Is Dodecanedioic Acid safe in cosmetics?
Dodecanedioic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Dodecanedioic Acid
Also known as: EINECS 211-746-3, UNII-978YU42Q6I, 1,10-Decanedicarboxylate, 1,12-Dodecanedioate, Decamethylenedicarboxylate (+5 more)
INCI: DODECANEDIOIC ACID
Dodecanedioic Acid (CAS 693-23-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; pH adjuster; monomer for polymer synthesis. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 693-23-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent; pH adjuster; monomer for polymer synthesis
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
dodecanedioic acid
InChIKey
TVIDDXQYHWJXFK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — TSCA listed; no 21 CFR cosmetic restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dodecanedioic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Dodecanedioic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1800 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =2400 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dodecanedioic Acid across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chemical reaction regulator
Corrosion inhibitor
Flow promoter
Softener and conditioner
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Dodecanedioic Acid.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Dodecanedioic Acid by CAS number or substance name.
Studies
17
Lowest NOAEL
460.6 mg/kg bw/day
Highest NOAEL
2400 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
EINECS 211-746-3
UNII-978YU42Q6I
1,10-Decanedicarboxylate
1,12-Dodecanedioate
Decamethylenedicarboxylate
Dodecanedioate
N-Dodecane-a,w-dioate
N-Dodecane-a,w-dioic acid
N-Dodecanedioate
SL-AH
Chemical Function
Softener and conditioner
Corrosion inhibitor
Chemical reaction regulator
Flow promoter
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182356
Frequently Asked Questions
Is Dodecanedioic Acid allowed in the EU?
Dodecanedioic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dodecanedioic Acid do in cosmetics?
Dodecanedioic Acid functions as: Skin conditioning agent; pH adjuster; monomer for polymer synthesis. It is classified as a cosmetic ingredient in our database. CAS number: 693-23-2.
What is the NOAEL for Dodecanedioic Acid?
The NOAEL (No Observed Adverse Effect Level) for Dodecanedioic Acid is =1800 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Dodecanedioic Acid used outside cosmetics?
Dodecanedioic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dodecanedioic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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