
short-term |
LONG_REF=Dev. Pharmacol. Ther.7(3): 177-187 Henderson,G.I., and S. Schenker Effects of Ethanol and/or Caffeine on Fetal Development and Placental Amino Acid Uptake in Rats 1984; TITLE=Effects of Ethanol and/or Caffeine on Fetal Development and Placental Amino Acid Uptake in Rats; AUTHOR=Henderson,G.I., and S. Schenker; DOI=10.1159/000457161; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113104; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15597406:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b48008a38127eead03bd9cd449e672d8 |
| ToxValDB_ECOTOX |
NOEL |
=13050 |
ppm |
Rat |
oral |
short-term; 22.03 days |
reproduction developmental |
LONG_REF=Neurotoxicol. Teratol.16(1): 31-39 Blanchard,B.A., and J.H. Hannigan Prenatal Ethanol Exposure: Effects on Androgen and Nonandrogen Dependent Behaviors and on Gonadal Development in Male Rats 1994; TITLE=Prenatal Ethanol Exposure: Effects on Androgen and Nonandrogen Dependent Behaviors and on Gonadal Development in Male Rats; AUTHOR=Blanchard,B.A., and J.H. Hannigan; DOI=10.1016/0892-0362(94)90006-x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=116927; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Population: Sex ratio|Reproduction: Gestation time; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597955_15604973:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=58ba578d5d7738d80e69c472c9de4f28 |
| ToxValDB_ECOTOX |
NOEL |
=2.5 |
mL/kg |
Rat |
injection |
acute; 1 days |
acute |
LONG_REF=Toxicology124:125-134 Valentovic,M.A., T. Yahia, J.G. Ball, S.K. Hong, P.I. Brown, and G.O. Rankin 3,4-Dicholoroaniline Acute Toxicity in Male Fischer 344 Rats 1997; TITLE=3,4-Dicholoroaniline Acute Toxicity in Male Fischer 344 Rats; AUTHOR=Valentovic,M.A., T. Yahia, J.G. Ball, S.K. Hong, P.I. Brown, and G.O. Rankin; DOI=10.1016/s0300-483x(97)00143-1; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=102307; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Growth: Weight|Physiology: Excretion rate; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598255_15598543:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e8ec70af18a0c167f98308e3d62216f1 |
| ToxValDB_ECOTOX |
NOEL |
=10 |
mmol/kg |
Rat |
oral |
short-term; 1.75 days |
short-term |
LONG_REF=Fundam. Appl. Toxicol.15(3): 429-440 Ray,S.D., and H.M. Mehendale Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols 1990; TITLE=Potentiation of CCL4 and CHCL3 Hepatotoxicity and Lethality by Various Alcohols; AUTHOR=Ray,S.D., and H.M. Mehendale; DOI=10.1016/0272-0590(90)90029-j; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=78954; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Aspartate aminotransferase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15598446:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7ed4d6709103a0e240381da7bea6ad93 |
| ToxValDB_ECOTOX |
NOEL |
=4 |
mL/kg |
Rat |
oral |
short-term; 9 days |
short-term |
LONG_REF=J. Toxicol. Environ. Health10:267-276 Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats 1982; TITLE=Teratogenic and Reproductive Effects of Ethanol in Long-Evans Rats; AUTHOR=Mankes,R.F., I. Rosenblum, K.F. Benitz, R. LeFevre, and R. Abraham; DOI=10.1080/15287398209530249; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112708; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Reproduction: Pregnant, Paris or Gravid; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598579_15601507_15601508:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ed2f9e6ebccce2fd63cd03a3872ef825 |
| ToxValDB_ECOTOX |
NOEL |
=8 |
% v/v |
Rat |
oral |
subchronic; 56 days |
subchronic |
LONG_REF=Pharmacol. Toxicol.76(2): 107-111 Nylen,P., M. Hagman, and A.C. Johnson Function of the Auditory System, the Visual System, and Peripheral Nerve and Long-Term Combined Exposure to Toluene and Ethanol in Rats 1995; TITLE=Function of the Auditory System, the Visual System, and Peripheral Nerve and Long-Term Combined Exposure to Toluene and Ethanol in Rats; AUTHOR=Nylen,P., M. Hagman, and A.C. Johnson; DOI=10.1111/j.1600-0773.1995.tb00113.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=52765; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598646_15609028:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=157d160f1cd8ef6c8ae521064678c035 |
| ToxValDB_ECOTOX |
NOEL |
=5 |
% |
Rat |
oral |
short-term; 18 days |
developmental |
LONG_REF=Exp. Pathol. (Jena)25(4): 205-213 Jones,W.L., and D.B. Stewart Effects of Orally-Administered Ethanol on Mammary Gland Morphology and Functional Efficiency in Lactating Rats 1984; TITLE=Effects of Orally-Administered Ethanol on Mammary Gland Morphology and Functional Efficiency in Lactating Rats; AUTHOR=Jones,W.L., and D.B. Stewart; DOI=10.1016/s0232-1513(84)80022-5; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=113117; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15598778:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0f0d95951138dd91ced58a9c06b3e611 |
| ToxValDB_ECOTOX |
NOEL |
=4000 |
mg/L |
Rat |
oral |
subchronic; 56 days |
subchronic |
LONG_REF=Alcohol16(2): 135-138 Cagiano,R., M. Tattoli, M. Persichella, M. Mazzoccoli, S. Govoni, and V. Cuomo Effects of Chronic Low-Dose Ethanol Intake on Sexual Behavior in Rats 1998; TITLE=Effects of Chronic Low-Dose Ethanol Intake on Sexual Behavior in Rats; AUTHOR=Cagiano,R., M. Tattoli, M. Persichella, M. Mazzoccoli, S. Govoni, and V. Cuomo; DOI=10.1016/s0741-8329(97)00182-1; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116873; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15599673:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=826d40ad7ebd2efe6062cc3090a29a93 |
| ToxValDB_ECOTOX |
NOEL |
=8500 |
mg |
Mouse |
oral |
short-term; 28 days |
short-term |
LONG_REF=Alcohol Alcohol.32(5): 563-572 Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno Impaired Mouse Fertilization by Low Chronic Alcohol Treatment 1997; TITLE=Impaired Mouse Fertilization by Low Chronic Alcohol Treatment; AUTHOR=Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno; DOI=10.1093/oxfordjournals.alcalc.a008297; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116874; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Fertilization; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595538_15598190_15600014:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=62ebd015aba801d32909bf7b58d2e1ad |
| ToxValDB_ECOTOX |
NOEL |
=1250 |
mg/kg bw/day |
Rat |
oral |
short-term; 4.5 days |
short-term |
LONG_REF=Alcohol Alcohol.35(5): 439-445 Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, M. Galazyn-Sidorczuk, and J. Rogalska Effect of Short-Term Ethanol Administration on Cadmium Retention and Bioelement Metabolism in Rats Continuously Exposed to Cadmium 2000; TITLE=Effect of Short-Term Ethanol Administration on Cadmium Retention and Bioelement Metabolism in Rats Continuously Exposed to Cadmium; AUTHOR=Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, M. Galazyn-Sidorczuk, and J. Rogalska; DOI=10.1093/alcalc/35.5.439; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=85532; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption|Growth: Weight gain|Physiology: Excretion rate; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600252_15604207:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=94f3f8ecded6a41a9701c8d2ab4b81e3 |
| ToxValDB_ECOTOX |
NOEL |
=2000 |
ppm |
Rat |
oral |
short-term; 5 days |
short-term |
LONG_REF=Biochem. Pharmacol.34(22): 3979-3982 Eriksson,C.J.P. Endogenous Acetaldehyde in Rats. Effects of Exogenous Ethanol, Pyrazole, Cyanamide and Disulfiram 1985; TITLE=Endogenous Acetaldehyde in Rats. Effects of Exogenous Ethanol, Pyrazole, Cyanamide and Disulfiram; AUTHOR=Eriksson,C.J.P.; DOI=10.1016/0006-2952(85)90375-2; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=99133; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: Acetaldehyde|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601244_15604577:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=746669d72c1094a43b0ee7b007a74e03 |
| ToxValDB_ECOTOX |
NOEL |
=1240 |
mg/kg bw/day |
Mouse |
oral |
short-term; 5 days |
short-term |
LONG_REF=Steroids23(6): 921-928 Badr,F.M., and A. Bartke Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice 1974; TITLE=Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice; AUTHOR=Badr,F.M., and A. Bartke; DOI=10.1016/0039-128x(74)90064-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112967; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601680_15602688_15602689:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4bf509f949d4ba14ceddf79e779d452b |
| ToxValDB_ECOTOX |
NOEL |
=2000 |
mg/kg bw/day |
Dog |
oral |
acute; 0.25 days |
acute |
LONG_REF=Toxicol. Appl. Pharmacol.18(3): 660-664 Reves,J.G., and W.H. Newman Blood Volume Following Acute Ethyl Alcohol Ingestion in Dogs 1971; TITLE=Blood Volume Following Acute Ethyl Alcohol Ingestion in Dogs; AUTHOR=Reves,J.G., and W.H. Newman; DOI=10.1016/s0041-008x(71)80020-0; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113099; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Biochemistry: Hematocrit (anemia)|Physiology: Volume; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX:15601788:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=edf86fbd349134d814e490e8c42f7310 |
| ToxValDB_ECOTOX |
NOEL |
=0.5 |
% |
Rat |
environmental |
short-term; 2 days |
short-term |
LONG_REF=Toxicology30(1): 45-57 Kitchin,K.T., and M.T. Ebron Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System 1984; TITLE=Further Development of Rodent Whole Embryo Culture: Solvent Toxicity and Water Insoluble Compound Delivery System; AUTHOR=Kitchin,K.T., and M.T. Ebron; DOI=10.1016/0300-483x(84)90061-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=115431; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602437_15602438:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3f0b680b8e5a0d0acfeb3c5ad51839aa |
| ToxValDB_ECOTOX |
NOEL |
=155 |
mg/kg bw/day |
Mouse |
oral |
short-term; 5 days |
short-term |
LONG_REF=Steroids23(6): 921-928 Badr,F.M., and A. Bartke Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice 1974; TITLE=Effect of Ethyl Alcohol on Plasma Testosterone Level in Mice; AUTHOR=Badr,F.M., and A. Bartke; DOI=10.1016/0039-128x(74)90064-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112967; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601680_15602688_15602689:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8f74191dfc6498e439242773213b4c37 |
| ToxValDB_ECOTOX |
NOEL |
=9504 |
mg/kg bw/day |
Dog |
injection |
acute; 0.125 days |
acute |
LONG_REF=Am. J. Physiol.267(5, Pt. 2): R1280 - R1287 Molina,P.E., K. Jabbour, P. Williams, and N.N. Abumrad Effect of Acute Ethanol Intoxication on Glucoregulation During Prolonged Insulin-Induced Hypoglycemia 1994; TITLE=Effect of Acute Ethanol Intoxication on Glucoregulation During Prolonged Insulin-Induced Hypoglycemia; AUTHOR=Molina,P.E., K. Jabbour, P. Williams, and N.N. Abumrad; DOI=10.1152/ajpregu.1994.267.5.R1280; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=112704; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Hormone(s): Cortisol; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15603496:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3e3f970bca0ef69fe118baf8c470bc0f |
| ToxValDB_ECOTOX |
NOEL |
=0.1 |
% v/v |
Mouse |
environmental |
short-term; 8 days |
developmental |
LONG_REF=J. Reprod. Fertil.80(1): 49-57 Wiebold,J.L., and W.C. Becker In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos 1987; TITLE=In-Vivo and In-Vitro Effects of Ethanol on Mouse Preimplantation Embryos; AUTHOR=Wiebold,J.L., and W.C. Becker; DOI=10.1530/jrf.0.0800049; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113118; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Development: Blastocyst stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15603581:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=98831727c27d1c97cb3ac3ac55b17832 |
| ToxValDB_ECOTOX |
NOEL |
=3000 |
mg/kg bw/day |
Rat |
oral |
short-term; 7.2917 days |
short-term |
LONG_REF=Braz. J. Med. Biol. Res.26(11): 1241-1244 Guedes,R.C.A., and S.F. Frade Effect of Ethanol on Cortical Spreading Depression 1993; TITLE=Effect of Ethanol on Cortical Spreading Depression; AUTHOR=Guedes,R.C.A., and S.F. Frade; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=115287; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Physiology: Nerve conduction velocity; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15603685:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=718e306e65d6c3bf291f21423824cd33 |
| ToxValDB_ECOTOX |
NOEL |
=2.5 |
% |
Mouse |
oral |
short-term; 28 days |
short-term |
LONG_REF=Alcohol Alcohol.32(5): 563-572 Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno Impaired Mouse Fertilization by Low Chronic Alcohol Treatment 1997; TITLE=Impaired Mouse Fertilization by Low Chronic Alcohol Treatment; AUTHOR=Cebral,E., A. Lasserre, V. Rettori, and M.A.F. De Gimeno; DOI=10.1093/oxfordjournals.alcalc.a008297; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116874; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Fertilization; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603004_15603970:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a1a6d599b5ee3de1aded85394e98e565 |
| ToxValDB_ECOTOX |
NOEL |
=40 |
mg/kg bw/day |
Dog |
injection |
acute; 0.0042 days |
acute |
LONG_REF=Alcohol. Clin. Exp. Res.5(1): 56-63 Stratton,R., K.J. Dormer, and A.R. Zeiner The Cardiovascular Effects of Ethanol and Acetaldehyde in Exercising Dogs 1981; TITLE=The Cardiovascular Effects of Ethanol and Acetaldehyde in Exercising Dogs; AUTHOR=Stratton,R., K.J. Dormer, and A.R. Zeiner; DOI=10.1111/j.1530-0277.1981.tb04865.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112741; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Physiology: Heart rate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604075_15604076:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7de78534f409346eba8946244b4eccd7 |
| ToxValDB_ECOTOX |
NOEL |
=3.6 |
% w/v |
Mouse |
oral |
short-term; 15 days |
reproduction developmental |
LONG_REF=J. Pharmacol. Exp. Ther.222(2): 294-300 Daniel,M.A., and M.A. Evans Quantitative Comparison of Maternal Ethanol and Maternal Tertiary Butanol Diet on Postnatal Development 1982; TITLE=Quantitative Comparison of Maternal Ethanol and Maternal Tertiary Butanol Diet on Postnatal Development; AUTHOR=Daniel,M.A., and M.A. Evans; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=112707; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15604388:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a22cedfb7c4ed6469744ff59680bd0a0 |
| ToxValDB_ECOTOX |
NOEL |
=20928 |
mg/kg bw/day |
Rat |
oral |
subchronic; 49 days |
subchronic |
LONG_REF=Biosci. Biotechnol. Biochem.56(12): 2037-2040 Mochizuki,S., Y. Watanabe, K. Kato, and A. Yoshida Effects of Ethanol and Polychlorinated Biphenyls in Combination on Ascorbic Acid Metabolism, Liver Drug-Metabolizing Enzymes, and Lipid Metabolism in Rats 1992; TITLE=Effects of Ethanol and Polychlorinated Biphenyls in Combination on Ascorbic Acid Metabolism, Liver Drug-Metabolizing Enzymes, and Lipid Metabolism in Rats; AUTHOR=Mochizuki,S., Y. Watanabe, K. Kato, and A. Yoshida; DOI=10.1271/bbb.56.576; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=74769; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604464_15605798:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d961b642257c534de8056766d29691d2 |
| ToxValDB_ECOTOX |
NOEL |
=1500 |
mg/kg bw/day |
Rat |
injection |
acute; 0.0174 days |
acute |
LONG_REF=Neurotoxicol. Teratol.21(5): 551-557 Virgolini,M.B., L.M. Cancela, and S. Fulginiti Behavioral Responses to Ethanol in Rats Perinatally Exposed to Low Lead Levels 1999; TITLE=Behavioral Responses to Ethanol in Rats Perinatally Exposed to Low Lead Levels; AUTHOR=Virgolini,M.B., L.M. Cancela, and S. Fulginiti; DOI=10.1016/s0892-0362(99)00020-3; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113348; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Behavior: Activity, general; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605082_15605083:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4c95e20f5bfb1a879606bfdbcd3974a1 |
| ToxValDB_ECOTOX |
NOEL |
=65.4 |
mL |
Rat |
oral |
short-term; 19 days |
reproduction developmental |
LONG_REF=Alcohol33(2): 83-89 Peres,W.A.F., M.G.T. Carmo, S. Zucoloto, A.C. Iglesias, and V.B. Braulio Ethanol Intake Inhibits Growth of the Epithelium in the Intestine of Pregnant Rats 2004; TITLE=Ethanol Intake Inhibits Growth of the Epithelium in the Intestine of Pregnant Rats; AUTHOR=Peres,W.A.F., M.G.T. Carmo, S. Zucoloto, A.C. Iglesias, and V.B. Braulio; DOI=10.1016/j.alcohol.2004.05.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113181; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Physiology: Digestion|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15605214:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7d8e0120949824aee6734a7d42f14caa |
| ToxValDB_ECOTOX |
NOEL |
=800 |
mg/100 mL |
Mouse |
environmental |
short-term; 3 days |
developmental |
LONG_REF=Experientia45(5): 484-487 Kalmus,G.W., and C.C. Buckenmaier III Effects of Ethanol and Acetaldehyde on Cultured Pre-Implantation Mouse Embryos 1989; TITLE=Effects of Ethanol and Acetaldehyde on Cultured Pre-Implantation Mouse Embryos; AUTHOR=Kalmus,G.W., and C.C. Buckenmaier III; DOI=10.1007/BF01952040; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112963; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Development: Stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15605635:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a7829ad2e9a6d183779fd5d0b8a2844d |
| ToxValDB_ECOTOX |
NOEL |
=5 |
mL/kg bw |
Mouse |
oral |
acute; 1 days |
acute |
LONG_REF=J. Toxicol. Environ. Health18(4): 575-587 Lin,S.C., H. Saito, T. Yohro, and J. Shiga Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus 1986; TITLE=Acute Hepatotoxicity Induced by Hepatotoxins in Suncus murinus; AUTHOR=Lin,S.C., H. Saito, T. Yohro, and J. Shiga; DOI=10.1080/15287398609530895; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=112721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT); TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606994_15606995_15606996:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=929bb90355eccf0a97d7d71f87d05bbb |
| ToxValDB_ECOTOX |
NOEL |
=2 |
% w/v |
Mouse |
oral |
short-term; 18 days |
developmental |
LONG_REF=Toxicology242(1-3): 109-122 Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts 2007; TITLE=Protective Effects of Resveratrol on Ethanol-Induced Apoptosis in Embryonic Stem Cells and Disruption of Embryonic Development in Mouse Blastocysts; AUTHOR=Huang,L.H., N.H. Shiao, Y.D. Hsuuw, and W.H. Chan; DOI=10.1016/j.tox.2007.09.015; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107979; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15607035:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=de7ed87d87d0783fea15430e88953eea |
| ToxValDB_ECOTOX |
NOEL |
=500 |
mg/kg bw/day |
Dog |
injection |
acute; 0.0208 days |
acute |
LONG_REF=Anesth. Analg.96(3): 665-672 Weber,T.P., M.A.G. Hartlage, N. Rolf, M. Booke, E. Berendes, H. Van Aken, and A. Meissner Short-Term Administration of Ethanol does Not Affect Functional Recovery from Myocardial Stunning in Awake Dogs 2003; TITLE=Short-Term Administration of Ethanol does Not Affect Functional Recovery from Myocardial Stunning in Awake Dogs; AUTHOR=Weber,T.P., M.A.G. Hartlage, N. Rolf, M. Booke, E. Berendes, H. Van Aken, and A. Meissner; DOI=10.1213/01.ANE.0000048712.95074.CD; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113175; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX:15607241:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e333ba8b772232856bde13a43b6aeedf |
| ToxValDB_ECOTOX |
NOEL |
=4.8 |
g/L |
Mouse |
environmental |
short-term; 2 days |
developmental |
LONG_REF=Neurotoxicol. Teratol.17(4): 497-506 Van Maele-Fabry,G., F. Gofflot, F. Clotman, and J.J. Picard Alterations of Mouse Embryonic Branchial Nerves and Ganglia Induced by Ethanol 1995; TITLE=Alterations of Mouse Embryonic Branchial Nerves and Ganglia Induced by Ethanol; AUTHOR=Van Maele-Fabry,G., F. Gofflot, F. Clotman, and J.J. Picard; DOI=10.1016/0892-0362(95)00009-g; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=55098; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Development: Organ/tissue formation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15607265:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=86c49e053ca5623c17b54a2e1e95bf0c |
| ToxValDB_ECOTOX |
NOEL |
=200 |
mg/100 mL |
Rat |
environmental |
short-term; 2 days |
short-term |
LONG_REF=Biochem. Pharmacol.31(22): 3641-3643 Priscott,P.K. The Effects of Ethanol on Rat Embryos Developing In Vitro 1982; TITLE=The Effects of Ethanol on Rat Embryos Developing In Vitro; AUTHOR=Priscott,P.K.; DOI=10.1016/0006-2952(82)90588-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Morphology: Length; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15607345_15607346:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=93c085a774a0ca2b75d3d4066ee41ea4 |
| ToxValDB_ECOTOX |
NOEL |
=390 |
mg/100 mL |
Rat |
environmental |
short-term; 2 days |
developmental |
LONG_REF=Biochem. Pharmacol.31(22): 3641-3643 Priscott,P.K. The Effects of Ethanol on Rat Embryos Developing In Vitro 1982; TITLE=The Effects of Ethanol on Rat Embryos Developing In Vitro; AUTHOR=Priscott,P.K.; DOI=10.1016/0006-2952(82)90588-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Development: Stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608138_15608139:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1c151691308d8909e58eafa7547e5af9 |
| ToxValDB_ECOTOX |
NOEL |
=5000 |
mg/kg bw/day |
Mouse |
oral |
short-term; 3 days |
short-term |
LONG_REF=Toxicol. Appl. Pharmacol.74(2): 230-236 Waalkes,M.P., J.J. Hjelle, and C.D. Klaassen Transient Induction of Hepatic Metallothionein Following Oral Ethanol Administration 1984; TITLE=Transient Induction of Hepatic Metallothionein Following Oral Ethanol Administration; AUTHOR=Waalkes,M.P., J.J. Hjelle, and C.D. Klaassen; DOI=10.1016/0041-008x(84)90147-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=87717; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15608653:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=80c61be7bf575c338e8889f1c020406c |
| ToxValDB_ECOTOX |
NOEL |
=5.5 |
mL/kg bw |
Mouse |
oral |
short-term; 8 days |
developmental |
LONG_REF=Dev. Pharmacol. Ther.11(4): 237-242 Kennedy,L.A., S. Mukerji, and B. Bhaumick Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration 1988; TITLE=Mouse Placental Receptor for Basic Somatomedin Following Maternal Ethanol Administration; AUTHOR=Kennedy,L.A., S. Mukerji, and B. Bhaumick; DOI=10.1159/000457694; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112739; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610158_15610159:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=64a5a3d9b4400e23443378d9d2556c79 |
| ToxValDB_ECOTOX |
NOEL |
=4 |
mg/mL |
Mouse |
environmental |
short-term; 2 days |
short-term |
LONG_REF=Toxicol. In Vitro18(5): 601-607 Jing,H., and Y. Li Effects of Ethanol on Mouse Embryonic Brain Development and Heat Shock Protein 73 Expression 2004; TITLE=Effects of Ethanol on Mouse Embryonic Brain Development and Heat Shock Protein 73 Expression; AUTHOR=Jing,H., and Y. Li; DOI=10.1016/j.tiv.2004.02.004; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=116709; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Heat shock protein 70; STUDY_GROUP=ECOTOX:15610249:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f1fc0786e10a495ef2eb593e6dd36ad1 |
| ToxValDB_ECOTOX |
NOEL |
=1 |
% |
Mouse |
oral |
subchronic; 70 days |
subchronic |
LONG_REF=Toxicol. Appl. Pharmacol.220(3): 302-310 Wahl,E.C., J. Aronson, L. Liu, Z. Liu, D.S. Perrien, R.A. Skinner, T.M. Badger, M.J.J. Ronis, and C.K.,Jr. Lumpkin Chronic Ethanol Exposure Inhibits Distraction Osteogenesis in a Mouse Model: Role of the TNF Signaling Axis 2007; TITLE=Chronic Ethanol Exposure Inhibits Distraction Osteogenesis in a Mouse Model: Role of the TNF Signaling Axis; AUTHOR=Wahl,E.C., J. Aronson, L. Liu, Z. Liu, D.S. Perrien, R.A. Skinner, T.M. Badger, M.J.J. Ronis, and C.K.,Jr. Lumpkin; DOI=10.1016/j.taap.2007.02.011; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113160; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610815_15610967:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0fa022030b5981bd5e7ce175d2a88649 |
| ToxValDB_ECOTOX |
NOEL |
=2.97 |
g/org-day |
Rat |
oral |
short-term; 28 days |
reproduction developmental |
LONG_REF=J. Pharmacobio-Dyn.6(12): 913-921 Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats 1983; TITLE=Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats; AUTHOR=Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi; DOI=10.1248/bpb1978.6.913; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113098; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome P-450|Growth: Weight|Morphology: Organ weight in relationship to body weight|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|organ weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610849_15610990_15611092:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8c2568334bb7d66cfecd9cfd007ce841 |
| ToxValDB_ECOTOX |
NOEL |
=12 |
% |
Rat |
oral |
subchronic; 34 days |
subchronic |
LONG_REF=Arch. Toxicol.55(4): 258-264 Elves,R.G., T.H. Ueng, and A.P. Alvares Comparative Effects of Ethanol Administration on Hepatic Monooxygenases in Rats and Mice 1984; TITLE=Comparative Effects of Ethanol Administration on Hepatic Monooxygenases in Rats and Mice; AUTHOR=Elves,R.G., T.H. Ueng, and A.P. Alvares; DOI=10.1007/BF00341022; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=105811; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Microsomal proteins|Enzyme(s): Cytochrome P-450|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610859_15610888:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=44df1eb75bf9435a9496e32c14edf737 |
| ToxValDB_ECOTOX |
NOEL |
=25000 |
mg/kg bw/day |
Mouse |
oral |
subchronic; 45 days |
subchronic |
LONG_REF=Biochem. Pharmacol.36(13): 2157-2167 Anderson,R.A.,Jr., B.R. Willis, J.F. Phillips, C. Oswald, and L.J.D. Zaneveld Delayed Pubertal Development of the Male Reproductive Tract Associated with Chronic Ethanol Ingestion 1987; TITLE=Delayed Pubertal Development of the Male Reproductive Tract Associated with Chronic Ethanol Ingestion; AUTHOR=Anderson,R.A.,Jr., B.R. Willis, J.F. Phillips, C. Oswald, and L.J.D. Zaneveld; DOI=10.1016/0006-2952(87)90145-6; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116882; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Biochemistry: Fructose|Cell(s): Number of cells|Enzyme(s): Acid phosphatase|Reproduction: Fertility; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|nonneoplastic histopathology|other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610861_15610884:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=309984ed8a7faad05481acac9d5317cf |
| ToxValDB_ECOTOX |
NOEL |
=2 |
% v/v |
Rat |
oral |
short-term (developmental); 20 days |
developmental |
LONG_REF=Pediatr. Res.19(1): 12-14 Inselman,L.S., S.E. Fisher, H. Spencer, and M. Atkinson Effect of Intrauterine Ethanol Exposure on Fetal Lung Growth 1985; TITLE=Effect of Intrauterine Ethanol Exposure on Fetal Lung Growth; AUTHOR=Inselman,L.S., S.E. Fisher, H. Spencer, and M. Atkinson; DOI=10.1203/00006450-198501000-00004; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113116; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610877_15610937:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=81cbdfd4576428f07192a9be7d037e99 |
| ToxValDB_ECOTOX |
NOEL |
=4 |
% |
Mouse |
oral |
short-term; 29 days |
reproduction developmental |
LONG_REF=Behav. Brain Funct.1(5): 1-10 Sluyter,F., L. Jamot, J.Y. Bertholet, and W.E. Crusio Prenatal Exposure to Alcohol does not Affect Radial Maze Learning and Hippocampal Mossy Fiber Sizes in Three Inbred Strains of Mouse 2005; TITLE=Prenatal Exposure to Alcohol does not Affect Radial Maze Learning and Hippocampal Mossy Fiber Sizes in Three Inbred Strains of Mouse; AUTHOR=Sluyter,F., L. Jamot, J.Y. Bertholet, and W.E. Crusio; DOI=10.1186/1744-9081-1-5; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113168; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Reproduction: Reproductive success (general); TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610898_15611094:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5465d8f8ca85bd741890d4c9a301c19a |
| ToxValDB_ECOTOX |
NOEL |
=2.4 |
% v/v |
Mouse |
oral |
subchronic; 37 days |
reproduction developmental |
LONG_REF=Alcohol. Clin. Exp. Res.30(10): 1791-1798 Parnell,S.E., D.B. Dehart, T.A. Wills, S.Y. Chen, C.W. Hodge, J. Besheer, H.G. Waage-Baudet, M.E. Charness, and K.K. Su Maternal Oral Intake Mouse Model for Fetal Alcohol Spectrum Disorders: Ocular Defects as a Measure of Effect 2006; TITLE=Maternal Oral Intake Mouse Model for Fetal Alcohol Spectrum Disorders: Ocular Defects as a Measure of Effect; AUTHOR=Parnell,S.E., D.B. Dehart, T.A. Wills, S.Y. Chen, C.W. Hodge, J. Besheer, H.G. Waage-Baudet, M.E. Charness, and K.K. Su; DOI=10.1111/j.1530-0277.2006.00212.x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113183; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15610964:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d1a51f7602a1d14ca87cfb0cf6ffefbd |
| ToxValDB_ECOTOX |
NOEL |
=2.8 |
g/org-day |
Rat |
oral |
short-term; 28 days |
reproduction developmental |
LONG_REF=J. Pharmacobio-Dyn.6(12): 913-921 Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats 1983; TITLE=Influences of Maternal Ethanol Intake on Maternal and Perinatal Hepatic Heme and Drug Metabolizing Enzymes in Rats; AUTHOR=Terada,N., T. Nakai, M. Yamaguchi, A. Hatta, K. Arizono, and T. Ariyoshi; DOI=10.1248/bpb1978.6.913; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113098; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome P-450|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610849_15610990_15611092:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0b9006a39cc4b8013785b2a6549139dd |
| ToxValDB_ECOTOX |
NOEL |
=2.5 |
% w/v |
Rat |
oral |
subchronic; 55 days |
subchronic |
LONG_REF=Anat. Rec.202:255-260 Bo,W.J., W.A. Krueger, P.K. Rudeen, and S.K. Symmes Ethanol-Induced Alterations in the Morphology and Function of the Rat Ovary 1982; TITLE=Ethanol-Induced Alterations in the Morphology and Function of the Rat Ovary; AUTHOR=Bo,W.J., W.A. Krueger, P.K. Rudeen, and S.K. Symmes; DOI=10.1002/ar.1092020210; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=112426; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Organ weight in relationship to body weight|Reproduction: Vaginal opening; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611236_15611237:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7bdbb42a9f24c3f33c199dee3be5d753 |
| ToxValDB_ECOTOX |
NOEL |
=6000 |
ppm |
Rat |
oral |
chronic; 97 days |
reproduction developmental |
LONG_REF=Alcohol Alcohol.37(1): 30-37 Ren,J., L.E. Wold, M. Natavio, B.H. Ren, J.H. Hannigan, and R.A. Brown Influence of Prenatal Alcohol Exposure on Myocardial Contractile Function in Adult Rat Hearts: Role of Intracellular Calcium and Apoptosis 2002; TITLE=Influence of Prenatal Alcohol Exposure on Myocardial Contractile Function in Adult Rat Hearts: Role of Intracellular Calcium and Apoptosis; AUTHOR=Ren,J., L.E. Wold, M. Natavio, B.H. Ren, J.H. Hannigan, and R.A. Brown; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112952; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Length|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611316_15611352:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=71750935ad2afedda90b3f232ba1289a |
| ToxValDB_ECOTOX |
NOEL |
=10000 |
mg/kg bw/day |
Rat |
oral |
chronic; 8 months |
chronic |
LONG_REF=- | Toxicol. Lett.32(1-2): 9-18 Opacka,J., B. Opalska, J. Kolakowski, and T. Wronska-Nofer Neurotoxic Effects of the Combined Exposure to Carbon Disulphide and Ethanol in Rats 1986; TITLE=Neurotoxic Effects of the Combined Exposure to Carbon Disulphide and Ethanol in Rats; AUTHOR=Opacka,J., B. Opalska, J. Kolakowski, and T. Wronska-Nofer; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Enzyme(s): beta-Glucuronidase | body weight changes, cerebtal cortex and hippocampus weight changes | morphological changes; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|gross pathology|multiple|urinalysis; STUDY_GROUP=ECOTOX:15613600:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=8d55828b2c219e719d8a8be30d780d9d |