NOAEL Studies Cosmetic Ingredient

Diphenyl Ether NOAEL Studies

INCI: DIPHENYL ETHER

CAS: 101-84-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 540 mg/kg bw/day rat oral 60 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =15 mg/kg bw/day Rat oral: unspecified 90 days subchronic EFSA FEEDAP - 2012 - OutputID 155 - body weight - systemic - Scientific Opinion on the safety and efficacy of aromatic ethers including anisole derivatives (chemical group 26) when used as feed additives for all animal species - doi:10.2903/j.efsa.2012.2678
NTP_ICE_acute_oral 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 <3210 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_215; row=15438; data_type=In Vivo; mixture=Chemical; chemical_name=Diphenyl oxide; preferred_name=Diphenyl oxide; dtxsid=DTXSID9021847; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021847; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021847; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =3990 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_216; row=15439; data_type=In Vivo; mixture=Chemical; chemical_name=Diphenyl oxide; preferred_name=Diphenyl oxide; dtxsid=DTXSID9021847; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021847; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021847; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2830 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_214; row=15440; data_type=In Vivo; mixture=Chemical; chemical_name=Diphenyl oxide; preferred_name=Diphenyl oxide; dtxsid=DTXSID9021847; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021847; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021847; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >2490 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_213; row=15441; data_type=In Vivo; mixture=Chemical; chemical_name=Diphenyl oxide; preferred_name=Diphenyl oxide; dtxsid=DTXSID9021847; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021847; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021847; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2450 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_212; row=15442; data_type=In Vivo; mixture=Chemical; chemical_name=Diphenyl oxide; preferred_name=Diphenyl oxide; dtxsid=DTXSID9021847; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021847; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021847; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=8472; RecordID=ARPathway2016_420; DatasetName=ARPathway2016; DTXSID=DTXSID9021847; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021847; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021847
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1802; Record_ID=skin_sensitization_invivo_561; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021847; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90244-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021847; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021847
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1801; Record_ID=skin_sensitization_invivo_561; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021847; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90244-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021847; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021847
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1804; Record_ID=skin_sensitization_invivo_561; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021847; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1974; Not available; 10.1016/0015-6264(74)90244-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021847; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021847
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =48731.4 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=DOE Protective Action Criteria:15518339:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afb8e096976eb89ceb58ee58e7ccc030
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat dermal subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d5de4b096bca8775808; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18130/7/6/4?documentUUID=4102217f-43fe-45f8-bc1a-f6d2da689e6a; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826143_15826144_15826145:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8692bb2d84f0a0fc4b370488682311e2
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab0de4b0a7c65d1b898f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/26601?documentUUID=2d328775-2b93-4ffa-9b20-2c0861103118; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=F1: gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECHA IUCLID:15861359:-:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f642cbe6c7c0e84a3717fdd2027f5a9e
ToxValDB_ECHA_IUCLID NOEL =100 mg/kg bw/day Rat dermal subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d5de4b096bca8775808; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18130/7/6/4?documentUUID=4102217f-43fe-45f8-bc1a-f6d2da689e6a; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826143_15826144_15826145:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5934c26117ab3a100f32e729bbea07b9
ToxValDB_ECHA_IUCLID NOEL =301 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c02df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18130/7/6/2?documentUUID=4102217f-43fe-45f8-bc1a-f6d2da689e6a; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15850143:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_18a1cbdbe71a5c0c53f27827fe587127
ToxValDB_ECHA_IUCLID NOEL =335 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaca9e4b0a7c65d1c02df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18130/7/6/2?documentUUID=4102217f-43fe-45f8-bc1a-f6d2da689e6a; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15850144:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0de6b52d76e0a4b89e2fe83d7e092f37
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =15 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of aromatic ethers including anisole derivatives (chemical group 26) when used as feed additives for all animal species. doi:10.2903/j.efsa.2012.2678.; TITLE=Scientific Opinion on the safety and efficacy of aromatic ethers including anisole derivatives (chemical group 26) when used as feed additives for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2678; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614084:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a8bfc20bf072f816d4402c4661edafe
ToxValDB_EU_SCOEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EU_SCOEL NOAEL =35 mg/m3 Rat inhalation subchronic; 33 days subchronic LONG_REF=Hefner RE, Leong BKJ, Kociba RJ. Gehring PJ (1975). Repeated inhalation toxicity of diphenyl oxide in experimental animals. Toxicol Appl Pharmacol 33:78-86.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d3559; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/130_diphenyl_ether_oel_en.pdf; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=irritation of the eyes and upper respiratory tract; STUDY_GROUP=EU SCOEL:15952406:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8afd7d800b6ee2416442e2322a9e3aca
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631548_15631549:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8bfe091d8bea580a03e43636f182f722
ToxValDB_GESTIS_DNEL DNEL systemic =59 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631548_15631549:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f932ded9c813b805cb6312a31beee58
ToxValDB_HPVIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS NOAEL >480 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=IITRI Project No. L8100 (Study no. 1482) Thirteen-Week Oral (diet) Toxicity Study of Diphenyl Ether in Rats; also published in The Toxicologist 12 (1):117 (1992).; TITLE=Thirteen-Week Oral (diet) Toxicity Study of Diphenyl Ether in Rats; AUTHOR=IITRI; QUALITY=1; EXTERNAL_SOURCE_ID=64279; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS:15639504:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b6c234b97abc3cf61d9e9f5c1a704a3a
ToxValDB_HPVIS NOAEL >=50 mg/kg bw/day Rat oral short-term; 10 days reproduction developmental LONG_REF=Solutia study no. BD-86-379. A Developmental Toxicity Study in Rats with THERMINOL VP-1 Heat Transfer Fluid.; TITLE=Solutia study no. BD-86-379. A Developmental Toxicity Study in Rats with THERMINOL VP-1 Heat Transfer Fluid; QUALITY=1; EXTERNAL_SOURCE_ID=59771; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS:15642854:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b3710cc94e61aa4d9293d8e9aafc08a6
ToxValDB_RSL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_RSL RfC =0.0004 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15656121:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a169112c60e5d45fcc38007737a11e2b
ToxValDB_RSL RfC =0.004 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663419:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_708738c6eac1a9e8dc395d8cc50b632f
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3O695R5M1U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3O695R5M1U"}
openFDA substances FDA UNII substance identifier 3O695R5M1U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3O695R5M1U"}
openFDA substances FDA UNII substance identifier 3O695R5M1U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3O695R5M1U"}
openFDA substances FDA UNII substance identifier 3O695R5M1U UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H10O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3O695R5M1U"}