Is Endonuclease V safe in cosmetics?
Endonuclease V has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Endonuclease V
INCI: ENDONUCLEASE
Endonuclease V (CAS Not specifically assigned for cosmetic grade; enzyme EC 3.2.2.28) is a cosmetic cosmetic ingredient functioning as Skin protecting — DNA repair enzyme that cleaves abasic sites in UV-damaged DNA. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
Not specifically assigned for cosmetic grade; enzyme EC 3.2.2.28
View industrial chemical safety profile →
Function
Skin protecting — DNA repair enzyme that cleaves abasic sites in UV-damaged DNA
Safety Rating
GOOD
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — not prohibited or restricted under 21 CFR; enzymes used in cosmetics subject to standard safety substantiation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Endonuclease V.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_pollution
{"cas_number": "9025-43-8", "ingredient_class": "other", "primary_mechanism": "DNA_repair", "pollution_types_targeted": "UV_A/PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibition": "…
Expert Verdict
Expert safety assessment and concern-level summary for Endonuclease V.
Regulatory Flags
potential-allergen
Frequently Asked Questions
Is Endonuclease V allowed in the EU?
Endonuclease V EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Endonuclease V do in cosmetics?
Endonuclease V functions as: Skin protecting — DNA repair enzyme that cleaves abasic sites in UV-damaged DNA. It is classified as a cosmetic ingredient in our database. CAS number: Not specifically assigned for cosmetic grade; enzyme EC 3.2.2.28.
Compliance Tools
Check Endonuclease V compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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