Is Diretinyl Ether safe in cosmetics?
Diretinyl Ether has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Diretinyl Ether
Also known as: UNII-3915JD4G86, Retin, 15,15'-oxybis-, Chebiretiether
INCI: DIRETINYL ETHER
Diretinyl Ether (CAS 442662-30-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent (retinoid derivative — ether of two retinol molecules). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 442662-30-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent (retinoid derivative — ether of two retinol molecules)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[(1E,3E,5E,7E)-9-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoxy]-3,7-dimethylnona-1,3,5,7-tetraenyl]-1,3,3-trimethylcyclohexene
InChIKey
ALMBISBNVAOMCL-XBWCUBMNSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — not restricted under 21 CFR Parts 700–740
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diretinyl Ether.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Diretinyl Ether.
Known Synonyms
UNII-3915JD4G86
Retin, 15,15'-oxybis-
Chebiretiether
Chemical Function
Softener and conditioner
Antioxidant
Frequently Asked Questions
Is Diretinyl Ether allowed in the EU?
Diretinyl Ether EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diretinyl Ether do in cosmetics?
Diretinyl Ether functions as: Skin conditioning agent (retinoid derivative — ether of two retinol molecules). It is classified as a cosmetic ingredient in our database. CAS number: 442662-30-8.
Compliance Tools
Check Diretinyl Ether compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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DISODIUM GLUCARATE/GLUCONATE/GLUCURONATE/GLYCOLATE/KETOGLUCONATE/OXALATE/TARTRATE/TARTRONATE
Good
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Chelating
DISODIUM SELENITE
Moderate
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Not Reported
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