Is Dodecene-1 safe in cosmetics?
Dodecene-1 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Dodecene-1
Also known as: alpha-Dodecene, alpha-Dodecylene, EINECS 203-968-4, UNII-WYE669F3GR, N-Dodecene
INCI: DODECENE
Dodecene-1 (CAS 112-41-4) is a cosmetic cosmetic ingredient functioning as Masking, Solvent, Viscosity controlling. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 112-41-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dodecene-1 is classified GHS Danger (H304, H315, H227, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Masking, Solvent, Viscosity controlling
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
dodec-1-ene
InChIKey
CRSBERNSMYQZNG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA cosmetic restriction; used at low levels as masking agent and solvent
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dodecene-1.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
If swallowed the substance easily enters the airways and could result in aspiration pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dodecene-1 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1567
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritating to the skin and eyes.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Defoamer
Deodorizer
Flavouring and nutrient
Solvent
Viscosity modifier
Expert Verdict
Expert safety assessment and concern-level summary for Dodecene-1.
Regulatory Flags
solvent
masking-agent
hydrocarbon
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dodecene-1 by CAS number or substance name.
Studies
9
Lowest NOAEL
101 mg/kg bw/day
Highest NOAEL
1010 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
alpha-Dodecene
alpha-Dodecylene
EINECS 203-968-4
UNII-WYE669F3GR
N-Dodecene
Chemical Function
Solvent
Deodorizer
Viscosity modifier
Flavouring and nutrient
Defoamer
Regulatory Lists
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1872885
Frequently Asked Questions
Is Dodecene-1 allowed in the EU?
Dodecene-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dodecene-1 do in cosmetics?
Dodecene-1 functions as: Masking, Solvent, Viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 112-41-4.
Is Dodecene-1 used outside cosmetics?
Dodecene-1 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dodecene-1 have different safety status in cosmetics vs industrial chemicals?
Dodecene-1 is classified GHS Danger (H304, H315, H227, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dodecene-1 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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